62nd ASH Annual Meeting and Exposition: 331. Pathophysiology of Thrombosis I

Oral and Poster Abstracts
Oral

Adult, SARS-CoV-2/COVID-19, anticoagulant drugs, viral, Drug-induced thrombocytopenia, Coronaviruses, autoimmune disorders, Bleeding and Clotting, Diseases, Non-Biological, Therapies, HIT, Thrombosis, Biological Processes, Immune Disorders, Platelet Disorders, Infectious Diseases, Study Population, Thromboembolism, genomics, Clinically relevant, Thrombocytopenias, Thrombotic Disorders, immune mechanism, inflammation, Vascular Wall, VTE, multi-systemic interactions, pathogenesis

Moderators:

Radhika Gangaraju, MD, University Of Alabama at Birmingham and Char M Witmer, MD, The Children's Hospital of Philadelphia

Disclosures:

Gangaraju: Sanofi Genzyme, Consultant for Cold Agglutinin Disease: Consultancy.

2:00 PM

442

Prior History of Venous Thromboembolism Is a Significant Risk Factor for Recurrence of Thrombosis after Cancer Diagnosis

Sargam Kapoor, MBBS¹, Aman Opneja, MBBS¹, Jahnavi Gollamudi, MD² and Lalitha V. Nayak, MD³

¹Division of Hematology Oncology, Alaska Native Medical Center, Anchorage, AK
²Department of Pathology and Medicine, Baylor College of Medicine, Houston, TX
³Department of Medicine, Division of Hematology and Oncology, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, OH

2:15 PM

443

Thromboembolic Outcomes of Hospitalized COVID-19 Patients in the 90-Day Post-Discharge Period: Early Data from the Northwell CORE-19 Registry

Dimitrios Giannis, MD, MSc¹^*, Steven L. Allen, MD^2,3, Anne Davidson, MD^4,5^*, Galina S. Marder, MD⁵^*, Sarah Flint, MD^1,6^*, David Garrett, MD^1,6^*, Richa Thakur, MD^1,6^*, Matthew Snyder, DO^1,6^*, Cristina Ghiuzeli, MD³, Thomas G. McGinn, MD, MPH^1,6, Karina W. Davidson, PhD, MASc^1,6^*, Michael Qiu, MD, PhD¹^*, Matthew Barish, MD⁷^* and Alex C. Spyropoulos, MD^1,8^*

¹Institute of Health Innovations and Outcomes Research, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY
²Monter Cancer Center, Northwell Health, Lake Success, NY
³Division of Hematology, Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY
⁴Institute of Molecular Medicine, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY
⁵Division of Rheumatology, Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Great Neck, NY
⁶Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY
⁷Department of Radiology, Northwell Health, Manhasset, NY
⁸Anticoagulation and Clinical Thrombosis Services, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Department of Medicine, New York, NY

2:30 PM

444

Polyreactivity and Somatic Hypermutation Analysis Reveals the Innate B Cell Origin of Human PF4/Heparin Reactive Antibodies

Wen Zhu, MBBS, MS^1,2^*, Lu Zhou¹^*, Ting Zhao¹^*, Yongwei Zheng, PhD³^*, Mei Yu, PhD¹^*, Jianhui Wei¹^*, Anand Padmanabhan, M.B.B.S., Ph.D.⁴^*, Richard H. Aster, MD¹, Demin Wang, PhD^2,3 and Renren Wen, PhD¹

¹BloodCenter of Wisconsin, part of Versiti, Milwaukee, WI
²Microbiology and Immunology, Medical College of Wisconsin, Wauwatosa, WI
³Versiti Blood Research Institute, Milwaukee, WI
⁴Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN

2:45 PM

445

Rare Inherited Defects of the Complement System in Purpura Fulminans

Pavan Bendapudi, MD^1,2, Justine Ryu, MD³^*, Onuralp Soylemez⁴^*, Betty Rouaisnel⁵^*, Meaghan Colling, MD⁶^*, Bryce Pasko⁷^*, Alissa Robbins⁸^*, Michael Bouzinier⁴^*, Lindsay Tomczak³^*, Sanjay Ram⁹^*, Agnes Toth-Petroczy⁴^*, Joel Krier⁴^*, Elizabeth Fieg⁴^*, Walter Dzik, MD¹⁰, James Hudspeth, MD¹¹^*, Olga Pozdnyakova, MD, PhD¹²^*, Valentina Nardi, MD¹³, Richard Maas⁴^* and Julie-Aurore Losman, MD, PhD¹⁴

¹Division of Thrombosis and Hemostasis, Beth Israel Deaconess Medical Center, Cambridge, MA
²Division of Hematology and Blood Transfusion Service, Massachusetts General Hospital, Boston, MA
³Beth Israel Deaconess Medical Center, Boston, MA
⁴Brigham and Women's Hospital, Boston, MA
⁵Dfci, Boston, MA
⁶National Institutes of Health, Bethesda, MD
⁷University of Colorado, Denver, CO
⁸Children's Cancer Institute Australia, Sydney NSW, AUS
⁹University of Massachusetts, Worcester, MA
¹⁰Massachusetts General Hospital, Boston, MA
¹¹Boston Medical Center, Boston, MA
¹²Department of Pathology, Brigham and Women's Hospital, Boston, MA
¹³Department of Pathology, Massachusetts General Hospital, Boston, MA
¹⁴Dana-Farber Cancer Institute, Boston, MA

3:00 PM

446

Extensive Characterization of the Hemostatic Derangement Occurring in COVID-19 Patients Admitted to the Bergamo Hospital

Patricia Gomez-Rosas, MD^1,2^*, Marina Marchetti¹^*, Eleonora Sanga¹^*, Sara Gamba¹^*, Cristina Verzeroli¹^*, Laura Russo¹^*, Francesco Restuccia³^*, Andrea D'Alessio⁴^*, Ezio Bonanomi⁵^*, Marco Rizzi⁶^*, Stefano Fagiuoli⁷^*, Luca Lorini³^* and Anna Falanga, MD^1,8

¹Immunohematology and Transfusion Medicine, Hospital Papa Giovanni XXIII, Bergamo, Italy
²Hematology Service, Hospital General Regional Tecamac IMSS, Mexico, Mexico
³Anesthesiology and Critical Care Medicine Unit, Hospital Papa Giovanni XXIII, Bergamo, Italy
⁴Medical Oncology and Internal Medicine, Policlinico San Marco, Zingonia, Bergamo, Italy
⁵Pediatric Anesthesiology and Critical Care Medicine, Hospital Papa Giovanni XXIII, Bergamo, Italy
⁶Infectious Diseases Unit, Hospital Papa Giovanni XXIII, Bergamo, Italy
⁷Gastroenterology and Transplant Hepatology Unit, Hospital Papa Giovanni XXIII, Bergamo, Italy
⁸School of Medicine, University of Milano Bicocca, Milano, Italy

3:15 PM

447

Machine Learning for Prediction of Cancer-Associated Venous Thromboembolism

Simon Mantha, MD, MPH¹, Andrew Dunbar, MD², Kelly L. Bolton, MD, PhD², Sean Devlin, PhD³^*, Dmitriy Gorenshteyn, PhD⁴^*, Mark Donoghue, PhD⁵^*, Maria E. Arcila, MD⁶^* and Gerald A. Soff, MD⁷

¹Department of Medicine, Hematology Service, Memorial Sloan Kettering Cancer Center, New York, NY
²Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY
³Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY
⁴Memorial Sloan Kettering Cancer Center, New York, NY
⁵Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY
⁶Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY
⁷Department of Medicine, Hematology Service, Memorial Sloan-Kettering Cancer Center, New York, NY

See more of: Oral and Poster Abstracts

<< Previous Session | Next Session >>

^*signifies non-member of ASH

331.O1.6 331. Pathophysiology of Thrombosis I