Zhigang Zhao, MD, PhD^1,2,3*, Lin Li, PhD^4*, Meelad Dawlaty, PhD^5*, Feng Pan, PhD^1,3*, Zhe Li, PhD^3*, Yuan Zhou, PhD^6*, Hui Shi, MD, PhD^6,7*, Shi Chen, MD, PhD^8*, Ophelia Weeks, PhD^9*, Weiping Yuan, PhD^10*, Hongyu Ni, PhD^11*, Feng-Chun Yang, MD, PhD^3,8, Rudolph Jaenisch, PhD^5*, Peng Jin, MD, PhD^4* and Mingjiang Xu, MD, PhD^1,3

¹Department of Biochemistry and Molecular Biology, Sylvester Cancer Center, University of Miami, Miami, FL
²Department of Hematology and Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
³Department of Pediatrics, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN
⁴Departments of Human Genetics, Emory University School of Medicine, Atlanda, GA
⁵Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA
⁶State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Center for Stem Cell Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
⁷University of Miami Leonard M. Miller School of Medicine, Miami, Florida 33136., Miami, FL
⁸Department of Biochemistry and Molecular Biology & Sylvester Comprehensive Cancer Center, University of Miami Leonard M. Miller School of Medicine, Miami, FL
⁹Department of Biological Sciences, Florida International University, Miami, FL
¹⁰State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
¹¹Department of Pathology, University of Illinois, Chicago, IL

Jevon Cutler^1*, Rahia Tahir^1*, Jingnan Han^1*, Raja Sekhar Nirujogi^1*, Tai-Chung Huang, M.D.^2*, Xianrong Wong^3*, Saradhi Mallampati^4*, Xiaoping Sun, MD, PhD⁴, Patrick Brown, MD⁵, Karen Reddy, PhD^3* and Akhilesh Pandey, MD, PhD^6*

¹McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD
²Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital & Cancer Center, Taipei City, Taiwan
³Johns Hopkins University, Department of Biological Chemistry, Center for Epigenetics, Baltimore, MD
⁴Laboratory Medicine, University of Texas M. D. Anderson Cancer Center, Houston, TX
⁵Pediatric Oncology, Johns Hopkins University School of Medicine, Baltimore, MD
⁶McKusick-Nathans Institute of Genetic Medicine and Departments of Biological Chemistry, Pathology and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD

Antonio Niro^1*, Rocco Piazza, MD, PhD^1*, Gabriele Merati^1*, Alessandra Pirola, MSc^1*, Carla Donadoni, MSc, PhD^1*, Diletta Fontana, MSc^1*, Sara Redaelli, PhD^1*, Caterina Mezzatesta^1*, Rossella Renso, MD^2*, Francesca Farina, MD^2*, Delphine Rea^3* and Carlo Gambacorti-Passerini, MD¹

¹Dept. of Health Sciences, University of Milano-Bicocca, Monza, Italy
²San Gerardo Hospital, Unit of Hematology, Monza, Italy
³Hematology department, Hôpital Saint-Louis, Paris, France

Edith Schneider, MSc^1*, Anna Staffas, PhD^2,3*, Linda Roehner, MSc^1*, Christian Buske⁴, Lars Bullinger, MD¹, Michael Heuser, M.D.⁵, Hartmut Döhner, MD¹, Konstanze Döhner, MD¹, R. Keith Humphries, MD, PhD⁶, Arefeh Rouhi, PhD^1*, Lars Palmqvist, MD, PhD^2,7 and Florian Kuchenbauer, MD, PhD¹

¹Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany
²Department of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden
³Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden
⁴Institute of Experimental Cancer Research, University Hospital of Ulm, Ulm, Germany
⁵Hematology, Hemostasis, Oncology and SCT, Hannover Medical School, Hannover, Germany
⁶Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada
⁷Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden

Iwona Wlodarska¹, Jo-Anne van der Krogt^1*, Julio Finalet Ferreiro^1*, Jacobs Kris^1,2*, Geerdens Ellen^1,2*, Anne Uyttebroeck^3*, Peter Vandenberghe, MD PhD⁴, Thomas Tousseyn, MD PhD^5* and Jan Cools, PhD^1,2

¹Center for Human Genetics, KU Leuven, Leuven, Belgium
²Center for the Biology of Disease, VIB, Leuven, Belgium
³Department of Pediatrics, University Hospitals Leuven, Leuven, Belgium
⁴Center for Human Genetics, University Hospitals Leuven, Leuven, Belgium
⁵Translational Cell and Tissue Research, KU Leuven, Leuven, Belgium

Connie Batlevi, MD, PhD¹, Franck Rapaport, PhD^2*, Lu Wang, MD, PhD^3*, Andrew M. Intlekofer, MD, PhD¹, Amanda R. Copeland, RN, MSN, CNS^1*, Achim A Jungbluth, MD^3*, Anne Reiner, MPH^4*, Janine D. Pichardo, BS^3*, Meighan Gallagher, MA^5*, Nancy Bouvier, BS^6*, Nicholas D. Socci, PhD^2*, Frederick Criscuolo, PhD^7*, Nikolaus Schultz, PhD^4*, Maria Arcila, MD^3*, Michael Berger, PhD^3*, Andrew D Zelenetz, MD, PhD¹, Venkatraman E Seshan, PhD^4*, Ahmet Dogan, MD, PhD³ and Anas Younes, MD¹

¹Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY
²Department of Bioinformatics, Memorial Sloan Kettering Cancer Center, New York, NY
³Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY
⁴Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY
⁵Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY
⁶Sloan Kettering Institute, Collaborative Research Centers, Memorial Sloan Kettering Cancer Center, New York, NY
⁷Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY

Sanghoon Lee, PhD, MSc¹, Changhong Yin, MD, MS^1*, Janet Ayello, MS^1*, Erin Morris, RN^1*, Carmella van de Ven, MA^1* and Mitchell S. Cairo, MD^1,2,3,4,5

¹Pediatrics, New York Medical College, Valhalla, NY
²Cell Biology & Anatomy, New York Medical College, Valhalla, NY
³Microbiology & Immunology, New York Medical College, Valhalla, NY
⁴Pathology, New York Medical College, Valhalla, NY
⁵Medicine, New York Medical College, Valhalla, NY

Zheng Ge, MD, PhD^1,2, Evelyn Song, BS^2*, Jianyong Li, MD, PhD¹, Sinisa Dovat, MD, PhD^2* and Chunhua Song, PhD²

¹Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China
²Pennsylvania State University College of Medicine, Hershey, PA

Guillermo rodriguez-Hernandez^1*, Julia Hauer, MD^2*, Alberto Martín-Lorenzo^1*, Daniel Schaefer^2*, Christoph Bartenhagen^3*, Idoia Garcia-Ramirez^1*, Franziska Auer^2*, Ines Gonzalez-Herrero^1*, Lucia Ruiz-Roca^1*, Vera Okpanyi^4*, Ute Fischer, PhD^5*, Martin Dugas^6*, Sanil Bhatia^7*, Michael Gombert, PhD^7*, Pina Krell^7*, Cai Chen^7*, Marta Garcia Suquia^1*, Maria Rascon Trincado^1*, Angel Garcia Sanchez^1*, Oscar Blanco^8*, Maria garcia Cenador^1*, Francisco Garcia-criado^1*, Cesar Cobaleda^9*, Diego Alonso-Lopez^10*, Javier de Las Rivas^11*, Carolina vicente-Duenas^1*, Isidro Sanchez-Gracia^1* and Arndt Borkhardt, MD¹²

¹CSIC/ Universidad de Salamanca, Salamanca, Spain
²Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich-Heine University Dusseldorf, Düsseldorf, Germany
³Institute of Medical Informatics, University of Münster, Münster, Germany
⁴Clinic of Pediatric Oncology and Hematology, Duesseldorf, Germany
⁵Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Heinrich-Heine-University, Medical Faculty, Duesseldorf, Germany
⁶Institute of Medical Informatics, University of Munster, Munster, Germany
⁷Heinrich-Heine University Dusseldorf, Düsseldorf, Germany
⁸Pathology Department, University Hospital of Salamanca, Salamanca, Spain
⁹CSIC/Universidad Autónoma de Madrid, Madrid, Spain
¹⁰Cancer Research Center (CSIC-USAL), Salamanca, Spain
¹¹Cancer Research Center (CSIC-USAL),, Salamanca, Spain
¹²Heinrich-Heine-University, Medical Faculty, Department of Pediatric Oncology, Hematology and Clinical Immunology, Duesseldorf, Germany

Dina Stroopinsky, PhD^1*, Hasan Rajabi, PhD^2*, Maxwell Douglas Coll^1*, Athalia Rachel Pyzer, MD^1*, Jacalyn Rosenblatt, MD¹, Salvia Jain, MD³, Katarina Luptakova, MD¹, Malgorzata McMasters, MD^1*, James D. Levine, MD¹, Robin Joyce, MD⁴, Jon E. Arnason, MD¹, Rebecca Karp Leaf, MD¹, Myrna Rita Nahas, MD^1*, Kristen Anna Palmer^1*, Michal Bar-Natan, MD^1*, Ashujit Tagde, PhD, BPharm^2*, Abigail Washington^1*, Poorvi Somaiya^1*, Donald Kufe, MD^2* and David E. Avigan, MD¹

¹Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
²Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
³Malignant Hematology and Bone Marrow Transplantation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
⁴Division of Hematology and Oncology, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA

Christoph Rummelt^1*, Sivahari Prasad Gorantla, PhD^1*, Philip Keye^1*, Kathrin Klaesener^2*, Venkatesh Rao^1*, Christian Peschel, MD³, Michael Reth, Prof., PhD^2*, Justus Duyster, MD, PhD^4* and Nikolas von Bubnoff, Prof., PhD^1*

¹Department of Hematology, Oncology and Stem Cell Transplantation, University Medical Center Freiburg, Freiburg im Breisgau, Germany
²Department of Cellular and Molecular Immunology, Max Planck Institute of Immunbiology and Epigenetics, Freiburg, Germany
³III. Medizinische Klinik, Klinikum rechts der Isar, Technical University Munich, Munich, Germany
⁴Department of Hematology&Oncology+Comprehensive Cancer Center Freiburg (CCCF), University of Freiburg Medical Center, Freiburg, Germany

Megha Desai, PhD^1*, Kyung-Hee Chang, PhD^2*, E. David Muench, BS³, Anjelika Gasilina^1*, Ashley Wellendorf^3*, Xose R Bustelo^4*, H. Leighton Grimes, PhD⁵, Nicolas Nassar, PhD^3* and Jose A Cancelas, MD, PhD⁶

¹Cincinnati Children's Hospital Medical Center, Cincinnati
²University of Cincinnati, Cincinnati, OH
³Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁴Universidad de Salamanca - CSIC, Salamanca, Spain
⁵Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁶Stem Cell Program, Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

Tao Zhen, PhD^1*, Ling Zhao, MD, PhD^1*, R. Katherine Hyde, PhD², Lemlem Alemu^1* and Pu Paul Liu, MD, PhD¹

¹Oncogenesis and Development Section/NHGRI, National Institutes of Health, Bethesda, MD
²University of Nebraska Medical Center, Omaha, NE

Liqi Li, PhD^1*, Justin H. Layer, PhD^2*, Claude Warzecha, PhD^3*, Rati Tripathi, PhD^2*, Paul Love, MD, PhD^3* and Utpal P. Dave, MD^4,5

¹Section of Cellular and Developmental Biology, NIH/NICHD, Bethesda
²Division of Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN
³Section of Cellular and Developmental Biology, NIH/NICHD, Bethesda, MD
⁴Nashville VA, Tennessee Valley Healthcare System, Nashville, TN
⁵Medicine and Cancer Biology, Vanderbilt University Medical Center, Nashville, TN

Tiffany M Tran^1*, Jayanth Kumar Palanichamy, MD, MBBS^2*, Jonathan Howard^3*, Jorge R. Contreras, BS^1*, Thilini Fernando^1*, Giuseppe Basso, Prof, MD⁴, Martina Pigazzi, PhD^4*, Jeremy R Sanford^3* and Dinesh S. Rao, MD, PhD¹

¹UCLA, Los Angeles, CA
²Pathology and Laboratory Medicine, UCLA, Los Angeles, CA
³UCSC, Santa Cruz, CA
⁴Woman and Child Health Department, University of Padova, Padova, Italy

Andrew Dunford^1*, Stephen E Schumacher, PhD^1*, Virginia Savova, PhD^2*, Alexander A Gimelbrant, PhD^2*, Rameen Beroukhim, MD, PhD^2*, Michael S Lawrence, PhD^1*, Gad Getz, PhD^1*, David M Weinstock, MD² and Andrew A Lane, MD, PhD³

¹Broad Institute, Cambridge, MA
²Dana-Farber Cancer Institute, Boston, MA
³Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA

Ling Zhao, MD, PhD^1*, Lemlem Alemu^1*, Jun Cheng^2*, Tao Zhen, PhD^1*, Alan D. Friedman, M.D.³ and Pu Paul Liu, MD, PhD¹

¹Oncogenesis and Development Section/NHGRI, National Institutes of Health, Bethesda, MD
²Transgenic Mouse Core/NHGRI, National Institutes of Health, Bethesda, MD
³Division of Pediatric Oncology, Johns Hopkins University School of Medicine, Baltimore, MD

Rui Su, PhD¹, Zejuan Li, MD, PhD^2,3, Ping Chen², Yuanyuan Li^4*, Hu Chao^4*, Yungui Wang, PhD^1,2*, Stephen Arnovitz^2*, Miao He^4*, Sandeep Gurbuxani, MBBS, PhD⁵, Zhixiang Zuo^6*, Abdel G. Elkahloun^7*, Shenglai Li^4*, Hengyou Weng, PhD^1,2, Hao Huang^4*, Mary Beth Neilly^2*, Shusheng Wang^8*, Richard A. Larson, MD⁴, Jiwang Zhang^9*, Xi Jiang, PhD^1,2, Minjie Wei^10*, Jie Jin, MD, PhD¹¹, Paul P. Liu^12* and Jianjun Chen, PhD^1,2

¹Department of Cancer Biology, University of Cincinnati, Cincinnati, OH
²Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL
³University of Chicago Medical Center, Chicago, IL
⁴Department of Medicine, University of Chicago, Chicago
⁵Department of Pathology, University of Chicago, Chicago, IL
⁶University of Cincinnati, Cincinnati, OH
⁷Genetics and Molecular Biology Branch, National Human Genome Research Institute, Bethesda
⁸Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas
⁹Oncology Institute, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood
¹⁰Department of Pharmacology, China Medical University, Shenyang, China
¹¹Department of Hematology & Institute of Hematology, The First Affiliated Hospital, Zhejiang University, Hangzhou, China
¹²Translational and Functional Genomics Branch and Microarray Core, National Human Genome Research Institute, NIH, Bethesda

Min Wu, PhD^1*, Li Li, PhD², Max Hamaker, BA^3*, Donald Small, MD, PhD⁴ and Amy S. Duffield, MD, PhD¹

¹Pathology, Johns Hopkins University School of Medicine, Baltimore, MD
²Oncology, Johns Hopkins University School of Medicine, Baltimore, MD
³University of Maryland Schoold of Medicine, Baltimore, MD
⁴Oncology and Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD

Shuyun Rao, Ph.D.^1*, Kathy Cai^2*, Jason Stadanlick^2*, Sang-Yun Lee^2*, Noa Greenberg-Kushnir^2* and Nehal Solanki-Patel^2*

¹Fox Chase Cancer Center, Temple Univeristy, Philadelphia, PA
²Fox Chase Cancer Center, Philadelphia, PA

Kevin M Watanabe-Smith, BS^1*, Cristina E. Tognon, PhD^2,3*, Jeffrey W. Tyner, PhD⁴, Brian J. Druker, MD^3,5 and Anupriya Agarwal, PhD⁵

¹Oregon Health and Science University, Portland, OR
²Knight Cancer Institute, Oregon Health and Science University, Portland, OR
³Howard Hughes Medical Institute, Portland, OR
⁴Knight Cancer Institute, Oregon Health & Science University, Portland, OR
⁵Knight Cancer Institute, Division of Hematology and Medical Oncology, Oregon Health & Science University, Portland, OR

Romain Duval^1*, Linh-Chi Bui, PhD^1*, Cécile Mathieu^2*, Emile Petit^1*, Jean-Marie Dupret, PhD^1*, Jan Cools, PhD³, Fabien Guidez, PhD^4*, Christine Chomienne, MD, PhD⁵ and Fernando Rodrigues-Lima, PhD^1*

¹Université Paris Diderot, Sorbonne Paris Cité, CNRS UMR 8251, Paris, France
²aUniversité Paris Diderot, Sorbonne Paris Cité, CNRS UMR 8251, Paris, France
³VIB Center for the Biology of Disease, Leuven, Belgium
⁴Université Paris Diderot, Sorbonne Paris Cité, INSERM UMR_S1131, Institut Universitaire d'Hématologie, Paris, France
⁵Service de Biologie Cellulaire, Assistance Publique des Hôpitaux de Paris (AP-HP), Hôpital Saint Louis, Université Paris Diderot, Sorbonne Paris Cité, INSERM UMR_S1131, Institut Universitaire d'Hématologie, Paris, France

Kenneth Lieuw, MD, PhD¹, Jayasree Krishnamurthy, MS^1* and Mignon L. Loh, MD²

¹Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD
²Department of Pediatrics, Benioff Children’s Hospital, University of California at San Francisco, San Francisco, CA

Chiara Pighi^1*, Mara Compagno^1*, Qi Wang^1*, Taek-Chin Cheong^1*, Teresa Poggio^2*, Fernanda Langellotto^1*, Paola Francia di Celle^3*, Alberto Zamò^4* and Roberto Chiarle^1,2

¹Department of Pathology, Boston Children's Hospital, Boston, MA
²Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy
³Azienda Ospedaliera Città della Salute, Turin, Italy
⁴Department of Pathology, University of Verona, Verona, Italy

Alexandre Puissant, PhD^1*, Nina Fenouille, PhD^2*, Christopher F. Bassil, BA^3*, Issam Ben-Sahra, PhD^4*, Gabriela Alexe, PhD^3*, Lina Benajiba^3*, Azucena Ramos^5*, Yana Pikman, MD⁶, Michael R. Burgess, MD, PhD⁷, Ilene Galinsky, ANP⁸, Daniel J. DeAngelo, MD, PhD⁸, Richard M. Stone, MD⁸, Kevin Shannon, MD^9*, Michael T. Hemann, PhD^2* and Kimberly Stegmaier, MD⁶

¹Department of Pediatric Oncology, Dana-Farber Cancer Instituté, Boston, MA
²Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, Massachusetts Institute of Technology, Cambridge, MA
³Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA
⁴Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA
⁵Koch Institute for Integrative Cancer Research, Cambridge, MA
⁶Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA
⁷Medicine, University of California, San Francisco, San Francisco, CA
⁸Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
⁹Dept. of Pediatrics and the Comprehensive Cancer Center, UCSF, San Francisco, CA

Manabu Kusakabe, MD, PhD¹, Claire Shanna^1*, Xuehai Wang, PhD^1*, Catherine Jenkins^2*, Vincenzo Giambra, PhD^1* and Andrew P Weng, MD, PhD¹

¹Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada
²Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, Canada