-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

612.O2.6 612. Acute Lymphoblastic Leukemia: Clinical Studies: Insights in Genomics, MRD, and Toxicities Clinically Relevant Abstract

Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
Leukemia, ALL, Adult, Diseases, Non-Biological, Therapies, Combinations, Pediatric, chemotherapy, Adverse Events, Biological Processes, Young Adult, Technology and Procedures, Study Population, Lymphoid Malignancies, Clinically relevant, genomics, flow cytometry, NGS
Monday, December 7, 2020: 9:00 AM-10:30 AM
Moderators:
Josep-Maria Ribera, Ico-Hospital Universitari Germans Trias Y Pujol and Maureen M O'Brien, MD, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine
Disclosures:
No relevant conflicts of interest to declare.
9:00 AM

Judith M. Boer, PhD1,2, Maria Grazia Valsecchi, PhD3*, Femke M. Hormann, MSc1,2*, Zeljko Antic, MD4*, Marketa Zaliova, MD, PhD5, Claire Schwab, PhD6*, Giovanni Cazzaniga, PhD7*, Chloé Arfeuille, MD8*, Hélène Cavé, PharmD, PhD9*, Andishe Attarbaschi, MD10*, Sabine Strehl, PhD11*, Gabriele Escherich, MD12*, Toshihiko Imamura, MD, PhD13, Kentaro Ohki, MD, PhD14*, Tanja A. Gruber, MD, PhD15, Rosemary Sutton, BSc MSc PhD16*, Agata Pastorczak17*, Tim Lammens, PhD18,19*, Frederic Lambert, MD20*, Chi Kong Li, MD21, Enrique Carrillo de Santa Pau, PhD22*, Steve Hoffmann, MD, PhD23*, Anja Möricke, MD24*, Christine J. Harrison, PhD, FRCPath6, Monique L. Den Boer, PhD1,2,25, Paola De Lorenzo7,26*, Ronald W. Stam, PhD1*, Anke K. Bergmann, MD, PhD4* and Rob Pieters, MD, PhD, MSc1

1Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
2Oncode Institute, Utrecht, Netherlands
3Centro Operativo di Ricerca Statistica, Fondazione Tettamanti, Monza, Italy
4Institute of Human Genetics, Medical School Hannover, Hannover, Germany
5CLIP, Department of Pediatric Hematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic
6Leukaemia Research Cytogenetics Group, Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom
7Tettamanti Research Center, Pediatric Clinic, University of Milan-Bicocca, Monza, Italy
8Department of Genetics, Robert Debré Hospital and University of Paris, Paris, France
9Institut de Recherche St Louis, Université de Paris, INSERM U1131, Paris, France
10Department of Pediatric Hematology and Oncology, St. Anna Children’s Hospital, Medical University of Vienna, Vienna, Austria
11CCRI, Children’s Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria
12Department of Pediatric Hematology and Oncology, University Medical Center Hamburg, Hamburg, Germany
13Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan
14Department of Pediatric Hematology and Oncology Research, National Research Institute for Child Health and Development, Tokyo, Japan
15Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN
16Children's Cancer Institute Australia, University of NSW, Randwick, NSW, Australia
17Department of Pediatric Oncology and Hematology, Medical University of Lodz, Lodz, CA, Poland
18Cancer Research Institute Ghent (CRIG), Ghent, Belgium
19Department of Pediatric Hemato-oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
20Centre Hospitalier Universitaire de Liège, Liege, Belgium
21Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong
22Computational Biology Group, Precision Nutrition and Cancer Research Program, IMDEA Food Institute, Madrid, Spain
23Computational Biology, Leibniz Institute on Ageing-Fritz Lipmann Institute (FLI), Jena, Germany
24Department of Pediatrics, Christian-Albrechts-University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany
25Erasmus MC-Sophia Children's Hospital, Department of Pediatric Oncology/Hematology, Rotterdam, Netherlands
26Centro Operativo di Ricerca Statistica, Fondazione Tettamanti, School of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy

9:15 AM

Nicholas J. Short, MD1, Hagop M. Kantarjian, MD1, Keyur Patel, MD, PhD2*, Steven M. Kornblau, MD1, Jeffrey L. Jorgensen, MD, PhD3*, Sa A Wang, MD3*, Marina Konopleva, MD, PhD4, Nitin Jain, MD1, Partow Kebriaei, MD5, Musa Yilmaz, MD1, Ghayas C. Issa, MD6, Jairo A. Matthews1*, Munazza Noor1*, Rebecca Garris, MSc1*, Farhad Ravandi, MBBS1 and Elias Jabbour, MD1

1Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
2Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX
3Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX
4Department of Leukemia, University of Texas, MD Anderson Cancer Center, Houston, TX
5Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX
6Department of Leukemia, Universit Y of Texas At Houston, Houston, TX

9:30 AM

Kelsey-Leigh A Garcia1*, Philip A. Stevenson, MS2,3*, Sindhu Cherian, MD4*, Christen N. Martino, NP5*, Andrei R Shustov, MD1,5,6, Pamela S. Becker, MD, PhD1,5,6, Mary-Beth M. Percival, MD1,5,6, Vivian G. Oehler, MD1,5,6, Anna B. Halpern, MD1,5,6, Roland P Walter, MD PhD1,5,6, Johnnie Orozco, MD1,5,6*, Colin D. Godwin, MD, MPhil1,5,6, Sioban Keel, MD1,5, Elihu H. Estey, MD1,5,6 and Ryan D. Cassaday, MD1,5,6

1Department of Medicine, University of Washington, Seattle, WA
2Clinical Statistics Division, Fred Hutchinson Cancer Research Center, Seattle, WA
3University of Washington, Department of Biostatistics, Seattle, WA
4Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA
5Seattle Cancer Care Alliance, Seattle, WA
6Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA

9:45 AM

Line Stensig Lynggaard1*, Lisbeth Moeller, PhD2*, Cecilie Utke Rank, MD3, Sofie Gottschalk Højfeldt, MD, PhD4*, Louise Tram Henriksen, MD, PhD5*, Kirsten Brunsvig Jarvis, MD6*, Susanna Ranta, MD, PhD7*, Riitta Niinimäki, MD8*, Arja Harila-Saari, MD, PhD,9, Benjamin Ole Wolthers, MD10*, Mats Heyman, MD, PhD11, Thomas Leth Frandsen, MD, PhD10*, Kjeld Schmiegelow, Professor, MD, DMSc12 and Birgitte Klug Albertsen, MD, PhD, professor associate13*

1Aarhus University Hospital, Galten, Denmark
2Department of Pediatrics and Adolescent Medicine, University Hospital Rigshospitalet, Copenhagen, Copenhagen, Denmark
3Department of Hematology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
4Child and Adolescent Health, Aarhus University Hospital, Aarhus N., Denmark
5Child and Adolescent Heath, Aarhus University Hospital, Aarhus N., Denmark
6Department of Pediatric Hematology and Oncology, Oslo University Hospital, Oslo, Norway
7Pediatric Coagulation Center, Karolinska University Hospital and Karolinska Institutet, Stockholm, SWE
8Department of Pediatrics, Oulu University Hospital and PEDEGO Research Unit, University of Oulu, Oulu, Finland
9Department of Women's and Children's Health, Uppsala University Hospital, Uppsala, Sweden
10Department of Pediatrics and Adolescent Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
11Childhood Cancer Research Unit, Karolinska Institute, Childhood Cancer Rsch. Unit, ALB Karolinska Hospital, Stockholm, Sweden
12The Institute of Clinical medicine, The Faculty of Medicine, University of Copenhagen, Hellerup, Denmark
13Children and Adolescent Health, Aarhus University Hospital, Aarhus, Denmark

10:00 AM

Lynda M. Vrooman, MD1, Yael Flamand, MS2*, Victoria Koch, BS1*, Melissa A. Burns, MD1, Sarah M. Cronholm, BA1*, Sarah K. Hunt, BS, MPH1*, Peter D. Cole, MD3, Lisa M. Gennarini, MD4*, Justine M. Kahn, MD, MSc5, Kara M. Kelly, MD6, Bruno Michon, MD, FRCPC7*, Donna S. Neuberg, ScD8, Andrew E. Place, MD, PhD1, Thai Hoa Tran, MD9, Jennifer J.G. Welch, MD10*, Kristen E. Stevenson, MS2*, Stephen E. Sallan, MD1 and Lewis B. Silverman, MD1

1Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA
2Department of Data Science, Dana-Farber Cancer Institute, Boston, MA
3Rutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ
4Children's Hospital at Montefiore, Bronx, NY
5Pediatric Hematoloy/Oncology, Columbia University Irving Medical Center, Brooklyn, NY
6Department of Pediatric Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY
7Division of Hematology-Oncology, Centre Hospitalier de l'Universite Laval (CHUL), Quebec, QC, Canada
8Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA
9Centre Hospitalier Universitaire De Quebec, Montreal, Canada
10Division of Pediatric Hematology-Oncology, Hasbro Children's Hospital, Providence, RI

10:15 AM

Yannis K. Valtis, MD1*, Kristen E. Stevenson, MS2*, Andrew E. Place, MD, PhD3, Lewis B. Silverman, MD3, Lynda M. Vrooman, MD4, Giacomo Gotti, MD5*, Andrew M. Brunner, MD6, Mary Nauffel1*, Daniel J. DeAngelo, MD, PhD7 and Marlise R Luskin, MD, MS8

1Brigham and Women's Hospital, Boston, MA
2Department of Data Science, Dana-Farber Cancer Institute, Boston, MA
3Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA
4Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA
5Dana-Farber Cancer Institute, Boston, MA
6Massachusetts General Hospital, Boston, MA
7Department of Medical Oncology, Dana-Farber Cancer Inst., Boston, MA
8Department of Medical Oncology, Dana-Farber Cancer Institute, Boston

*signifies non-member of ASH