Hartmut Döhner¹, Andrew H Wei, MBBS, PhD^2,3, Pau Montesinos, MD, PhD^4,5*, Hervé Dombret, MD^6,7, Farhad Ravandi, MBBS⁸, Hamid Sayar, MD, MSc⁹, Kimmo Porkka^10,11, Irwindeep Sandhu, MD^12*, Francesco Passamonti^13*, Fabrizio Pane, MD¹⁴, Tadeusz Robak, MD PhD¹⁵, José F. Falantes^16*, Andre C. Schuh¹⁷, Gert Ossenkoppele, MD, PhD^18*, Ignazia La Torre^19*, Barry Skikne, MD^20,21*, Keshava Kumar, PhD^21*, Qian Dong, DrPH^21*, C.L. Beach, PharmD^21* and Gail J. Roboz, MD²²

¹Ulm University Hospital, Ulm, Germany
²The Alfred Hospital, Melbourne, Australia
³Australian Centre for Blood Diseases, Monash University, Melbourne, Australia
⁴CIBERONC, Instituto de Salud Carlos III, Madrid, Spain
⁵Hematology Department, Hospital Universitario La Fe de Valencia,, Valencia, Spain, Spain
⁶Institut de Recherche Saint Louis, Université de Paris, Paris, France
⁷Hôpital Saint-Louis, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France
⁸Department of Leukemia, University of Texas- MD Anderson Cancer Center, Houston, TX
⁹Indiana University Cancer Center, Indianapolis, IN
¹⁰iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Helsinki, Finland
¹¹Hematology Research Unit Helsinki, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland
¹²University of Alberta Hospital, Edmonton, Canada
¹³Department of Medicine and Surgery, University of Insubria, Varese, Italy
¹⁴Azienda Ospedaliera Universitaria Federico II, Naples, Italy
¹⁵Department of Hematology, Medical University of Lodz, Copernicus Memorial Hospital, Lodz, Poland
¹⁶Hospital Virgen del Rocío. Hematología, Seville, Spain
¹⁷Princess Margaret Cancer Centre, Toronto, ON, Canada
¹⁸Amsterdam UMC, Location VU University Medical Center, Amsterdam, Netherlands
¹⁹Celgene, a Bristol-Myers Squibb Company, Boudry, Switzerland
²⁰Kansas University Medical Center, Kansas City, KS
²¹Bristol Myers Squibb, Princeton, NJ
²²Weill Medical College of Cornell University New York-Presbyterian Hospital, New York, NY

Stephane De Botton, MD, PhD^1*, Thomas Cluzeau, MD, PhD², Carlos Enrique Vigil, MD³, Rachel J. Cook, MD⁴, Philippe Rousselot, MD PhD^5*, David A Rizzieri, MD⁶, Jane L. Liesveld, MD⁷, Pierre Fenaux, MD, PhD⁸, Thorsten Braun, MD, PhD⁹, Anne Banos, MD^10*, Michael R. Savona, MD¹¹, Don Park, MD^12*, Michael J. Kelly, MD, MPH, MS^13*, Angela Volkert^13*, Li Zhou, PhD^13*, Qing Kang-Fortner, PhD^13*, David A. Roth, MD¹³ and Eytan M. Stein, MD¹⁴

¹Institut Gustave Roussy, Villejuif, France
²CHU De Nice, Nice, France
³Division of Hematology,Oncology, and Blood & Marrow Transplantation, The University of Iowa, Iowa City, IA
⁴Knight Cancer Institute, Oregon Health and Science University, Portland, OR
⁵Centre Hospitalier de Versailles, Le Chesnay, France
⁶Division of Hematologic Malignancies, Duke University, Durham, NC
⁷Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY
⁸Hôpital Saint-Louis, Paris, France
⁹Hematology, Avicenne Hospital, Bobigny, France
¹⁰Hematology department, CH Côte Basque, Bayonne, France
¹¹Department of Medicine and Program in Cancer Biology, Vanderbilt University Medical Center, Nashville, TN
¹²Lehigh Valley Health Network Muhlenberg, Allentown, PA
¹³Syros Pharmaceuticals, Inc., Cambridge, MA
¹⁴Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY

Benjamin J. Huang, MD^1,2*, Xinyue Wang, BA^2*, Max Harris, BA^2*, Anica Wandler, PhD^2*, Eugene Hwang, BA^2*, Michael R. Burgess, MD, PhD^3,4, Qing Li, MD, PhD^5,6, Paul Severson, PhD^7*, Ben Powell, PhD^7*, Edward A. Kolb, MD⁸, Soheil Meshinchi, MD, PhD^9,10, Barry S Taylor, PhD^11*, Gideon Bollag, PhD¹² and Kevin M. Shannon, MD²

¹Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA
²Department of Pediatrics, University of California, San Francisco, San Francisco, CA
³Department of Medicine, University of California San Francisco, San Francisco, CA
⁴Immuno-Oncology and Cell Therapy Department, Bristol-Myers Squibb, San Francisco, CA
⁵Department of Internal Medicine, Division of Hematology-Oncology, Michigan Medicine, Ann Arbor, MI
⁶Department of Cell and Developmental Biology,, University of Michigan, Ann Arbor, MI
⁷Plexxikon Inc., Berkeley, CA
⁸Division of Oncology, Nemours Alfed I. duPont Hospital For Children, Wilmington, DE
⁹Department of Pediatrics, University of Washington, Seattle, WA
¹⁰Clinical Research Division, Fred Hutchinson Cancer Rsrch. Ctr., Seattle, WA
¹¹Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY
¹²Plexxikon, Berkeley, CA

Eytan M. Stein, MD¹, Stephane De Botton, MD, PhD^2*, Thomas Cluzeau, MD, PhD³, Arnaud Pigneux, MD, PhD^4*, Jane L. Liesveld, MD⁵, Rachel J. Cook, MD⁶, Philippe Rousselot, MD PhD^7*, David A Rizzieri, MD⁸, Thorsten Braun, MD, PhD⁹, Dale L. Bixby, MD^10*, Gail J. Roboz, MD¹¹, Delphine Lebon, MD^12*, Mael Heiblig^13*, Michael J. Kelly, MD, MPH, MS^14*, Angela Volkert^14*, Li Zhou, PhD^14*, Qing Kang-Fortner, PhD^14*, David A. Roth, MD¹⁴ and Pierre Peterlin, MD^15*

¹Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY
²Department of Haematology, Institut Gustave Roussy, Villejuif, France
³CHU De Nice, Nice, France
⁴Bordeaux Haut-Leveque University Hospital, Pessac, France
⁵Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY
⁶Knight Cancer Institute, Oregon Health and Science University, Portland, OR
⁷Centre Hospitalier de Versailles, Le Chesnay, France
⁸Division of Hematologic Malignancies, Duke University, Durham, NC
⁹Hematology, Avicenne Hospital, Bobigny, France
¹⁰Comprehensive Cancer Center, University of Michigan, Grass Lake, MI
¹¹Weill Medical College of Cornell University New York-Presbyterian Hospital, New York, NY
¹²Hematology department, CHU Amiens, Amiens, France
¹³Centre Hospitalier Lyon Sud, Pierre Benite, France
¹⁴Syros Pharmaceuticals, Inc., Cambridge, MA
¹⁵Service d'Hématologie Clinique, Centre Hospitalier Universitaire Nantes, Nantes, France

Eunice S. Wang, MD¹, Jessica K. Altman, MD², Kristen M. Pettit, MD³, Stephane De Botton, MD, PhD^4*, Roland P Walter, MD PhD⁵, Pierre Fenaux, MD, PhD⁶, Francis Burrows, PhD^7*, Blake E. Tomkinson, PhD, MBA⁸, Bridget Martell, MA, MD^8* and Amir T. Fathi, M.D.⁹

¹Roswell Park Comprehensive Cancer Center, BUFFALO, NY
²Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine; Robert H. Lurie Comprehensive Cancer Center, Chicago, IL
³University of Michigan, Ann Arbor
⁴Institut Gustave Roussy Service d'Hématologie Clinique, Villejuif, France
⁵Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
⁶Hôpital Saint-Louis, Paris, France
⁷Kura Oncology, San Diego, CA
⁸Kura Oncology, Boston, MA
⁹Massachusetts General Hospital , Harvard Medical School, Cambridge, MA

Inge Van Der Werf, MSc^1,2, Phoebe Mondala, BS^2,3*, Raymond Diep, BS^3*, Larissa Balaian, PhD^4*, Cayla Mason, BS^3*, Jacqueline Cloos, PhD^5*, Gertjan J.L. Kaspers, Prof. MD, PhD⁶, Jim La Clair^7*, Peggy Wentworth^8*, Leslie A Crews, PhD³, Thomas Whisenant, PhD^9*, Kathleen Fisch, PhD^9*, Michael Burkart, PhD^7* and Catriona Jamieson, MD, PhD^10,11

¹Amsterdam UMC, Voorschoten, Netherlands
²authors contributed equally, .
³Division of Regenerative Medicine, University of California, San Diego, La Jolla, CA
⁴Moores Cancer Center, UCSD, La Jolla, CA
⁵Cancer Center Amsterdam, Department of Hematology, VU University Medical Center, Amsterdam, Netherlands
⁶Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands
⁷Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA
⁸UCSD, La Jolla
⁹Center for Computational Biology and Bioinformatics, University of California San Diego, La Jolla, CA
¹⁰Moores Cancer Center, University of California, San Diego, La Jolla, CA
¹¹Division of Regenerative Medicine, Department of Medicine, Moores Cancer Center, and Sanford Stem Cell Clinical Center, University of California, San Diego, La Jolla, CA