Jakob Woerner^1*, Yidi Huang, MS^2*, Yimin Huang^3*, Janet Wang, BS^4*, Jesus M Hernández-Sánchez, PhD^5*, Jaroslaw P. Maciejewski, MD, PhD⁶, Mehmet Koyuturk, PhD^1*, Stephan Hutter, PhD^7*, Torsten Haferlach, MD⁷ and Thomas Laframboise, PhD^4*

¹Case Western Reserve University, Cleveland
²Case Western Reserve University, Cleveland, OH
³Case Western Reserve University, Clevelans, OH
⁴Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH
⁵Universidad de Salamanca, IBSAL, Salamanca, Spain
⁶Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
⁷MLL Munich Leukemia Laboratory, Munich, Germany

Yang Mei, PhD^1,2, Yijie Liu, PhD², Xu Han, PhD^2*, Jing Yang, PhD^2* and Peng Ji, MD, PhD²

¹College of Biology, Hunan University, Changsha, Hunan, China
²Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL

David B. Beck, MD, PhD^1*, Zhijie Wu, MD^2*, Bhavisha A Patel, MD², Marcela A Ferrada, MD^3*, Keith A Sikora, MD^4*, Amanda Ombrello, MD^5*, Alina E. Dulau Florea, MD^4*, Weixin Wang, Ph.D.^6*, Emma M. Groarke, MD², Shawn M. Burgess, PhD^7*, Ivona A Aksentijevich, MD^1*, Achim A Werner, PhD^1*, Neal S. Young, MD², Katherine Calvo, MD, PhD⁸, Daniel L Kastner, MD PhD^9* and Peter C Grayson, MD^10*

¹National Institutes of Heath, Bethesda, MD
²Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
³National Institutes of Heath, Bethesda, DC
⁴National Institutes of Health, Bethesda, MD
⁵National Human Genome Research Institute, NIH, National Institutes of Health, Bethesda, MD
⁶Hematology Section, Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD
⁷NHGRI, NIH, Bethesda, MD
⁸Hematology Section, Department of Laboratory Medicine, National Institutes of Health, Bethesda, MD
⁹National Human Genome Research Institute, National Institutes of Heath, Bethesda, MD
¹⁰NIAMS/NIH, Bethesda

Monika M Kutyna, MSc^1,2*, Li Yan A Wee, BSc (Hons)^1,3*, Sharon Paton, BSc^1,4*, Dimitrios Cakouros, PhD^1,4*, Agnieszka Arthur, PhD^1,4*, Rakchha Chhetri, MBBS^1,3*, Andreas W Schreiber, PhD^5,6*, Chung Hoow Kok, PhD, BSc^1,7, Deepak Singhal, MBBS, MD, FRACP, FRCPA^1,2,8, Daniel Thomas, MD, PhD^9,10,11,12, Timothy P. Hughes, MD, MBBS, FRACP, FRCPA^1,11,13,14, David Campbell, PhD, B.M.B.S., F.R.A.C.S., F.A.Oth.A^11,15*, Stan Gronthos, PhD^1,4* and Devendra Hiwase, MBBS, MD, FRACP, FRCPA, PhD^8,11,16

¹Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia
²Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, Australia
³Department of Haematology, Central Adelaide Local Health Network, Adelaide, SA, Australia
⁴Mesenchymal Stem Cell Laboratory, Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, Australia
⁵School of Biological Sciences, University of Adelaide, Adelaide, SA, Australia
⁶ACRF Cancer Genomics Facility, SA Pathology, Adelaide, Australia
⁷Adelaide Medical School, The University of Adelaide, Adelaide, Australia
⁸Department of Haematology, Royal Adelaide Hospital and SA Pathology, Adelaide, SA, Australia
⁹Department of Medicine, Division of Hematology, Stanford University, Stanford, CA
¹⁰Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA
¹¹Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, Australia
¹²Precision Medicine Theme, South Australian Health and Medical Research Instiute, Adelaide, SA, Australia
¹³Australasian Leukaemia and Lymphoma Group, Melbourne, Australia
¹⁴Department of Haematology, Royal Adelaide Hospital, Adelaide, Australia
¹⁵Wakefield Orthopaedic Clinic, Calvary Wakefield Hospital, Adelaide, Australia
¹⁶Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, Australia

Hideki Makishima, MD, PhD¹, Yasuhito Nannya, MD, PhD¹, June Takeda, MD^2*, Yukihide Momozawa, DVM, Ph.D^3*, Ryunosuke Saiki, MD^4*, Tetsuichi Yoshizato, MD, PhD⁴, Yoshiko Atsuta, MD, PhD^5,6*, Yuka Iijima-Yamashita^7*, Kenichi Yoshida, MD, PhD^1*, Yuichi Shiraishi, PhD^8*, Yasunobu Nagata, MD, PhD^1*, Yusuke Shiozawa, MD, PhD^9*, Makoto Onizuka, MD, PhD¹⁰, Kenichi Chiba^11*, Hiroko Tanaka^12*, Nobuyuki Kakiuchi, M.D.^1*, Yotaro Ochi, MD^1*, Hiroo Ueno, MD, PhD^2*, Hidehiro Itonaga, MD, PhD^13*, Yoshinobu Kanda, MD, PhD¹⁴, Masashi Sanada, MD¹⁵, Ayana Kon, MD, PhD^1*, Yasushi Miyazaki, MD, PhD¹⁶, Keizo Horibe, MD, PhD^15*, Maria Creignou^17*, Magnus Tobiasson, MD^18,19*, Hisashi Tsurumi, MD, PhD²⁰, Senji Kasahara, MD, PhD²¹, Chantana Polprasert, MD^22*, Eva Hellstrom Lindberg, MD, PhD^23,24, Akifumi Kondo Takaori, MD, PhD^25*, Toru Kiguchi, MD, PhD^26*, Mario Cazzola²⁷, Fumihiko Matsuda, MD, PhD^28*, Kazuma Ohyashiki, MD, PhD²⁹, Jaroslaw P. Maciejewski, MD, PhD³⁰, Torsten Haferlach, MD³¹, Yoichiro Kamatani, MD, Ph.D^32*, Michiaki Kubo, MD, Ph.D^33*, Satoru Miyano, PhD^34* and Seishi Ogawa, MD, PhD^4,35

¹Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan
²Department of Pathology and Tumor Biology, Kyoto University, Kyoto, KYO, Japan
³Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
⁴Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
⁵Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan
⁶Department of Healthcare Administration, Nagoya University, Nagoya, Japan
⁷Department of Advanced Diagnosis, Clinical Research Center, Nagoya Medical Center, Nagoya, Japan
⁸Center for Cancer Genomics and Advanced Therapeutics, National Cancer Center Research Institute, Tokyo, Japan
⁹Department of Biochemistry and Molecular Biology, Nippon Medical School, Tokyo, Japan
¹⁰Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Japan
¹¹Division of Cellular Signaling, National Cancer Center Research Institute, Tokyo, Japan
¹²Department of Integrated Data Science, M&D Data Science Center, Tokyo Medical and Dental University, Tokyo, Japan
¹³Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan
¹⁴Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan
¹⁵Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
¹⁶Atomic Bomb Disease Institute, Nagasaki University Hospital, Nagasaki, Japan
¹⁷Karolinska University Hospital, Stockholm, Sweden, Karolinska Institutet, Linköping, SWE
¹⁸Karolinska University Hospital, Stockholm, Sweden
¹⁹Center for Hematology and Regenerative Medicine, Department of Medicine, Karolinska University Hospital Huddinge, Karolinska Institute, Stockholm, Sweden
²⁰Hematology, Gifu University Graduate School of Medicine, Gifu, Japan
²¹Hematology, Gifu Municipal Hospital, Gifu, Japan
²²Division of Hematology, Department of Medicine, King Chulalongkorn Memorial Hospital, Bangkok, Thailand
²³Center for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
²⁴HERM, Dept. of Medicine, Huddinge, Karolinska Institute, and PO Hematology, Karolinska University Hospital, Stockholm, Sweden
²⁵Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
²⁶Department of Hematology, Chugoku Central Hospital, Fukuyama, HIR, Japan
²⁷Department of Molecular Medicine, University of Pavia, Pavia, Italy
²⁸Kyoto University Graduate School of Medicine, Kyoto, JPN
²⁹Department of Advanced Cellular Therapy, Tokyo Medical University, Tokyo, Japan
³⁰Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
³¹MLL Munchner Leukamie Labor Gmbh, Munchen, Germany
³²Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
³³RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
³⁴The University of Tokyo, Human Genome Centre, Institute of Medical Science, Tokyo, Japan
³⁵Department of Medicine, Center for Haematology and Regenerative Medicine, Karolinska Institutet, Stockholm, Sweden

Timothy M Chlon, PhD¹, Emily Stepanchick^2*, Daniel Starczynowski, PhD³ and Kathleen Hueneman^4*

¹Cancer and Blood Diseases Institute, Cincinnati Children's Hospital, Cincinnati, OH
²Cancer and Blood Diseases Institute, Cincinnati Chidlrens, Cincinnati, OH
³Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁴Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH