62nd ASH Annual Meeting and Exposition: 203. Lymphocytes, Lymphocyte Activation, and Immunodeficiency, including HIV and Other Infections: Hematologic Malignancies and COVID-19

Oral and Poster Abstracts
Oral

Coronaviruses, Adult, ALL, AML, autoimmune disorders, Follicular Lymphoma, HSCs, Leukemia, multiple myeloma, SARS-CoV-2/COVID-19, viral, cell division, Diseases, CML, Lymphoma (any), cell regulation, Elderly, Hodgkin Lymphoma, LGLL, Pediatric, Adverse Events, MDS, Non-Hodgkin Lymphoma, Biological Processes, DLBCL, immunodeficiency, Immune Disorders, immune cells, T-Cell Lymphoma, Technology and Procedures, Cell Lineage, Infectious Diseases, Plasma Cell Disorders, Study Population, Lymphoid Malignancies, Myeloid Malignancies, Clinically relevant, genomics, hematopoiesis, Proliferative disorders, immune mechanism, inflammation, mass cytometry, pathogenesis, signal transduction

Moderators:

Curtis J. Henry, PhD, Emory University School of Medicine and Victor Yazbeck, MD, VCU Massey Cancer Center

Disclosures:

Yazbeck: AstraZeneca: Consultancy; Celgene: Consultancy; Gilead: Research Funding; Seattle Genetics: Consultancy; Verastem: Speakers Bureau.

9:30 AM

312

Impact of Sars-CoV2 Infection on 491 Hematological Patients: The Ecovidehe Multicenter Study

Cristina De Ramón¹^*, Jose Angel Hernandez-Rivas, MD, PhD²^*, Jose Antonio Rodríguez García³^*, Enrique M. Ocio, MD, PhD⁴, María Teresa Gómez-Casares, MD, PhD⁵^*, Javier López Jiménez, MD, PhD⁶^*, Carlos Solano, MD, PhD⁷, Joaquín Martínez-López⁸^*, Anna Sureda⁹^*, Manuel Jurado, MD, PhD¹⁰, Raul Córdoba, MD, PhD¹¹, Celina Benavente¹²^*, Pascual Marco¹³^*, Jose Antonio Pérez-Simón, MD¹⁴^*, Jose Maria Moraleda, MD, PhD¹⁵^*, Angela Figuera¹⁶^*, Emilia Pardal¹⁷^*, Cristina Pascual Izquierdo, PhD, MD¹⁸^* and Ramon Garcia-Sanz¹⁹

¹Hospital Universitario de Salamanca, SALAMANCA, Spain
²University Hospital Infanta Leonor, Madrid, Spain
³Hospital Universitario de Leon, Leon, Spain
⁴Hospital Universitario Marqués de Valdecilla (IDIVAL), Santander, Spain
⁵Hospital Universitario de Gran Canaria Dr. Negrin, Las Palmas de Gran Canaria, Spain
⁶Hematology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain
⁷Hematology Department, Hospital Clínico Universitario de Valencia, Valencia, Spain
⁸Hematology Department, Hospital Universitario 12 de Octubre, Madrid, Spain
⁹Hospital De La Santa Creu I Sant Pau, Barcelona, ESP
¹⁰Servicio de Hematología y Hemoterapia, Hospital Universitario Virgen de las Nieves, Granada, Spain
¹¹Department of Hematology, Function Jimenez Diaz University Hospital, Health Research Institute IIS-FJD, Madrid, Spain
¹²Hospital Clinico San Carlos. Madrid, Madrid, Spain
¹³Hospital General Universitario de Alicante, Alicante, Spain
¹⁴Department of Hematology, Hospital Universitario Virgen del Rocio; Instituto de Biomedicina de Sevilla (IBIS)/CSIC/Universidad de Sevilla,Spain, Sevilla, Spain
¹⁵Hematopoietic Transplant and Cellular Therapy Unit, Instituto Murciano de Investigación Biosanitaria IMIB-Arrixaca, Virgen de la Arrixaca University Hospital, University of Murcia, Murcia, Spain, Murcia, Spain
¹⁶Servicio De HematologíA. Hospital De La Princesa. Madrid. Spain, Madrid, ESP
¹⁷Hospital de Plasencia, Plasencia, Spain
¹⁸Department of Hematology, Hospital General Universitario Gregorio Marañón, Madrid, Spain
¹⁹Hematology Department, Hospital Universitario de Salamanca, Salamanca, Spain

9:45 AM

313

COVID-19 in Patients with Hematological Malignancies: High False Negative Rate with High Mortality

Alex Niu, MD¹, Bo Ning, PhD²^*, Francisco Socola, MD¹, Hana Safah, MD¹, Tim Reynolds¹^*, Moayed Ibrahim, MD¹, Firas Safa, MD¹, Tina Alfonso¹^*, Alfred Luk, MD³^*, David M Mushatt, MD³^*, Tony Hu, PhD²^* and Nakhle S. Saba, MD¹

¹Section of Hematology and Medical Oncology, Department of Medicine, Tulane University, New Orleans, LA
²Department of Biochemistry & Molecular Biology, Tulane University, New Orleans, LA
³Section of Infectious Disease, Department of Medicine, Tulane University, New Orleans, LA

10:00 AM

314

CD28 Expression Distinguishes Plasma Cell Fate in Pediatric Patients Suffering from COVID-19/Kawasaki's Disease Vs MIS-C

Adam Utley, PhD¹, Kelvin P. Lee, MD¹ and Mark Hicar, MD²^*

¹Roswell Park Cancer Institute, Buffalo, NY
²University at Buffalo, Buffalo, NY

10:15 AM

315

The ACE2 Receptor for COVID-19 Entry Is Expressed on the Surface of Hematopoietic Stem/Progenitor Cells and Endothelial Progenitors As Well As Their Precursor Cells and Becomes Activated in Nlrp3 Inflammasome-Dependent Manner By Virus Spike Protein - a Potential Pathway Leading to a “Cytokine Storm”

Magdalena Kucia, PhD, DSci^1,2, Kamila Bujko, MSc^3,4^*, Andrzej Ciechanowicz, PhD²^*, Monika Cymer, MS⁵^*, Katarzyna Sielatycka, PhD⁶^*, Janina Ratajczak, MD, PhD, DSci⁴ and Mariusz Z Ratajczak, MD, PhD, DSc^2,4

¹Stem Cell Institute, University Of Louisville Brown Cancer Center, Louisville, KY
²Department of Regenerative Medicine, Warsaw Medical University, Warsaw, Poland
³Stem Cell Institute at JGB CC, University of Louisville, Louisville
⁴Stem Cell Institute at JGB CC, University of Louisville, Louisville, KY
⁵Warsaw Medical University, Warsaw, Poland
⁶Stem Cell Institute at JGB CC, Louisville

10:30 AM

316

Mezagitamab Induces Immunomodulatory Effect in Patients with Relapsed/Refractory Multiple Myeloma (RRMM)

Michael Abadier, PhD^*, Jose Estevam, MSc^*, Deborah Berg, RN, MSN and Eric Robert Fedyk, PhD^*

Takeda Pharmaceuticals Inc., Cambridge, MA

10:45 AM

317

Germline Gain-of-Function JAK3 Mutation in Familial Chronic Lymphoproliferative Disorder of NK Cells

Harry Lesmana, MD^1,2, Marcela Popescu, MD³^*, Sara Lewis, MS, LCGC⁴^*, Sushree Sangita Sahoo, PhD⁵^*, Charnise Goodings-Harris, PhD⁶, Mihaela Onciu, MD, FACP⁷, John Kim Choi, MD, FACP⁷^*, Clifford Takemoto, MD¹^*, Kim E. Nichols, MD⁸ and Marcin Wlodarski, MD, PhD⁹

¹Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN
²Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH
³Department of Pediatrics, East Tennessee State University, Johnson City, TN
⁴St. Jude Children's Research Hospital, Memphis, TN
⁵Hematology, St. Jude Children's Research Hospital, Memphis, TN
⁶St Jude Children's Research Hospital, Memphis, TN
⁷Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN
⁸Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN
⁹Department of Hematology, St. Jude Children’s Research Hospital, Memphis, TN

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^*signifies non-member of ASH

203.O1.6 203. Lymphocytes, Lymphocyte Activation, and Immunodeficiency, including HIV and Other Infections: Hematologic Malignancies and COVID-19