Beena E Thomas^1*, Pruthvi Perumalla, MS^2*, Swati S Bhasin, PhD^3*, Debasree Sarkar, PhD^4*, Bhakti Dwivedi, PhD^5*, Sunita I Park, M.D.^6*, Deborah DeRyckere, BS, PhD⁷, Curtis J. Henry, PhD⁸, Sunil S. Raikar, MD⁹, Christopher C. Porter, MD^10,11, Melinda Pauly, MD^11,12*, Ryan J Summers, MD¹³, Sharon M. Castellino, MD, MSc¹⁴, Daniel S. Wechsler, MD, PhD¹⁵, Douglas K Graham, MD, PhD¹⁶ and Manoj Bhasin, PhD^1*

¹Emory School of Medicine, Aflac Cancer and Blood Disorders Center, Atlanta, GA
²Department of Biomedical Informatics, Emory School of Medicine, Atlanta, GA
³Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Atlanta, GA
⁴Emory University, Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Atlanta, GA
⁵Winship Cancer Insitute , Emory School of Medicine, Atlanta, GA
⁶Department of Pathology, Children's Healthcare of Atlanta, Atlanta, GA
⁷Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Department of Pediatrics, Emory University, Atlanta, GA
⁸Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA
⁹Aflac Cancer and Blood Disorders Center, Emory University/Children's Healthcare of Atlanta, Atlanta, GA
¹⁰Pediatrics, Emory University, Atlanta, GA
¹¹Department of Pediatrics, Emory University, Atlanta, GA
¹²Department of Pediatrics, Children’s Healthcare of Atlanta, Atlanta, GA
¹³Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta/Emory, Atlanta, GA
¹⁴Aflac Cancer and Blood Disorders Center, Emory University School of Medicine / Children's Healthcare of Atlanta, Atlanta, GA
¹⁵Aflac Cancer & Blood Disorders Center of Children's Healthcare of Atlanta and Department of Pediatrics, Emory University, Atlanta, GA
¹⁶Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta and Emory University, Atlanta, GA

Shuting Jiang^1*, Fuhong He, PhD^1*, Li Gao, MD^2*, Aili Chen, PhD^1*, Yixin Hu, MD^2*, Liyan Fan, MD^2*, Lin Zhang, MS^1,3*, Yongping Zhang^2*, Haiyang Hu^1,3*, Dan Liu, MS^1*, Zihan Zhou^1,3*, Yanxun Su^1,3*, Lei Qin^1,3*, Jun Lu, MD^2*, Peifang Xiao, MD^2*, Raul Ribeiro, MD⁴, Shaoyan Hu, MD, PhD² and Qian-fei Wang, PhD^1,3

¹CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, Beijing Institute of Genomics, Chinese Academy of Sciences(China National Center for Bioinformation), Beijing, China
²Department of Pediatric Hematology and Oncology, Children's Hospital of Soochow University, Suzhou, China
³University of Chinese Academy of Sciences, Beijing, China
⁴Department of Oncology and Global Medicine, International Outreach Program, St. Jude Children's Research Hospital, Memphis, TN

Muharrem Muftuoglu, MD¹, Zoe Alaniz, BS^1*, Duncan Mak, BSc, MPhil^1*, Angelique J. Lin, MS^2*, Jared K. Burks, PhD^1*, Bing Z Carter, PhD³ and Michael Andreeff, MD, PhD¹

¹Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas, MD Anderson Cancer Center, Houston, TX
³Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX

Jayakumar Vadakekolathu, PhD^1*, Tung On Yau^1*, Heidi Altmann, PhD^2*, Sarah E. Church, PhD^3*, Hanna A Knaus, MD^4*, Mark D. Minden⁵, Jan K Davidson-Moncada, MD, PhD⁶, Sarah K Tasian, MD⁷, Martin Bornhäuser, MD^2*, Ivana Gojo, MD⁸, Leo Luznik, MD⁸ and Sergio Rutella, MD, PhD, FRCPath^1,9

¹John van Geest Cancer Research Centre, Nottingham Trent University, Nottingham, United Kingdom
²Medical Clinic and Policlinic I, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany
³NanoString Technologies, Inc., Everett, WA
⁴Medical University of Vienna, Vienna, Vienna, AUT
⁵Leukemia Program, Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
⁶MacroGenics, Inc., Washington, DC
⁷Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA
⁸Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD
⁹Centre for Health, Ageing and Understanding Disease (CHAUD), Nottingham Trent University, Nottingham, United Kingdom

Hassan Awada, MD¹, Arda Durmaz^2*, Carmel Gurnari, MD^3*, Ashwin Kishtagari, MBBS¹, Manja Meggendorfer, PhD⁴, Cassandra M. Kerr, MS^5*, Teodora Kuzmanovic^5*, Jibran Durrani, MD^1*, Yasunobu Nagata, MD, PhD^5*, Tomas Radivoyevitch, PhD^5,6*, Anjali S Advani, MD⁷, Farhad Ravandi, MBBS⁸, Hetty E. Carraway, MD, MBA⁹, Aziz Nazha, MD¹⁰, Claudia Haferlach, MD¹¹, Yogenthiran Saunthararajah, MD¹², Jacob Scott, MD^5*, Valeria Visconte, PhD¹, Hagop M. Kantarjian, MD¹³, Tapan M. Kadia, MD⁸, Mikkael A. Sekeres¹⁰, Torsten Haferlach, MD¹⁴ and Jaroslaw P. Maciejewski, MD, PhD⁵

¹Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
²Translational hematology and Oncology research, Taussic Cancer Center, Cleveland Clinic, Cleveland
³Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland
⁴MLL Munich Leukemia Laboratory, Munich, Bavaria, Germany
⁵Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
⁶Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH
⁷Cleveland Clinic, Taussig Cancer Institute, Cleveland, OH
⁸Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁹Department of Hematology and Medical Oncology, Leukemia Program, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH
¹⁰Leukemia Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland
¹¹MLL Munich Leukemia Laboratory, Inning am Ammersee, Germany
¹²Department of Translational Hematology and Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
¹³University of Texas MD Anderson Cancer Center, Houston, TX
¹⁴MLL Munich Leukemia Laboratory, Munich, Germany

Hidemasa Matsuo^1*, Kenichi Yoshida, MD, PhD², Kana Nakatani^3*, Yutarou Harata^4*, Moe Higashitani^5*, Yuri Ito^6*, Yasuhiko Kamikubo^4*, Yusuke Shiozawa, MD, PhD^7*, Yuichi Shiraishi, PhD^8*, Kenichi Chiba^9*, Hiroko Tanaka, BA^10*, Ai Okada^11*, Yasuhito Nannya, MD, PhD¹², June Takeda, MD^13*, Hiroo Ueno, MD, PhD^13*, Nobutaka Kiyokawa, MD, PhD^14*, Daisuke Tomizawa, MD, PhD¹⁵, Takashi Taga, MD, PhD^16*, Akio Tawa, MD, PhD^17*, Satoru Miyano, PhD^18*, Manja Meggendorfer, PhD¹⁹, Claudia Haferlach, MD²⁰, Seishi Ogawa, MD, PhD²¹ and Souichi Adachi, MD, PhD⁴

¹Department of Human Health Sciences, Kyoto University, Kizugawa, KYO, Japan
²Kyoto Univeristy, Kyoto, Japan
³Department of Human Health Sciences, Kyoto University, Kyoto-Shi, Japan
⁴Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan
⁵Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, JPN
⁶Kyoto University, Kyoto, Japan
⁷Department of Pediatrics, The University of Tokyo, Tokyo, Japan
⁸Center for Cancer Genomics and Advanced Therapeutics, National Cancer Center Research Institute, Tokyo, Japan
⁹Division of Cellular Signaling, National Cancer Center Research Institute, Tokyo, Japan
¹⁰Laboratory of DNA Information Analysis, Human Genome Center, The University of Tokyo, Tokyo, Japan
¹¹Laboratory of DNA Information Science, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
¹²Department of Pathology and Tumor Biology, Kyoto University, Kyoto City, Japan
¹³Department of Pathology and Tumor Biology, Kyoto University, Kyoto, KYO, Japan
¹⁴Department of Pediatric Hematology and Oncology Research, National Center for Child Health and Development, Tokyo, Japan
¹⁵Children’s Cancer Center, National Center for Child Health and Development, Tokyo, Japan
¹⁶Department of Pediatrics, Shiga University of Medical Science, Ohtsu, Japan
¹⁷Higashiosaka Aramoto Hiewa Clinic, Higashiosaka, Japan
¹⁸Department of Integrated Data Science, M&D Data Science Center, Tokyo Medical and Dental University, Tokyo, Japan
¹⁹MLL Munich Leukemia Laboratory, Munich, Bavaria, Germany
²⁰MLL Munich Leukemia Laboratory, Inning am Ammersee, Germany
²¹Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan