-Author name in bold denotes the presenting author
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503.P1.12 503. Clonal Hematopoiesis: Aging and Inflammation: Poster I

Program: Oral and Poster Abstracts
Type: Poster
Hematology Disease Topics & Pathways:
Adult, AML, HSCs, Animal models, Diseases, Non-Biological, Therapies, Adverse Events, chemotherapy, MDS, Biological Processes, DNA repair, Technology and Procedures, Cell Lineage, epigenetics, Lymphoid Malignancies, Study Population, Clinically relevant, genomics, Myeloid Malignancies, hematopoiesis, pharmacology, immune mechanism, WGS
Saturday, December 5, 2020: 7:00 AM-3:30 PM
920
Therapy Related Myeloid Neoplasm Post PARP Inhibitors: Potential Clonal Selection.

Jean-Edouard Martin1*, Sabine Khalife-Hachem1*, Thomas Grinda1*, Maria Kfoury1*, Sylvain Garciaz2*, Florence Pasquier, MD, PhD3*, Jacques Vargaftig4*, Madalina Uzunov, MD5*, Amine Belhabri, MD6*, Sarah Bertoli, MD, PhD7*, Nathalie Auger1*, Veronique Saada8*, Christel Guillouf1*, Iléana Antony-Debre, PhD9*, Etienne Rouleau1*, Flore Salviat1*, Olivier Caron1*, Patricia Pautier1*, Gabriel Etienne, MD, PhD10*, Norbert Vey, MD11, Filippo Rosselli1*, Stephane De Botton, MD, PhD12*, Alexandra Leary1*, Christophe Marzac, MD13* and Jean-Baptiste Micol, MD14

1Gustave Roussy, Villejuif, France
2Institut Paoli Calmettes, Institut Paoli-Calmettes, Marseille, France
3Gustave Roussy, Département clinique d'hématologie, INSERM UMR1170, Villejuif, FRA
4Institut Curie, Paris, France
5Hopital Pitié-Salpetriere, Paris, France
6Centre Leon Berard, Departement Oncologie Medicale, Lyon, France
7Hematology Department, Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse, France
8Département de Biologie-Pathologie, Gustave Roussy, Université Paris-Saclay, Villejuif, France
9Inserm UMR1170, Gustave Roussy, Villejuif, France
10Institute Bergonie; Institut National de la Sante et de la Recherche Medicale; Groupe France Intergroupe des Leucemies Myeloides Chroniques, Hopital Haut-Leveque, Pessac, France
11Hematologie clinique, Institut Paoli Clamettes, Marseille, France
12Department of Haematology, Institut Gustave Roussy, Villejuif, France
13Département de biologie-pathologie, Gustave Roussy, Université Paris-Saclay, Villejuif, France
14Gustave Roussy cancer center, Villejuif, France
921
Rhesus Macaques As Natural Models for Age-Related Clonal Hematopoiesis

Yifan Zhou, MS1,2*, Kyung-Rok Yu, PhD1, Taehoon Shin3*, Xing Fan, MD1*, Margarete Alice Fabre2*, Naoya Uchida, MD4, John F. Tisdale, MD4, So Gun Hong, PhD1*, George S. Vassiliou, MD, PhD, FRCPath, MRCP2* and Cynthia E. Dunbar, MD1

1Translational Stem Cell Biology Branch, National Heart, Lung, and Blood Institute, National Institute of Health, Bethesda, MD
2Wellcome Trust Sanger Institute, University of Cambridge, Cambridge, United Kingdom
3Translational Stem Cell Biology Branch, National Heart, Lung, and Blood Institute, National Institute of Health, BETHESDA, MD
4Cellular and Molecular Therapeutics Branch, NHLBI, National Heart, Lung, and Blood Institute, Bethesda, MD
922
Clonal Hematopoiesis in Patients Receiving Immune Checkpoint Inhibitor Therapy

Abhay Singh, MBBS, MPH1, Nuria Mencia-Trinchant, PhD2*, Elizabeth A. Griffiths, MD3,4, Matthew Gravina, MD5*, Rutaba Tajammal, MD5*, Mark G. Faber, DO6, Annmarie Nowak4*, Marc S. Ernstoff, MD4*, LunBiao Yan, PhD7*, Megan M. Herr, PhD8*, Duane C. Hassane, PhD9,10, Monica L. Guzman, PhD11,12, Eunice S. Wang, MD13,14, Amanda Przespolewski, DO15,16 and Swapna Thota, MD4

1Roswell Park Comprehensive Cancer Center, Williamsville, NY
2Division of Hematology and Oncology, Weill Cornell Medicine and The New York-Presbyterian Hospital, New York, NY
3Leukemia Service, Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY
4Roswell Park Comprehensive Cancer Center, Buffalo, NY
5University at Buffalo, Buffalo, NY
6University at Buffalo/Roswell Park Comprehensive Cancer Center, Buffalo, NY
7Weill Cornell Medicine, New York
8Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY
9Caryl & Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY
10Division of Hematology and Oncology, Weill Cornell Medical College, New York, NY
11Division of Hematology and Oncology, Weill Cornell Medical College Division of Hematology/Oncology, New York, NY
12Department of Pharmacology in Medicine, Weill Medical College of Cornell University, New York, NY
13Leukemia Service, Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY
14Roswell Park Comprehensive Cancer Center, BUFFALO, NY
15Medicine, Roswell Park Comprehensive Cancer Center, East Aurora, NY
16Department of Medicine, Leukemia Division, Roswell Park Comprehensive Cancer Center, Buffalo, NY
923
Correlation of Mutation Patterns with Patient Age in 2656 Cases with 11 Different Hematological Malignancies

Anna Stengel, PhD, Manja Meggendorfer, PhD, Wolfgang Kern, MD, Torsten Haferlach, MD and Claudia Haferlach, MD

MLL Munich Leukemia Laboratory, Munich, Germany
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*signifies non-member of ASH