Susanne Saussele¹, Mareike Stein^1*, Arthur Gil^2*, Ute Kossak-Roth^1*, Michael Lauseker, PhD^2*, Ulrike Proetel^1*, Hermann Einsele, MD³, Philippe Schafhausen^4*, Elisabeth Lange^5*, Mathias Hänel^6*, Karsten Spiekermann, MD⁷, Martin Sökler, MD^8*, Clemens Wendtner^9*, Stephan Kremers^10*, Michael Pfreundschuh¹¹, Ernst Holler^12*, Wolf-Karsten Hofmann¹, Andreas Hochhaus, MD¹³, Martin C. Müller^1*, Ruediger Hehlmann, MD¹ and Markus Pfirrmann^2*

¹III. Medizinische Klinik, Universität Heidelberg, Medizinische Fakultät, Mannheim, Germany
²Institut für medizinische Informationsverarbeitung, Biometrie und Epidemiologie, Ludwig-Maximilians-Universität, München, Germany
³Medizinischen Klinik und Poliklinik II, Universitätsklinikum, Würzburg, Germany
⁴II. Medizinische Klinik und Poliklinik, Universitätsklinikum Eppendorf, Hamburg, Germany
⁵Medizinische Klinik, Evangelisches Krankenhaus, Hamm, Germany
⁶Klinik für Innere Medizin III, Klinikum, Chemnitz, Germany
⁷Medizinische Klinik und Poliklinik III, Klinikum der Universität, München, Germany
⁸Department II of Internal Medicine, University Hospital, Tübingen, Germany
⁹Klinikum Schwabing, Städtisches Klinikum, München, Germany
¹⁰Abteilung Hämatologie und Onkologie, Caritaskrankenhaus, Lebach, Germany
¹¹Klinik für Innere Medizin I, Universitätsklinikum des Saarlandes, Homburg/Saar, Germany
¹²Abteilung für Hämatologie und internistische Onkologie, Universitätsklinikum, Regensburg, Germany
¹³Department of Hematology and Oncology, University Hospital Jena, Jena, Germany

Franck E. Nicolini, MD, PhD^1,2,3, Marie Balsat, MD^4*, Maud Lekieffre, MD^1*, Vincent Alcazer, MD^1*, Hélène Labussière-wallet, MD^1*, Sarah Huet, PharmD, PhD^5*, Sandrine Hayette^2,6*, Stéphanie Dulucq, PharmD, PhD^2,7*, Stéphane Morisset, Stat^1*, Jeremy Ruby, CRA^1,2*, Isabelle Tigaud, MD^5*, Marie-Pierre Fort, CRA^8*, Mael Heiblig, MD^1*, Rémi Chapelon, CRA^1*, Madeleine Etienne, CRA^1,2*, Mohamad Sobh, PharmD^1*, Francois-Xavier Mahon, MD, PhD, Professor^2,8*, Mauricette Michallet, MD, PhD^1,2 and Gabriel Etienne, MD, PhD^2,8*

¹Hematology department 1G, Centre Hospitalier Lyon Sud, Pierre Bénite, France
²Hôpital Haut Lévêque, Fi-LMC group, Pessac, France
³INSERM U1052, Centre de Recherche en Cancérologie de Lyon, Lyon, France
⁴Hematology department 1G, Centre Hospitalier Lyon-Sud, Pierre Bénite, France
⁵Laboratory of Hematology, Centre Hospitalier Lyon Sud, Pierre Bénite, France
⁶Hematology Laboratory, Centre Hospitalier Lyon-Sud, Pierre Bénite, France
⁷Laboratory of Hematology, Hôpital Haut Lévêque, Pessac, France
⁸Hematology department, Institut Bergonié, Bordeaux, France

Silvia Mori, PhD^1*, Philipp le Coutre, MD², Elisabetta Abruzzese, MD^3,4, Bruno Martino, MD^5*, Ester Pungolino, MD^6*, Chiara Elena, MD^7,8*, Ivana Pierri, MD^9*, Sarit E. Assouline, MD MSc¹⁰, Anna D'Emilio, MD^11*, Antonella Gozzini, MD^12*, Pilar Giraldo, MD, PhD¹³, Fabio Stagno, MD, PhD¹⁴, Alessandra Iurlo, MD, PhD^15*, Andrea Aroldi, MD^16*, Michela Luciani, RN^1*, Giulia De Riso, RN^1*, Kim Dong-Wook, MD, PhD^17*, Alessandra Pirola, MSc^1*, Anna Petroccione^18*, Maria Luisa Bonanomi^18*, Patrizia Crivori, PhD^18*, Rocco Piazza, MD, PhD^1* and Carlo Gambacorti-Passerini, MD^1,19

¹Dept. of Health Sciences, University of Milano-Bicocca, Monza, Italy
²Hematology and Oncology, Charité, Humboldt University, Campus Virchow, Berlin, Berlin, Germany
³Tor Vergata University, Roma, Italy
⁴Hematology, S. Eugenio Hospital, Roma, Italy
⁵Hematology, Bianchi Melacrino Morelli Hospital, REggio Calabria, Italy
⁶Niguarda Cà Granda Hospital, Milan, Italy
⁷Dept. of Molecular Medicine, University of Pavia, Pavia, Italy
⁸Dept Oncology-Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
⁹Hematology Clinic, IRCSS AOU S.Martino-IST, University of Genova, Genova, Italy
¹⁰Jewish General Hospital, Montreal, QC, Canada
¹¹Hematology, San Bortolo Hospital, Vicenza, Italy
¹²Hematology, AOU Careggi, University of Florence, Firenze, Italy
¹³Miguel Servet University Hospital and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Zaragoza, Spain
¹⁴Chair of Hematology, University of Catania, Catania, Italy
¹⁵Division of Hematology, IRCCS Maggiore Policlinico Hospital Foundation, Milano, Italy
¹⁶University of Milano-Bicocca, Monza, Italy
¹⁷Seoul St. Mary's Hospital, Catholic University of Korea, Seoul, South Korea
¹⁸Clioss s.r.l., Nerviano, Italy
¹⁹Hematology and Clinical Research Unit, San Gerardo Hospital, Monza, Italy

Valentín García-Gutierrez^1*, Maria Teresa Gómez Casares^2*, Jimenez Velasco Antonio^3*, Alonso Juan Manuel^4*, Santiago Osorio^5*, Juan Carlos Hernández-Boluda^6*, Jose Manuel Puerta^7*, Rosa Collado^8*, Maria Jose Ramirez^9*, Fatima Ibañez^10*, María Luisa Martín Mateos^10*, Juan Diego Rodriguez Gambarte^11*, Carolina Martinez Laperche^5*, Sara Redondo^5*, Montse Gomez^12*, DV Suarez Fiallo^13*, Alicia Rodriguez Fernandez^14*, Concepcion Ruiz^15* and Juan Luis Steegmann, MD¹⁶

¹Hematology Department, Hospital Ramón y Cajal, Madrid, Spain
²Hospital Universitario Doctor Negrin. Hematology department, Las Palmas de Gran Canaia, Spain
³Hospital Regional Universitario de Málaga, servicio de Hematología., Málaga, Spain
⁴Laboratorio Central Br Salud, Hospital Infanta Sofía, Madrid, Spain
⁵Hospital Universitario Gregorio Marañón. Servicio de Hematología, Madrid, Spain
⁶Hematology Department, Hospital Clínico, Valencia, Spain
⁷Unidad de Gestión Clínica Hematología y Hemoterapia, Hospital Universitario Virgen de las Nieves, Granada, Spain
⁸Laboratorio de Genética. Servicio de Hematología. Consorcio Hospital General Universitario, Valencia, Spain
⁹Department of Hematology, Hospital de Jerez de la Frontera, Jerez de la Frontera. Cádiz, Spain
¹⁰Servicio de Hematología. Hospital San Pedro de Alcántara.Servicio Extremeño de Salud, Caceres, Spain
¹¹Hospital Universitario Ramón y Cajal. Hematology department, Madrid, Spain
¹²Hematology Department, Hospita Clinico, Valencia, Spain
¹³Hospital Universitario Doctor Negrin. Hematology department, Las Palmas de Gran Canaria, Spain
¹⁴Servicio de Hematologia, Hospital Virgen de la Macarena, Sevilla, Spain
¹⁵Hospital Regional Universitario de Málaga, servicio de Hematología., Malaga, Spain
¹⁶Instituto de Investigación Sanitaria, Hospital Universitario de la Princesa, Madrid, Spain

David T Yeung, BSc, MBBS, FRACP, FRCPA^1,2,3, Wendy Tara Parker, PhD^4*, Stuart Phillis, B Biotech^5*, Jasmina Georgievski, BSc^5*, Hamish S Scott, BSc, PhD, FFSc (RCPA)^6,7, Timothy P. Hughes, MD, MBBS, FRACP, FRCPA⁸ and Susan Branford, PhD FFSc (RCPA)^3,6,9,10,11

¹Haematology, SA Pathology, Adelaide, Australia
²Department of Genetics and Molecular Pathology, Centre for Cancer Biology, Adelaide, Australia
³School of Medicine, University of Adelaide, Adelaide, Australia
⁴SA Pathology, Adelaide, Australia
⁵Genetics and Molecular Pathology, SA Pathology, Adelaide, Australia
⁶Department of Genetics and Molecular Pathology, SA Pathology, Adelaide, Australia
⁷Centre for Cancer Biology, University of South Australia, Adelaide, Australia
⁸SA Pathology and South Australian Health and Medical Research Institute, University of Adelaide, Adelaide, Australia
⁹School of Molecular and Biomedical Science, University of Adelaide, Adelaide, Australia
¹⁰School of Pharmacy and Medical Science, University of South Australia, Adelaide, Australia
¹¹Centre for Cancer Biology, SA Pathology, University of Adelaide, Adelaide, Australia

Adi J Klil-Drori, MD^1,2, Laurent Azoulay, PhD^1*, Hui Yin, MSc^1*, Michel-Olivier Gratton, MSc^2,3*, Michaël Harnois, MSc^2,3*, Ines Chamakhi, MD^2,4, Robert Delage, MD, MSc, FRCP^2,5, Pierre Laneuville, MD, FRCPC^2,6, Luigina Mollica, MD, FRCPC, PhD^2,7, Harold J. Olney, MD, CM^2,8, Lambert Busque, MD^2,3 and Sarit E. Assouline, MD MSc^1,2

¹Jewish General Hospital, Montreal, QC, Canada
²Groupe Québécois de Recherche sur la Leucémie Myéloïde Chronique et Néoplasies Myéloprolifératives (GQR-LMC/NMP), Quebec, Canada
³Hôpital Maisonneuve-Rosemont, Montreal, QC, Canada
⁴Hôpital Sacré-Coeur, Montreal, QC, Canada
⁵Hôpital de l'Enfant-Jesus, Quebec, QC, Canada
⁶McGill University Health Centre, Montreal, QC, Canada
⁷Hôpital Maisonneuve-Rosemont, Montreal, Canada
⁸CHUM Notre-Dame, Montreal, QC, Canada

Magnus Bjorkholm, MD, PhD¹, Hannah Bower^2*, Paul W Dickman, MSc PhD^2*, Paul C Lambert, PhD^2,3*, Martin Höglund, MD, PhD⁴ and Therese M-L Andersson, PhD^2*

¹Department of Medicine, Division of Hematology, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden
²Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
³Department of Health Sciences, University of Leicester, Leicester, United Kingdom
⁴Department of Medical Sciences, Uppsala University, Uppsala, Sweden

Verena Sophia Hoffmann, Dr.^1*, Michele Baccarani², Joerg Hasford, MD^3*, Doris Lindoerfer^1*, Sonja Burgstaller, MD^4*, Dubravka Sertic, MD^5*, Paul Costeas^6*, Jiri Mayer⁷, Karel Indrak, MD^8*, Hele Everaus, MD, PhD⁹, Perttu Koskenvesa^10*, Joelle Guilhot, PhD¹¹, Gabriele Schubert-Fritschle^12*, Fausto Castagnetti, MD/PhD¹³, Francesco Di Raimondo, MD/PhD¹⁴, Sandra Lejniece, PhD, MD^15*, Laimonas Griskevicius^16*, Noortje Thielen, MD, PhD^17*, Thomas Sacha^18*, Andrzej Hellmann, MD, PhD¹⁹, Anna Turkina, Prof., MD²⁰, Andrey Zaritskey, MD^21*, Andrija Bogdanovic, MD, PhD, MSc,^22*, Zuzana Sninska^23*, Irena Zupan^24*, Felipe Casado^25*, Bengt Simonsson, MD^26*, Richard E. Clark, MD^27*, Susanne Saussele²⁸, Andreas Hochhaus, MD²⁹ and Ruediger Hehlmann, MD³⁰

¹Institut für medizinische Informationsverarbeitung, Biometrie und Epidemiologie (IBE), Ludwig-Maximilians-Universität München, Munich, Germany
²Institute of Hematology, University of Bologna, Bologna, Italy
³Institut für Medizinische Informationsverarbeitung, Biometrie und Epidemiologie (IBE), Ludwig-Maximilians-Universität München, Munich, Germany
⁴Klinikum Wels-Grieskirchen, Wels, Austria
⁵Dpt. of Medicine, Division of Hematology, University Hospital Center Zagreb, Zagreb, Croatia
⁶The Karaiskakio Foundation, Nicosia, Cyprus
⁷Masaryk University Hospital, Brno, Czech Republic
⁸Dpt. of Hematology-Oncology, University Hospital, Palacky University, Olomouc, Czech Republic
⁹Hematology-Oncology, Tartu University Hosptial, Tartu, Estonia
¹⁰Helsinki University Central Hospital and Hematology Research Unit, Biomedicum Helsinki, Helsinki, Finland
¹¹INSERM CIC 1402, CHU Poitiers, Poitiers, France
¹²Munich Cancer Registry, Ludwig-Maximilians-Universität München, Munich, Germany
¹³Bologna University School of Medicine, Bologna, Italy
¹⁴Division of Hematology, Azienda Policlinico-OVE, University of Catania, Catania, Italy
¹⁵National Hematology Centre, Riga Eastern Clinical University Hospital, Riga, Latvia
¹⁶Vilnius University Hospital Santariskiu Klinikos, Vilnius, Lithuania
¹⁷Department of Hematology, VU University Medical Center, Amsterdam, Netherlands
¹⁸Dpt. of Hematology, Jagellonian University Hospital, Krakow, Poland
¹⁹Dpt. of Hematology and Transplantation, Medical University of Gdansk, Gdansk, Poland
²⁰National Research Center for Hematology, Moscow, Russia
²¹St. Petersburg State Medical University, St. Petersburg, Russia
²²Clinical Center of Serbia, University of Belgrade, Belgrade, Serbia
²³Department of Hematology, University Hospital Bratislava, Bratislava, Slovakia
²⁴Department of Hematology, University Clinical Centre Ljubljana, Ljubljana, Slovenia
²⁵Servicio de Hematologia, Hospital Virgen de la Salud, Toledo, Spain
²⁶University of Uppsala, Uppsala, Sweden
²⁷Royal Liverpool University Hospital, Liverpool, United Kingdom
²⁸Medizinische Fakultät Mannheim, Universität Heidelberg, Mannheim, Germany
²⁹Department of Hematology and Oncology, University Hospital Jena, Jena, Germany
³⁰III. Medizinische Klinik, University of Heidelberg at Mannheim, Mannheim, Germany

Andreas Hochhaus, MD¹, Giuseppe Saglio, MD², Timothy P. Hughes, MD, MBBS, FRACP, FRCPA³, Richard A. Larson, MD⁴, Lilia Taningco, MSc^5*, Weiping Deng^5*, Hans D Menssen, MD, PhD^6* and Hagop M. Kantarjian, MD⁷

¹Abteilung Hämatologie/Onkologie, Universitätsklinikum Jena, Jena, Germany
²University of Turin, Orbassano, Italy
³SA Pathology and South Australian Health and Medical Research Institute, University of Adelaide, Adelaide, Australia
⁴The University of Chicago, Chicago, IL
⁵Novartis Pharmaceuticals Corporation, East Hanover, NJ
⁶Novartis Pharma AG, Basel, Switzerland
⁷Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX

Hiroyuki Shimada, MD, PhD^1*, Hidemitsu Kurosawa, MD², Akihiro Watanabe^3*, Masaki Ito^4*, Chikako Tono^5*, Haruko Shima, MD, PhD^1*, Yuki Yuza, MD, PhD^6*, Hideki Muramatsu, MD, PhD⁷, Noriko Hotta^8*, Masahiko Okada^9* and Akihiko Tanizawa^10*

¹Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan
²Dokkyo Medical University, Tochigi, Japan
³Niigata Cancer Center Hospital, Niigata, Japan
⁴Fukushima Medical University School of Medicine, Fukushima, Japan
⁵Aomori Rosai Hospital, Aomori, Japan
⁶Tokyo Metropolitan Children’s Medical Center, Tokyo, Japan
⁷Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
⁸Tokuyama Central Hospital, Tokuyama, Japan
⁹Nagasaki University School of Medicine, Nagasaki, Japan
¹⁰University of Fukui Faculty of Medical Sciences, Fukui, Japan

Eda Tanrikulu Simsek, MD^1*, Ahmet Emre Eskazan, MD², Mahir Cengiz, MD^3*, M. Cem Ar, MD, PhD^2*, Seda Ekizoglu, PhD^4*, Ayse Salihoglu, MD^2*, Emine Gulturk, MD^2*, Tugrul Elverdi, MD^5*, Seniz Ongoren Aydin, MD^2*, Ahu Senem Demiroz, MD^6*, Ayse Nur Buyru, MD^4*, Zafer Baslar, MD^2*, Ugur Ozbek, MD, PhD^7*, A. Burhan Ferhanoglu, MD⁸, Yildiz Aydin, MD^2*, Nukhet Tuzuner, MD, Professor^6* and Teoman Soysal, MD^2*

¹Department of Internal Medicine, Istanbul University, Cerrahpasa Medicine Faculty, Istanbul, Turkey
²Department of Internal Medicine, Division of Hematology, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey
³Department of Internal Medicine, Istanbul University, Cerrahpasa Faculty of Medicine, Istanbul, Turkey
⁴Department of Medical Biology, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey
⁵Department of Internal Medicine, Division of Hematology, Van Training and Research Hospital, Van, Turkey
⁶Department of Pathology, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey
⁷Institute of Experimental Medicine, Department of Genetics, Istanbul University, Istanbul, Turkey
⁸Department of Internal Medicine, Division of Hematology, Koc University, Medical Faculty, Istanbul, Turkey

Jaspal Kaeda, PhD, FRCPath^1*, Simone Bonecker^2*, Frauke Ringel^1*, Michaela Schwarz^1*, Bernd Dörken^1*, Ilana Zalcberg^2* and Philipp Le Coutre, MD¹

¹Charité - Universitätsmedizin Berlin, Berlin, Germany
²Centro de Transplante de Medula Ossea, Rio de Janeiro, Brazil

Jonathan Douxfils, Pharm.D Ph.D Candidate^1*, Hélène Haguet, MSc^1*, Christian J. Chatelain, MD², Carlos Graux, MD PhD^2* and Jean-Michel Dogné, Pharm.D Ph.D^1*

¹Department of Pharmacy, University of Namur, Namur, Belgium
²Department of Hematology, CHU UcL Namur, Mont-Godinne, Belgium

Valentín García-Gutiérrez^1*, Dragana  Milojkovic^2*, María Luisa Martín Mateos^3*, Simone Claudiani^4*, Concepcion Boque, PhD^5*, Luis Felipe Casado^6*, Gloria González^7*, Antonio Jiménez^8*, Alejandra Martinez Trillos^9*, Isabel Mata Vázquez^10*, Ángel Ramírez Payer^11*, Alberto Álvarez Larran^12*, Elena Amutio Díez^13*, Abelardo Bárez García, MD^14*, Guiomar Bautista Carrascosa^15*, Sabela Bobillo Varela^16*, Beatriz Cuevas Ruiz^17*, Mª Ángeles Fernández Fernández^18*, María del Carmen García Garay^19*, Pilar Giraldo, MD, PhD^20,21, Jose María Guinea de Castro^22*, Natalia De Las Heras Rodríguez, MD^23*, Nuria Hernanz Soler^24*, Ana Iglesias Pérez^25*, José Luis López Lorenzo^26*, Josep Maria Martí Tutusaus, MD, PhD^27*, Rolando Omar Vallansot^28*, Fernando Ortega Rivas^29*, Jose Manuel Puerta^30*, Maria Jose Ramírez Sánchez^31*, Esperanza Romero Picos^32*, Mario Andrés Romo Collada^18*, Ana Rosell Mas^33*, Silvana Saavedra Gerosa^34*, Ana Sebrango Sadia^35*, José Tallón Pérez^36*, Sandra Valencia^37* and Juan Luis Steegmann, MD³⁸

¹Hospital Universitario Ramón y Cajal, Madrid, Spain
²The Hammersmith Hospital, Imperial College, London, United Kingdom
³Servicio de Hematología. Hospital San Pedro de Alcántara.Servicio Extremeño de Salud, Caceres, Spain
⁴Haematology, Hammersmith Hospital (Imperial College Healthcare NHS Trust), London, United Kingdom
⁵Insitute Cotele d'Oncologie, Barcelona, Spain
⁶Servicio de Hematologíay Hematoterapia, Hospital Virgen de la Salud, Toledo., Toledo, Spain
⁷Hospital Universitario de Canarias, Tenerife, Spain
⁸Hospital Universitario Carlos Haya, Málaga, Spain
⁹Hospital Clinic, Barcelona, Spain
¹⁰Hospital Costa del Sol, Málaga, Spain
¹¹Hospital Universitario Central de Asturias, Oviedo, Spain
¹²Hospital del Mar, Barcelona, Spain
¹³Hospital de Cruces, Vizcaya, Spain
¹⁴Department of Hematology, Hospital Nuestra Señora de Sonsoles, Avila, Spain
¹⁵Hospital Universitario Puerta de Hierro, Majadahonda, Spain
¹⁶Hospital Vall d'Hebron, Barcelona, Spain
¹⁷Hospital Universitario de Burgos, Burgos, Spain
¹⁸Hospital Meixoeiro, Vigo, Spain
¹⁹Hospital Santa Lucia, cartagena, Spain
²⁰Haematology, Miguel Servet University Hospital, Zaragoza, Spain
²¹ISS, CIBERER, Zaragoza, Spain
²²Hospital de Txagorritxu, Vitoria, Spain
²³Complejo Hospitalario de Leon, Leon, Spain
²⁴Hospital Virgen de la Candelaria, Santa Cruz de Tenerife, Spain
²⁵Hospital Universitario de Cruces, Bilbao, Spain
²⁶Fundación Jiménez Díaz, Madrid, Spain
²⁷Hospital Mútua de Terrassa, Terrassa, Spain
²⁸Hospital Universitari Joan XXIII, Tarragona, Spain
²⁹Servicio de Hematología., Hospital de Palencia, Palencia, Spain
³⁰Unidad de Gestión Clínica Hematología y Hemoterapia, Hospital Universitario Virgen de las Nieves, Granada, Spain
³¹Department of Hematology, Hospital de Jerez de la Frontera, Jerez de la Frontera. Cádiz, Spain
³²Hospital Arquitecto Marcide, Ferrol, Spain
³³Hospital Virgen de la Victoria, Málaga, Spain
³⁴Hospital Santa Creu i Sant Pau, Barcelona, Spain
³⁵Hospital de Torrejón, Madrid, Spain
³⁶Hospital de Jaén, Jaén, Spain
³⁷Hospital de Segovia, Segovia, Spain
³⁸Instituto de Investigación Sanitaria, Hospital Universitario de la Princesa, Madrid, Spain

Verena Sophia Hoffmann, Dr.^1*, Joerg Hasford, MD^2* and Ruediger Hehlmann, MD³

¹Institut für medizinische Informationsverarbeitung, Biometrie und Epidemiologie (IBE), Ludwig-Maximilians-Universität München, Munich, Germany
²Institut für Medizinische Informationsverarbeitung, Biometrie und Epidemiologie (IBE), Ludwig-Maximilians-Universität München, Munich, Germany
³Medizinische Fakultät Mannheim, Universität Heidelberg, Mannheim, Germany

Fiorina Giona, MD¹, Giuseppe Saglio, MD², Michelina Santopietro, MD^1*, Giuseppe Menna, MD^3*, Grazia Iaria^4*, Maria Caterina Putti, MD^5*, Concetta Micalizzi, MD^6*, Nicola Santoro, MD^7*, Saverio Ladogana, MD^8*, Rosa Maria Mura, MD^9*, Roberta Burnelli, MD^10*, Caterina Consarino, MD^11*, Carlo Cosmi, MD^12*, Maria Luisa Moleti, MD^1*, Stefania Varotto, MD^5*, Francesca Tucci, MD^3*, Mauro Nanni, PhD^1*, Daniela Diverio, PhD^1*, Andrea Biondi, MD¹³, Franco Locatelli, Prof, MD, PhD^14* and Robin Foà, Prof, MD¹

¹Department of Cellular Biotechnologies and Hematology, Sapienza University, Rome, Italy
²Department of Clinical and Biological Sciences, University of Turin at Orbassano, Orbassano, Turin, Italy
³Pediatric Hematology, Pausilipon Hospital, Naples, Italy
⁴hematology, azienda ospedaliera bianchi-melacrino-morelli, reggio calabria, Italy
⁵Department of Women’s and Chidren’s Health, University of Padua, Padua, Italy
⁶Clinical Experimental Hematology Unit, Gaslini Research Institute, Genoa, Italy
⁷Department of Pediatrics, Policlinico di Bari, Bari, Italy
⁸Department of Pediatrics, "Casa Sollievo della Sofferenza" Hospital, San Giovanni Rotondo, Italy
⁹Pediatric Hemato-Oncology Unit, Ospedale Regionale per le Microcitemie, Cagliari, Italy
¹⁰Pediatric Hemato-Oncology Unit, Sant'Anna Hospital, Ferrara, Italy
¹¹Hemato-Oncology Unit, Pugliese-Ciaccio Hospital, Catanzaro, Italy
¹²Pediatric Unit, Ospedale di Sassari, Sassari, Italy
¹³Pediatric Clinic University of Milan Bicocca, Monza, Italy
¹⁴Department of Pediatric Hematology and Oncology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy

Deborah Meyran^1*, Arnaud Petit^2*, Joelle Guilhot, PhD³, Meinolf Suttorp⁴, Eveline S. de Bont⁵, Chi Kong Li^6*, Krzysztof Kalwak^7*, Birgitte Lausen⁸, Srdjana Culic^9*, Marie-Françoise Dresse^10*, Andrea Biondi, Prof, MD¹¹ and Frédéric Millot^12*

¹Department of Pediatric Hematology, Robert Debré Hospital, paris, France
²Armand Trousseau Hospital, PARIS, France
³Clinical Investigation Center, INSERM CIC 1402, CHU de Poitiers, Poitiers, France
⁴Paediatrische Haematologie/Onkologie, Universitatsklinikum Carl Gustav Carus, Dresden, Germany
⁵Department of Pediatric Oncology/Hematology, Beatrix Children’s Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
⁶Department of Pediatrics, Prince of Wales Hospital, Hong Kong, China
⁷Department of Pediatric Hematology Oncology and Transplantation, Wroclaw Medical University, Wroclaw, Poland
⁸Department of Pediatrics, Rigshospitalet, Copenhagen, Denmark
⁹Department of Pediatric Hematology Oncology Immunology and Medical Genetic, University Hospital, Split, Croatia
¹⁰Department of Pediatrics, CHR La Citadelle, Liège, Belgium
¹¹Centro Ricerca Tettamanti, Clinica Pediatrica, Università Milano Bicocca, Osp. San Gerardo/Fondazione MBBM, Monza (MB), Italy
¹²Inserm CIC 1402, University Hospital, Poitiers, France

Victor M. Rivera¹, Susan Branford^2*, Franck E. Nicolini³, Justin R. Pritchard^1*, Joseph M. Gozgit^1*, Wolfgang Kern, MD⁴, Dragana Milojkovic^5*, Simone Claudiani^6*, Martin C. Muller^7*, Srinivas K Tantravahi⁸, Michael W. Deininger⁹, Michael Heinrich¹⁰, Simona Soverini¹¹, Michele Baccarani¹², Jerald P. Radich¹³, Elias Jabbour¹⁴, Jorge E. Cortes¹⁴, Gabriel Etienne^15* and Torsten Haferlach⁴

¹ARIAD Pharmaceuticals, Inc., Cambridge, MA
²School of Pharmacy and Medical Science, University of South Australia, Department of Genetics and Molecular Pathology, SA Pathology, Centre for Cancer Biology, School of Medicine and School of Molecular and Biomedical Science, University of Adelaide, Adelaide, Australia
³Hématologie, Centre Hospitalier Lyon Sud, Pierre Benite, & INSERM, Lyon, France
⁴MLL Munich Leukemia Laboratory, Munich, Germany
⁵Department of Haematology, Hammersmith Hospital (Imperial College Healthcare NHS Trust), London, United Kingdom
⁶Haematology, Hammersmith Hospital (Imperial College Healthcare NHS Trust), London, United Kingdom
⁷III. Medizinische Klinik, Universitätsmedizin Mannheim, Universität Heidelberg, Mannheim, Germany
⁸Huntsman Cancer Institute, The University of Utah, Salt Lake City, UT
⁹Huntsman Cancer Institute, University of Utah, Salt Lake City, UT
¹⁰Knight Cancer Institute, Oregon Health and Science University, Portland, OR
¹¹Institute of Hematology, S.Orsola-Malpighi University Hospital, Bologna, Italy
¹²Department of Hematology-Oncology 'L. and A. Seragnoli', S Orsola-Malpighi University Hospital, Bologna, Italy
¹³Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
¹⁴Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
¹⁵Institut Bergonié, Bordeaux, France

Juan Manuel Alonso-Dominguez, MD^1*, Felipe Casado^2*, MariaTeresa Gómez Casares, MD, PhD^3*, Ismael Buno^4,5*, Francisca Ferrer-Marin^6*, Eduardo Anguita, MD, PhD⁷, Alicia Arenas^8*, Rafael Del Orbe, MD^9*, Rosa M. Ayala, MD, PhD¹⁰, Pilar Llamas, MD^11*, Pedro Sanchez-Godoy, MD^12*, Carmen Burgaleta, MD^13*, Valentín García-Gutierrez^14*, Juan Luis Steegmann, MD, PhD¹⁵ and Joaquin Martinez-Lopez^16*

¹Madrid Central Laboratory, BRSalud, Madrid, Spain
²Servicio de Hematologia, Hospital Virgen de la Salud, Toledo, Spain
³Hospital Dr. Negrín, Las Palmas De Gran Canaria, Spain
⁴Hospital General Universitario Gregorio Marañón, Madrid, Spain
⁵Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain
⁶Hematology and Medical Oncology Department, Hospital Morales Meseguer. Centro Regional de Hemodonación. Universidad de Murcia. IMIB, MURCIA, Spain
⁷Department of Hematology, Hosp. Clínico U., Madrid, Spain
⁸Instituto Investigacion Hospital Doce de Octubre, Madrid, Spain
⁹Biocruces Health Research Institute, Barakaldo, Spain
¹⁰Hematology Department, Hospital 12 de Octubre, Madrid, Spain
¹¹Hospital Universitario Fundacion Jimenez Diaz, Madrid, Spain
¹²Hospital Severo Ochoa, Leganes, Spain
¹³Hematology, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Spain
¹⁴Hematology Department, Hospital Ramón y Cajal, Madrid, Spain
¹⁵Department of Hematology and IIS-IP, Hospital Universitario de la Princesa, Madrid, Spain
¹⁶Hospital-12-de-Octubre, Madrid, Spain

Fausto Castagnetti, MD/PhD¹, Gabriele Gugliotta, MD/PhD^1*, Massimo Breccia, MD^2*, Fabio Stagno, MD, PhD³, Alessandra Iurlo, MD, PhD^4*, Francesco Albano, MD^5*, Elisabetta Abruzzese, MD⁶, Bruno Martino, MD^7*, Luciano Levato, MD^8*, Tamara Intermesoli, MD^9*, Patrizia Pregno, MD^10*, Giuseppe Rossi, MD¹¹, Filippo Gherlinzoni, MD¹², Pietro Leoni, Prof¹³, Francesco Cavazzini, MD¹⁴, Dario Ferrero, MD^15*, Emilio Usala, MD^16*, Monica Bocchia, MD^17*, Mario Tiribelli, MD^18*, Enrico Montefusco, MD^19*, Simona Sica^20*, Claudia Venturi, PhD^1*, Simona Soverini¹, Michele Cavo, MD^1*, Giuliana Alimena, MD², Giovanni Martinelli, MD^1*, Fabrizio Pane, MD²¹, Giuseppe Saglio, MD²², Michele Baccarani, MD²³ and Gianantonio Rosti, MD^1*

¹Institute of Hematology, S.Orsola-Malpighi University Hospital, Bologna, Italy
²Chair of Hematology, "Sapienza" University, Roma, Italy
³Chair of Hematology, University of Catania, Catania, Italy
⁴Division of Hematology, IRCCS Maggiore Policlinico Hospital Foundation, Milano, Italy
⁵Hematology - Dept. of Emergency and Organ Transplantation, University of Bari, Bari, Italy
⁶Hematology, S. Eugenio Hospital, Roma, Italy
⁷Az.Osp. Bianchi-Melacrino’-Morelli, Reggio Calabria, Italy
⁸Section of Hematology, A.O. Pugliese-Ciaccio, Catanzaro, Italy
⁹Hematology and Bone Marrow Transplant Unit, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy
¹⁰Hematology Unit, AZ OSP. CITTA' DELLA SALUTE E SCIENZA TORINO, TORINO, Italy
¹¹Department of Hematology, Spedali Civili di Brescia, Brescia, Italy
¹²Unita Operativa Ematologia, Ospedale Ca' Foncello, Treviso, Italy
¹³Haematology Clinic, Ospedali Riuniti di Ancona, Ancona, Italy
¹⁴Hematology Section, Azienda Ospedaliero-Universitaria S. Anna, University of Ferrara, Ferrara, Italy
¹⁵Chair of Hematology, Department of Medicine and Experimental Oncology, Torino, Italy
¹⁶Hematology Unit, "A.Businco" Hospital, Cagliari, Italy
¹⁷Department of Hematology and Transplants, University of Siena, Siena, Italy
¹⁸Division of Hematology and BMT, Department of Experimental and Clinical Medical Sciences, Azienda Ospedaliero-Universitaria di Udine, Udine, Italy
¹⁹Hematology Unity, Sant'Andrea Hospital, Rome, Italy
²⁰Institute of Hematology, Catholic University, Rome, Italy
²¹Department of Biochemistry and Medical Biotechnologies, Federico II University, Napoli, Italy
²²Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy
²³Institute of Hematology, University of Bologna, Bologna, Italy

Gwo-Jen Day, Ph.D.^1*, Christina Lockwood, Ph.D.^2*, Jacqueline E. Payton, MD, PhD³, Geoffrey L. Uy, MD⁴, Charles Schiffer⁵, Gerald Feldman, MD, PhD, FACMG^6*, Aaron Bossler, MD, PhD^7*, Julie Woolworth, Ph.D.^8*, Alice S. Mims, MD⁹, Alba Levitas^1*, Krupa Shridhar^1*, Sandy Huang^1*, Vivian Xiao, Ph.D.^1*, Natalie Wu, Ph.D.^1*, Michael P. Bates, MD¹ and Wendy Wong^1*

¹Cepheid, Sunnyvale, CA
²University of Washington, Department of Laboratory Medicine, Seattle, WA
³Pathology & Immunology, Washington University School of Medicine, Saint Louis, MO
⁴Division of Oncology, Washington University School of Medicine, St. Louis, MO
⁵Wayne State University, Detroit, MI
⁶Department of Pathology, Wayne State University School of Medicine and Detroit Medical Center University Laboratory, Detroit, MI
⁷University of Iowa Carver College of Medicine, Molecular Pathology Laboratory, Iowa City, IA
⁸Medical University of South Carolina, Department of Pathology & Laboratory Medicine, Charleston, SC
⁹Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH

Simone Claudiani^1*, Nikhita Gupta, BSc^2*, Ji Soo Baik, BSc^2*, Simona Deplano, MD PhD^3*, Renuka Palanicawander^1*, Gareth Gerrard^2*, Alistair G Reid, BSc, PhD^1*, Richard M Szydlo, BSc, PhD^4*, Dragana Milojkovic^3*, Letizia Foroni^2* and Jane F. Apperley, MD^1,2

¹Haematology Department, Hammersmith Hospital (Imperial College Healthcare NHS Trust), London, United Kingdom
²Centre for Haematology, Imperial College London, London, United Kingdom
³Department of Haematology, Hammersmith Hospital (Imperial College Healthcare NHS Trust), London, United Kingdom
⁴Centre for Haematology, Imperial College, London, United Kingdom

Jeeyune Bahk, BSc^1*, Simone Claudiani, MD^2*, Richard M Szydlo, BSc, PhD^1*, Sarmad Toma, BSc^3*, Faisal Abdillah, BSc^3*, Sandra Hing, BSc^3*, Simona Deplano, MD PhD^2*, Dragana Milojkovic^1*, Jane F Apperley, MD¹ and Letizia Foroni, MD, PhD^1*

¹Centre for Haematology, Imperial College, London, United Kingdom
²Department of Haematology, Hammersmith Hospital (Imperial College Healthcare NHS Trust), London, United Kingdom
³Molecular Pathology, Hammersmith Hospital (Imperial College Healthcare NHS Trust), London, United Kingdom

Binsah Susan George, MBBS^1*, Hagop M Kantarjian, MD², Guillermo Garcia-Manero, MD³, Farhad Ravandi, MD², Srdan Verstovsek, MD², Gautam Borthakur, MD², Nitin Jain, MD², Sherry Pierce, BSN, BA^4*, Koichi Takahashi, MD², Elias Jabbour² and Jorge E. Cortes²

¹Department of Leukemia, MD Anderson Cancer Center, Houston, TX
²Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX
⁴Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX

Stuart L. Goldberg, MD¹, Yun Su, MD, MPH, MS^2*, Candace Gunnarsson, EdD, MA^3*, William D Irish, PhD^3*, Michael Ryan, MS^3*, Mabel Woloj, MD^4*, Roxanne Ferdinand, MBBS MRCP MFPM^5* and Mark Shapiro, MD⁶

¹Division of Leukemia, John Theurer Cancer Center of Hackensack University Medical Center, Hackensack, NJ
²Outcomes & Evidence, Global Health & Value, Pfizer Inc, New York, NY
³CTI Clinical Trials and Consulting, Cincinnati, OH
⁴Pfizer Inc, New York, NY
⁵Haematology Europe/AfME, Pfizer Oncology, Pfizer Ltd, Walton-on-the-Hill, United Kingdom
⁶Pfizer Inc, Cambridge, MA

Ayala Gover-Proaktor, PhD^1*, Oren Pasvolsky, MD^2,3*, Pia Raanani, MD^2,3, Arnon Nagler, MD, MSc^3,4, Saar Shapira, MSc^1,3*, Ido Lubin, PhD^1,3*, Galit Granot, PhD^1* and Avi Leader, MD^2,3*

¹Felsenstein Medical Research Center, Beilinson Hospital, Rabin Medical Center, Petah-Tikva, Israel
²Division of Hematology, Davidoff Center, Beilinson Hospital, Rabin Medical Center, Petah-Tikva, Israel
³Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
⁴Hematology Division, Chaim Sheba Medical Center and Tel Aviv University, Tel-Hashomer, Ramat-Gan, Israel