62nd ASH Annual Meeting and Exposition: 622. Lymphoma Biology—Non-Genetic Studies: Mechanisms of Lymphomagenesis, Progression, and Response

Oral and Poster Abstracts
Oral

Leukemia, CLL, Diseases, Lymphoma (any), Marginal Zone Lymphoma, Non-Hodgkin Lymphoma, Biological Processes, B-Cell Lymphoma, DLBCL, Lymphoid Malignancies, genomics, integrative -omics, molecular interactions, pathogenesis, pathways, proteomics

Moderators:

Alexey Danilov, MD, Oregon Health & Science University and Megan S. Lim, MD, PhD, University of Pennsylvania

Disclosures:

Lim: Seattle Genetics: Honoraria; EUSA: Honoraria; USCAP: Membership on an entity's Board of Directors or advisory committees.

7:30 AM

Large-Scale Proteomics Identifies Distinct Signatures for Richter Syndrome and De Novo Diffuse Large B-Cell Lymphoma: A French Study from the Filo Group

Romain Morizot¹^*, Sebastien Hergalant²^*, Romain Piucco³^*, Florian Bouclet⁴^*, Anne Quinquenel, MD, PhD⁵^*, Caroline Dartigeas, MD⁶^*, Hélène Augé¹^*, Eugen Tausch, MD⁷^*, Sandra Lomazzi⁸^*, Hélène Busby, MD⁹^*, Cécile Tomowiak, MD¹⁰^*, Veronique Leblond, MD, PhD¹¹^*, Catherine Thieblemont, MD, PhD¹², Florence Cymbalista, MD, PhD¹³^*, Marie C Bene, PharmD, DPhil¹⁴^*, Stephan Stilgenbauer, MD¹⁵, Romain Guieze, MD¹⁶^*, Christine Carapito, PhD¹⁷^*, Aurore Perrot, MD, PhD¹⁸^*, Luc Mathieu Fornecker, MD, PhD¹⁹^*, Pierre Feugier, MD, PhD²⁰^* and Julien Broséus, Dr²¹^*

¹Haematology Department, Nancy University Hospital, Vandoeuvre-lès-Nancy, France
²U1256, Inserm, Vandoeuvre-lès-Nancy, France
³U1256, Inserm, VANDOEUVRE, France
⁴CHU Estaing, Unit of adult cell therapy and clinical hematology, University Hospital of Clermont-Ferrand, Clermont-Ferrand, Auvergne, France
⁵Haematology Department, Robert Debré University Hospital, Reims, France
⁶CHU Tours, Tours, France
⁷Department of Internal Medicine III, Ulm University, Ulm, Germany
⁸Biocollection repository, Nancy University Hospital, Vandoeuvre-lès-Nancy, France
⁹Pathology Department, Nancy University Hospital, Vandoeuvre-lès-Nancy, France
¹⁰Department of Oncology-Haematology and Cell Therapy, University Hospital of Poitiers, Poitiers, France
¹¹Département d’ Hématologie Hôpital Pitié-Salpêtrière APHP, UPMC Université Paris, Paris, France
¹²Hôpital Saint-Louis, Paris, France
¹³Laboratoire d'Hématologie, APHP Hôpital Avicenne, Bobigny, France
¹⁴Hematology Biology, Nantes University Hospital, Nantes, France
¹⁵Department of Internal Medicine III, University Hospital Ulm, Ulm, Germany
¹⁶CHU Estaing, Unit of adult cell therapy and clinical hematology, University Hospital of Clermont-Ferrand, Brookline, MA
¹⁷Laboratoire de Spectrométrie de Masse BioOrganique, Université de Strasbourg, CNRS, IPHC, UMR 7178, Strasbourg, France
¹⁸Institut Universitaire du Cancer de Toulouse-Oncopole, Toulouse, France
¹⁹Department of Hematology, Strasbourg University Hospital, Strasbourg, France
²⁰Hematology Department, Nancy University Hospital, Vandoeuvre-lès-Nancy, France
²¹Laboratory Department, CHRU Nancy, Vandoeuvre-lès-Nancy, France

7:45 AM

Modeling Marginal Zone Lymphomagenesis

Victor Yazbeck, MD¹, Ian McConnell²^*, Emily Harris³^*, Joseph Lownik⁴^*, Ariel Sindel, DO⁵, Roy Sabo, PhD⁶^*, Alden Chesney, MD⁷, Guanhua Lai, MD, PhD⁸^*, Adolfo Mauro, PhD⁸^*, Chad Cain⁹^*, Fadi N. Salloum⁹^*, Jamal Zweit, PhD¹⁰^*, Steven Grant, MD¹, Jolene Windle, PhD⁴^* and Steven Grossman, MD¹^*

¹VCU Massey Cancer Center, Richmond, VA
²Massey Cancer Center, Virginia Commonwealth University, Richmond, VA
³Virginia Commonwealth University School of Medicine, Richmond, VA
⁴Virginia Commonwealth University, Richmond, VA
⁵Department of Hematology/Oncology, VCU Health System, Richmond, VA
⁶Department of Biostatistics, Virginia Commonwealth University, Richmond, VA
⁷Department of Pathology, VCU School of Medicine, Richmond, VA
⁸VCU Health System, Richmond, VA
⁹Virginia Commonwealth University, Richmond
¹⁰Department of Radiology, VCU Health System, Richmond, VA

8:00 AM

Nfkbiz 3′ UTR Mutations Confer Selective Growth Advantage and Affect Drug Response in Diffuse Large B-Cell Lymphoma

Sarah E Arthur, BSc¹, Nicole Thomas, BSc¹^*, Christopher Rushton, BSc¹^*, Jeffrey Tang¹^*, Miguel Alcaide, PhD¹^*, Shannon Healy, PhD²^*, Adele Telenius²^*, Anja Mottok, MD, PhD^2,3, David W. Scott, MBChB, PhD², Christian Steidl, MD² and Ryan D Morin, PhD, BSc, MSc^1,4

¹Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada
²Centre for Lymphoid Cancer, BC Cancer, Vancouver, BC, Canada
³Institute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, BC, Germany
⁴Canada's Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, BC, Canada

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^*signifies non-member of ASH

622.O2.6 622. Lymphoma Biology—Non-Genetic Studies: Mechanisms of Lymphomagenesis, Progression, and Response