62nd ASH Annual Meeting and Exposition: 602. Disordered Gene Expression in Hematologic Malignancy, including Disordered Epigenetic Regulation: Aberrant Nuclear Architecture and Chromatin Remodeling

Oral and Poster Abstracts
Oral

Adult, ALL, AML, Leukemia, HSCs, iPSCs, cell division, Diseases, Animal models, cell regulation, Elderly, Therapies, MDS, Biological Processes, Young Adult, Technology and Procedures, epigenetics, Cell Lineage, Lymphoid Malignancies, Study Population, gene editing, genomics, Myeloid Malignancies, hematopoiesis, flow cytometry, integrative -omics, molecular testing, NGS, RNA sequencing, molecular interactions, pathogenesis, WGS, pathways

Moderators:

Zuzana Tothova, MD, PhD, Dana Farber Cancer Institute and Eirini P. Papapetrou, MD, Icahn School of Medicine at Mount Sinai

Disclosures:

No relevant conflicts of interest to declare.

9:30 AM

105

Hottip-Mediated R-Loops Regulate CTCF TAD Boundary to Control WNT/b-Catenin Pathway in AML Genome

Huacheng Luo, PhD¹, Ganqian Zhu, PhD², Xiaoyan Ma, MD, PhD³^*, David F. Claxton, MD^4,5, Yi Qiu, PhD³, Mingjiang Xu, MD, PhD² and Suming Huang, PhD⁶

¹Pennsylvania State University Hershey College of Medicine, Hershey, PA
²Department of Molecular Medicine, the University of Texas Health Science Center at San Antonio, San Antonio, TX
³Pennsylvania State University College of Medicine, Hershey, PA
⁴Penn State Cancer Institute, Penn State Hershey Medical Center, Hershey, PA
⁵Penn State Cancer Institute, Penn State University College of Medicine, Hershey, PA
⁶Department of Pediatrics, Division of Hematology and Oncology, Penn State Cancer Institute, Pennsylvania State University Hershey College of Medicine, Hershey, PA

9:45 AM

106

3D Genomics of Acute Meyloid Leukemia Reveals the Imbalance between DNA Methylation Canyon Interactions and Leukemic Specific Enhancer Network Interactions

Xiaotian Zhang, PhD^1,2, Xue Qing David Wang, PhD³^*, Haley Gore, MS³^*, Pamela Himadewi, BSc³^*, Fan Feng⁴^* and Jie Liu, PhD⁴^*

¹Pathology, University of Michigan, Ann Arbor, MI
²Center for Epigenetics, Van Andel Research Institute, Ann Arbor, MI
³Center for Epigenetics, Van Andel Research Institute, Grand Rapids, MI
⁴Computational Biology, University of Michigan, Ann Arbor, MI

10:00 AM

107

Single-Cell Multi-Omics in Human Clonal Hematopoiesis Reveals That DNMT3A R882 Mutations Perturb Early Progenitor States through Selective Hypomethylation

Anna S Nam, MD¹, Neville Dusaj, MS²^*, Franco Izzo, PhD³^*, Rekha Murali, MS⁴^*, Tarek H Mouhieddine, MD⁵, Robert M Myers⁶^*, Jesus Sotelo⁷^*, Salima Benbarche, PhD⁸, Federico Gaiti, PhD³^*, Sabrin Tahri, MD, MSc⁹^*, Omar Abdel-Wahab, MD ⁸, Irene M. Ghobrial, MD¹⁰, Ronan Chaligne, PhD¹¹^* and Dan A. Landau, MD, PhD¹²

¹Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, NEW YORK, NY
²Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program, New York, NY
³Meyer Cancer Center & Institute of Computational Biomedicine, Weill Cornell Medicine, New York, NY
⁴Weill Cornell Medicine, New York, NY
⁵Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, New York, NY
⁶Tri-Institutional MD-PhD Program, Weill Cornell Medicine, Rockefeller University, Memorial Sloan Kettering Cancer Center, New York
⁷Weill Cornell Medicine, New York
⁸Memorial Sloan Kettering Cancer Center, New York, NY
⁹Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
¹⁰Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
¹¹Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY
¹²Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY

10:15 AM

108

High-Density Domain-Focused CRISPR Screens Reveal Epigenetic Regulators of Hox/Meis Gene Expression in Acute Myeloid Leukemia

Karina Barbosa, BSc¹, Anagha Deshpande, PhD²^*, Ping Xiang, PhD³^*, Bo-Rui Chen, PhD¹^*, Adam Brown, MSc⁴^*, Neil Robertson⁵^*, Younguk Sun, PhD¹^*, John Doench, PhD⁴^*, Peter D Adams, PhD¹^*, R. Keith Humphries, MD, PhD³, Prashant Mali, PhD⁶^* and Aniruddha J. Deshpande, PhD¹^*

¹Tumor Initiation and Maintenance Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA
²Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA
³Terry Fox Laboratory BC Cancer Agency, Vancouver, BC, Canada
⁴Broad Institute, Cambridge, MA
⁵Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom
⁶Department of Bioengineering, University of California San Diego, La Jolla, CA

10:30 AM

109

RNA Binding Protein CELF2 Mutation Cooperates with MLL-AF9 in Driving Acute Myeloid Leukemia Development

Xiaomin Wang¹^*, Tengxiao Guo¹^*, Yuxia Wang¹^*, Shengnan Yuan¹^*, Shuaibing Hou¹^*, Yanjie Lan¹^*, Shuang Yang¹^* and Weiping Yuan, PhD, MD^2,3

¹Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences/Peking Union Medical College, Tianjin, China
²State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
³State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China

10:45 AM

110

NSD2-E1099K Mutation Leads to Glucocorticoid-Resistant B Cell Lymphocytic Leukemia in Mice

Jianping Li, MD^1,2, Crissandra Piper, LATG^2,3^*, Daphne Dupere-Richer, PhD^2,3, Heidi Casellas Roman, MS^2,3^*, Alok Swaroop, PhD^2,3^*, Catalina Troche, PhD^2,3^*, Jon Oyer, PhD⁴^*, Christine Will, MS⁴^*, Alberto Riva, PhD²^*, Richard Lynn Bennett, PhD^2,3 and Jonathan D. Licht, MD^2,3

¹Department of Medicine, University of Florida, Newberry, FL
²Cancer and Genetics Research Complex, University of Florida, Gainesville, FL
³Department of Medicine, University of Florida, Gainesville, FL
⁴Northwestern University, Chicago, IL

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^*signifies non-member of ASH

602.O1.6 602. Disordered Gene Expression in Hematologic Malignancy, including Disordered Epigenetic Regulation: Aberrant Nuclear Architecture and Chromatin Remodeling