Samantha L Savage^1*, Christopher A. Eide^2,3*, Kyle F Concannon^1,3*, Daniel Bottomly, MS^4*, Beth Wilmot, PhD^4*, Shannon K. McWeeney, PhD^4*, Julia Elizabeth Maxson, PhD⁵, Jeffrey W. Tyner, PhD⁶, Cristina E. Tognon, PhD^1,3* and Brian J. Druker, MD^1,3

¹Knight Cancer Institute, Oregon Health and Science University, Portland, OR
²Knight Cancer Institute, Division of Hematology and Medical Oncology, Oregon Health & Science University, Portland, OR
³Howard Hughes Medical Institute, Portland, OR
⁴Department of Bioinformatics and Computational Biology, Oregon Health & Science University, Portland, OR
⁵Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
⁶Knight Cancer Institute, Oregon Health & Science University, Portland, OR

Mika Kontro, MD^1*, Samuli Eldfors, MSc^2*, Muntasir Mamun Majumder, MSc, MPharm^2*, Alun Parsons, MSc^2*, Tea Pemovska, MSc^2*, Olli Kallioniemi, MD, PhD^2*, Krister Wennerberg, PhD^2*, Caroline A Heckman, PhD² and Kimmo Porkka, MD, PhD¹

¹Hematology Research Unit Helsinki, University of Helsinki and Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland
²Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland

Monika Jaruskova^1,2*, Rajna Hercog^3*, Nikola Curik^1,4*, Vladimir Benes^3*, Hana Klamova^1,2* and Katerina Machova Polakova^1,2*

¹Institute of Hematology and Blood Transfusion, Prague, Czech Republic
²Institute of Clinical and Experimental Hematology, First Faculty of Medicine, Charles University, Prague, Czech Republic
³Genomics Core Facility, Heidelberg, Germany
⁴Pathological Physiology, First Faculty of Medicine, Charles University, Prague, Czech Republic

Chun Zhou, PhD^1*, Daniela Di Marcantonio, PhD¹, Esteban Martinez^1*, Nehal Solanki-Patel^1*, Suraj Peri, PhD^1*, Claudia Scholl², Stefan Fröhling², David L. Wiest, PhD¹ and Stephen Matthew Sykes, PhD¹

¹Fox Chase Cancer Center, Philadelphia, PA
²National Center for Tumor Diseases, Heidelberg, Germany

Jacqueline Martinez, MS^1*, Nathalie Javidi-Sharifi^1*, Isabel English^1*, Shelton A. Viola, MD^2*, Danielle Jorgens, PhD^3*, Brian J. Druker, MD^4,5 and Elie Traer, MD, PhD⁵

¹Knight Cancer Institute, Oregon Health & Science University, Portland, OR
²Oregon Health & Sciences University, Portland, OR
³Oregon Health & Science University, Portland, OR
⁴Howard Hughes Medical Institute, Portland, OR
⁵Knight Cancer Institute, Division of Hematology and Medical Oncology, Oregon Health & Science University, Portland, OR

Linda Resar, M.D.¹, Stuart A Rushworth, PhD, BSc^2*, Lingling Xian, MD, PhD^3* and Kristian Bowles, MB BS, PhD, FRCP, FRCPath^4*

¹Department of Medicine; Division of Hematology, Department of Oncology, Institute of Cellular Engineering, Johns Hopkins University SOM, Baltimore, MD
²Norwich Medical School, University of East Anglia, Norwich, United Kingdom
³Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD
⁴Division of Hematology, University of East Anglia, Norwich, United Kingdom

Irum Khan, MD¹, Maryam Zia, M.D.², Marianna Halasi, Ph.D.^3*, Peter Gann, M.D., ScD^4*, Sujata Gaitonde, MD, FACP^5* and Andrei Gartel, Ph.D.^6*

¹Division of Hematology/Oncology, University of Illinois at Chicago, Chicago, IL
²Division of Hematology/Oncology, University of Illinois College of Medicine At Chicago, Chicago, IL
³Division of Gastroenterology and Hepatology, University of Illinois-Chicago, Chicago
⁴Division of Pathology Research, University of Illinois-Chicago Hospital and Health Sciences System, Chicago
⁵Department of Pathology, University of Illinois at Chicago, Chicago
⁶Division of Gastroenterology and Hepatology, University of Illinois-Chicago Hospital and Health Sciences Center, Chicago, IL

Haijiao Zhang, MD^1*, Kevin Matthew Watanabe-Smith, BS^2*, Daniel Bottomly, MS^3*, Beth Wilmot, PhD^3*, Shannon K. McWeeney, PhD^3*, Hagop M. Kantarjian, MD⁴, Judy Ho^5*, Jeremy Davis^5*, Blake Pond, MS^6*, Gautam Borthakur, MD⁴, Abhijit Ramachandran, MS^7*, Jorge E. Cortes⁴, Robert Collins, MD⁸ and Jeffrey W. Tyner, PhD⁹

¹Oregon Health & Science University Knight Cancer Institute, Portland, OR
²Oregon Health and Science University, Portland, OR
³Department of Bioinformatics and Computational Biology, Oregon Health & Science University, Portland, OR
⁴Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁵AROG Pharmaceuticals, Dallas, TX
⁶Clinical Research Manager, University of Texas Southwestern Medical Center, Dallas, TX
⁷Clinical Operations, AROG Pharmaceuticals, Dallas, TX
⁸University of Texas Southwestern Medical Center, Dallas, TX
⁹Knight Cancer Institute, Oregon Health & Science University, Portland, OR

Jianyun Zhao^1*, Xiaojia Niu^1*, Holly Edwards^2*, Yue Wang^3*, Jeffrey W Taub, MD⁴, Hai Lin^3* and Yubin Ge, PhD⁵

¹Jilin University, Changchun, China
²Wayne State University, Detroit, MI
³The First Hospital of Jilin University, Changchun, China
⁴Department of Pediatric Hematology/Oncology, Children's Hospital of Michigan, Detroit, MI
⁵Department of Oncology, Karmanos Cancer Institute, Detroit, MI

Marisa J Hornbaker, B.S., Mary E Irwin, Ph.D.^*, LaNisha Patterson, B.S.^*, Shelley M Herbrich, MS^*, Patrick Zweidler-McKay, MD, PhD and Joya Chandra, Ph.D.

Department of Pediatrics Research, The University of Texas M D Anderson Cancer Center, Houston, TX

Shaneice Mitchell, BS^1,2*, Shelley Orwick, BS^1*, Matthew Cannon, BS^1*, Virginia M. Goettl, DVM , PhD^1*, Taylor D. LaFollette^1*, Erkan Baloglu, PhD^3*, William Senapedis, PhD^3*, Alison R. Walker, MD¹, Bhavana Bhatnagar^1*, Alice S. Mims, MD¹, Rebecca B. Klisovic, MD¹, Sumithira Vasu, MBBS⁴, William Blum, MD¹, David M. Lucas, PhD¹, James S. Blachly, MD¹, Ramiro Garzon, MD⁴, Clara D. Bloomfield, MD⁴, Rosa Lapalombella, PhD¹ and John C. Byrd, MD^1,5

¹Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH
²Biomedical Science Graduate Program, The Ohio State University, Columbus, OH
³Karyopharm Therapeutics, Inc, Newton, MA
⁴Comprehensive Cancer Center, The Ohio State University, Columbus, OH
⁵Division of Medicinal Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH

Oscar Lindblad^1,2,3*, Eugenio Cordero^1*, Alexandre Puissant^4*, Lucy Macaulay^1,2*, Nuzhat N. Kabir^5*, Jianmin Sun^1,2*, Karin Haraldsson^6*, Åke Borg^6*, Fredrik Levander^7*, Kimberly Stegmaier, MD⁸, Kristian Pietras^1*, Lars Ronnstrand^1,2 and Julhash U. Kazi^1,2,5*

¹Division of Translational Cancer Research, Department of Laboratory Medicine, Lund University, Medicon Village 404, Lund, Sweden
²Lund Stem Cell Center, Department of Laboratory Medicine, Lund University, Lund, Sweden
³Department of Hematology and Vascular Disorders, Skåne University Hospital, Lund, Sweden
⁴Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, MA
⁵Laboratory of Computational Biochemistry, KN Biomedical Research Institute, Barisal, Bangladesh
⁶Department of Oncology and Pathology, Lund University, Medicon Village 404, Lund, Sweden
⁷Bioinformatics Infrastructure for Life Sciences (BILS), Department of Immunotechnology, Lund University, Medicon Village 406, Lund, Sweden
⁸Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA

Myrna Rita Nahas, MD^1*, Dina Stroopinsky, PhD^1*, Hasan Rajabi, PhD^2*, Ashujit Tagde, PhD^2*, Athalia Rachel Pyzer, MD^1*, Salvia Jain, MD³, Maxwell Douglas Coll^1*, Michal Bar-Natan, MD^1*, Rebecca Karp, MD¹, Katarina Luptakova, MD¹, Kristen Anna Palmer^1*, Poorvi Somaiya^1*, Jon Arnason, MD¹, Malgorzata McMasters, MD^1*, Robin Joyce, MD¹, James D. Levine, MD¹, Donald Kufe, MD^2*, David E. Avigan, MD¹ and Jacalyn Rosenblatt¹

¹Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
²Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
³Malignant Hematology and Bone Marrow Transplantation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

Kelly J Norsworthy, MD¹, Daniela Hernandez, MD^1*, Meng Su, BS¹, Megan E McCray, BA^1*, Christopher A Esteb, BS^1*, Roshantha A Chandraratna, PhD^2*, B. Douglas Smith, MD¹, Richard J Jones, MD¹ and Gabriel Ghiaur, MD, PhD¹

¹Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD
²Io Therapeutics, Inc., Santa Ana, CA

Sinto Sebastian Chirackal, PhD^1*, Yuan Xiao Zhu, PhD^2*, Esteban Braggio, PhD^3*, Chang-Xin Shi, Ph.D.^4*, Sonali Panchabhai, MBBS^5*, Gregory Ahmann, BS⁶, Scott A. Van Wier, BS^7*, Marta Chesi, PhD⁵, Leif Bergsagel, MD, PhD⁸, Keith Stewart, MD⁹ and Rafael Fonseca, MD⁷

¹Haematology and Oncology, Mayo Clinic, Scottsale, AZ
²Research, Mayo Clinic, Scottsdale, AZ
³Department of Medicine, Mayo Clinic, Scottsdale, AZ
⁴Division of Hematology/Oncology, Mayo Clinic, Scottsdale, AZ
⁵Mayo Clinic, Scottsdale, AZ
⁶Division of Hematology - Oncology, Mayo Clinic, Scottsdale, AZ
⁷Mayo Clinic, Scottsdale
⁸Comprehensive Cancer Center, Mayo Clinic, Scottsdale, AZ
⁹Mayo Clinic Arizona, Scottsdale, AZ