62nd ASH Annual Meeting and Exposition: 502. Hematopoiesis: Regulation of Gene Transcription, Cytokines, Signal Transduction, Apoptosis, and Cell Cycle Regulation: Poster I

Oral and Poster Abstracts
Poster

AML, Bleeding and Clotting, Diseases, platelets, ITP, Biological Processes, Cell Lineage, epigenetics, Myeloid Malignancies, Thrombocytopenias, hematopoiesis, iron metabolism, iron transport

915

Regulation of Ribosomal RNA Synthesis in Myeloid Progenitors By Cell Type Specific Transcription Factors

Charlesantony Aruljothi, PhD¹, Subin S George¹^*, Patrick Somers¹^*, Justin Blum¹^*, Chelsea Thorsheim²^*, Maxim Pimkin, MD, PhD³ and Vikram R Paralkar, MD¹

¹Division of Hematology/Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA
²University of Pennsylvania, Philadelphia, PA
³Dana-Farber Cancer Institute, Boston Children's Hospital, Harvard Medical School, Brookline, MA

916

TWIST1 Preserves Hematopoietic Stem Cell Function Via Repression of Cacna1b Expression

Nan Wang¹^*, Jing Yin²^*, Na You²^*, Dan Guo²^*, Yangyang Zhao³^*, Yongxin Ru, MD⁴^*, Xiaoyan Liu¹^*, Hui Cheng³^*, Qian Ren⁵^*, Tao Cheng⁶ and Xiao-Tong Ma, PhD⁷^*

¹Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sc, Tianjin, China
²Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sc, Tianjin, CHN
³State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
⁴Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, Tianjin, China
⁵State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
⁶State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, China
⁷State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, CHN

917

Reduction of ARHGAP21 Alters Platelet Biogenesis in Vitro and Accelerates Hemostatic Response In Vivo

Mariana Lazarini, PhD^1,2^*, Vanessa Bernusso, MSc²^*, Karla P.V Ferro, Ph.D²^*, Adriana Silva Santos Duarte, PhD²^*, Cristina Pontes Vicente, PhD³^*, Erich V De Paula, MD, PhD² and Sara T Olalla Saad, MD, PhD²

¹Department of Pharmaceutical Sciences, Federal University of São Paulo, Diadema, Brazil
²Hematology and Blood Transfusion Center, University of Campinas, Campinas, Brazil
³Department of Structural and Functional Biology, University of Campinas, Campinas, Brazil

918

Pp90RSK Isoforms Play Distinct Roles during Hematopoiesis

Minyoung Youn, PhD^*, Hee-Don Chae, PhD^*, Jesus Omar Gomez^* and Kathleen M. Sakamoto, MD, PhD

Department of Pediatrics, Stanford University School of Medicine, Stanford, CA

919

The Role of 5-HT on Proplatelet Formation and Thrombopoietin Production

Mo Yang¹^*, Enyu Liang, PhD²^*, Jieyu Ye, PhD³^*, Beng H Chong, MBBS, PhD^4,5 and Liang Li, PhD¹^*

¹The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China
²Department of Laboratory Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
³Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China
⁴Medicine, University of New South Wales, Kogarah, Australia
⁵St George Hospital, Sydney, Australia

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^*signifies non-member of ASH

502.P1.15 502. Hematopoiesis: Regulation of Gene Transcription, Cytokines, Signal Transduction, Apoptosis, and Cell Cycle Regulation: Poster I