Marina Konopleva, MD, PhD¹, Michael Thirman, MD², Keith W. Pratz, MD³, Anthony G. Letai, MD, PhD⁴, Christian Recher, MD, PhD⁵, Vinod A. Pullarkat, MD⁶, Hagop M. Kantarjian, MD⁷, Monique Dail, PhD^8*, Yinghui Duan, PhD^9*, Brenda J. Chyla⁹, Jalaja Potluri, MD⁹, Catherine Miller, PharmD^9*, Courtney D. Dinardo, MD, MSc⁷ and Andrew H. Wei, MBBS, PhD¹⁰

¹University of Texas, MD Anderson Cancer Center, Houston, TX
²Department of Medicine, Section of Hematology-Oncology, University of Chicago, Chicago, IL
³Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA
⁴Department of Medical Oncology, Dana-Farber Cancer Institute & HMS, Boston, MA
⁵Université de Toulouse III, Toulouse, France
⁶Department of Hematology and Hematopoietic Cell Transplantation and Gehr Family Center for Leukemia Research, City of Hope Comprehensive Cancer Center, Duarte, CA
⁷Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
⁸Genentech Inc., South San Francisco, CA
⁹AbbVie Inc., North Chicago, IL
¹⁰The Alfred Hospital and Monash University, Melbourne, VIC, Australia

Sabine Kayser, MD^1,2, Jan Moritz Middeke, MD^3*, Michael Kramer^4*, Katja Sockel, MD^3*, Sebastian Stasik, PhD^4*, Regina Herbst, MD^5*, Lars R. Fransecky, MD^6*, Dominik Wolf, Univ. Prof. Dr.⁷, Schumacher Martin, MD^8*, Alwin Krämer, MD^9,10*, Richard Noppeney, MD^11*, Juergen Novotny, MD^11*, Gesine Bug^12*, Katharina S. Götze¹³, Karsten Spiekermann, MD¹⁴, Matthias Stelljes, MD¹⁵, Jan-Henrik Mikesch, PD, MD^16*, Marion Subklewe, MD¹⁷, Antje Schubert^3*, Anke Mütherig, MD^3*, Tilmann Bochtler, MD^18,19*, Marika Mende, MD^3*, Friedrich Stoelzel, PD, MD⁴, Anne Kubasch, MD^20*, Malte Von Bonin, MD^21*, Mathias Haenel, MD^5*, Ulrich Duehrsen, MD²², Johannes Schetelig, MD, MSc⁴, Christoph Rollig, MD, MSC^4*, Claudia D Baldus, MD^23*, Gerhard Ehninger, MD^24,25, Carsten Müller-Tidow, MD^26*, Hubert Serve, MD, PhD²⁷, Martin Bornhäuser, MD^28*, Uwe Platzbecker, MD²⁹ and Christian Thiede, MD³

¹Department of Hematology, University Hospital of Leipzig, Leipzig, Germany
²German Cancer Research Center (DKFZ), Heidelberg, Germany
³Dept. of Internal Medicine I, University Hospital Carl Gustav Carus Dresden, Dresden, Germany
⁴Department of Internal Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany
⁵Department of Internal Medicine III, Klinikum Chemnitz, Chemnitz, Germany
⁶Hematology and Oncology, University Hospital Schleswig-Holstein, Kiel, Germany
⁷Department of Internal Medicine V, Medical University of Innsbruck, Innsbruck, Austria
⁸University Hospital Bonn, Bonn, Germany
⁹Department of Internal Medicine V, University Hospital Heidelberg, Heidelberg, Germany
¹⁰Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ) and Department of Internal Medicine V, Heidelberg, Germany
¹¹Department of Hematology, University Hospital of Essen, Essen, Germany
¹²Department of Medicine II, Hematology and Oncology, University Hospital Frankfurt, Goethe University, Frankfurt, Germany
¹³Department of Medicine III, Technical University of Munich, Munich, Germany
¹⁴Laboratory of Leukemia Diagnostics, Department of Medicine III, University Hospital, LMU Munich, Munich, Germany
¹⁵Deptartment of Medicine A, University of Muenster, Muenster, Germany
¹⁶University Hospital of Muenster, Muenster, Germany
¹⁷Department of Medicine III, University Hospital, LMU Munich, Munich, Germany
¹⁸Department of Internal Medicine V, University Hospital of Heidelberg, Heidelberg, Germany
¹⁹Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center, Heidelberg, Germany
²⁰Medical Clinic and Policlinic 1, Hematology and Cellular Therapy, University Hospital Leipzig, Leipzig, Germany
²¹Department of Internal Medicine I, University Hospital 'Carl Gustav Carus', TU Dresden, Dresden, Germany
²²Department of Hematology, University Hospital Essen, Essen, Germany
²³Medical Department II, Hematology and Oncology, University Hospital Schleswig-Holstein, Kiel, Germany
²⁴Cellex Gesellschaft für Zellgewinnung mbH, Dresden, Germany
²⁵Internal Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany
²⁶Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany
²⁷University Hospital, Department of Medicine II, Hematology/Oncology, Goethe University, Frankfurt, Germany
²⁸Department of Hematology and Oncology, University Hospital Carl Gustav Carus Dresden, Dresden, Germany
²⁹Hematology and Cellular Therapy, University Hospital Leipzig, Leipzig, Germany

William Donnellan, MD¹, Tao Xu^2*, Esprit Ma^3*, Huan Jin^3*, Melissa Montez^3*, Michelle Choi^4*, Grace Ku^3*, Raj Anand Rajeswaran^2*, Giridharan Ramsingh^3* and Evelyn M. Flahavan^5*

¹Sarah Cannon Research Institute, Nashville, TN
²F. Hoffmann-La Roche Ltd, Basel, Switzerland
³Genentech, Inc., South San Francisco, CA
⁴AbbVie Inc., North Chicago, IL
⁵Roche Products Ltd, Welwyn Garden City, United Kingdom

Katharina Waack^1,2,3*, Markus Schneider, PhD^4*, Christiane Walter, MSc^5*, Ursula Creutzig, MD^6*, Jan-Henning Klusmann⁷, Mareike Rasche, MD^4*, Heidrun Boztug^8*, Katharina Jansen, PhD^2,9*, Gabriele Escherich, MD^10*, Michael Frühwald, MD^11*, Michael Dworzak, MD, PhD^8* and Dirk Reinhardt, MD¹²

¹Center for Research Acceleration in Pediatrics, Essen, Germany
²Pediatric Research Network, Essen, Germany
³Pediatric Hematology/Oncology, University Hospital Essen, Essen, DEU
⁴Department of Pediatric Hematology and Oncology, University Hospital Essen, Essen, Germany
⁵Department of Pediatrics III, University Children's Hospital Essen, University of Duisburg-Essen, Essen, Germany
⁶Pediatric Hematology and Oncology, Medical School Hannover, Hannover, Germany
⁷Pediatric Hematology and Oncology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany
⁸St. Anna Children's Hospital and Cancer Research Institute, Medical University of Vienna, Vienna, Austria
⁹Pediatrics III, University Hospital Essen, Essen, Germany
¹⁰Department of Pediatric Hematology and Oncology, University Medical Center Hamburg, Hamburg, Germany
¹¹7Pediatric and Adolescent Medicine, Swabian Children´s Cancer Center, University Medical Center Augsburg, Augsburg, Germany
¹²Department of Pediatric Hematology and Oncology, Essen University Hospital, Essen, Germany

Sonja Loges, MD, PhD^1,2*, Michael Heuser³, Jörg Chromik, MD^4*, Carlos Enrique Vigil, MD⁵, Peter Paschka, MD⁶, Francesca Re, MD^7*, Nicola Di Renzo, MD^8*, Roberto M. Lemoli⁹, Daniele Giovanni Mattei, MD¹⁰, Isabel Ben-Batalla, PhD^11*, Monica Hellesoy, PhD^12*, Katherine Lorens, MD^13*, Joseph Birkett, PhD^13*, Stuart McPherson, BSc^13*, Jaya Nautiyal, PhD^13*, David Micklem, PhD^13*, Hani Gabra, MD, PhD, FRCPE, FRCP^13*, James B. Lorens, PhD^13,14*, Walter Fiedler, MD¹⁵, Yesid Alvarado, MD¹⁶ and Bjorn T. Gjertsen, MD, PhD¹⁷

¹University Medical Centre Manheim, Manheim, Germany
²German Cancer Research Centre (DKFZ), Heidelberg, Germany
³Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
⁴University Hospital Frankfurth, Frankfurt, Germany
⁵Vanderbilt Ingram Cancer Centre, Nashville, TN
⁶University Hospital Ulm, Ulm, Germany
⁷University of Parma, Parma, Italy
⁸Hematology and SCT Unit, Vito Fazzi Hospital, Lecce, Italy
⁹University of Genoa, Genoa, Italy
¹⁰Azienda Ospedaliera S. Croce e Carle, Cuneo, Italy
¹¹Medical Clinic and Institute of Tumor Biology, Campus Forschung, University Hospital Hamburg-Eppendorf, Hamburg, Germany
¹²Haukeland University Hospital, Bergen, Norway
¹³BerGenBio ASA, Bergen, Norway
¹⁴Centre for Cancer Biomarkers, University of Bergen, Bergen, Norway
¹⁵University Medical Center, Hamburg-Eppendorf, Hubertus-Wald University Cancer Center, Hamburg, Germany
¹⁶Department of Leukemia, MD Anderson Cancer Center, Houston, TX
¹⁷Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway

Amer M. Zeidan, MBBS, MHS¹, Prajwal C Boddu, MBBS², Brent L Wood, MD, PhD³, Daniel Zelterman^4*, Richard F. Little, MD, MPH⁵, S. Percy Ivy, MD^6*, Anne Caldwell^7*, Beatriz Sanchez-Espiridion^8*, Gheath Alatrash⁸, Elad Sharon, MD, MPH^9* and Jerald P. Radich, MD¹⁰

¹Section of Hematology, Department of Internal Medicine, Yale University School of Medicine and Yale Cancer Center, New Haven, CT
²Yale cancer center, Department of Hematology, Yale University School of Medicine, new haven, CT
³Department of Laboratory Medicine,, University of Washington, Seattle, WA
⁴Yale School of Public Health, New Haven, CT
⁵National Cancer Institute, Washington, DC
⁶National Cancer Institute Cancer Therapy Evaluation Program, Rockville, MD
⁷Yale cancer center, Yale University, new haven, CT
⁸MD Anderson Cancer Center, Houston, TX
⁹Division of Cancer Treatment and Diagnosis, National Cancer Institute, Cancer Therapy Evaluation Program, Bethesda, MD
¹⁰Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA

Nicholas J. Short, MD¹, Shouhao Zhou^2*, Chenqi Fu^2*, Donald Berry, MD, PhD^3*, Roland P Walter, MD PhD⁴, Sylvie D Freeman^5*, Christopher S. Hourigan, MD, DPhil⁶, Xuelin Huang, PhD^3*, Graciela M. Nogueras González, MPH^3*, Hyunsoo Hwang^3*, Xinyue Qi^3*, Hagop M. Kantarjian, MD¹ and Farhad Ravandi, MBBS¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA
³Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
⁵Institute of Immunology and Immunotherapy, University of Birmingham, Cheltenham, United Kingdom
⁶Laboratory of Myeloid Malignancies, Hematology Branch, NHLBI, Bethesda, MD

J. Erika Haydu, MD, PhD^1*, Yael Flamand^2*, Rahul S. Vedula, MD¹, Jurjen Versluis^3*, Anne Charles, BS^1*, Kevin Copson, MA^1*, Donna S. Neuberg, ScD², R. Coleman Lindsley, MD, PhD¹ and Marlise R Luskin, MD, MS⁴

¹Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
²Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA
³Department of Medical Oncology, Dana-Farber Cancer Institute, Jamaica Plain, MA
⁴Department of Medical Oncology, Dana-Farber Cancer Institute, Boston

Andrew J Klink, PhD, MPH^1*, Ronda Copher, PhD^2*, Russell L. Knoth^2*, Landon Marshall, PharmD, PhD^1*, Ying Hou, MD^1*, Ajeet Gajra, MD, MBBS¹ and Raoul Tibes, MD, PhD^3*

¹Cardinal Health Specialty Solutions, Dublin, OH
²Bristol Myers Squibb, Princeton, NJ
³Department of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany

Daehun Kwag, M.D.^1*, Byung Sik Cho, M.D., Ph.D.^2*, Gi June Min, M.D.^2,3*, Sung-Soo Park^2*, Silvia Park, M.D, Ph.D.^4*, Jae-Ho Yoon, M.D, Ph.D.^5*, Sung-Eun Lee, M.D, Ph.D.^6*, Ki-Seong Eom, M.D., Ph.D.^5*, Yoo-Jin Kim, M.D., Ph.D.⁵, Seok Lee, M.D., Ph.D.⁵, Chang-Ki Min, M.D, Ph.D.^7*, Seok-Goo Cho, M.D., Ph.D.^8*, Dong-Wook Kim, MD⁵, Jong Wook Lee, M.D., Ph.D.⁹ and Hee-Je Kim, M.D, Ph.D.⁵

¹Catholic Hematology Hospital, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)
²Department of Hematology, Catholic Hematology Hospital and Leukemia Research Institute, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)
³Catholic Blood and Marrow Transplantation Center, Division of Hematology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)
⁴Department of Hematology, Catholic Hematology Hospital and Leukemia Research Institute, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Seoul, Gangnam-Gu, Korea, Republic of (South)
⁵Department of Hematology, Catholic Hematology Hospital and Leukemia Research Institute, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Seoul, Korea, Republic of (South)
⁶Department of Hematology, Catholic Hematology Hospital and Leukemia Research Institute, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Houston, TX
⁷Division of Hematology, Department of Internal Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul, Korea, Republic of (South)
⁸Department of Haematology, Catholic Blood and Marrow Transplantation Center, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul, Korea, Republic of (South)
⁹Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)

Takeshi Kondo, MD, PhD¹, David Sanford, MD², Ciprian Tomuleasa, MD^3*, Hui-Hua Hsiao, MD^4*, Leonardo José Enciso Olivera, MD^5*, Anoop Kumar Enjeti, MBBS, FRCPA, FRACP, PhD, MD, MRCP⁶, Alberto Giménez Conca, MD^7*, Teresa Bernal del Castillo, MD, PhD^8*, Larisa Girshova, MD, PhD^9*, Maria Paola Martelli, MD, PhD¹⁰, Birol Güvenç, MD^11*, Alexander Tayco Delgado, MD^12*, Yinghui Duan, PhD^13*, Maria Belen Garbayo Guijarro, MBBS^14*, Cynthia Llamas, MS^13* and Je-Hwan Lee, MD, PhD¹⁵

¹Blood Disorders Center, Aiiku Hospital, Sapporo, Japan
²Leukemia/Bone Marrow Transplant Program of British Columbia, University of British Columbia, Vancouver, BC, Canada
³Department of Hematology, Ion Chiricuta Clinical Cancer Center, Cluj-Napoca, Romania
⁴Division of Hematology‐Oncology, Department of Internal Medicine, Kaohsiung Medical University Hospital and Kaohsiung Medical University, Kaohsiung, Taiwan
⁵Instituto Nacional de Cancerologia, Bogatá, Colombia
⁶Calvary Mater Newcastle Hospital, Sydney, Australia
⁷Section of Hematology, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
⁸Hospital Universitario Central Asturias, ISPA, IUOPA, Oviedo, Spain
⁹Federal State Budgetary Institution “Almazov National Medical Research Centre” of the Ministry of Health of the Russian Federation, St. Petersburg, Russian Federation
¹⁰Department of Medicine – Section of Hematology and Clinical Immunology, Perugia University, "Santa Maria della Misericordia" Hospital, Perugia, Italy
¹¹Department of Hematology, Faculty of Medicine, Çukurova University, Adana, Turkey
¹²AbbVie Inc., Singapore, Singapore
¹³AbbVie Inc., North Chicago, IL
¹⁴AbbVie Inc., Madrid, Spain
¹⁵Department of Hematology, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea, Republic of (South)

Daniel Rivera, MD^1*, Hagop M. Kantarjian, MD¹, Gautam Borthakur, MD¹, Marina Konopleva, MD, PhD², Rashmi Kanagal-Shamanna, MD³, Naveen Pemmaraju, MD⁴, Naval Daver, MD¹, Courtney D. DiNardo, MD, MSc⁵, Koichi Takahashi, MD, PhD¹, Elias Jabbour, MD¹, Guillermo Montalban-Bravo, MD^1*, Musa Yilmaz, MD¹, Sherry A. Pierce, BSN, BA^1*, Michael Andreeff, MD, PhD⁶, Kapil N. Bhalla, MD⁷, Guillermo Garcia-Manero, MD¹, Farhad Ravandi, MBBS¹ and Tapan M. Kadia, MD¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, University of Texas, MD Anderson Cancer Center, Houston, TX
³Department of Hematopathology, Division of Pathology/Lab Medicine, University of Texas MD Anderson Cancer Center, Houston, TX
⁴University of Texas MD Anderson Cancer Center, Department of Leukemia, Houston, TX
⁵Department of Leukemia, UT MD Anderson Cancer Center, Houston, TX
⁶Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁷Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX

Olga Salamero, MD^1*, Tim C.P Somervaille, PhD, FRCP, FRCPath², Antonieta Molero, MD^3*, Evelyn Acuña, MD^4*, Ana Perez, MD^5*, Isabel Cano, MD^4*, Rebeca Rodríguez-Veiga, MD^4*, Sonia Gutierrez^6*, Roger Bullock, MD^6*, Carlos Buesa, PhD^6*, Francesc Bosch, MD, PhD³ and Pau Montesinos, MD, PhD^7*

¹Department of Hematology, University Hospital Vall d’Hebron, Experimental Hematology, Vall d’Hebron Institute of Oncology (VHIO), Vall d’Hebron Barcelona Hospital Campus, Passeig Vall d'Hebron 119-129, 08035, Barcelona, Spain
²The Christie Hospital, Cancer Research UK Manchester Institute, Manchester, United Kingdom
³1. Servei d’Hematologia, Vall d’Hebron Hospital Universitari, Experimental Hematology, Vall d’Hebron Institute of Oncology (VHIO), Departament de Medicina, Universitat Autònoma de Barcelona,, Barcelona, Spain
⁴Hospital Universitario y Politécnico La Fe, Valencia, Spain
⁵Department of Hematology, University Hospital Vall d’Hebron, Barcelona, Spain
⁶Oryzon Genomics SA, Cornella de Llobregat, Spain
⁷Hospital Universitari i Politècnic La Fe, Valencia, Spain

Farhad Ravandi, MBBS¹, Christopher Pocock, MBBS², Dominik Selleslag, MD³, Pau Montesinos, MD, PhD^4*, Hamid Sayar, MD, MSc⁵, Maurizio Musso, MD^6*, Angela Figuera Alvarez^7*, Hana Safah, MD⁸, William Tse, MD, FACP^9*, Sang Kyun Sohn, MD, PhD^10*, Devendra Hiwase, MBBS, MD, FRACP, FRCPA, PhD¹¹, Timothy Chevassut^12*, Francesca Pierdomenico^13*, Ignazia La Torre^14*, Barry Skikne, MD^15,16*, Keshava Kumar, PhD^16*, Qian Dong, DrPH^16*, C.L. Beach, PharmD^16* and Hervé Dombret, MD^17,18

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Kent & Canterbury Hospital, Canterbury, United Kingdom
³AZ Sint-Jan Brugge-Oostende AV, Bruges, Belgium
⁴Hospital Universitari i Politecnic la Fe, Valencia, and CIBERONC Instituto de Salud Carlos III, Madrid, Spain
⁵Indiana University Cancer Center, Indianapolis, IN
⁶La Maddalena - Casa di Cura, Palermo, Italy
⁷Hospital Universitario de La Princesa, Madrid, Spain
⁸Section of Hematology and Medical Oncology, Department of Medicine, Tulane University, New Orleans, LA
⁹University of Louisville School of Medicine, Louisville, KY
¹⁰Kyungpook National University Hospital, Daegu, Korea, Republic of (South)
¹¹Royal Adelaide Hospital, Adelaide, Australia
¹²Haematology Department, Brighton & Sussex University Hospitals NHS Trust, Brighton, United Kingdom
¹³Portuguese Institute of Oncology Lisbon, Lisbon, Portugal
¹⁴Celgene, a Bristol-Myers Squibb Company, Boudry, Switzerland
¹⁵Kansas University Medical Center, Kansas City, KS
¹⁶Bristol Myers Squibb, Princeton, NJ
¹⁷Hôpital Saint-Louis, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France
¹⁸Institut de Recherche Saint Louis, Université de Paris, Paris, France

Giulia Petrone, MD, MBBS¹, Charles Gaulin, MBBS^2*, Andriy Derkach, PhD^3*, Sean M. Devlin, PhD^3*, Ashwin Kishtagari, MBBS⁴, Rekha Parameswaran, MD^5* and Eytan M. Stein, MD⁶

¹Internal Medicine, Icahn School of Medicine/Mount Sinai Morningside and West Hospital, New York City, NY
²Division of Hematology and Medical Oncology, Mayo Clinic, Phoenix, AZ
³Department of Biostatistics and Epidemiology, Memorial Sloan Kettering Cancer Center, New York, NY
⁴Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
⁵Department of Medicine, Hematology Service, Memorial Sloan Kettering Cancer Center, New York City, NY
⁶Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY

Mareike Rasche, MD^1*, Emma Steidel^1*, Martin Zimmermann^2*, Jean-Pierre Bourquin, MD, PhD³, Heidrun Boztug^4*, Iveta Janotová^5*, Edward A. Kolb, MD⁶, Thomas Lehrnbecher^7*, Nils Von Neuhoff, PhD^1*, Naghmeh Niktoreh^1*, Nora Muehlegger^4*, Lucie Sramkova, MD^5*, Jan Stary, MD, PhD^5*, Christiane Walter, MSc^1*, Ursula Creutzig, MD, PhD^2*, Michael Dworzak, MD, PhD^4* and Dirk Reinhardt, MD¹

¹Department of Pediatric Hematology and Oncology, University Hospital Essen, Essen, Germany
²Department of Paediatric Haematology and Oncology, Hannover Medical School, Hannover, Germany
³Division of Pediatric Oncology, and Children Research Center, University Children´s Hospital, Zurich, Switzerland
⁴St. Anna Children's Hospital and Cancer Research Institute, Medical University of Vienna, Vienna, Austria
⁵Department of Pediatric Hematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic
⁶Nemours/Alfred I. Dupont Hospital for Children, Wilmington, DE
⁷Division for Pediatric Hematology and Oncology, University of Frankfurt, Frankfurt, DEU

Anand Ashwin Patel, MD¹, Alexandra E Rojek, MD^2*, Howard Weiner^1*, Michael W. Drazer, MD^1*, Lucy A. Godley, MD, PhD¹, Michelle M. Le Beau, PhD³ and Richard A. Larson, MD^3,4

¹Department of Medicine, Section of Hematology-Oncology, University of Chicago, Chicago, IL
²Department of Medicine, University of Chicago, Chicago, IL
³University of Chicago Comprehensive Cancer Center, Chicago, IL
⁴Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL

Uttam K. Rao, MD, MBA¹, Heidi Chen, PhD^2*, Katie S. Gatwood, PharmD^3*, Michael T. Byrne, DO¹, Salyka M. Sengsayadeth, MD^1*, Stacey A. Goodman, MD^1*, Bhagirathbhai Dholaria, MBBS⁴, Adetola A. Kassim, MD, MS¹, Bipin N. Savani, MD¹, Wichai Chinratanalab, MD¹, Kathryn A. Culos, PharmD^3*, Michael R. Savona, MD¹ and Brian G. Engelhardt, MD¹

¹Department of Medicine, Division of Hematology and Oncology, Vanderbilt University Medical Center, Nashville, TN
²Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN
³Department of Pharmacy, Vanderbilt University Medical Center, Nashville, TN
⁴Department of Medicine, Division of Hematology and Oncology, Vanderbilt University Medical center, Nashville, TN

Veronica A Guerra, MD¹, Yasmin Alwash, MD², Yan Yuanqing, PhD^3*, Jorge M. Ramos Perez, MD^4*, Guillaume Richard-Carpentier, MD⁴, Ahmad S Alotaibi^4*, Hycienth O Ahaneku, MD, MPH, PhD⁴, Bachar Samra, MD^4*, Arrvind Raghunath, MD^4*, Guillermo Montalban-Bravo, MD^4*, Naveen Pemmaraju, MD⁴, Courtney D. DiNardo, MD, MSc⁴, Naval Daver, MD⁴, Gautam Borthakur, MD⁵, Jorge E. Cortes, MD^4,6, Farhad Ravandi, MBBS⁴, Hagop M. Kantarjian, MD⁴, Guillermo Garcia-Manero, MD⁴ and Tapan M. Kadia, MD⁴

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Miami, FL
²Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
³University of Texas Health Science Center, Department of Neurosurgery, Houston
⁴Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX
⁶Georgia Cancer Center Augusta University, Augusta, GA

Andrea Massimiliano Tomirotti, PhD^1*, Daniela Bellarosa^2*, Scott R. Solomon, MD³, Aziz Nazha, MD⁴, Stephen A Strickland, MD, MSCI⁵, Roland P Walter, MD PhD⁶, Farhad Ravandi, MBBS⁷, Krzysztof Brzózka, PhD⁸, Milena Mazan, PhD^9*, Simone Baldini, MD^10*, Massimiliano Salerno^11*, Monica Binaschi, PhD^12*, Dirk Laurent, MD^13* and Andrea Pellacani, PhD, MD^14*

¹Experimental and Translational Oncology Department, Menarini Ricerche S.p.A., Pomezia, Italy
²Experimental and Translational Oncology Department, Menarini Ricerche S.p.A., Pomezia (Rome), Italy
³Leukemia Program, Northside Hospital Cancer Center Institute, Atlanta, GA
⁴Cleveland Clinic, Cleveland
⁵Vanderbilt University Medical Center, Nashville, TN
⁶Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
⁷MD Anderson Cancer Center, Houston, TX
⁸Ryvu Therapeutics S.A., Cracow, Poland
⁹Ryvu Therapeutics, Cracow, Poland
¹⁰Menarini Ricerche S.p.A., Firenze, Italy
¹¹Experimental and Translational Oncology Department, Menarini Ricerche S.p.A., Pomezia (RM), Italy
¹²Preclinical and Translational Sciences, Menarini Ricerche S.p.A., Pomezia (RM), Italy
¹³Menarini Ricerche/BERLIN-CHEMIE AG, Berlin, Germany
¹⁴Menarini Ricerche S.p.A., Firenze, Florence, Italy

Kensuke Matsuda, MD¹, Taisuke Jo^2*, Kazuhiro Toyama, MD, PhD^3*, Kumi Nakazaki^3*, Hideo Yasunaga, MD, PhD^4* and Mineo Kurokawa, MD, PhD³

¹University, Bunkyo-Ku, TKY, Japan
²Department of Health Services Research, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
³Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
⁴Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Tokyo, Japan

Caitlin R. Rausch, PharmD^1*, Adam DiPippo, PharmD^1*, Prithviraj Bose, MD² and Dimitrios P. Kontoyiannis, MD^3*

¹Department of Pharmacy, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Infectious Diseases, The University of Texas MD Anderson Cancer Center, Houston, TX

Claire Andrews^1*, Eshetu G Atenafu, M.Sc., P.Stat^2*, Georgina S. Daher-Reyes, MD^1*, Taylor Young^1*, Steven M Chan, MD, PhD¹, Vikas Gupta, MD, FRCP, FRCPath¹, Dawn Maze, MD, FRCPC, MSc³, Caroline J McNamara, MBBS¹, Mark D. Minden¹, Tracy Murphy, MD, FRCP, FRCPath¹, Aaron D Schimmer, MD, PhD¹, Andre C. Schuh¹, Karen W.L. Yee, MD¹ and Hassan Sibai, MBBS^1*

¹Leukemia Program, Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
²Department of Biostatistics, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
³Leukemia Program, Division of Medical Oncology and Hematology, The Ottawa Hospital, Toronto, ON, Canada

Jacopo Nanni, MD^1*, Ernesta Audisio, MD^2*, Maria Benedetta Giannini, MD^3*, Barbara MD Scappini^4*, Benedetta Cambò, MD^5*, Francesco Albano^6*, Maria Paola Martelli, MD, PhD⁷, Alessandro Cignetti, MD, PhD⁸, Gian Matteo Rigolin^9*, Nicola Fracchiolla, MD^10*, Monica Bocchia^11*, Claudio Romani^12*, Elisabetta Todisco, MD PhD^13*, Monia Lunghi, MD, PhD^14*, Anna Maria Mianulli, MD^15*, Daniela Cilloni, MD, PhD^16*, Elisabetta Petracci^17*, Irene Valli^17*, Chiara Zingaretti^17*, Claudio Cerchione, MD, PhD³, Delia Cangini^3*, the FLAM collaborative Group^17*, Cristina Papayannidis, MD, PhD¹⁸ and Giovanni Martinelli, MD¹⁹

¹Institute of Hematology “L. and A. Seràgnoli”, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy
²SC Ematologia 2, Dipartmento di Ematologia e Oncologia, AOU Città della Salute e della Scienza, Torino, Italy
³Hematology Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola (FC), Italy
⁴Azienda Ospedaliero-Universitaria Careggi, AOU Careggi, SODc Ematologia, Florence, ITA
⁵Department of Medicine and Surgery, Hematology and BMT Unit, University of Parma, Parma, Italy
⁶Hematology and Stem cell Transplantation Unit - Department of Emergency and Organ Transplantation (D.E.T.O.) - University of Bari, Bari, Italy
⁷Department of Medicine – Section of Hematology and Clinical Immunology, Perugia University, "Santa Maria della Misericordia" Hospital, Perugia, Italy
⁸Divisione Universitaria di Ematologia e Terapie Cellulari, A.O. Ordine Mauriziano, Turin, Italy
⁹Hematology, St. Anna University Hospital, Cona, Ferrara, Italy
¹⁰UOC Oncoematologia, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Di, Milan, ITA
¹¹Hematology, University of Siena, Siena, Italy
¹²Ematologia e CTMO, Ospedale Businco, AOB, Cagliari, Cagliari, CA, ITA
¹³European Institute of Oncology, Milano, Italy
¹⁴Division of Hematology, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy
¹⁵Ospedale Infermi, AUSL Romagna, UOC Ematologia, Rimini, ITA
¹⁶Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
¹⁷IRST IRCCS, Istituto Scientifico per lo Studio e la Cura dei Tumori, Meldola, Italy
¹⁸Institute of Hematology "L. e A. Seràgnoli", Department of Oncology and Hematology, Azienda Ospedaliero-Universitaria S. Orsola-Malpighi, Bologna, Italy
¹⁹Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori IRST IRCCS, Meldola, Italy

Daniel R Reed, MD¹, John Wang^2*, Ramey Elsarrag, MS/MD^3*, Krista M. Isaac, MD^4* and Michael K Keng, MD⁴

¹Section on Hematology/Oncology, Wake Forest Baptist Health Comprehensive Cancer Center, Clemmons, NC
²University of Virginia, Charlottesville, VA
³University of Virginia Health System, Charlottesville, VA
⁴Division of Hematology/Oncology, University of Virginia Health System, Charlottesville, VA

Alex Legg^1*, Tracey Ellison^2*, Matthew O'Connell^2* and Mark Evans^2*

¹Jazz Pharmaceuticals, Oxford, United Kingdom
²Harvey Walsh, Runcorn, United Kingdom

Xia Bi, MD, MS¹, Zachary French, MD^2*, Margaret Kasner, MD, MSc³, Gina Keiffer, MD³, Lindsay Wilde, MD³ and Neil Palmisiano, MD, MS³

¹Department of Medical Oncology, Thomas Jefferson University, Bear, DE
²Department of Medicine, Thomas Jefferson University, Philadelphia, PA
³Division of Hematologic Malignancies and Hematopoietic Stem Cell Transplantation, Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA

Zaid Abdel Rahman, MD¹, Yesesri Cherukuri^2*, Michael G. Heckman^3*, Laura E. Finn, MD⁴, Liuyan Jiang, MD⁵, Lisa Z. Sproat, MD⁶, James R. Cerhan, MD, PhD⁷, Yan Asmann, PhD² and James M. Foran, MD¹

¹Division of Hematology and Medical Oncology, Mayo Clinic, Jacksonville, FL
²Division of Biomedical Statistics and Informatics, Mayo Clinic, Jacksonville, FL
³Biostatistics & Health Sciences Research, Mayo Clinic, Jacksonville, FL
⁴Ochsner Medical Center, New Orleans, LA
⁵Department of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL
⁶Division of Hematology and Medical Oncology, Mayo Clinic, Phoenix, AZ
⁷Division of Hematology, Mayo Clinic, Rochester, MN