Heejin Cheon, BSc^1,2, Jeffrey C Xing, BS^1,2,3,4, David S Chung, BS^2,3*, Mariella F Toro, BA^2,3*, Cait E Hamele, BS^2,3*, Thomas L. Olson, PhD^2,5*, David J Feith, PhD^2,3*, Aakrosh Ratan, PhD^6* and Thomas P. Loughran Jr., MD^7,8

¹Medical Scientist Training Program, University of Virginia School of Medicine, Charlottesville, VA
²University of Virginia Cancer Center, Charlottesville, VA
³Department of Medicine, Division of Hematology/Oncology, University of Virginia Health System, Charlottesville, VA
⁴Contributed equally, Co-first
⁵Department of Medicine, Division of Hematology/Oncology, University of Virginia, Charlottesville, VA
⁶Center for Public Health Genomics, University of Virginia, Charlottesville, VA
⁷Division of Hematology-Oncology; Program for T-Cell Lymphoma Research, University of Virginia, Charlottesville, VA
⁸Department of Medicine, Division of Hematology/Oncology, University of Virginia Cancer Center, Charlottesville, VA

Yuting Yan^1,2*, Shuhua Yi, MD^3*, Meiling Jin, PhD^2*, Yi Wang^4*, Ying Yu^1*, Wang Jun^5*, Dehui Zou, MD^3*, Tingyu Wang^1*, Zhen Yu, MD^6*, Lanting Liu^7*, Rui Cui, MD^8*, Wei Liu^9*, Ryu Lv^10*, Weiwei Sui, MD^11*, Wenyang Huang^12*, Xiong Wenjie^5*, Huijun Wang^12*, Qi Sun^12*, Mu Hao^3*, Jianxiang Wang, MD⁶, Cheng Tao^13*, Lugui Qiu, MD¹ and Lili Wang, MD, PhD²

¹National Clinical Research Center for Blood Diseases, State Key Laboratory of Experimental Hematology, Blood Diseases Hospital & Institute of Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
²Department of Systems Biology, Beckman Research Institute, City of Hope, Monrovia, CA
³State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, TIANJIN, China
⁴State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
⁵Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
⁶State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
⁷Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical S, Tianjin, China
⁸Tianjin First Central Hospital, Tianjin, China
⁹State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood, TIANJIN, China
¹⁰Lymphoma and Myeloma Center, Institute of Hematology & Blood Disease Hpspital,Cams &PUMC, Tianjin, China
¹¹State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin City, China
¹²Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, China
¹³Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences/Peking Union Medical College, tianjin, China

Yasunori Kogure, MD, PhD^1*, Takuro Kameda, MD², Junji Koya, PhD, MD^1*, Ayako Kamiunten, MD^3*, Kotaro Shide, MD, PhD³, Tomonori Hidaka, MD^3*, Yoko Kubuki, MD, PhD^3*, Makoto Yoshimitsu, MD, PhD⁴, Kisato Nosaka, MD, PhD⁵, Yoshitaka Imaizumi, MD, PhD^6*, Mizuki Watanabe, MD^7*, Yuki Saito, MD^1,8*, Marni B McClure, MD, PhD^1*, Mariko Tabata, MD^1,9*, Sumito Shingaki, PhD, MD^1*, Kota Yoshifuji, MD^1,10*, Yuichi Shiraishi, PhD^11*, Michihiro Hidaka, MD, PhD^12*, Atae Utsunomiya, MD¹³, Urvi A. Shah, MD^14*, Ana Acuna-Villaorduna, MD¹⁴, Aditi Shastri, MD¹⁵, R. Alejandro Sica, MD^14*, Murali Janakiram, MD¹⁴, Juan Carlos Ramos, MD, BS¹⁶, Tatsuhiro Shibata, MD, PhD^17*, Akifumi Takaori-Kondo, MD, PhD⁷, Yasushi Miyazaki, MD, PhD⁶, Masao Matsuoka, MD, PhD⁵, Kenji Ishitsuka, MD, PhD⁴, Seishi Ogawa, MD, PhD¹⁸, B. Hilda Ye, PhD¹⁹, Kazuya Shimoda, MD, PhD³ and Keisuke Kataoka, MD, PhD¹

¹Division of Molecular Oncology, National Cancer Center Research Institute, Tokyo, Japan
²Department of Gastroenterology and Hematology, University of Miyazaki, Miyazaki, Japan
³Department of Gastroenterology and Hematology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
⁴Department of Hematology and Rheumatology, Kagoshima University Hospital, Kagoshima, Japan
⁵Department of Hematology, Kumamoto University Hospital, Kumamoto, Japan
⁶Department of Hematology, Nagasaki University Hospital, Nagasaki, Japan
⁷Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
⁸Department of Gastroenterology, Keio University School of Medicine, Tokyo, Japan
⁹Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
¹⁰Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
¹¹Center for Cancer Genomics and Advanced Therapeutics, National Cancer Center Research Institute, Tokyo, Japan
¹²Department of Hematology, National Hospital Organization Kumamoto Medical Center, Kumamoto, Japan
¹³Department of Hematology, Imamura General Hospital, Kagoshima, Japan
¹⁴Department of Oncology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY
¹⁵Department of Hematology and Oncology, Albert Einstein College of Medicine/Montefiore Medical Center, Astoria, NY
¹⁶Division of Hematology/Oncology, University of Miami, Miami, FL
¹⁷Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan
¹⁸Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
¹⁹Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY

Joseph G Schroers-Martin, MD¹, Joanne Soo, MD², Gabriel Brisou, MD^3*, Florian Scherer, MD^4*, David M. Kurtz, MD, PhD^5,6, Brian Sworder, MD, PhD⁷, Michael S. Khodadoust, MD, PhD⁸, Michael C. Jin, BS^1*, Agnès Bru^3*, Chih Long Liu, PhD^9*, Henning Stehr, PhD^10*, Paolo Vineis, PhD^11*, Yasodha Natkunam, MD, PhD¹², Bertrand Nadel, PhD¹³, Maximilian Diehn, MD, PhD^14*, Sandrine Roulland, PhD^15* and Ash A. Alizadeh, MD, PhD¹

¹Department of Medicine, Divisions of Hematology & Oncology, Stanford University Medical Center, Stanford, CA
²Division of Oncology, Stanford University Medical Center, Stanford, CA
³Centre d'Immunologie de Marseille Luminy, Aix Marseille Univ, CNRS, INSERM, Marseille, France
⁴Department of Medicine, Divisions of Hematology & Oncology, University of Freiburg, Freiburg, CA, Germany
⁵Department of Medicine, Divisions of Hematology & Oncology, Stanford University, Stanford, CA
⁶Stanford University, San Francisco, CA
⁷Department of Oncology and Hematology, Stanford University Medical Center, Stanford, CA
⁸Division of Medical Oncology, Stanford University School of Medicine, Stanford, CA
⁹Division of Oncology, Department of Medicine, Stanford Cancer Institute, Stanford University, Stanford, CA
¹⁰Department of Pathology, Stanford University School of Medicine, Stanford, CA
¹¹MRC/PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, GBR
¹²Department of Pathology, Stanford University Medical Center, Stanford, CA
¹³Genomic instability and human hemopathies, Centre D'Immunologie De Marseille-Luminy, Marseilles, France
¹⁴Department of Radiation Oncology, Stanford University Medical Center, Stanford, CA
¹⁵Genomic instability and human hemopathies, Centre d' Immunologie de Marseille - Luminy, Marseille, Cedex 09, France

Ana Isabel Jiminez Ubieto^1*, Yanira Heredia^1,2*, Juan Manuel de la Rosa^3*, Antonia Rodriguez Izquierdo^1*, Laura Rufian^1,2*, Jaime Carrillo^2*, Ricardo Sanchez^1,2*, Esther Onecha, PhD^3*, Chongwu Wang^4*, Pilar Sarandeses^5*, María Poza, MD^3*, Carmen Bárcena^6*, Carlos Grande^1,7*, Miguel A Canales, MD, PhD⁸, Inmaculada Rapado, PhD^3*, Rosa Ayala^1*, Miguel Gallardo^9*, Joaquin Martinez-López^1,9* and Santiago Barrio^1,2*

¹Hematology Department, Hospital Universitario 12 de Octubre, Madrid, Spain
²Altum sequencing Co., Madrid, Spain
³Hematology Department, Hospital Universitario 12 de Octubre,, Madrid, Spain
⁴Hosea Precision Medical Technology Co., Ltd., Weihai, Shangdong, China
⁵Nuclear Medicine Department, Hospital Universitario 12 de Octubre, Madrid, Spain
⁶Pathology Department, Hospital Universitario 12 de Octubre, Madrid, Spain
⁷Clinica Universitaria de Navarra, Madrid, Spain
⁸Hematology and Hemotherapy Unit, La Paz University Hospital-IdiPAZ, Madrid, Spain
⁹H12O-CNIO Clinical research unit, CIBERONC, Complutense University, Madrid, Spain

Heng Pan, PhD^1,2,3*, Loïc Renaud, MD, MSc^4,5,6,7*, Ronan Chaligne, PhD^5,6,7*, Johannes Bloehdorn, MD^8*, Eugen Tausch, MD^8*, Daniel Mertens, PhD^9*, Anna-Maria Fink, MD^10*, Kirsten Fischer, MD^10*, Chao Zhang, PhD^3,7*, Doron Betel, PhD^3,7*, Andreas Gnirke^11*, Marcin Imielinski^1,3,5,6,12*, Jerome Moreaux, PhD^13,14,15,16, Michael Hallek¹⁰, Alexander Meissner, PhD^11,17*, Stephan Stilgenbauer, MD⁸, Catherine J. Wu, MD^11,18, Olivier Elemento, PhD^1,2,3,6* and Dan A. Landau, MD, PhD^3,5,6,7

¹Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY
²Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY
³Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY
⁴Service des Maladies du Sang, Centre Hospitalier Régional Universitaire De Lille, Lille, France
⁵New York Genome Center, New York, NY
⁶Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY
⁷Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY
⁸Department of Internal Medicine III, Ulm University, Ulm, Germany
⁹German Cancer Research Center (DKFZ), Heidelberg, Germany
¹⁰German CLL Study Group, and Department I of Internal Medicine, and Center of Integrated Oncology ABCD, University of Cologne, Cologne, Germany
¹¹Broad Institute of MIT and Harvard, Cambridge, MA
¹²Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY
¹³UFR Médecine, Université Montpellier, Montpellier, France
¹⁴Laboratory for Monitoring Innovative Therapies, Department of Biological Hematology, CHU Montpellier, Montpellier, France
¹⁵Institute of Human Genetics, UMR 9002 CNRS-UM, Montpellier, France
¹⁶Institut Universitaire de France, Paris, France
¹⁷Max Planck Institute for Molecular Genetics, Berlin, Germany
¹⁸Dana-Farber Cancer Institute, Boston, MA