Itaru Matsumura, MD, PhD¹, Shigeki Ohtake, MD, PhD², Yoshiko Atsuta, MD, PhD^3*, Mio Kurata^3*, Yosuke Minami, MD, PhD⁴, Naoto Takahashi, MD, PhD⁵, Chiaki Nakaseko, MD, PhD⁶, Noriyoshi Iriyama, MD, PhD^7*, Katsumichi Fujimaki, MD^8*, Kazuhiko Kakihana, MD, PhD⁹, Yoji Ogasawara^10*, Takaaki ONO, MD, PhD^11*, Masaya Okada, MD^12*, Tetsuzo Tauchi, MD, PhD^13*, Toshihiro Miyamoto, MD, PhD¹⁴, Kazunori Ohnishi, MD¹⁵, Emiko Sakaida, MD, PhD¹⁶, Shin Fujisawa, MD^17*, Yukio Kobayashi, MD, DSc¹⁸, Norio Asou, MD, PhD¹⁹, Hitoshi Kiyoi, MD, PhD²⁰, Yasushi Miyazaki, MD, PhD²¹ and Tomoki Naoe, MD, PhD²²

¹Department of Hematology and Rheumatology, Kindai University Faculty of Medicine, Osakasayama, Japan
²Kanazawa University, Kanazawa, Japan
³Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan
⁴National Cancer Center Hospital East, Kashiwa, Japan
⁵Akita University School of Medicine, Akita, Japan
⁶Department of Hematology, International University of Health and Welfare, Narita, Japan
⁷Nihon University, Tokyo, Japan
⁸Fujisawa City Hospital, Fujisawa, Japan
⁹Department of Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan
¹⁰Division of Clinical Oncology and Hematology, The Jikei University Hospital, Tokyo, Japan
¹¹Hamamatsu University Hospital, Hamamatsu, Shizuoka, Japan
¹²Division of Hematology, Department of Internal Medicine, Hyogo College Of Medicine, nishinomiya city, Japan
¹³Department of Hematology, Tokyo Medical University, Tokyo, Japan
¹⁴Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
¹⁵Shubun University, Ichinomiya　City, Japan
¹⁶Department of Hematology, Chiba University Hospital, Chiba City, Japan
¹⁷Department of Hematology, Yokohama City University Medical Center, Yokohama, Japan
¹⁸Hematology Division, IUHW Mita Hospital, Tokyo, Japan
¹⁹Department of Hemato-Oncology, International Medical Center, Saitama Medical University, Hidaka, Japan
²⁰Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
²¹Atomic Bomb Disease Institute, Nagasaki University Hospital, Nagasaki, Japan
²²National Hospital Organization, Nagoya Medical Center, Nagoya, Japan

Tim H Brümmendorf, MD^1,2, Jorge E. Cortes, MD³, Dragana Milojkovic^4*, Carlo Gambacorti-Passerini, MD⁵, Richard E. Clark, MA, MD, MRCP, FRCPath^6*, Philipp D le Coutre, MD⁷, Valentín Garcia-Gutiérrez, MD, PhD⁸, Charles Chuah, MD⁹, Vamsi Kota, MD³, Jeffrey H. Lipton, MD, PhD¹⁰, Philippe Rousselot, MD PhD^11*, Michael J. Mauro, MD¹², Andreas Hochhaus, MD¹³, Rafael Hurtado Monroy, MD¹⁴, Eric Leip^15*, Simon Purcell^16*, Anne Yver, PharmD^17*, Andrea Viqueira, MD^18* and Michael W. Deininger, MD, PhD¹⁹

¹Dept. of Hematology and Oncology, Center for Integrated Oncology (CIO), Uniklinik RWTH Aachen, Aachen, Germany
²Department of Hematology and Oncology, Center for Integrated Oncology (CIO), Uniklinik RWTH Aachen, Aachen, Germany
³Georgia Cancer Center Augusta University, Augusta, GA
⁴Department of Haematology, Hammersmith Hospital, Imperial College NHS Trust, London, United Kingdom
⁵Dept of Medicine and Surgery, University of Milano Bicocca, Monza, MB, Italy
⁶Department of Haematology, Royal Liverpool University Hospital, Liverpool, United Kingdom
⁷Charité – Universitätsmedizin Berlin, Berlin, Berlin, Germany
⁸Hematology, Hospital Universitario Ramón y Cajal, Madrid, Spain
⁹Department of Haematology, Singapore General Hospital, Singapore, Singapore
¹⁰Hans Messner Allogeneic Transplant Program, Division of Medical Oncology and Haematology, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON, Canada
¹¹Centre Hospitalier de Versailles, Le Chesnay, France
¹²Myeloproliferative Neoplasms Program, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY
¹³Klinik für Innere Medizin II, Jena, Germany
¹⁴Head Hematology Department, Hospital Angeles del Pedregal, Mexico, Mexico
¹⁵Pfizer Inc., Cambridge, MA
¹⁶Pfizer Ltd, London, GBR
¹⁷Pfizer Inc, Paris, France
¹⁸Pfizer SLU, Madrid, Spain
¹⁹Division of Hematology and Hematologic Malignancies, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT

Massimiliano Bonifacio, MD^1*, Chiara Elena, MD^2*, Mariella D'Adda, MD^3*, Luigi Scaffidi, MD^1*, Mairi Pucci, MD^4*, Fiorenza Aprili^4*, Jacqueline Ferrari, MD^2*, Alessandra Tucci, MD^3*, Fabio Stagno, MD, PhD⁵, Anna Rita Scortechini, MD^6*, Gianni Binotto, MD^7*, Mario Annunziata, MD^8*, Maria Cristina Miggiano, MD^9*, Isabella Capodanno, MD^10*, Sara Galimberti, MD, PhD^11*, Mario Tiribelli, MD^12*, Emilia Giugliano^13*, Giovanni Caocci, MD¹⁴, Monica Crugnola, MD^15*, Paola Ronchi, MD^16*, Sabina Russo, MD^17*, Martina Tinelli, MD^18*, Agostino Tafuri, MD¹⁹, Monica Bocchia^20*, Alessandra Malato, MD, PhD^21*, Mauro Krampera, MD, PhD¹, Giuseppe Lippi, MD, PhD^4*, Massimo Breccia, MD^22*, Giuseppe Saglio, MD, PhD²³ and Antonella Gozzini, MD^24*

¹Department of Medicine, Section of Hematology, University of Verona, Verona, Italy
²Department of Hematology Oncology, Foundation IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
³Department of Hematology, ASST Spedali Civili di Brescia, Brescia, Italy
⁴Department of Neurosciences, Biomedicine and Movement Sciences, Section of Clinical Biochemistry, University of Verona, Verona, Italy
⁵Hematology Section and BMT Unit, Rodolico Hospital, AOU Policlinico - V. Emanuele, Catania, Catania, Italy
⁶Division of Hematology, Department of Molecular and Clinical Sciences, Polytechnic University of Marche, Ancona, Italy
⁷Department of Medicine, Hematology and Clinical Immunology, Padua School of Medicine, Padua, Italy
⁸Hematology Unit, Cardarelli Hospital, Naples, Italy
⁹Hematology Department, San Bortolo Hospital, Azienda ULSS8 "Berica" di Vicenza, Vicenza, Italy
¹⁰Hematology Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy
¹¹Department of Clinical and Experimental Medicine, Section of Hematology, University of Pisa, Pisa, Italy
¹²Division of Hematology and BMT, Department of Medical Area, University of Udine, Udine, Italy
¹³Division of Internal Medicine and Hematology, San Luigi Gonzaga Hospital, University of Turin, Orbassano (TO), Italy
¹⁴Department of Medical Sciences and Public Health, University of Cagliari, Businco Hospital, Cagliari, Italy
¹⁵Hematology and BMT Center, Department of Medicine and Surgery, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy
¹⁶Unit of Hematology and Bone Marrow Transplantation, IRCCS San Raffaele Scientific Institute, Milan, Italy
¹⁷Division of Hematology, Policlinico “G. Martino”, University of Messina, Messina, Italy
¹⁸Oncology Department, Fracastoro Hospital, Azienda ULSS9 “Scaligera” di Verona, San Bonifacio (VR), Italy
¹⁹Hematology Unit, University Hospital Sant'Andrea-Sapienza, Rome, ITA
²⁰Hematology, University of Siena, Siena, Italy
²¹Department of Hematology, Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy
²²Department of Translational and Precision Medicine, University "Sapienza", Roma, Italy
²³Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
²⁴Hematology Unit, AOU Careggi, University of Florence, Florence, ITA

Jorge E. Cortes, MD¹, Jane Apperley, FRCP, FRCPath, MB ², Andreas Hochhaus, MD³, Michael J. Mauro, MD⁴, Philippe Rousselot, MD PhD^5*, Tomasz Sacha, MD PhD^6*, Moshe Talpaz, MD⁷, Charles Chuah, MD⁸, Jeffrey H. Lipton, MD, PhD⁹, Michael W. Deininger, MD, PhD¹⁰, Charles A. Schiffer, MD¹¹, Lori J. Maness, MD¹², James K. McCloskey, MD¹³, Valentín García Gutiérrez, MD, PhD¹⁴, Hugues de Lavallade, MD, PhD^15*, Gabriel Etienne, MD, PhD^16*, Vickie Lu, PhD^17*, Shouryadeep Srivastava, MBBS, PhD^18* and Gianantonio Rosti, MD^19*

¹Georgia Cancer Center Augusta University, Augusta, GA
²Centre for Haematology, Imperial College, London, United Kingdom
³Jena University Hospital, Jena, Germany
⁴Myeloproliferative Neoplasms Program, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY
⁵Hospital Mignot University de Versailles Saint-Quentin-en-Yvelines, Paris, France
⁶Department of Hematology, Jagiellonian University Medical College, Krakow, Poland
⁷Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI
⁸Singapore General Hospital and Duke-NUS Medical School, Singapore, Singapore
⁹Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada
¹⁰Huntsman Cancer Institute, University of Utah, Salt Lake City, UT
¹¹Department of Oncology, Karmanos Cancer Institute at Wayne State University, Detroit, MI
¹²University of Nebraska Medical Center, Omaha, NE
¹³John Theurer Cancer Center at Hackensack Meridian Health, Hackensack, NJ
¹⁴Hematology Department, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain
¹⁵Haematological Medicine, King's College Hospital NHS Foundation Trust, London, United Kingdom
¹⁶Institute Bergonie; Institut National de la Sante et de la Recherche Medicale; Groupe France Intergroupe des Leucemies Myeloides Chroniques, Hopital Haut-Leveque, Pessac, France
¹⁷Millennium Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, Cambridge, MA
¹⁸Millennium Pharmaceuticals, Inc., Cambridge, MA, USA, a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, Cambridge, MA
¹⁹University of Bologna, Bologna, Italy

Naranie Shanmuganathan, FRACP, FRCPA, MBBS^1,2,3,4, Carol Wadham, PhD^4*, Nur Hezrin Shahrin, PhD^4*, Daniel Thomson, PhD, BSc^5*, Jinghua Feng, PhD^6*, Verity A Saunders^2*, Ming Lin^6*, Rosalie Kenyon^6*, Rob King^6*, Paul Wang, PhD^6*, David M Ross, MBBS, PhD, FRACP, FRCPA^1,2,7,8*, David T Yeung, BSc, PhD, FRACP, FRCPA, MBBS^1,2,8, Andreas W Schreiber, PhD^6*, Timothy P. Hughes, MD, MBBS, FRACP, FRCPA^9,10 and Susan Branford, PhD^4,11

¹Department of Haematology, Royal Adelaide Hospital and SA Pathology, Adelaide, SA, Australia
²Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, Australia
³Haematology Society of Australia & New Zealand, Sydney, Australia
⁴Centre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, Australia
⁵Department of Genetic and Molecular Pathology, Monash Medical Centre, Melbourne, Australia
⁶ACRF Cancer Genomics Facility, SA Pathology, Adelaide, Australia
⁷Department of Haematology, Flinders Medical Centre and University, Adelaide, SA, Australia
⁸Australasian Leukaemia and Lymphoma Group, Melbourne, Australia
⁹Department of Haematology, Royal Adelaide Hospital, Adelaide, Australia
¹⁰Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA, Australia
¹¹Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, Australia

Giorgina Specchia, MD¹, Patrizia Pregno^2*, Massimo Breccia, MD^3*, Chiara Monagheddu^4*, Fausto Castagnetti, MD, PhD^5,6, Massimiliano Bonifacio, MD^7*, Mario Tiribelli, MD^8*, Fabio Stagno, MD, PhD⁹, Giovanni Caocci, MD¹⁰, Bruno Martino, MD^11*, Luigiana Luciano, MD¹², Michele Pizzuti, MD^13*, Antonella Gozzini, MD^14*, Anna Rita Scortechini, MD^15*, Francesco Albano^16*, Micaela Bergamaschi, MD^17*, Isabella Capodanno, MD^18*, Andrea Patriarca, MD^19*, Carmen Fava²⁰, Giovanna Rege Cambrin, MD, PhD^21*, Federica Sorà, MD^22*, Sara Galimberti, MD, PhD^23*, Monica Bocchia^24*, Gianni Binotto, MD^25*, Giovanni Reddiconto^26*, Attilio Guarini, MD^27*, Alessandro Maggi^28*, Grazia Sanpaolo, MD^29*, Maria Stella De Candia^30*, Valentina Giai, MD, PhD³¹, Elisabetta Abruzzese, MD ³², Maria Cristina Miggiano, MD^33*, Franca Falzetti, MD^34*, Gaetano La Barba^35*, Giuseppe Pietrantuono^36*, Anna Guella, MD^37*, Luciano Levato, MD^38*, Olga Mulas^39*, Fabio Saccona^40*, Gianantonio Rosti, MD^41*, Pellegrino Musto, MD⁴², Francesco Di Raimondo, MD⁴³, Fabrizio Pane, MD⁴⁴, Robin Foà, MD⁴⁵, Michele Baccarani, MD⁴⁶, Giovannino Ciccone^4* and Giuseppe Saglio, MD, PhD⁴⁷

¹Hematology Section, Department of Emergency and Transplantation - GIMEMA WP CML, University of Bari Aldo Moro, Bari, Italy
²Hematology Unit, Az Ospedaliero Universitaria Città' della Salute e della Scienza, Torino, Italy
³Department of Cellular Biotechnologies and Hematology, Sapienza University, Rome, Italy
⁴Unit of Clinical Epidemiology and CPO, Città della Salute Hospital and University, Torino, Italy
⁵Institute of Hematology "L. e A. Seràgnoli", University of Bologna, Bologna, Italy
⁶Institute of Hematology "L. and A. Seràgnoli", Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, "S. Orsola-Malpighi" Hospital, Bologna, Italy
⁷Department of Medicine, Section of Hematology, University of Verona, Verona, Italy
⁸Division of Hematology and BMT, Department of Medical Area, University of Udine, Udine, Italy
⁹Chair and Hematology Section, Ferrarotto Hospital, Catania, Italy
¹⁰Department of Medical Sciences and Public Health, University of Cagliari, Businco Hospital, Cagliari, Italy
¹¹Hematology Unit, A.O. Bianchi-Melacrino-Morelli, Reggio Calabria, Italy
¹²Hematology Unit, Federico II University of Naples, Napoli, Italy
¹³Ematologia, Azieda Ospedaliera S. Carlo, Potenza, Italy
¹⁴Hematology Unit, AOU Careggi, University of Florence, Florence, ITA
¹⁵Division of Hematology, Azienda Ospedaliero Universitaria Ospedali Riuniti Ancona, Ancona, Italy
¹⁶University of Bari, Department of Emergency and Organ Transplantation (D.E.T.O.), Hematology Section, Bari, Italy
¹⁷Clinical Hematology Unit, IRCCS AOU S.Martino-IST, Genova, Italy
¹⁸Hematology Unit, Azienda Unità Sanitaria Locale - IRCCS, Reggio Emilia, Italy
¹⁹Division of Hematology, Department of Translational Medicine, Università del Piemonte Orientale, Novara, Italy
²⁰Hematology Division, Ospedale Mauriziano, University of Turin, Torino, Italy
²¹Division of Internal Medicine - Hematology, AUO San Luigi, Orbassano, Italy
²²Institute of Hematology, Università Cattolica del Sacro Cuore - Policlinico A. Gemelli, ROMA, Italy
²³Department of Clinical and Experimental Medicine, Section of Hematology, University of Pisa, Pisa, Italy
²⁴Hematology, University of Siena, Siena, Italy
²⁵Department of Medicine, Hematology and Clinical Immunology, Padua School of Medicine, Padua, Italy
²⁶U.O.Hematology Hospital V.Fazzi - Lecce Italy, Lecce, Italy
²⁷Haematology Unit, Istituto Tumori Giovanni Paolo II I.R.C.C.S. Ospedale Oncologico, Bari, Italy
²⁸Hematology, " Giuseppe Moscati" Hospital, Taranto, Italy
²⁹Division of Hematology, Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
³⁰Hematology Unit, Ospedale Perrino, Brindisi, Italy
³¹Università Degli Studi Di Torino, Turin, Turin, Italy
³²Hemoglobinopathies Unit, Hematology Department, S. Eugenio Hospital (ASL Roma 2), Tor Vergata University, Rome Italy, Rome, Italy
³³Hematology Department, San Bortolo Hospital, Vicenza, Italy
³⁴Institute of Hematology, Centro di Ricerche Emato-Oncologiche (CREO), University of Perugia, Perugia, Italy
³⁵Department of Hematology, "Spirito Santo" Hospital, Pescara, ITA
³⁶IRCCS Centro Oncologico Della Basilicata, Rionero In Vulture, ITA
³⁷Ematology section, Ematology section,U.O. Medicina II,Ospedale Santa Chiara, trento, Italy
³⁸Hematology Unit, A. Pugliese Hospital, Azienda Ospedaliera Pugliese Ciaccio, Catanzaro, Italy
³⁹Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy
⁴⁰SCDU Epidemiologia dei Tumori-CPO Piemonte, Az Osp Citta della salute e della Scienza, Turin, Italy
⁴¹Department of Experimental, Diagnostic and Specialty Medicine - DIMES, Institute of Hematology "L. and A. Seràgnoli", S.Orsola-Malpighi University Hospital, Bologna, Italy
⁴²Hematology and Stem cell Transplantation Unit - Department of Emergency and Organ Transplantation (D.E.T.O.) - University of Bari, Bari, Italy
⁴³Division of Hematology, A.O.U. "Policlinico-Vittorio Emanuele", University of Catania, Catania, Italy
⁴⁴Federico II University of Naples, Hematology Department, Naples, Italy
⁴⁵Hematology, Department of Cellular Biotechnologies and Hematology, Sapienza University of Rome, Policlinico Umberto I, Rome, Italy
⁴⁶Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna-GIMEMA WP CML, Institute of Hematology and Medical Oncology "L. & A. Seràgnoli", Bologna, Italy
⁴⁷Divisione Universitaria di Ematologia e Terapie Cellulari, A.O. Ordine Mauriziano, Turin, Italy