57th ASH Annual Meeting and Exposition (December 5-8, 2015): 635. Myeloproliferative Syndromes: Basic Science: Poster III

Myeloproliferative Syndromes: Basic Science Oral and Poster Abstracts
Poster

Hall A, Level 2 (Orange County Convention Center)

Genome-Wide Molecular Portrait of Aggressive Systemic Mastocytosis and Mast Cell Leukemia Depicted By Whole Exome Sequencing and Copy Number Variation Analysis

Simona Soverini, PhD¹, Caterina De Benedittis, PhD¹^*, Manuela Mancini, PhD¹^*, Michela Rondoni, MD²^*, Cristina Papayannidis, MD, PhD³, Antonella Padella⁴^*, Giorgina Specchia, Pr, MD⁵, Roberta Zanotti, MD⁶^*, Livio Pagano⁷^*, Viviana Guadagnuolo, PhD¹^*, Maria Chiara Fontana¹^*, Massimo Delledonne, PhD⁸^*, Alberto Ferrarini, PhD⁹^*, Italo Do Valle¹⁰^*, Daniel Remondini, PhD¹¹^*, Gastone Castellani¹¹^*, Raffaele Calogero¹²^*, Serena Merante, MD¹³^*, Chiara Elena, MD¹³^*, Peter Valent, MD¹⁴, Michele Cavo¹⁵^* and Giovanni Martinelli, MD, PhD³

¹"Seràgnoli" Institute of Hematology, Bologna University School of Medicine, Bologna, Italy
²Area Vasta Romagna, Centro Servizi Pievesestina, AUSL Romagna, Pievesestina di Cesena (FC), Italy
³Bologna University School of Medicine, Bologna, Italy
⁴University of Bologna, Bologna, Italy
⁵Department of Emergency and Organ Transplantation, Section of Hematology with Transplantation, Medical Sch, University of Bari, Bari, Italy
⁶Section of Haematology, Verona, Italy
⁷Institute of Hematology, Catholic University, Rome, Italy
⁸Personal Genomics, Verona, Italy
⁹Department of Biotechnology, University of Verona, Verona, Italy
¹⁰CAPES Foundation, Ministry of Education of Brazil, Brasília, Brazil
¹¹Department of Physics and Astronomy, University of Bologna, Bologna, Italy
¹²University of Turin, Bioinformatics and Genomics Unit, Turin, Italy
¹³Policlinico S. Matteo IRCCS, Pavia, Italy
¹⁴Ludwig Boltzmann Cluster Oncology, Medical University of Vienna, Vienna, Austria
¹⁵Seràgnoli Institute of Hematology, Bologna University School of Medicine, Bologna, Italy

4086

Reactivation of the X-Chromosome Genes within PV Clone

Soo Jin Kim, MS¹^*, Jaroslav Jelinek, MD, PhD², Jean-Pierre J Issa, MD², Josef T. Prchal, M.D.¹ and Sabina Swierczek, Ph.D.¹

¹Division of Hematology, University of Utah, Salt Lake City, UT
²Fels Institute for Cancer Research, Philadelphia, PA

4087

Mutational Profile of Patients with Polycythemia Vera Treated with Ruxolitinib in the Phase III Controlled Response Study

Paola Guglielmelli, MD, PhD^1,2^*, Annalisa Pacilli, PhD^1,2^*, Giada Rotunno, MSc^1,2^*, Alessandro Pancrazzi, BS^1,2^*, Tiziana Fanelli, MSc²^*, Lisa Pieri, MD, PhD^1,2^*, Raimonda Fjerza, MD^1,2^*, Chiara Paoli, BS^1,2^*, Lucia Merli, BSN^1,2^*, Marker Mahtab³^*, Ana Rodriguez³^* and Alessandro M. Vannucchi^1,2

¹Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
²CRIMM-Centro Ricerca e Innovazione delle Malattie Mieloproliferative, Azienda Ospedaliera-Universitaria Careggi, Florence, Italy
³Novartis Pharma AG, Basel, Switzerland

4088

Common Variation at 6q25.3 (TULP4) Influences Risk for Arterial Thrombosis in Myeloproliferative Neoplasms

Roland Jäger, PhD¹^*, Ashot S Harutyunyan, PhD¹^*, Elisa Rumi, MD²^*, Bettina Gisslinger³^*, Martin Schalling, MSc³^*, Virginia Ferretti, PhD²^*, Daniela Pietra, PhD²^*, Mario Cazzola, MD⁴, Heinz Gisslinger, MD³ and Robert Kralovics, PhD^1,3

¹CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria
²Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
³Department of Internal Medicine I, Division of Hematology and Blood Coagulation, Medical University of Vienna, Vienna, Austria
⁴Department of Hematology Oncology, University of Pavia & Fondazione IRCCS Policlinico San Matteo, Pavia, Italy

4089

An Inhibitor of TGF-β Promotes Proliferation of Normal but Not MPN Hematopoietic Cells and Is a Candidate Therapeutic Agent for the Treatment of MPN Patients Carrying JAK2V617F or CalrpQ365fs Mutations

Anna Rita Migliaccio, PhD^1,2, Camelia Iancu-Rubin, PhD³, Rona Singer Weinberg, PhD⁴, Ronald Hoffman, M.D.¹, Amylou Constance Dueck, PhD⁵^* and John O. Mascarenhas, MD, MS⁶

¹Tish Cancer Institute, Mount Sinai School of Medicine, New York, NY
²Department of Biomedical Sciences, Alma Mater University, Bologna, Italy
³Tish Cancer Institute, Mount Sinai School of Medicine, New York
⁴NY Blood Center, New York, NY
⁵Division of Health Sciences Research, Mayo Clinic Arizona, Scottsdale, AZ
⁶Tisch Cancer Institute, Mount Sinai School of Medicine, New York, NY

4090

The JAK2^V617F Stem Cell Burden Is Mosaic, Dynamic and Correlates with Clinical Disease Burden in the MPN: An Exploitable Target

Alison R Moliterno, MD¹, Donna Marie Williams, PhD²^*, Jonathan M. Gerber, MD³, Michael A McDevitt, MD, PhD¹, Ophelia Rogers⁴^* and Jerry L. Spivak, MD⁵

¹Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD
²Hematology Division, Johns Hopkins University School of Medicine, Baltimore, MD
³Department of Hematology, Levine Cancer Institute of Carolinas HealthCare System, Charlotte, NC
⁴Hematology Division, Johns Hopkins University School of Medicine, Baltimore, MD
⁵Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD

4091

Mutational Landscape of Patients with Myelofibrosis That Do Not Harbor Mutations in JAK2, MPL and Calreticulin Driver Genes

Giada Rotunno, MSc^1,2^*, Paola Guglielmelli, MD, PhD^1,2^*, Annalisa Pacilli, PhD^1,2^*, Tiziana Fanelli, MSc¹^*, Carmela Mannarelli, MSc¹^*, Alessandro Pancrazzi, BS^1,2^* and Alessandro M. Vannucchi^1,2

¹CRIMM-Centro Ricerca e Innovazione delle Malattie Mieloproliferative, Azienda Ospedaliera-Universitaria Careggi, Florence, Italy
²Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy

4092

A Recombinant Antibody to Siglec-8 Shows Selective ADCC Activity Against Mast Cells from Systemic Mastocytosis Patients

Rustom Falahati, PhD¹^*, Jessica Bright¹^*, Alejandro Dorenbaum, MD¹^*, Christopher Bebbington, PhD¹^*, Nenad Tomasevic, PhD¹^*, Diane Lidke, PhD²^*, Tracy I. George, MD² and Jason Gotlib, MD³

¹Allakos, Inc., San Carlos, CA
²University of New Mexico, Albuquerque, NM
³School of Medicine/ Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA

4093

Fusion Gene Detection Using Whole Transcriptome Analysis in Patients with Chronic Myeloproliferative Neoplasms and Secondary Acute Myeloid Leukemia

Fiorella Schischlik, MSc¹^*, Jelena D. Milosevic Feenstra, PhD¹^*, Elisa Rumi, MD²^*, Daniela Pietra, PhD²^*, Bettina Gisslinger³^*, Martin Schalling, MSc³^*, Edith Bogner¹^*, Heinz Gisslinger, MD³, Mario Cazzola, MD^2,4 and Robert Kralovics, PhD^1,3

¹CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria
²Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
³Department of Internal Medicine I, Division of Hematology and Blood Coagulation, Medical University of Vienna, Vienna, Austria
⁴Department of Molecular Medicine, University of Pavia, Pavia, Italy

4094

Crucial Factors of the Inflammatory Microenvironment (IL-1 beta/TNF-alpha/TIMP-1) Promote Maintenance of the Malignant Hemopoietic Clone of Myelofibrosis By Stimulating the in Vitro Survival/Proliferation/Migration of Circulating CD34⁺stem/Progenitor Cells

Dorian Forte, Ph.D. Student¹^*, Daria Sollazzo, PhD²^*, Nicola Polverelli, MD¹^*, Romano Marco, BS¹^*, Lara Rossi, PhD¹^*, Margherita Perricone, BS¹^*, Emanuela Ottaviani, BS¹^*, Giovanni Martinelli, MD, PhD³, Nicola Vianelli, MD¹^*, Michele Cavo, MD⁴^*, Francesca Palandri, MD, PhD⁵^* and Lucia Catani, Ph.D.¹^*

¹Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy
²Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy
³Bologna University School of Medicine, Bologna, Italy
⁴"Seràgnoli" Institute of Hematology, Bologna University School of Medicine, Bologna, Italy
⁵University of Bologna, Bologna, Italy

4095

HH-002 Effectively Suppresses Myeloproliferative Neoplasm Phenotypes in JAK2V617F Transgenic Mice

Wan-Ting Ho¹^*, Wanke Zhao¹^*, Paul Hallenbeck²^*, Frank Rong³^* and Zhizhuang Joe Zhao, PhD⁴

¹Pathology, Oklahoma University Health Sciences Center, Oklahoma City, OK
²Hangzhou Bensheng Pharmaceutical Corp. Ltd, Hangzhou, China
³Hangzhou Bensheng Pharmaceutical Corp. Ltd., Hangzhou, China
⁴Pathology, Univ.of Oklahoma Health Sciences Center, Oklahoma City

4096

Ruxolitinib Does Not Affect Bone Marrow Stromal Cell (BMSC) Clonogenicity and Growth but Interferes with JAK Signaling Under Inflammatory Conditions - Implications for Fibrosis in Myeloproliferative Diseases?

Dimitra Zacharaki¹^*, Hongzhe Li, PhD¹^*, Roshanak Ghazanfari¹^* and Stefan Scheding, MD^1,2

¹Lund Stem Cell Center, Lund University, Lund, Sweden
²Department of Hematology, Skåne University Hospital, Lund, Sweden

4097

The Impact of Interferon-alpha2 on HLA-Genes in Patients with Polycythemia Vera and Related Neoplasms

Vibe Skov, MSc, PhD¹^*, Caroline H Riley²^*, Mads Thomassen, MSc, PhD³^*, Lasse Kjær, MSc, PhD¹^*, Thomas Stauffer Larsen, MD, PhD⁴^*, Morten K Jensen²^*, Ole Weis Bjerrum, MD, DMSc⁵^*, Torben A Kruse, Professor, PhD³^* and Hans Carl Hasselbalch, MD, Professor, DMSc¹

¹Department of Hematology, Roskilde University Hospital, Roskilde, Denmark
²Department of Hematology, Roskilde Hospital, University of Copenhagen, Roskilde, Denmark
³Department of Clinical Genetics, Odense University Hospital, Odense C, Denmark
⁴Department of Hematology, Odense University Hospital, Odense, Denmark
⁵Department of Hematology, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark

4098

Activation of AP-1 By JAK2V617F through Induction and Stabilization of c-FOS

Yoko Edahiro, MD, PhD¹^*, Marito Araki, PhD,²^*, Yumi Hironaka¹^*, Yinjie Yang, PhD¹^*, Soji Morishita, PhD²^*, Yoshitaka Sunami, MD, PhD¹^*, Akimichi Ohsaka, MD, PhD²^* and Norio Komatsu, MD, PhD¹

¹Department of Hematology, Juntendo University Faculty of Medicine, Tokyo, Japan
²Department of Transfusion Medicine and Stem Cell Regulation, Juntendo University Faculty of Medicine, Tokyo, Japan

4099

The JAK1/2 Inhibitor Momelotinib Does Not Inhibit Thiamine Uptake in Vitro

Marilyn Giacomini¹^*, Jia Hao¹^*, Xiaomin Liang²^*, Jayaraman Chandrasekhar³^*, Jolyn Twelves¹^*, Andy Whitney³^*, Irene Lepist¹^* and Adrian Ray¹^*

¹Gilead Sciences, Foster City, CA
²University of California, San Francisco, San Francisco, CA
³Gilead Sciences, Branford, CT

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^*signifies non-member of ASH