Tiziano Barbui, MD^1*, Alessandro M. Vannucchi², Veronika Buxhofer-Ausch^3*, Valerio De Stefano, MD^4*, Silvia Betti, MD^5*, Alessandro Rambaldi^6*, Elisa Rumi, MD^7*, Marco Ruggeri, MD⁸, Francesco Rodighiero^9*, Maria Luigia Randi^10*, Irene Bertozzi^10*, Heinz Gisslinger, MD¹¹, Guido Finazzi, MD^12*, Alessandra Carobbio^13*, Juergen Thiele, MD^14*, Francesco Passamonti, MD^15*, Chiara Falcone^13* and Ayalew Tefferi, MD¹⁶

¹Hospital Papa Giovanni XXIII and Research Foundation, Bergamo, Italy
²CRIMM-Centro Ricerca e Innovazione delle Malattie Mieloproliferative, Azienda Ospedaliera-Universitaria Careggi, Florence, Italy
³Langobardenstraße 122, Wien, Austria
⁴Hematology, Catholic University, Rome, Italy
⁵Institute of Hematology, Catholic University, Rome, Italy
⁶Hospital Papa Giovanni XXIII, Bergamo, Italy
⁷Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
⁸Department of Hematology, San Bortolo Hospital, Vicenza, Italy
⁹S. Bortolo Hospital, Vicenza, Italy
¹⁰University of Padua, Padua, Italy
¹¹Medical University of Vienna, Vienna, Austria
¹²Department of Hematology, Hospital Papa Giovanni XXIII, Bergamo, Italy
¹³Research foundation, Hospital Papa Giovanni XXIII, Bergamo, Italy
¹⁴Institute of Pathology, University of Cologne, Cologne, Germany
¹⁵University Hospital Ospedale Di Circolo E Fondazione Macchi, Varese, Italy
¹⁶Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN

Heinz Gisslinger, MD¹, Veronika Buxhofer-Ausch^2*, Josef Thaler, MD^3*, Ernst Schlögl, MD^4*, Gunther Gastl, MD, Prof,⁵, Dominik Wolf, MD^6*, Martin Schalling, MSc^7*, Bettina Gisslinger^7*, Sarita Ban, MD^8*, Alexander Egle, MD⁹, Thomas Melchardt, MD^10*, Sonja Burgstaller, MD^3*, Ella Willenbacher^11*, Maria Theresa Krauth, MD^7*, Nicole C.C. Them^12*, Robert Kralovics, PhD¹², Michael Zörer^13*, Oliver Ammann-Mwathi^13*, Pavla Kadlecova^14*, Oleh Zagrijtschuk^13*, Christoph Klade^13* and Richard Greil, MD¹⁵

¹Medical University of Vienna, Vienna, Austria
²Hospital Elisabethinen, Linz, Austria
³Department of Internal Medicine IV, Klinikum Wels-Grieskirchen, Wels, Austria
⁴Hanusch Hospital, Vienna, Austria
⁵Internal Medicine V, Hematology and Oncology, Medical University Innsbruck, Innsbruck, Austria
⁶Department of Internal Medicine III, Oncology, Hematology and Rheumatology, University Hospital Bonn, Bonn, Germany
⁷Department of Internal Medicine I, Division of Hematology and Blood Coagulation, Medical University of Vienna, Vienna, Austria
⁸Sozialmedizinisches Zentrum Ost - Donauspital, Vienaa, Austria
⁹Department of Internal Medicine III, Paracelsus Medical University, Salzburg, Austria
¹⁰Hospital Salzburg, Salzburg, Austria
¹¹Internal Medicine V, Hematology and Oncology, Innsbruck Medical University, Innsbruck, Austria
¹²CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria
¹³AOP Orphan Pharmaceuticals AG, Vienna, Austria
¹⁴Aprova CRO, Brno, Czech Republic
¹⁵3rd Medical Department with Hematology and Medical Oncology, Hemostaseology, Rheumatology and Infectious Diseases, Laboratory for Immunological and Molecular Cancer Research, Oncologic Center, Paracelsus Medical University Hospital Salzburg, and Center for Clinical Cancer and Immunology Trials at Salzburg Cancer Research Institute, Salzburg, Austria

Sabrina Cordua, MD^1*, Lasse Kjaer, PhD^1*, Morten Orebo Holmström, MD^1*, Niels Pallisgaard, MSc^2*, Vibe Skov, MSc, PhD^1* and Hans Hasselbalch, MD¹

¹Department of Hematology, Roskilde University Hospital, Roskilde, Denmark
²Department of Pathology, Roskilde University Hospital, Roskilde, Denmark

Andres C Garcia-Montero, PhD^1*, Maria Jara-Acevedo, MSc^1*, Ivan Alvarez-Twose, MD^2*, Cristina Teodosio^3*, Laura Sanchez-Muñoz^2*, Javier Ignacio Muñoz-Gonzalez^1*, Andrea Mayado^1*, Almudena Matito, MD, PhD^2*, Carolina Caldas^1*, Jose M Morgado, MSc^2*, Luis Escribano, MD, PhD^1* and Alberto Orfao, MD, PhD⁴

¹Centro de Investigación del Cáncer (IBMCC-CSIC/USAL and IBSAL) and Departamento de Medicina, Universidad de Salamanca, Spain, Salamanca, Spain
²Instituto de Estudios de Mastocitosis de Castilla La Mancha (CLMast), Hospital Virgen del Valle, Toledo, Spain, Toledo, Spain
³Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands, Rotterdam, Netherlands
⁴Centro de Investigación del Cáncer (CIC, IBMCC USAL-CSIC), Servicio General de Citometría, Universidad de Salamanca, Salamanca, Spain

Erin Peckham, PhD^1,2*, Philip J Lupo, PhD, MPH^1,2*, Michael E Scheurer, PhD, MPH^1,2*, Rikhia Chakraborty, PhD, BSc, MSc^2*, John Belmont, MD, PhD^3*, Spiridon Tsavachidis, MS^4*, Albert Shih, BS^2*, Harshal Abhyankar, MS^2*, Karen Phaik Har Lim, MS^2*, Brooks Scull, MS^2*, Kenneth L. McClain, MD, PhD² and Carl Allen, MD, PhD²

¹Department of Pediatrics , Hematology-Oncology Section, Baylor College of Medicine, Houston, TX
²Texas Children’s Hospital, Texas Children's Cancer Center, Houston, TX
³Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX
⁴Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX

Claire N. Harrison¹, Jean-Jacques Kiladjian², Florian H. Heidel, MD³, Alessandro M. Vannucchi, MD⁴, Francesco Passamonti^5*, Amjad Hayat, MBBS, MRCP, FRCPath, PhD⁶, Eibhlin Conneally, MB, MRCP, MRCPath, PhD⁷, Bruno Martino, MD^8*, Thomas Kindler, MD^9*, Daniel B. Lipka, MD^10*, Suddhasatta Acharyya, PhD^11*, Prashanth Gopalakrishna, MBBS, MRCS^12*, Susan Ide, PhD^11*, Tracy Liu^11*, Song Mu, PhD^11* and Vincent Ribrag, MD¹³

¹Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom
²Hôpital Saint-Louis and Paris Diderot University, Paris, France
³Otto-von-Guericke-University Magdeburg, Magdeburg, Germany
⁴University of Florence, Florence, Italy
⁵Ospedale di Circolo e Fondazione Macchi, Varese, Italy
⁶National University of Ireland, Galway, Galway, Ireland
⁷St James’s Hospital, Dublin, Ireland
⁸Az.Osp. Bianchi-Melacrino’-Morelli, Reggio Calabria, Italy
⁹University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
¹⁰German Cancer Research Center, Heidelberg, Germany
¹¹Novartis Pharmaceuticals Corporation, East Hanover, NJ
¹²Novartis Pharma AG, Basel, Switzerland
¹³Service d'Hématologie, Institut Gustave Roussy, Villejuif, France

Bartlomiej Getta, MBBS,^1*, Franck Rapaport, PhD^2*, Sean Devlin, PhD^3*, Chen Zhao, MD¹, Kristina Marie Knapp^4*, Minal Patel, BA^5*, Abhinita Mohanty^6*, Marcel Van Den Brink, MD, PhD⁷, Ross L. Levine, MD¹, Maria Arcila, MD^8* and Raajit K. Rampal, M.D., Ph.D.⁹

¹Memorial Sloan Kettering Cancer Center, New York, NY
²Department of Bioinformatics, Memorial Sloan Kettering Cancer Center, New York, NY
³Department of Biostatistics and Epidemiology, Memorial Sloan Kettering Cancer Center, New York, NY
⁴Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York
⁵Hematologic Oncology Tissue Bank, Memorial Sloan Kettering Cancer Center, New York
⁶Pathology, Memorial Sloan Kettering Cancer Center, New York, NY
⁷Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
⁸Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY
⁹Leukemia Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY

Ayalew Tefferi, MD¹, Ramy Abdelrahman, M.B., B.Ch.^2*, Christy Finke, BS^3*, Terra L. Lasho, PhD^2*, Kebede H. Begna, MD¹, Aref Al-Kali, MD², William J Hogan, MD², Mark R Litzow, MD², Curtis A. Hanson, MD⁴, Rhett P. Ketterling, MD^5*, Naseema Gangat, MBBS² and Animesh Pardanani, MBBS, PhD⁶

¹Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN
²Division of Hematology, Mayo Clinic, Rochester, MN
³Hematology, Mayo Clinic, Rochester, MN
⁴Division of Hematopathology, Mayo Clinic, Rochester, MN
⁵Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
⁶Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN

Ardaman Shergill, MD¹, Santosh L. Saraf, MD¹, Sujata Gaitonde, MD, FCAP^2*, Damiano Rondelli, MD³ and Irum Khan, MD¹

¹Division of Hematology/Oncology, University of Illinois at Chicago, Chicago, IL
²Divison of Pathology, University of Illinois at Chicago, Chicago, IL
³Section of Hematology/Oncology, Dept. of Medicine, University of Illinois at Chicago, Chicago

Frank Stegelmann, MD^1*, Stefanie Schauer^2*, Rebecca Kirschbaum^2*, Hartmut Döhner, Prof. Dr.², Richard F. Schlenk, MD³, Martin Griesshammer, MD^4* and Konstanze Döhner, MD²

¹Department of Internal Medicine III, University Hospital Ulm, Ulm, Germany
²Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany
³University Hospital of Ulm, Ulm, Germany
⁴Department of Hematology and Oncology, Johannes-Wesling Clinic Minden, Minden, Germany

Jose Maria Segovia, MD^1*, Emilio Ojeda, MD^2*, Gomez-Bueno Manuel Francisco, MD^1*, Rafael Fores, MD^2*, Jose A Garcia-Marco, MD, PhD², Francisco Javier Haro, MD^3*, Isabel Salcedo, PhD^4* and Carlos DeMiguel, MD^2*

¹Advanced Heart Failure, Transplant and Pulmonary Hypertension Unit, University Hospital Puerta de Hierro Majadahonda, Majadahonda, Spain
²Hematology, University Hospital Puerta de Hierro Majadahonda, Majadahonda, Spain
³Nuclear Medicine Service, University Hospital Puerta de Hierro Majadahonda, Majadahonda, Spain
⁴Pharmacology Unit, University Hospital Puerta de Hierro Majadahonda, Madrid, Spain, Majadahonda, Spain

Alessandra Iurlo, MD, PhD^1*, Mariarita Sciumè, MD^2*, Veronica Mattiello, MD^3*, Daniele Cattaneo, MD^4*, Nicola Orofino, MD^2*, Ivan Cortinovis^5*, Umberto Gianelli, MD^6*, Alberto Pierini, MD^3* and Agostino Cortelezzi, MD⁷

¹Division of Hematology, IRCCS Maggiore Policlinico Hospital Foundation, Milano, Italy
²Oncohematology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
³Cardiovascular Unit, IRCCS Ca’ Granda Ospedale Maggiore Policlinico and University of Milan, Milano, Italy
⁴Department of Hematology, IRCCS Maggiore Policlinico Hospital Foundation, Milan, Italy
⁵Department of Clinical Sciences and Community Healt, University of Milan, Milano, Italy
⁶University of Milano and IRCCS Ca' Granda, Ospedale Maggiore Policlinico Foundation, Milano, Italy
⁷Oncohematology Unit, University of Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy

Mrinal M Patnaik, MBBS¹, Terra L. Lasho, PhD^1*, Pooja Vijayvargiya^1*, Christy Finke, BS^2*, Curtis A. Hanson, MD³, Rhett P. Ketterling, MD^4*, Naseema Gangat, MBBS¹ and Ayalew Tefferi, MD⁵

¹Division of Hematology, Mayo Clinic, Rochester, MN
²Mayo Clinic, rochester, MN
³Division of Hematopathology, Mayo Clinic, Rochester, MN
⁴Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
⁵Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN

Daniela Barraco, MD^1*, Terra L. Lasho, PhD^2*, Kebede H. Begna, MD³, Naseema Gangat, MBBS², Christy Finke, BS^4*, Curtis A. Hanson, MD⁵, Rhett P. Ketterling, MD^6*, Animesh Pardanani, MBBS, PhD⁷ and Ayalew Tefferi, MD²

¹Mayo Clinic, Rochester, MN
²Division of Hematology, Mayo Clinic, Rochester, MN
³Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN
⁴Hematology, Mayo Clinic, Rochester, MN
⁵Division of Hematopathology, Mayo Clinic, Rochester, MN
⁶Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
⁷Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN

Lucia Masarova, MD^1*, Naval Daver, MD¹, Naveen Pemmaraju, MD¹, Prithviraj Bose, MD^1*, Sherry Pierce, BSN, BA^1*, Taghi Manshouri, PhD^2*, Jorge E. Cortes¹, Hagop M. Kantarjian, MD¹ and Srdan Verstovsek, MD¹

¹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX

Carole B. Miller, MD¹, Jean-Jacques Kiladjian², Martin Griesshammer, MD^3*, Ahmad B. Naim, MD^4*, William Sun, PhD^4*, Brian Gadbaw, MD⁵, Srdan Verstovsek, MD, PhD⁶ and Alessandro M. Vannucchi⁷

¹St Agnes Hospital, Baltimore, MD
²Hôpital Saint-Louis and Paris Diderot University, Paris, France
³Johannes Wesling Clinic, Mindin, Germany
⁴Incyte Corporation, Wilmington, DE
⁵Novartis Pharmaceuticals Corporation, East Hanover, NJ
⁶The University of Texas MD Anderson Cancer Center, Houston, TX
⁷University of Florence, Florence, Italy

Luigi Gugliotta, MD¹, Alessandra Iurlo, MD, PhD^2*, Gabriele Gugliotta, PhD^3*, Alessia Tieghi, MD^4*, Giorgina Specchia⁵, Gianluca Gaidano^6*, Anna Candoni, MD^7*, Maria Luigia Randi, MD^8*, Potito Rosario Scalzulli, MD^9*, Alfredo Dragani, MD^10*, Vincenzo Martinelli, MD^11*, Giuseppe Tagariello, MD¹², Elisabetta Antonioli, MD^13*, Anna Marina Liberati, MD¹⁴, Raffaele Palmieri, MD^15*, Maria Langella, MD^16*, Angela Rago, MD^17*, Rossella R Cacciola, MD¹⁸, Ivana Pierri, MD^19*, Alessandra Ricco, MD^20*, Daniele Cattaneo, MD^21*, Umberto Santoro, MD^22*, Serena Rupoli, MD^23*, Cristina Santoro, MD^24*, Lucia Mastrullo, MD^25*, Bruno Martino, MD^26*, Maria Gabriella Mazzucconi, MD^27*, Nicola Vianelli, MD^28*, Valerio De Stefano, MD^29*, Francesco Passamonti^30* and Alessandro M. Vannucchi, MD, PhD³¹

¹Hematology/Oncology Dept, Bologna University, Istituto Seragnoli, S Orsola Malpighi University Hospital, Bologna, Italy
²Division of Hematology, IRCCS Maggiore Policlinico Hospital Foundation, Milano, Italy
³Institute of Hematology, University of Bologna and S.Orsola - Malpighi Hospital, Bologna, Italy
⁴Hematology Dept., A.O. Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy
⁵Hematology - Dept. of Emergency and Organ Transplantation, University of Bari, Bari, Italy
⁶Division of Haematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy
⁷Hematology, Santa Maria della Misericordia University Hospital, Udine, Italy
⁸Internal Medicine, University Hospital, Padova, Italy
⁹Hematology and BMT Unit, Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
¹⁰Hematology Dept, Santo Spirito Hospital, Pescara, Italy
¹¹Hematology Dept., University Federico II, Napoli, Italy
¹²Hematology, Transfusion Service, Hemophilia and Regional Blood Disease Centre, Castelfranco Veneto, Italy
¹³Hematology Dept., AOU Careggi University Hospital, Firenze, Italy
¹⁴Hematology, Ospedale Perugia, Perugia, Italy
¹⁵Hematology Dept., S. Giuseppe Moscati Hospital, Avellino, Italy
¹⁶Hematology Unit, Civic Hospital, Nocera Inferiore, Italy
¹⁷UOC of Hematology, University, Latina, Italy
¹⁸Biomedical Science, Section of Hematology, Catania, Italy
¹⁹Hematology Clinic, IRCSS AOU S.Martino-IST, University of Genova, Genova, Italy
²⁰Department of Hematology, University of Bari, Bari, Italy
²¹Department of Hematology, IRCCS Maggiore Policlinico Hospital Foundation, Milan, Italy
²²Statistical Sciences Dept., University of Bologna, Bologna, Italy
²³Haematology Clinic, Ospedali Riuniti di Ancona, Ancona, Italy
²⁴University of Rome “Sapienza”, Department of Cellular Biotechnologies and Hematology, Rome, Italy
²⁵Hematology Dept., S. Gennaro/S. Giovanni Bosco Hospitals, Napoli, Italy
²⁶Hamatology Dept., Ospedali Riuniti Bianchi Melacrino Morelli, Reggio Calabria, Italy
²⁷Centro Regionale di Riferimento per l’Emofilia e Sindromi Correlate, Università Sapienza, Policlinico Umberto I, Rome, Italy
²⁸Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy
²⁹Hematology, Catholic University, Rome, Italy
³⁰Ospedale di Circolo e Fondazione Macchi, Varese, Italy
³¹Department of Hematology, Universitá degli Studi di Firenze, Firenze, Italy

Daniel Zinn, MD^1,2, Howard Lin^3*, Albert Shih, BS^3*, Brooks Scull, MS^4*, Miguel Dario Cantu⁵, Harshal Abhyankar, MS^3*, Rikhia Chakraborty, PhD, BSc, MSc^4,6*, Karen Phaik Har Lim³, Tricia L. Peters, MD^2,7,8*, Sergio Lira, MD, PhD^9*, Chris Tsz-Kwong, Ph.D.^3,10*, Kenneth McClain, MD, PhD¹¹, Miriam Merad, MD, PhD^12,13,14 and Carl Allen, MD, PhD^15,16

¹Texas Childrens Cancer Center, Texas Childrens Hospital, Houston, TX
²Department of Pediatric Hematology-Oncology-Oncology, Baylor College of Medicine, Houston, TX
³Department of Pediatric Hematology-Oncology, Baylor College of Medicine, Houston, TX
⁴Texas Children’s Hospital, Texas Children's Cancer Center, Houston, TX
⁵University of Texas Medical School At Houston, Houston, TX
⁶Department of Pediatrics , Hematology-Oncology Section, Baylor College of Medicine, Houston, TX
⁷Texas Children's Cancer Center, Texas Children's Hospital, Houston, TX
⁸Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX
⁹Immunology Institute, Mount Siani School of Medicine, New York, NY
¹⁰Texas Childrens Cancer Center, Texas Children's Hospital, Houston, TX
¹¹Texas Childrens Cancer and Hematology Centers, Houston, TX
¹²Gene and Cell Medicine, Mount Sinai Medical Center, New York, NY
¹³Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY
¹⁴Tisch Cancer Institure, Mount Sianai Medical Center, New York, NY
¹⁵Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and Houston Methodist Hospital, Houston, TX
¹⁶Texas Children’s Cancer and Hematology Centers, Texas Children`s Hospital, Houston, TX

Robyn M. Scherber, MD, MPH¹, Holly Geyer, MD^2*, Claire N. Harrison³, Heidi E. Kosiorek, MS^2*, Amylou C. Dueck, PhD², Jean-Jacques Kiladjian⁴, Stefanie Slot^5*, Zhijian Xiao, DO^6*, Sonja Zweegman, MD, PhD⁷, Federico Sackmann^8*, Ana Kerguelen Fuentes^9*, Dolores Hernandez-Maraver, PhD^10*, Konstanze Döhner, MD¹¹, Deepti Radia, MBBS, MRCPI, FRCPath MSc, MEd^12*, Pablo J. Muxi, MD¹³, Carlos Besses¹⁴, Francisco Cervantes, MD, PhD¹⁵, Peter L. Johansson, MD, PhD^16*, Bjorn Andreasson, MD PhD^16*, Alessandro Rambaldi, MD¹⁷, Tiziano Barbui, MD^18*, Karin Bonatz^19*, Andreas Reiter, MD^20*, Francoise Boyer, MD^21*, Gabriel Etienne, MD, PhD^22*, Jean-Christophe Ianotto^23*, Dana Ranta^24*, Jean Roy, MD²⁵, Jean-Yves Cahn²⁶, Norman I Maldonado, MD²⁷, Giovanni Barosi, MD^28*, Maria Ferrari^17*, Robert Peter Gale, MD, PhD, DSc²⁹, Gunnar Birgegard, MD, PhD³⁰, Zefeng Xu, MD³¹, Yu Zhang, B.S.^32*, Xiujuan Sun, MD^31*, Junqing Xu^33*, Peihong Zhang^33*, Peter A. te Boekhorst^34*, Suzan Commandeur^35*, Harry C. Schouten³⁶, Heike L Pahl, Ph.D.³⁷, Martin Griesshammer, MD^38*, Frank Stegelmann, MD^39*, Thomas Lehmann^40*, Alessandro M. Vannucchi, MD⁴¹, Francesco Passamonti, MD^42*, Jan Samuelsson, MD, PhD⁴³ and Ruben A. Mesa, MD⁴⁴

¹Hematology and Oncology, Oregon Health and Sciences University, Portland, OR
²Mayo Clinic, Scottsdale, AZ
³Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom
⁴Hôpital Saint-Louis and Paris Diderot University, Paris, France
⁵Hematology Department, VU University Medical Center, Amsterdam, Netherlands
⁶Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
⁷Department of Hematology, VUMC, Amsterdam, Netherlands
⁸Fundaleu, Buenos Aires, Argentina
⁹University Hospital La Paz, Madrid, Spain
¹⁰La Paz University Hospital, Madrid, Spain
¹¹Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany
¹²Guy's & St Thomas NHS Trust, London, United Kingdom
¹³Hospital Britanico, Montevideo, Uruguay
¹⁴Hematology Department, Hospital del Mar, Barcelona, Spain
¹⁵Hospital Clínic, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain
¹⁶NU Hospital Organization, Uddavella, Sweden
¹⁷Ospedali Riuniti di Bergamo, Bergamo, Italy
¹⁸Hospital Papa Giovanni XXIII and Research Foundation, Bergamo, Italy
¹⁹Universitätsmedizin, Mannheim, Germany
²⁰III. Medizinische Klinik, Medizinische Fakultät Mannheim der Uni Heidelberg, Mannheim, Germany
²¹Centre Hospitalier Universitaire, Angers, France
²²Fi-LMC group, Pessac, France
²³Centre Hospitalier Universitaire, brest, France
²⁴Hospitalier Universitaire, Nancy, Nancy, France
²⁵Division of Hematology and Oncology, Maisonneuve-Rosemont Hospital, Montreal, QC, Canada
²⁶Clinique Universitaire d'Hématologie, Grenoble University Hospital, Grenoble, France
²⁷School of Medicine, University of Puerto Rico, San Juan, PR
²⁸Laboratorio Epidemiologia Clinica e Registro Italiano Mielofibrosi, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
²⁹Celgene Corp., Summit, NJ
³⁰Dept. of Hem., Div. of Med., Institution for Medical Sciences, Uppsala, Sweden
³¹State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
³²Biopharmaceutical R&D Center, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
³³Institute of Hematology and Blood Diseases Hospital, Tianjin, China
³⁴Erasmus MC/Centrumlocatie, Rotterdam, Netherlands
³⁵Leiden University Medical Center, Leiden, Netherlands
³⁶Department of Internal Medicine - Hematology, Maastricht University Medical Center, Maastricht, Netherlands
³⁷Department of Experimental Anaesthesiology, University Hospital Freiburg, Freiburg, Germany
³⁸Department of Hematology and Oncology, Johannes-Wesling Clinic Minden, Minden, Germany
³⁹Department of Internal Medicine III, University Hospital Ulm, Ulm, Germany
⁴⁰University Hospital, Basel, Switzerland
⁴¹Hematology, Universita  degli Studi di Firenze, Firenze, Italy
⁴²Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
⁴³Department of Internal Medicin, Section of Hematology, Stockholm South Hospital, Stockholm, Sweden
⁴⁴Division of Hematology and Medical Oncology, Mayo Clinic Cancer Center, Scottsdale, AZ

Phu V. Troung, MD, F.A.C.P.^1*, Marc Saltzman, MD^2*, Alberto Bessudo, MD^3*, William Jawien, MD⁴, Roger M. Lyons, MD, F.A.C.P.⁵, Dmitriy Berenzon, MD^6*, Raul Mena, MD^7*, Nasiema Wingate-Pearse^8*, Olivier Barriere, PhD^9*, Hali E. Beeson^10*, Paul F. Glidden, PhD^8*, Gavin S. Choy, PharmD, MBA^8* and Srdan Verstovsek, MD, PhD¹¹

¹Cancer Center of Kansas, Wichita, KS
²Innovative Medical Research of South Florida, Aventura, FL
³California Cancer Associates for Research and Excellence, Encinitas, CA
⁴California Cancer Associates for Research and Excellence, Fresno, CA
⁵Cancer Care Centers of South Texas/US Oncology, San Antonio, TX
⁶Wake Forest University Health Sciences, Winston-Salem, NC
⁷East Valley Hematology & Oncology Medical Group, Burbank, CA
⁸Galena Biopharma, Inc., Portland, OR
⁹inVentiv Health Clinique, Inc., Montreal, QC, Canada
¹⁰Chiltern International Inc., Willmington, NC
¹¹Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX

Gabriella Hobbs, MD^1*, Rivka Litvin^2*, Jihae Ahn^3*, Anna Sophia Mckenney^3*, Michael J. Mauro, MD⁴, Martin S Tallman, MD⁴, Ellin Berman, MD⁴, Mark Lawrence Heaney, MD, PhD⁵, Ross L. Levine, MD³ and Raajit K. Rampal, M.D., Ph.D.⁶

¹Massachusetts General Hospital/Harvard Medical School, Boston, MA
²Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY
³Memorial Sloan Kettering Cancer Center, New York, NY
⁴Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
⁵Columbia University Medical Center, New York, NY
⁶Leukemia Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY

Song Jinming, M.D., Ph.D^1*, Mohammad Omar Hussaini, MD^1*, Haipeng Shao, M.D., Ph.D.^1*, Eric Padron, M.D.², Jeffrey E Lancet, M.D.³, Rami S. Komrokji, MD⁴, Ling Zhang, MD¹ and Lynn C. Moscinski, M.D.¹

¹Dept. of Hematopathology, Moffitt Cancer Center, Tampa, FL
²Division of Hematologic Malignancies, Moffitt Cancer Center and Research Institute, Tampa, FL
³Dept. of Malignant Hematology. H. Lee Moffitt Cancer Center, Tampa, FL
⁴H. Lee Moffitt Cancer Center, Tampa, FL

Ruben A. Mesa¹, Carole B. Miller, MD², John O. Mascarenhas, MD, MS³, Maureen Thyne, PA^4*, Sara Goldberger, LCSW-R^5*, Dilan C. Paranagama, PhD^6*, Shreekant V. Parasuraman, PhD⁶, Salman Fazal, MD⁷, Ahmad B. Naim, MD^6* and James Mangan, MD, PhD⁸

¹Mayo Clinic Cancer Center, Scottsdale, AZ
²St Agnes Hospital, Baltimore, MD
³Icahn School of Medicine at Mount Sinai, New York, NY
⁴Weill Cornell Medical College, New York, NY
⁵Cancer Support Community, New York, NY
⁶Incyte Corporation, Wilmington, DE
⁷Allegheny Health Network Cancer Institute, Pittsburgh, PA
⁸University of Pennsylvania, Philadelphia, PA

Kebede H. Begna, MD¹, Amro Abdelatif, MD^1*, Susan M. Schwager^1*, Curtis A. Hanson, MD², Animesh Pardanani, MBBS, PhD¹ and Ayalew Tefferi, MD¹

¹Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN
²Division of Hematopathology, Mayo Clinic, Rochester, MN

Jun Yamanouchi, MD, PhD¹, Takaaki Hato, MD, PhD², Etsuko Matsubara, MD, PhD³, Taichi Azuma, MD, PhD^3*, Hiroshi Fujiwara, MD, PhD⁴, Yoshihiro Yakushijin, MD, PhD³ and Masaki Yasukawa, MD, PhD⁴

¹Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Japan
²Division of Blood Transfusion and Cell Therapy, Ehime University Graduate School of Medicine, Toon, Japan
³Ehime University Graduate School of Medicine, Toon, Japan
⁴Department of Hematology, Clinical Immunology and Infectious disease, Ehime University Graduate School of Medicine, Toon, Japan

Holly Geyer, MD^1*, Robyn M Scherber, MD, MPH^2*, Heidi Kosiorek^1*, Amylou C. Dueck, PhD¹, Jean-Jacques Kiladjian³, Zhijian Xiao, MD^4*, Stefanie Slot^5*, Sonja Zweegman, MD, PhD⁶, Federico Sackmann^7*, Ana Kerguelen Fuentes^8*, Dolores Hernandez-Maraver, PhD^9*, Konstanze Dohner, M.D.¹⁰, Claire N. Harrison¹¹, Deepti Radia, MBBS, MRCPI, FRCPath MSc, MEd^12*, Pablo J. Muxi, MD¹³, Carlos Besses¹⁴, Francisco Cervantes¹⁵, Peter L. Johansson, MD, PhD^16*, Bjorn Andreasson, MD PhD^16*, Alessandro Rambaldi, MD¹⁷, Tiziano Barbui, MD^18*, Karin Bonatz^19*, Andreas Reiter, MD^20*, Francoise Boyer, MD^21*, Gabriel Etienne, MD, PhD^22*, Jean-Christophe Ianotto, MD^23*, Dana Ranta^24*, Lydia Roy, MD^25*, Jean-Yves Cahn²⁶, Norman I Maldonado, MD²⁷, Giovanni Barosi^28*, Maria Ferrari^17*, Robert Peter Gale, MD, PhD, DSc²⁹, Gunnar Birgegard, MD, PhD³⁰, Zefeng Xu, MD⁴, Yue Zhang, MD^4*, Xiujuan Sun, MD^4*, Junqing Xu^31*, Peihong Zhang^31*, Peter te Boekhorst^32*, Suzan Commandeur^33*, Harry C. Schouten³⁴, Heike L Pahl, Ph.D.³⁵, Martin Griesshammer, MD^36*, Frank Stegelmann, MD^37*, Thomas Lehmann^38*, Alessandro M. Vannucchi³⁹, Francesco Passamonti, MD^40*, Jan Samuelsson, MD, PhD⁴¹ and Ruben A. Mesa, MD⁴²

¹Mayo Clinic, Scottsdale, AZ
²Mayo Clinic Arizona, Scottsdale, AZ
³Hôpital Saint-Louis and Paris Diderot University, Paris, France
⁴State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
⁵VU University Medical Center, Amsterdam, Netherlands
⁶Department of Hematology, VUMC, Amsterdam, Netherlands
⁷Fundaleu, Buenos Aires, Argentina
⁸University Hospital La Paz, Madrid, Spain
⁹La Paz University Hospital, Madrid, Spain
¹⁰University Hospital of Ulm, Ulm, Germany
¹¹Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom
¹²Guy's & St Thomas NHS Trust, London, United Kingdom
¹³Hospital Britanico, Montevideo, Uruguay
¹⁴Hematology Department, Hospital del Mar, Barcelona, Spain
¹⁵Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain
¹⁶NU Hospital Organization, Uddavella, Sweden
¹⁷Ospedali Riuniti di Bergamo, Bergamo, Italy
¹⁸Hospital Papa Giovanni XXIII and Research Foundation, Bergamo, Italy
¹⁹Universitätsmedizin, Mannheim, Germany
²⁰Haematology and Oncology, University Hospital of Mannheim, Mannheim, Germany
²¹Centre Hospitalier Universitaire, Angers, France
²²Hematology department, Institut Bergonié, Bordeaux, France
²³Centre Hospitalier Universitaire, Brest, France
²⁴Hospitalier Universitaire, Nancy, Nancy, France
²⁵Hematology department, CHU de Poitiers, Poitiers, France
²⁶Clinique Universitaire d'Hématologie, Grenoble University Hospital, Grenoble, France
²⁷School of Medicine, University of Puerto Rico, San Juan, PR
²⁸IRCCS Policlinico S. Matteo Foundation, Pavia, Italy
²⁹Celgene Corporation, Summit, NJ
³⁰Dept. of Hem., Div. of Med., Institution for Medical Sciences, Uppsala, Sweden
³¹Institute of Hematology and Blood Diseases Hospital, Tianjin, China
³²Erasmus Medical Center, Rotterdam, Netherlands
³³Leiden University Medical Center, Leiden, Netherlands
³⁴Department of Internal Medicine - Hematology, Maastricht University Medical Center, Maastricht, Netherlands
³⁵University Medical Center, Freiburg, Freiburg, Germany
³⁶Department of Hematology and Oncology, Johannes-Wesling Clinic Minden, Minden, Germany
³⁷Department of Internal Medicine III, University Hospital Ulm, Ulm, Germany
³⁸University Hospital, Basel, Switzerland
³⁹CRIMM-Centro Ricerca e Innovazione delle Malattie Mieloproliferative, Azienda Ospedaliera-Universitaria Careggi, Florence, Italy
⁴⁰Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
⁴¹Department of Internal Medicin, Section of Hematology, Stockholm South Hospital, Stockholm, Sweden
⁴²Division of Hematology and Medical Oncology, Mayo Clinic Cancer Center, Scottsdale, AZ

Noa Lavi, MD^1*, Maya Koren-Michowitz, MD^2*, Avi Leader, MD^3,4*, Adi Shacham-Abulafia, MD^5*, Shirley Shapira, MD^6*, Najib Dally, MD^7*, Evgeni Chubar, MD^8*, Elena Mishchenko, MD^9* and Martin H. Ellis, MD^6,10*

¹Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, Haifa, Israel
²Hematology, Assaf Harofeh Medical Center, Zerifin, Israel
³Division of Hematology, Davidoff Center, Beilinson Hospital, Rabin Medical Center, Petah-Tikva, Israel
⁴Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
⁵Institute of Hematology, Davidoff Cancer Center, Beilinson Hospital, Rabin Medical Center, Petah Tikva, Israel
⁶Department of Hematology, Meir Medical Center, Kfar Saba, Israel
⁷Department of Hematology, Ziv Medical Center, Safed, Israel
⁸Department of Hematology, The Emek Medical Center, Afula, Israel
⁹Hematology Unit, Bnai-Zion Medical Center, Haifa, Israel
¹⁰Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

Neelam Varma, MBBS, MD^1*, Sreejesh S., MD^2*, Shano Naseem, MD^2*, Man Updesh Singh Sachdeva, MD^2*, Subhash Varma, MBBS, MD^3* and Pankaj Malhotra, MD, MBBS⁴

¹Department of Hematology, Postgraduate Institute of Medical Education & Research, Chandigarh, India
²Department of Hematology, PGIMER, Chandigarh, India
³Department of Internal Medicine (Clinical Hematology Division), PGIMER, Chandigarh, India
⁴Department of Internal Medicine (Clinical Hematology Division), Postgraduate Institute of Medical Education & Research, Chandigarh, India

Ming-Chung Kuo, MD^1*, Tzung-Chih Tang, MD^1*, Tung-Liang Lin, MD^2*, Po-Nan Wang, MD², Po Dunn, MD^1*, Jin-Hou Wu, MD^2*, Hung Chang, MD^1*, Tung-Huei Lin, MS^2*, Chia-Hui Chang, BS^2*, I-Jung Wu, MS^2* and Lee-Yung Shih, MD¹

¹Chang Gung Memorial Hospital-Linkou and Chang Gung University, Taoyuan, Taiwan
²Chang Gung Memorial Hospital-Linkou, Taoyuan, Taiwan

Ruben A. Mesa¹, Ralph V. Boccia, MD², Alison Moliterno, MD³, Ahmad B. Naim, MD^4*, Joseph A. Cordaro, PharmD, MBA^4*, Wei Peng, PhD^4*, Hao Sun, MS^4*, Shreekant V. Parasuraman, PhD⁴ and Brady Stein, MD⁵

¹Mayo Clinic Cancer Center, Scottsdale, AZ
²The Center for Cancer and Blood Disorders, Bethesda, MD
³Johns Hopkins University School of Medicine, Baltimore, MD
⁴Incyte Corporation, Wilmington, DE
⁵Northwestern University Feinberg School of Medicine, Chicago, IL