62nd ASH Annual Meeting and Exposition: 502. Hematopoiesis: Regulation of Gene Transcription, Cytokines, Signal Transduction, Apoptosis, and Cell Cycle Regulation: Molecular regulation of cell fate and regeneration

Oral and Poster Abstracts
Oral

HSCs, Adult, AML, cell division, Animal models, Diseases, cell regulation, Bone Marrow Failure, platelets, cellular interactions, Genetic Disorders, MDS, red blood cells, white blood cells, Biological Processes, Technology and Procedures, cell expansion, immune cells, Cell Lineage, Xenograft models, epigenetics, gene editing, Study Population, erythropoiesis, genomics, Myeloid Malignancies, hematopoiesis, flow cytometry, inflammation, integrative -omics, NGS, microenvironment, RNA sequencing, molecular interactions, pathways, signal transduction

Moderators:

Xuan Pan, PhD, DVM, University of Wisconsin and Eric Pietras, PhD, University of Colorado

Disclosures:

No relevant conflicts of interest to declare.

9:30 AM

324

Identification of Potent Human Hematopoietic Stem Cells (HSCs) Using Mitochondrial Profile Towards Improving HSC Transplantation

Jiajing Qiu, PhD^*, Jana Gjini, MS^*, Miao Lin^*, Tasleem Arif, PhD^* and Saghi Ghaffari, MD, PhD

Department of Cell, Developmental and Regenerative Biology, Tisch Cancer Institute, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY

9:45 AM

325

Cytokine Rescue and Targeting of Inflammation-Sensitive RUNX1 Deficient Human CD34⁺ Hematopoietic Stem and Progenitor Cells

Amy Fan¹^*, Armon Azizi, BS¹^*, Kevin Nuno, BS¹^*, Yusuke Nakauchi, MD, PhD¹, Feifei Zhao, MD¹^*, Andreas Reinisch, MD, PhD^1,2^*, David Cruz Hernandez, MS^1,3^* and Ravindra Majeti, MD, PhD¹

¹Department of Medicine, Division of Hematology, Cancer Institute, and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA
²Medical University of Graz, Graz, Austria
³MRC MHU, BRC Hematology Theme, Oxford Biomedical Research Centre, Oxford Centre for Hematology, WIMM, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom

10:00 AM

326

Cell Cycle Regulates Phosphorylation of RUNX1 to Modulate Megakaryocyte-Erythroid Progenitor Fate Specification

Yi-Chien Lu, PhD¹, Vanessa M Scanlon, PhD¹^*, Juliana Xavier-Ferrucio, PhD¹^*, Lin Wang, MS²^*, Alan Friedman³^*, Alan B. Cantor, MD, PhD⁴ and Diane S. Krause, MD, PhD¹

¹Laboratory Medicine, Yale University School of Medicine, Yale University, New Haven, CT
²Yale University, New Haven, CT
³Johns Hopkins University,, Baltimore, MD
⁴Division of Pediatric Hematology-Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA

10:15 AM

327

GATA2 Enhancer Modules Governing Hematopoietic Regeneration

Alexandra Soukup, PhD¹, Daniel R Matson, MD, PhD²^*, Kirby D Johnson, PhD²^* and Emery H Bresnick, PhD²

¹University of Wisconsin - Madison, Madison, WI
²UW-Madison Blood Cancer Research Institute, Department of Cell and Regenerative Biology; UW Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin - Madison, Madison, WI

10:30 AM

328

Ing4 Suppresses Quiescence and Inflammation in Hematopoietic Stem Cells

Zanshe Thompson, MS¹^*, Melanie Rodriguez, MS²^*, Georgina Anderson, MS, MA²^*, Seth Gabriel, MS²^*, Vera Binder, MD³^*, Leonard I. Zon, MD⁴ and Katie L Kathrein, PhD²

¹Department of Biomedical Engineering, University of South Carolina, Saint Petersburg, FL
²Department of Biological Sciences, University of South Carolina, Columbia, SC
³Dr. von Hauner University Children's Hospital, Ludwig Maximilian University, Munich, Germany
⁴Stem Cell Program and Division of Hematology/Oncology, Harvard University, Boston, MA

10:45 AM

329

Atlas of Blood Cells

Xiaowei Xie¹^*, Tao Cheng², Ping Zhu³^*, Sha Hao¹^*, Mengyao Liu³^* and Yawen Zhang¹^*

¹State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
²State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, China
³State Key Laboratory of Experimental Hematology and National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China

See more of: Oral and Poster Abstracts

<< Previous Session | Next Session >>

^*signifies non-member of ASH

502.O1.6 502. Hematopoiesis: Regulation of Gene Transcription, Cytokines, Signal Transduction, Apoptosis, and Cell Cycle Regulation: Molecular regulation of cell fate and regeneration