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506.O1.6 506. Hematopoiesis and Stem Cells: Microenvironment, Cell Adhesion, and Stromal Stem Cells

Program: Oral and Poster Abstracts
Type: Oral
Hematology Disease Topics & Pathways:
HSCs, cellular interactions, Biological Processes, white blood cells, immune cells, Technology and Procedures, Cell Lineage, hematopoiesis, imaging, microenvironment
Sunday, December 6, 2020: 2:00 PM-3:30 PM
Moderators:
Ingrid G Winkler, PhD, Mater Research Institute - University of Queensland and Lei Ding, PhD, Columbia
Disclosures:
No relevant conflicts of interest to declare.
2:00 PM
448
Ultrastructure of the Adult Hematopoietic Stem Cell Niche Defined Using Correlative Light and Electron Microscopy

Sobhika Agarwala1*, Keun-Young Kim, PhD2*, Sebastien Phan2*, Saeyeon Ju2*, Ye Eun Kong2*, Eric A Bushong, PhD2*, Mark H Ellisman, PhD2* and Owen J. Tamplin, PhD1

1Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, WI
2National Center for Microscopy and Imaging Research, University of California at San Diego, La Jolla, CA
2:15 PM
449
Cxcl8/PKC Signaling in the Endothelial Cell Niche Regulates Long-Term Hematopoietic Stem Cell Fate

Jami L Shaffer, B.S.1*, Donn L Calkins, BS1*, Emily M Teets, B.S.1*, Muhammad Faisal1*, William Deruelle1*, Elliott J. Hagedorn, PhD2, Julie R. Perlin, Ph.D.3*, Serine Avagyan, MD, PhD4, Leonard I. Zon, MD3 and Bradley W Blaser, MD, PhD1

1The Ohio State University Comprehensive Cancer Center and Division of Hematology, Columbus, OH
2Stem Cell Program and Hematology/Oncology, Boston Children's Hospital, Howard Hughes Medical Institute, Jamaica Plain, MA
3Stem Cell Program and Hematology/Oncology, Boston Children's Hospital, Howard Hughes Medical Institute, Boston, MA
4Dana-Farber Cancer Institute/Boston Children's Hospital, Boston, MA
2:30 PM
450
In Situ Fate Mapping of Native and Stress Myelopoiesis Reveals a Unique Niche for Mono- and Dendritic Cell –Poiesis

Jizhou Zhang, M.D.1, Qingqing Wu, PhD1, Courtney Johnson, BS1*, Giang Pham, PhD2*, Jeremy M. Kinder3*, Immanuel Kwok4*, Keith Leong5*, André Olsson, MS, PhD6, Anastasiya Slaughter, BA1, Margot Lindsay May, BS1, Benjamin Weinhaus, BS1*, Angelo D’Alessandro7*, James Douglas Engel, PhD8*, Jean X. Jiang, PhD9*, J.Matthew Koffron3*, Lei Huang, PhD10*, Lai Guang Ng11*, Sing Sing Way, MD PhD2*, Nathan Salomonis, PhD12*, H. Leighton Grimes, PhD13 and Daniel Lucas-Alcaraz, PhD1

1Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Medical center, Cincinnati, OH
2Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
3Cincinnati Children's Hospital Medical Center, Cincinnati, OH
4A*STAR (Agency for Science, Technology and Research), Singapore Immunology Network (SIgN),, Biopolis, Singapore
5Singapore Immunology Network (SIgN), Biopolis, Singapore
6Division of Immunobiology and Center for Systems Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
7Department of Biochemistry and Molecular Genetics, University of Colorado Denver – Anschutz Medical Campus, Aurora, CO
8University of Michigan, Ann Arbor, MI
9Department of Biochemistry, University of Texas Health Science Center, San Antonio, TX
10Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
11Singapore Immunology Network, Agency for Science, Technology and Research, Biopolis, Singapore
12Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH
13Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
2:45 PM
451
Enhanced Free Fatty Acid Uptake Via CD36 Promotes a Metabolic Switch to B-Oxidation within Hematopoietic Stem Cells in Response to Acute Infection

Jayna J Mistry, BSc1*, Jamie A Moore, BSc, MSc2*, Charlotte Hellmich3*, Aisha Jibril, BSc4*, Iain Macauley, PhD, BSc5*, Mar Moreno-Gonzalez6*, Federica Di Palma, PhD5*, Naiara Beraza, PhD7*, Kristian M Bowles, MBBS, PhD4,8 and Stuart A Rushworth, PhD4

1Norwich Medical School, The University of East Anglia, Leicester, United Kingdom
2Norwich Medical School, The University of East Anglia, Attleborough, ENG, United Kingdom
3The University of East Anglia, Norwich, GBR
4Norwich Medical School, University of East Anglia, Norwich, United Kingdom
5Earlham Institute, Norwich, United Kingdom
6Quadram Institute, Norwich, United Kingdom
7Quadram Institute Bioscience, Norwich, United Kingdom
8Department of Haematology, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, United Kingdom
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