-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

603. Oncogenes and Tumor Suppressors: Poster III

Oncogenes and Tumor Suppressors Program: Oral and Poster Abstracts
Type: Poster
Monday, December 7, 2015: 6:00 PM-8:00 PM
Hall A, Level 2 (Orange County Convention Center)

Zhigang Zhao, MD, PhD1,2,3*, Lin Li, PhD4*, Meelad Dawlaty, PhD5*, Feng Pan, PhD1,3*, Zhe Li, PhD3*, Yuan Zhou, PhD6*, Hui Shi, MD, PhD6,7*, Shi Chen, MD, PhD8*, Ophelia Weeks, PhD9*, Weiping Yuan, PhD10*, Hongyu Ni, PhD11*, Feng-Chun Yang, MD, PhD3,8, Rudolph Jaenisch, PhD5*, Peng Jin, MD, PhD4* and Mingjiang Xu, MD, PhD1,3

1Department of Biochemistry and Molecular Biology, Sylvester Cancer Center, University of Miami, Miami, FL
2Department of Hematology and Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
3Department of Pediatrics, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN
4Departments of Human Genetics, Emory University School of Medicine, Atlanda, GA
5Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA
6State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Center for Stem Cell Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
7University of Miami Leonard M. Miller School of Medicine, Miami, Florida 33136., Miami, FL
8Department of Biochemistry and Molecular Biology & Sylvester Comprehensive Cancer Center, University of Miami Leonard M. Miller School of Medicine, Miami, FL
9Department of Biological Sciences, Florida International University, Miami, FL
10State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
11Department of Pathology, University of Illinois, Chicago, IL

Jevon Cutler1*, Rahia Tahir1*, Jingnan Han1*, Raja Sekhar Nirujogi1*, Tai-Chung Huang, M.D.2*, Xianrong Wong3*, Saradhi Mallampati4*, Xiaoping Sun, MD, PhD4, Patrick Brown, MD5, Karen Reddy, PhD3* and Akhilesh Pandey, MD, PhD6*

1McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD
2Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital & Cancer Center, Taipei City, Taiwan
3Johns Hopkins University, Department of Biological Chemistry, Center for Epigenetics, Baltimore, MD
4Laboratory Medicine, University of Texas M. D. Anderson Cancer Center, Houston, TX
5Pediatric Oncology, Johns Hopkins University School of Medicine, Baltimore, MD
6McKusick-Nathans Institute of Genetic Medicine and Departments of Biological Chemistry, Pathology and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD

Antonio Niro1*, Rocco Piazza, MD, PhD1*, Gabriele Merati1*, Alessandra Pirola, MSc1*, Carla Donadoni, MSc, PhD1*, Diletta Fontana, MSc1*, Sara Redaelli, PhD1*, Caterina Mezzatesta1*, Rossella Renso, MD2*, Francesca Farina, MD2*, Delphine Rea3* and Carlo Gambacorti-Passerini, MD1

1Dept. of Health Sciences, University of Milano-Bicocca, Monza, Italy
2San Gerardo Hospital, Unit of Hematology, Monza, Italy
3Hematology department, Hôpital Saint-Louis, Paris, France

Edith Schneider, MSc1*, Anna Staffas, PhD2,3*, Linda Roehner, MSc1*, Christian Buske4, Lars Bullinger, MD1, Michael Heuser, M.D.5, Hartmut Döhner, MD1, Konstanze Döhner, MD1, R. Keith Humphries, MD, PhD6, Arefeh Rouhi, PhD1*, Lars Palmqvist, MD, PhD2,7 and Florian Kuchenbauer, MD, PhD1

1Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany
2Department of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden
3Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden
4Institute of Experimental Cancer Research, University Hospital of Ulm, Ulm, Germany
5Hematology, Hemostasis, Oncology and SCT, Hannover Medical School, Hannover, Germany
6Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada
7Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

Iwona Wlodarska1, Jo-Anne van der Krogt1*, Julio Finalet Ferreiro1*, Jacobs Kris1,2*, Geerdens Ellen1,2*, Anne Uyttebroeck3*, Peter Vandenberghe, MD PhD4, Thomas Tousseyn, MD PhD5* and Jan Cools, PhD1,2

1Center for Human Genetics, KU Leuven, Leuven, Belgium
2Center for the Biology of Disease, VIB, Leuven, Belgium
3Department of Pediatrics, University Hospitals Leuven, Leuven, Belgium
4Center for Human Genetics, University Hospitals Leuven, Leuven, Belgium
5Translational Cell and Tissue Research, KU Leuven, Leuven, Belgium

Connie Batlevi, MD, PhD1, Franck Rapaport, PhD2*, Lu Wang, MD, PhD3*, Andrew M. Intlekofer, MD, PhD1, Amanda R. Copeland, RN, MSN, CNS1*, Achim A Jungbluth, MD3*, Anne Reiner, MPH4*, Janine D. Pichardo, BS3*, Meighan Gallagher, MA5*, Nancy Bouvier, BS6*, Nicholas D. Socci, PhD2*, Frederick Criscuolo, PhD7*, Nikolaus Schultz, PhD4*, Maria Arcila, MD3*, Michael Berger, PhD3*, Andrew D Zelenetz, MD, PhD1, Venkatraman E Seshan, PhD4*, Ahmet Dogan, MD, PhD3 and Anas Younes, MD1

1Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY
2Department of Bioinformatics, Memorial Sloan Kettering Cancer Center, New York, NY
3Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY
4Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY
5Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY
6Sloan Kettering Institute, Collaborative Research Centers, Memorial Sloan Kettering Cancer Center, New York, NY
7Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY

Sanghoon Lee, PhD, MSc1, Changhong Yin, MD, MS1*, Janet Ayello, MS1*, Erin Morris, RN1*, Carmella van de Ven, MA1* and Mitchell S. Cairo, MD1,2,3,4,5

1Pediatrics, New York Medical College, Valhalla, NY
2Cell Biology & Anatomy, New York Medical College, Valhalla, NY
3Microbiology & Immunology, New York Medical College, Valhalla, NY
4Pathology, New York Medical College, Valhalla, NY
5Medicine, New York Medical College, Valhalla, NY

Zheng Ge, MD, PhD1,2, Evelyn Song, BS2*, Jianyong Li, MD, PhD1, Sinisa Dovat, MD, PhD2* and Chunhua Song, PhD2

1Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China
2Pennsylvania State University College of Medicine, Hershey, PA

Guillermo rodriguez-Hernandez1*, Julia Hauer, MD2*, Alberto Martín-Lorenzo1*, Daniel Schaefer2*, Christoph Bartenhagen3*, Idoia Garcia-Ramirez1*, Franziska Auer2*, Ines Gonzalez-Herrero1*, Lucia Ruiz-Roca1*, Vera Okpanyi4*, Ute Fischer, PhD5*, Martin Dugas6*, Sanil Bhatia7*, Michael Gombert, PhD7*, Pina Krell7*, Cai Chen7*, Marta Garcia Suquia1*, Maria Rascon Trincado1*, Angel Garcia Sanchez1*, Oscar Blanco8*, Maria garcia Cenador1*, Francisco Garcia-criado1*, Cesar Cobaleda9*, Diego Alonso-Lopez10*, Javier de Las Rivas11*, Carolina vicente-Duenas1*, Isidro Sanchez-Gracia1* and Arndt Borkhardt, MD12

1CSIC/ Universidad de Salamanca, Salamanca, Spain
2Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich-Heine University Dusseldorf, Düsseldorf, Germany
3Institute of Medical Informatics, University of Münster, Münster, Germany
4Clinic of Pediatric Oncology and Hematology, Duesseldorf, Germany
5Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Heinrich-Heine-University, Medical Faculty, Duesseldorf, Germany
6Institute of Medical Informatics, University of Munster, Munster, Germany
7Heinrich-Heine University Dusseldorf, Düsseldorf, Germany
8Pathology Department, University Hospital of Salamanca, Salamanca, Spain
9CSIC/Universidad Autónoma de Madrid, Madrid, Spain
10Cancer Research Center (CSIC-USAL), Salamanca, Spain
11Cancer Research Center (CSIC-USAL),, Salamanca, Spain
12Heinrich-Heine-University, Medical Faculty, Department of Pediatric Oncology, Hematology and Clinical Immunology, Duesseldorf, Germany

Dina Stroopinsky, PhD1*, Hasan Rajabi, PhD2*, Maxwell Douglas Coll1*, Athalia Rachel Pyzer, MD1*, Jacalyn Rosenblatt, MD1, Salvia Jain, MD3, Katarina Luptakova, MD1, Malgorzata McMasters, MD1*, James D. Levine, MD1, Robin Joyce, MD4, Jon E. Arnason, MD1, Rebecca Karp Leaf, MD1, Myrna Rita Nahas, MD1*, Kristen Anna Palmer1*, Michal Bar-Natan, MD1*, Ashujit Tagde, PhD, BPharm2*, Abigail Washington1*, Poorvi Somaiya1*, Donald Kufe, MD2* and David E. Avigan, MD1

1Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
2Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
3Malignant Hematology and Bone Marrow Transplantation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
4Division of Hematology and Oncology, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA

Christoph Rummelt1*, Sivahari Prasad Gorantla, PhD1*, Philip Keye1*, Kathrin Klaesener2*, Venkatesh Rao1*, Christian Peschel, MD3, Michael Reth, Prof., PhD2*, Justus Duyster, MD, PhD4* and Nikolas von Bubnoff, Prof., PhD1*

1Department of Hematology, Oncology and Stem Cell Transplantation, University Medical Center Freiburg, Freiburg im Breisgau, Germany
2Department of Cellular and Molecular Immunology, Max Planck Institute of Immunbiology and Epigenetics, Freiburg, Germany
3III. Medizinische Klinik, Klinikum rechts der Isar, Technical University Munich, Munich, Germany
4Department of Hematology&Oncology+Comprehensive Cancer Center Freiburg (CCCF), University of Freiburg Medical Center, Freiburg, Germany

Megha Desai, PhD1*, Kyung-Hee Chang, PhD2*, E. David Muench, BS3, Anjelika Gasilina1*, Ashley Wellendorf3*, Xose R Bustelo4*, H. Leighton Grimes, PhD5, Nicolas Nassar, PhD3* and Jose A Cancelas, MD, PhD6

1Cincinnati Children's Hospital Medical Center, Cincinnati
2University of Cincinnati, Cincinnati, OH
3Cincinnati Children's Hospital Medical Center, Cincinnati, OH
4Universidad de Salamanca - CSIC, Salamanca, Spain
5Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
6Stem Cell Program, Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

Tao Zhen, PhD1*, Ling Zhao, MD, PhD1*, R. Katherine Hyde, PhD2, Lemlem Alemu1* and Pu Paul Liu, MD, PhD1

1Oncogenesis and Development Section/NHGRI, National Institutes of Health, Bethesda, MD
2University of Nebraska Medical Center, Omaha, NE

Liqi Li, PhD1*, Justin H. Layer, PhD2*, Claude Warzecha, PhD3*, Rati Tripathi, PhD2*, Paul Love, MD, PhD3* and Utpal P. Dave, MD4,5

1Section of Cellular and Developmental Biology, NIH/NICHD, Bethesda
2Division of Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN
3Section of Cellular and Developmental Biology, NIH/NICHD, Bethesda, MD
4Nashville VA, Tennessee Valley Healthcare System, Nashville, TN
5Medicine and Cancer Biology, Vanderbilt University Medical Center, Nashville, TN

Tiffany M Tran1*, Jayanth Kumar Palanichamy, MD, MBBS2*, Jonathan Howard3*, Jorge R. Contreras, BS1*, Thilini Fernando1*, Giuseppe Basso, Prof, MD4, Martina Pigazzi, PhD4*, Jeremy R Sanford3* and Dinesh S. Rao, MD, PhD1

1UCLA, Los Angeles, CA
2Pathology and Laboratory Medicine, UCLA, Los Angeles, CA
3UCSC, Santa Cruz, CA
4Woman and Child Health Department, University of Padova, Padova, Italy

Andrew Dunford1*, Stephen E Schumacher, PhD1*, Virginia Savova, PhD2*, Alexander A Gimelbrant, PhD2*, Rameen Beroukhim, MD, PhD2*, Michael S Lawrence, PhD1*, Gad Getz, PhD1*, David M Weinstock, MD2 and Andrew A Lane, MD, PhD3

1Broad Institute, Cambridge, MA
2Dana-Farber Cancer Institute, Boston, MA
3Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA

Ling Zhao, MD, PhD1*, Lemlem Alemu1*, Jun Cheng2*, Tao Zhen, PhD1*, Alan D. Friedman, M.D.3 and Pu Paul Liu, MD, PhD1

1Oncogenesis and Development Section/NHGRI, National Institutes of Health, Bethesda, MD
2Transgenic Mouse Core/NHGRI, National Institutes of Health, Bethesda, MD
3Division of Pediatric Oncology, Johns Hopkins University School of Medicine, Baltimore, MD

Rui Su, PhD1, Zejuan Li, MD, PhD2,3, Ping Chen2, Yuanyuan Li4*, Hu Chao4*, Yungui Wang, PhD1,2*, Stephen Arnovitz2*, Miao He4*, Sandeep Gurbuxani, MBBS, PhD5, Zhixiang Zuo6*, Abdel G. Elkahloun7*, Shenglai Li4*, Hengyou Weng, PhD1,2, Hao Huang4*, Mary Beth Neilly2*, Shusheng Wang8*, Richard A. Larson, MD4, Jiwang Zhang9*, Xi Jiang, PhD1,2, Minjie Wei10*, Jie Jin, MD, PhD11, Paul P. Liu12* and Jianjun Chen, PhD1,2

1Department of Cancer Biology, University of Cincinnati, Cincinnati, OH
2Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL
3University of Chicago Medical Center, Chicago, IL
4Department of Medicine, University of Chicago, Chicago
5Department of Pathology, University of Chicago, Chicago, IL
6University of Cincinnati, Cincinnati, OH
7Genetics and Molecular Biology Branch, National Human Genome Research Institute, Bethesda
8Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas
9Oncology Institute, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood
10Department of Pharmacology, China Medical University, Shenyang, China
11Department of Hematology & Institute of Hematology, The First Affiliated Hospital, Zhejiang University, Hangzhou, China
12Translational and Functional Genomics Branch and Microarray Core, National Human Genome Research Institute, NIH, Bethesda

Min Wu, PhD1*, Li Li, PhD2, Max Hamaker, BA3*, Donald Small, MD, PhD4 and Amy S. Duffield, MD, PhD1

1Pathology, Johns Hopkins University School of Medicine, Baltimore, MD
2Oncology, Johns Hopkins University School of Medicine, Baltimore, MD
3University of Maryland Schoold of Medicine, Baltimore, MD
4Oncology and Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD

Shuyun Rao, Ph.D.1*, Kathy Cai2*, Jason Stadanlick2*, Sang-Yun Lee2*, Noa Greenberg-Kushnir2* and Nehal Solanki-Patel2*

1Fox Chase Cancer Center, Temple Univeristy, Philadelphia, PA
2Fox Chase Cancer Center, Philadelphia, PA

Kevin M Watanabe-Smith, BS1*, Cristina E. Tognon, PhD2,3*, Jeffrey W. Tyner, PhD4, Brian J. Druker, MD3,5 and Anupriya Agarwal, PhD5

1Oregon Health and Science University, Portland, OR
2Knight Cancer Institute, Oregon Health and Science University, Portland, OR
3Howard Hughes Medical Institute, Portland, OR
4Knight Cancer Institute, Oregon Health & Science University, Portland, OR
5Knight Cancer Institute, Division of Hematology and Medical Oncology, Oregon Health & Science University, Portland, OR

Romain Duval1*, Linh-Chi Bui, PhD1*, Cécile Mathieu2*, Emile Petit1*, Jean-Marie Dupret, PhD1*, Jan Cools, PhD3, Fabien Guidez, PhD4*, Christine Chomienne, MD, PhD5 and Fernando Rodrigues-Lima, PhD1*

1Université Paris Diderot, Sorbonne Paris Cité, CNRS UMR 8251, Paris, France
2aUniversité Paris Diderot, Sorbonne Paris Cité, CNRS UMR 8251, Paris, France
3VIB Center for the Biology of Disease, Leuven, Belgium
4Université Paris Diderot, Sorbonne Paris Cité, INSERM UMR_S1131, Institut Universitaire d'Hématologie, Paris, France
5Service de Biologie Cellulaire, Assistance Publique des Hôpitaux de Paris (AP-HP), Hôpital Saint Louis, Université Paris Diderot, Sorbonne Paris Cité, INSERM UMR_S1131, Institut Universitaire d'Hématologie, Paris, France

Kenneth Lieuw, MD, PhD1, Jayasree Krishnamurthy, MS1* and Mignon L. Loh, MD2

1Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD
2Department of Pediatrics, Benioff Children’s Hospital, University of California at San Francisco, San Francisco, CA

Chiara Pighi1*, Mara Compagno1*, Qi Wang1*, Taek-Chin Cheong1*, Teresa Poggio2*, Fernanda Langellotto1*, Paola Francia di Celle3*, Alberto Zamò4* and Roberto Chiarle1,2

1Department of Pathology, Boston Children's Hospital, Boston, MA
2Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy
3Azienda Ospedaliera Città della Salute, Turin, Italy
4Department of Pathology, University of Verona, Verona, Italy

Alexandre Puissant, PhD1*, Nina Fenouille, PhD2*, Christopher F. Bassil, BA3*, Issam Ben-Sahra, PhD4*, Gabriela Alexe, PhD3*, Lina Benajiba3*, Azucena Ramos5*, Yana Pikman, MD6, Michael R. Burgess, MD, PhD7, Ilene Galinsky, ANP8, Daniel J. DeAngelo, MD, PhD8, Richard M. Stone, MD8, Kevin Shannon, MD9*, Michael T. Hemann, PhD2* and Kimberly Stegmaier, MD6

1Department of Pediatric Oncology, Dana-Farber Cancer Instituté, Boston, MA
2Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, Massachusetts Institute of Technology, Cambridge, MA
3Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA
4Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA
5Koch Institute for Integrative Cancer Research, Cambridge, MA
6Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA
7Medicine, University of California, San Francisco, San Francisco, CA
8Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
9Dept. of Pediatrics and the Comprehensive Cancer Center, UCSF, San Francisco, CA

Manabu Kusakabe, MD, PhD1, Claire Shanna1*, Xuehai Wang, PhD1*, Catherine Jenkins2*, Vincenzo Giambra, PhD1* and Andrew P Weng, MD, PhD1

1Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada
2Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, Canada

*signifies non-member of ASH