62nd ASH Annual Meeting and Exposition: 301. Vascular Wall Biology, Endothelial Progenitor Cells, and Platelet Adhesion, Activation, and Biochemistry

Oral and Poster Abstracts
Oral

Animal models, Bleeding and Clotting, Diseases, Hemostasis, platelets, cellular interactions, Biological Processes, MPN, Thrombosis, Polycythemia vera, Technology and Procedures, Cell Lineage, thrombocythemia, Study Population, Myeloid Malignancies, imaging, Thrombotic Disorders, signal transduction

Moderators:

Peter L. Gross, MD, Thrombosis and Atherosclerosis Research Institute McMaster University and Christopher J. Ng, MD, University of Colorado/Children's Hospital Colora

Disclosures:

No relevant conflicts of interest to declare.

9:30 AM

318

The Secreted Tyrosine Kinase Vlk Is Essential for Normal Platelet Activation and Thrombus Formation

Leila Revollo, PhD¹^*, Glenn Merrill-Skoloff²^*, Karen De Ceunynck²^*, James Dilks²^*, Mattia Bordoli¹^*, Christian Peters²^*, Leila Noetzli³^*, Andreia Ionescu¹^*, Vicki Rosen¹^*, Joseph E. Italiano Jr.⁴, Malcolm Whitman¹^* and Robert Flaumenhaft, MD, PhD⁵

¹Harvard School of Dental Medicine, Boston, MA
²Beth Israel Deaconess Medical Center, Boston, MA
³Brigham and Women's Hospital, Harvard Medical School, Boston, MA
⁴Brigham and Women's Hospital, Boston, MA
⁵Beth Israel Deaconess Medical Center, Newton, MA

9:45 AM

319

Extracellular Protein Disulfide Isomerase Cleaves Allosteric Disulfides in Histidine-Rich Glycoprotein to Regulate Thrombus Formation

Shuai Chen, M.S.¹^*, Xu-Lin Xu, Ph.D.¹^*, Joyce Chiu, Ph.D.²^*, Sheryl Bowley, Ph.D.³^*, Yi Wu, M.D., Ph.D.⁴^*, Philip J. Hogg, Ph.D.²^* and Chao Fang, PhD⁵

¹Department of Pharmacology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan, China
²The Centenary Institute, National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney, NSW, Australia
³Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
⁴The Cyrus Tang Hematology Center, Soochow University, Suzhou, China
⁵Department of Pharmacology, School of Basic Medicine, Tongji Medical College, HUST, Wuhan, China

10:00 AM

320

Blockade of Human PAR4 in Novel Humanized Mouse Strains Supports PAR4 As a Potential Target in Stroke: Ex Vivo Demonstration of Platelet Hyperreactivity of the Thr120 Variant

Robert A. Campbell, PhD^1,2, Michelle L. Stoller, PhD¹^*, Frederik Denorme, PhD¹^*, Bhanu Kanth Manne, PhD²^*, Seema Bhatlekar, PhD¹^*, Emilia A Tugolukova, B.S.¹^* and Paul F. Bray, MD^1,3

¹Program in Molecular Medicine, University of Utah, Salt Lake City, UT
²University of Utah, Salt Lake City, UT
³Division of Hematology and Hematologic Malignancies, University of Utah, Eccles Institute of Human Genetics, Salt Lake City, UT

10:15 AM

321

Bleeding Diathesis in Mice Lacking JAK2 in Platelets

Nathan Eaton, BS^1,2^*, Saravanan Subramaniam, PhD¹^*, Marie L Schulte, PhD¹^*, Caleb Drew, BS¹^*, David Jakab, BS¹^*, Sandra L Haberichter, PhD^1,3,4, Hartmut Weiler, PhD^1,5 and Herve Falet, PhD^1,2

¹Blood Research Institute, Versiti, Milwaukee, WI
²Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI
³Children's Wisconsin Research Institute, Children's Wisconsin, Milwaukee, WI
⁴Department of Pediatrics- Hematology/Oncology, Medical College of Wisconsin, Milwaukee, WI
⁵Department of Physiology, Medical College of Wisconsin, Milwaukee, WI

10:30 AM

322

Plasmacytoid Dendritic Cells Surveil Megakaryocyte Sialic Acid to Regulate Thrombopoiesis

Melissa M. Lee-Sundlov, PhD¹, Robert Burns, PhD¹^*, Renata Grozovsky, PhD², Silvia Giannini, PhD³, Leonardo Rivadeneyra, PhD¹^*, Yongwei Zheng, PhD⁴^*, Simon Glabere¹^*, Walter H. Kahr, MD, PhD, FRCPC⁵, Reza Abdi⁶^*, Demin Wang, PhD⁴ and Karin M. Hoffmeister, MD⁷

¹Translational Glycomics Center, Versiti Blood Research Institute, Milwaukee, WI
²Hematology Division, Brigham & Women's Hospital/Harvard Medical School, Boston, MA
³Brigham & Women's Hospital/Harvard Medical School, Boston, MA
⁴Versiti Blood Research Institute, Milwaukee, WI
⁵The Hospital for Sick Children, Toronto, ON, Canada
⁶Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Boston, MA
⁷Translational Glyomics Center, Versiti Blood Research Institute, Milwaukee, WI

10:45 AM

323

Bleeding Cessation in a Mouse Jugular Vein Puncture Wound Model Is Caused By Extravascular Capping, Not Hole Infill

Brian Storrie, PhD¹, Sung Rhee, Ph.D.²^*, Timothy J. Stalker, PhD³, Irina D Pokrovskaya, MS¹^*, Kenny Ling, BS⁴^*, Yajnesh Vedanaparti, BS⁴^*, Joshua Cohen, B.S.⁵^*, Maria Aronova, PhD⁴^*, Sidney W Whiteheart, PhD⁶ and Lawrence Brass, MD, PhD⁷^*

¹Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR
²Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR
³Department of Medicine, University of Pennsylvania, Philadelphia, PA
⁴Laboratory for Cellular Imaging and Molecular Biophysics, NIH, NIBIB, Bethesda, MD
⁵Laboratory of Cellular Imaging and Moecular Biophysics, NIH, NIBIB, Bethesda, MD
⁶Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, KY
⁷Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA

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^*signifies non-member of ASH

301.O1.6 301. Vascular Wall Biology, Endothelial Progenitor Cells, and Platelet Adhesion, Activation, and Biochemistry