Shawn Lee, MBBS¹, Maoxiang Qian, PhD², Wentao Yang, PhD¹, Jonathan Diedrich, PhD^1*, Elizabeth A. Raetz, MD³, Wenjian Yang, PhD^1*, Qian Dong, PhD^1*, Meenakshi Devidas, PhD^4*, Deqing Pei, MS^5*, Allen Eng Juh Yeoh, MD^6*, Cheng Cheng, PhD^5*, Ching-Hon Pui, MD⁷, William E. Evans, PharmD¹, Charles G Mullighan, MBBS, MD⁸, Stephen P Hunger, MD⁹, Daniel Savic, PhD¹, Mary V. Relling, PharmD¹, Mignon L. Loh, MD¹⁰ and Jun J. Yang, PhD¹

¹Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN
²Children's Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, TN
³New York University Langone Medical Center, New York, NY
⁴Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TN
⁵Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN
⁶Centre for Translational Research in Acute Leukaemia, Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
⁷Department of Oncology, Member, St Jude Faculty, Chair, Oncology Department, Coleader, Hematological Malignancies Program, Director, China Region, St Jude Global, American Cancer Society Professor, Fahad Nassar Al-Rashid Chair of Leukemia Research, St Jude Children’s Research H, Memphis, TN
⁸Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN
⁹Department of Pediatrics, Division of Oncology and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
¹⁰Department of Pediatrics, Division of Pediatric Hematology/Oncology, University of California Benioff Children’s Hospital, San Francisco, CA

Martin Neumann^1*, Lorenz Bastian^2*, Sonja Hänzelmann^1*, Alina Hartmann^1*, Heiko Trautmann, PhD^1*, Jutta Ortiz Tanchez^3*, Cornelia Schlee^3*, Michael P Schroeder, PhD^3*, Lars R. Fransecky, MD^2*, Sebastian Vosberg^4*, Walter Fiedler, MD⁵, Nael Alakel, MD^6*, Mustafa Kondakci, MD^7*, Michael Starck, MD^8*, Stefan Schwartz, MD, PhD^3*, Carsten Müller-Tidow, MD^9*, Folker Schneller^10*, Albert Reichle^11*, Thomas Burmeister^3*, Philipp A. Greif, MD, PD⁴, Monika Brüggemann, MD^1*, Nicola Goekbuget, MD¹² and Claudia D Baldus, MD^1*

¹Medical Department II, Hematology and Oncology, University Hospital Schleswig-Holstein, Kiel, Germany
²Hematology and Oncology, University Hospital Schleswig-Holstein, Kiel, Germany
³Department of Hematology / Oncology, Charité - Universitätsmedizin Berlin, Berlin, Germany
⁴Department of Internal Medicine III, Ludwig-Maximilians-University, Munich, Germany
⁵Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald University Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
⁶University Hospital, Dresden, Germany
⁷Dept. of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany
⁸Medical Department I, Hospital München-Schwabing, München, Germany
⁹Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany
¹⁰Medical Department III, Klinikum rechts der Isar, Technical University Munich, Munich, Germany
¹¹Department of Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany
¹²University Hospital, Department of Medicine II, Hematology/Oncology, Head of Study Center Depart of Medicine II, Hematology/Oncology Goethe University Hospital, Frankfurt, Germany

Daniela Kužílková, PhD^1*, Tomas Kalina, MD, PhD^1*, Cristina Bugarin, Dr.^2*, Katerina Rejlová, Dr.^1*, Daniel Thurner, Dr.^1*, Pavel Semerák, Dr.^1*, Jan Stuchly, MSc^1*, Andrea Biondi, MD, PhD² and Giuseppe Gaipa, PhD³

¹CLIP - Childhood Leukaemia Investigation Prague, Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic
²Tettamanti Research Center, Department of Pediatrics, University of Milano-Bicocca/Fondazione MBBM, Monza, Italy
³Tettamanti Research Center, Department of Pediatrics, University of Milano - Bicocca/Fondazione MBBM, Monza, Italy

Caroline Duault, PharmD, PhD^1*, Anil Kumar, PhD^2*, Adeleh Taghi Khani, PhD^2*, Sung June Lee, BA^2*, Lu Yang, PhD^3*, Min Huang, PhD^4*, Christian Hurtz, PhD⁵, Bryan Manning, BS^6*, Lucy Ghoda, PhD^7*, Tinisha McDonald, BS^8*, Norman J. Lacayo, MD⁴, Kathleen M. Sakamoto, MD, PhD⁴, Martin P. Carroll, MD⁹, Guido Marcucci, MD¹⁰, Jianhua Yu, PhD^11*, Michael A. Caligiuri, MD¹², Holden T. Maecker, PhD^13* and Srividya Swaminathan, PhD^2,14

¹Institute for Immunity, Transplantation and Infections, Stanford University - School of Medicine, Stanford, CA
²Department of Systems Biology, Beckman Research Institute of City of Hope, City of Hope, Duarte, CA
³Department of Systems Biology, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA
⁴Department of Pediatrics, Stanford University School of Medicine, Stanford, CA
⁵Medicine, University Of Pennsylvania, Philadelphia, PA
⁶University of Pennsylvania, Philadelphia, PA
⁷Department of Hematologic Malignancies Translational Science, Gehr Family Center for Leukemia Research, Beckman Research Institute, City of Hope, Duarte, CA
⁸Hematogic Malignancies Translational Science, Gehr Family Center for Leukemia Research, City of Hope, Duarte, CA
⁹Medicine, University of Pennsylvania, Philadelphia, PA
¹⁰Department of Hematologic Malignancies Translational Science, Gehr Family Center for Leukemia Research, Hematologic Malignancies and Stem Cell Transplantation Institute, Beckman Research Institute, City of Hope, Monrovia, CA
¹¹Department of Hematology and Hematopoietic Stem Cell Transplantation, Beckman Research Institute of City of Hope, City of Hope, Duarte, CA
¹²City of Hope National Medical Center, Duarte, CA
¹³Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA
¹⁴Department of Hematological Malignancies and Translational Science, Beckman Research Institute of City of Hope, City of Hope, Duarte, CA

Yuya Sasaki, MD, PhD¹, Hagop M. Kantarjian, MD², Nicholas J. Short, MD¹, Nitin Jain, MD³, Koji Sasaki, MD⁴, Farhad Ravandi, MBBS⁵, Marina Konopleva, MD, PhD⁶, Guillermo Garcia-Manero, MD¹, Latasha Little, BS^7*, Curtis Gumbs^8*, Li Zhao, PhD^9*, P Andrew Futreal, PhD^10*, Feng Wang, PhD^11*, Ken Furudate, DDM, PhD^1*, Rebecca Garris, MSc^1*, Koichi Takahashi, MD, PhD¹¹ and Elias Jabbour, MD¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²University of Texas MD Anderson Cancer Center, Houston, TX
³Associate Professor of Medicine Department of Leukemia The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Leukemia, MD Anderson Cancer Center, Houston, TX
⁵Department of Leukemia, University of Texas- MD Anderson Cancer Center, Houston, TX
⁶Department of Leukemia, University of Texas, MD Anderson Cancer Center, Houston, TX
⁷Department of Genomics Medicine, UT M. D. Anderson Cancer Center, Houston, TX
⁸The University of Texas MD Anderson Cancer Center, Houston, TX
⁹UT MD Anderson Cancer Center, Houston, TX
¹⁰Department of Genomic Medicine, UT M. D. Anderson Cancer Center, Houston, TX
¹¹Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Janine Stutterheim, MD, PhD¹, Inge M. van der Sluis, MD, PhD², Paola De Lorenzo^3*, Julia Alten, MD^4*, Philip Ancliff, MD^5*, Andishe Attarbaschi, MD^6,7*, Benoit Brethon, MD^8*, Andrea Biondi, MD^9,10, Myriam Campbell, MD^11*, Giovanni Cazzaniga, PhD¹², Gabriele Escherich, MD^13,14*, Alina Ferster, MD¹⁵, Rishi Sury Kotecha, MBBChir, PhD^16,17*, Birgitte Lausen, MD^18,19*, Chi Kong Li, MD²⁰, Luca Lo Nigro, PhD, MD²¹, Franco Locatelli, MD, PhD²², Rolf Marschalek, PhD^23*, Martin Schrappe, MD PhD²⁴, Jan Stary, MD, PhD^25*, Ajay Vora, MD^26,27, Jan Zuna, PhD²⁸, Vincent H.J. Van Der Velden, PhD^29*, Tomasz Szczepanski, MD, PhD^30,31, Maria Grazia Valsecchi, PhD^32* and Rob Pieters, MD, PhD, MSc³³

¹Princess Maxima Center, Utrecht, Netherlands
²Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
³University of Milano-Bicocca, Monza, Italy
⁴Dept. of Pediatrics, UKSH, Kiel, DEU
⁵Department of Haematology, Great Ormond Street Hospital, London, UK, London, GBR
⁶St. Anna Children's Hospital, Vienna, Austria
⁷BFM-A – Berlin-Frankfurt-Münster Austria, Vienna, Austria
⁸FRALLE - French Acute Lymphoblastic Leukemia Study Group, Paris, France
⁹Dept. Pediatrics, University of Milano-Bicocca, Fondazione MBBM/San Gerardo Hospital, Monza, Italy
¹⁰AIEOP - Associazione Italiana Ematologia Oncologia Pediatrica, Monza, Italy
¹¹Hospital Roberto del Rio Santiago, Chilean National Pediatric Oncology Group, PINDA., Santiago, Chile
¹²Tettamanti Research Center, Department of Pediatrics, University of Milano-Bicocca/Fondazione MBBM, Monza, Italy
¹³Department of Pediatric Hematology and Oncology, University Medical Center Hamburg, Hamburg, Germany
¹⁴COALL - German Cooperative Study Group for Childhood Acute Lymphoblastic Leukemia, Hamburg, Germany
¹⁵Hematology Oncology, Hôpital Universitaire des Enfants Reine Fabiola, Université Libre de Bruxelles, Brussels, Belgium
¹⁶Telethon Kids Institute, University of Western Australia, Perth, Australia
¹⁷ANZCHOG - Australia New Zealand Children Oncology Group, Perth, Australia
¹⁸NOPHO – Nordic Society of Pediatric Hematology/Oncology, Copenhagen, Denmark
¹⁹Department of Pediatrics and Adolescent Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
²⁰Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong
²¹Head of Cytogenetic-Cytofluorimetric-Molecular Biology Lab - Azienda Policlinico OVE - Center of Pediatric Hematology Oncology, Catania, Italy
²²IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Sapienza, University of Rome, Rome, Italy
²³DCAL, Institute of Pharmaceutical Biology, Goethe-University, Frankfurt am Main, Germany
²⁴BFM-G - Berlin-Frankfurt-Münster Group Germany, Kiel, Germany
²⁵CPH- Czech Working Group for Pediatric Hematology, Prague, Czech Republic
²⁶Great Ormond Hospital, London, United Kingdom
²⁷UKCCSG - United Kingdom Children Cancer Study Group, London, United Kingdom
²⁸CLIP, Dept. of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic
²⁹Department of Immunology, Erasmus University Medical Center, Rotterdam, NLD
³⁰Department of Pediatrics Hematology and Oncology in Zabrze, Medical University of Silesia, Zabrze, Poland
³¹PPLLSG - Polish Pediatric Leukemia/Lymphoma Study Group, Zabrze, Poland
³²University of Milano Bicocca, Monza, Italy
³³Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands