Laura M Kettyle, BSc^1*, Ivan Grishagin, PhD^1*, Glenda J Dickson, PhD^2*, Charles-Etienne Lebert-Ghali, PhD^3*, Janetta Jacoba Bijl, PhD^3*, Mary Frances McMullin, MD, FRCPath, FRCP⁴, Terence R.J. Lappin, PhD, FRCPath⁵, Ken I Mills, Ph.D., FRCPath¹ and Alexander Thompson, PhD¹

¹Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, United Kingdom
²Rayne Institute/Department of Haemato-Oncology, King's College London, London, United Kingdom
³HMR Research Center, Université de Montréal, Montréal, QC, Canada
⁴Queen's University Belfast, Belfast, United Kingdom
⁵Haematology, Queen's University Belfast, Belfast, United Kingdom

Yoko Tabe, MD, PhD^1,2, Marina Konopleva, MD, PhD³, Norikazu Monma, PhD^4*, Kazuho Ikeo, PhD^4*, Kaoru Mogushi, PhD^5*, Yasunari Yamanaka, MD, PhD^6*, Hiromichi Matsushita, MD, PhD⁷, Takashi Miida, MD.PhD^8*, Yoshihide Hayashizaki, MD, PhD^6* and Michael Andreeff, MD, PhD⁹

¹Section of Molecular Hematology & Therapy, Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston
²Department of Clinical Laboratory Medicine, Juntendo Univerisity School of Medicine, Tokyo, Japan
³Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Center for Information Biology, National Institute of Genetics, Sizuoka, Japan
⁵Center for Genomic and Regenerative Medicine, , Juntendo University Graduate School of Medicine, Tokyo, Japan
⁶Preventive Medicine & Diagnosis Innovation Program, RIKEN, kanagawa, Japan
⁷Department of Laboratory Medicine, Tokai University School of Medicine, Kanagawa, Japan
⁸Department of Clinical Laboratory Medicine, Juntendo University School of Medicine, Tokyo, Japan
⁹Section of Molecular Hematology and Therapy, Leukemia Department, UT MD Anderson Cancer Center, Houston, TX

Hengyou Weng, PhD^1,2, Huilin Huang, PhD², He Huang, PhD^3*, Okwang Kwon^3*, Ping Chen¹, Xi Jiang, PhD^1,2, Chao Hu^1,2,4*, Hao Huang, PhD¹, Yungui Wang, PhD^1,2,4*, Xi Qin^5*, Stephen Arnovitz^1*, Shenglai Li^1*, Jennifer Strong^2*, Rui Su, PhD², Mary Beth Neilly^1*, Zejuan Li, MD, PhD¹, Yingming Zhao^3* and Jianjun Chen, PhD^1,2

¹Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL
²Department of Cancer Biology, University of Cincinnati, Cincinnati, OH
³Ben May Department for Cancer Research, University of Chicago, Chicago
⁴Department of Hematology, The First Affiliated Hospital Zhejiang University, Hangzhou, China
⁵University of Cincinnati, Cincinnati

Hiroto Ohguchi, MD, PhD^1*, Teru Hideshima, MD, PhD¹, Manoj Bhasin, PhD^2*, Gullu Gorgun, PhD¹, Loredana Santo, MD^3*, Michele Cea, MD^1*, Naoya Mimura, MD, PhD¹, Rikio Suzuki, MD, PhD¹, Yu-Tzu Tai, PhD⁴, Ruben D. Carrasco, MD, PhD⁵, Noopur S. Raje, MD³, Paul G. Richardson, MD¹, Hideo Harigae, MD, PhD⁶, Takaomi Sanda, MD, PhD⁷ and Kenneth C. Anderson, MD⁸

¹Dana-Farber Cancer Institute, Boston, MA
²BIDMC Genomics, Proteomics, Bioinformatics and Systems Biology Center, Boston, MA
³Massachusetts General Hospital Cancer Center, Boston, MA
⁴Harvard Medical School, the Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Boston, MA
⁵Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA
⁶Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan
⁷Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore
⁸Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA

Yawei Zheng^1*, Hongyan Zhang^1*, Yajie Wang^1*, Fang Dong, PhD^1*, Sha Hao, Ph.D.^1*, Xiaobing Zhang, PhD^1,2,3* and Tao Cheng, MD^1,3,4

¹State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Tianjin, China
²Department of Medicine, Loma Linda University, Loma Linda, CA
³Department of Stem Cell and Regenerative Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
⁴Center for Stem Cell Medicine, Tianjin, China

Anjali Mishra, Ph.D.¹, Sonya Kwiatkowski^2*, Laura Sullivan^2*, Leah Grinshpun^2*, Giandomenico Russo, MD, PhD³, Pierluigi Porcu, MD^4,5 and Michael A. Caligiuri, MD⁶

¹The Ohio State University Comprehensive Cancer Center, Columbus, OH
²The Ohio State University Comprehensive Cancer Center, Columbus
³Istituto - Dermopatico Dell 'Immacolata, Rome, Italy
⁴The Ohio State University Wexner Medical Center, Columbus, OH
⁵Division of Hematology, The Ohio State University, Columbus, OH
⁶Comprehensive Cancer Center, The Ohio State University, Columbus, OH

Sarah Lynn Ondrejka, DO¹, Elaine S Jaffe, MD², Shunyou Gong^3*, Deepthi Rajagopalan^4*, Cassandra Love^4* and Sandeep Dave, MD⁵

¹Cleveland Clinic, Cleveland, OH
²Laboratory of Pathology, National Cancer Institute, Bethesda, MD
³Northwestern University, Chicago, IL
⁴Duke University, Durham, NC
⁵Duke Cancer Institute, Duke University Medical Center, Durham, NC

Vincenzo Giambra, PhD^1*, Sonya H Lam^2*, Miriam Belmonte^2*, Sam Gusscott^3*, Sohrab Salehi^2*, Fong Chun Chan^4*, Robert Kridel, MD, MPH⁵, Alireza Lorzadeh^6*, Catherine Hoofd, PhD^2*, Christian Steidl, MD⁵, Connie J. Eaves, PhD¹, Martin Hirst, PhD^6* and Andrew P. Weng, MD, PhD⁷

¹Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada
²Terry Fox Laboratory, BC Cancer Agency, Vancouver, Canada
³Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC, Canada
⁴Centre for Lymphoid Cancer, BC Cancer Agency, Vancouver, Canada
⁵Centre for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver, BC, Canada
⁶Dept of Microbiology and Immunology, University of British Columbia, Vancouver, Canada
⁷Terry Fox Laboratory/Dept of Pathology, BC Cancer Agency, Vancouver, BC, Canada

Xianhuo Wang, M.D.^1,2*, Huaqing Wang^1*, Chengfeng Bi^2*, Xiaoyan Zhang^2,3*, Xin Huang^2*, Xuan Zhang^2*, Javeed Iqbal^2*, George W Wright^4*, Louis M Staudt^5*, Wing C Chan^6*, Timothy W McKeithan^6*, Ping Wang^1*, Huilai Zhang^1* and Kai Fu, MD, PhD^1,2

¹Department of Lymphoma, Sino-US Center for Lymphoma and Leukemia, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
²Department of Pathology and Microbiology and Internal Medicine, University of Nebraska Medical Center, Omaha, NE
³Department of Pediatrics, State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
⁴Biometric Research Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD
⁵Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD
⁶Department of Pathology, City of Hope National Medical Center, Duarte, CA

Tzung-Huei Lai, PhD¹, Alma Zecevic^2*, Brett Ewald, PhD^2*, Liu Chaomei^2*, Lara Rizzotto, PhD³, Melanie Sulda^2*, Dimitrios Papaioannou, MD^4*, Ramiro Garzon, MD⁵, William Plunkett, PhD² and Deepa Sampath, PhD⁶

¹The Ohio State University, Columbus, OH
²Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Internal Medicine, Division of Hematology, The Ohio State University Comprehensive Cancer Center, Columbus, OH
⁴Division of Hematology, Comprehensive Cancer center, The Ohio State university, Columbus
⁵Comprehensive Cancer Center, The Ohio State University, Columbus, OH
⁶Department of Internal Medicine, Division of Hematology, The Ohio State University, Columbus, OH

Ryo Shimizu, MD^1*, Tomoya Muto, MD, PhD^1*, Masahiro Takeuchi, MD, PhD¹, Shuhei Koide^2*, Yuhei Nagao, MD^1*, Chika Kawajiri, MD^1*, Emi Togasaki, MD^1*, Nagisa Hasegawa, MD^1*, Shio Sakai, M.D., PhD.^1,3*, Yusuke Takeda, MD, PhD^1*, Naoya Mimura, MD, PhD^1,3, Chikako Ohwada, MD, PhD.¹, Emiko Sakaida, MD, PhD^1*, Tohru Iseki, MD, PhD^1,3*, Koutaro Yokote, MD, PhD^4*, Atsushi Iwama, MD, PhD² and Chiaki Nakaseko, MD, PhD¹

¹Department of Hematology, Chiba University Hospital, Chiba, Japan
²Department of Cellular and Molecular Medicine, Chiba University Graduate School of Medicine, Chiba, Japan
³Department of Transfusion Medicine and Cell Therapy, Chiba University Hospital, Chiba, Japan
⁴Department of Clinical Cell Biology and Medicine, Graduate School of Medicine, Chiba University, Chhiba, Japan

Maya D. Hughes, MD^1,2*, Valerie A. Morris, PhD^2*, Carrie Cummings^2*, Soheil Meshinchi, MD, PhD^2,3,4 and Vivian G. Oehler, MD^2,5

¹Seattle Children's Hospital, Seattle, WA
²Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
³Department of Pediatrics, University of Washington, Seattle
⁴Children's Oncology Group, Monrovia, CA
⁵Division of Hematology, University of Washington, Seattle, WA

Eva Gentner, BSc, MSc^1,2*, Naidu Vegi, Dr.^1*, Medhanie A. Mulaw, Jun. Prof. Dr.^1*, Leticia Quintanilla-Fend, Prof. Dr.^3*, Hartmut Döhner, Prof. Dr.⁴, Konstanze Döhner, MD⁴, Christian Buske¹, Vijay P.S. Rawat, Jun. Prof. Dr.^1* and Michaela Feuring-Buske, PD Dr.^4*

¹Institute of Experimental Cancer Research, University Hospital of Ulm, Ulm, Germany
²International Graduate School in Molecular Medicine Ulm, Ulm University, Ulm, Germany
³Eberhard Karls University, Institute of Pathology, Tuebingen, Germany
⁴Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany

Qingxiao Chen, M.Med^1*, Jingsong He, PhD^1*, Xing Guo, M.Med^1*, Jing Chen, M.Med^1*, Li Yang, PhD^1*, Xuanru Lin, M.Med^1*, Yi Li, PhD^1*, Enfan Zhang, M.Med^1*, Yang Yang, PhD^1*, Wenjun Wu, MD^1*, Donghua He, PhD^1*, He Huang, MD, PhD¹, Shizhou Liu, MD, PhD^2* and Zhen Cai, MD, PhD^1*

¹Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University, School of Medicine., Hangzhou, China
²Institute of Translational Medicine
 ,Zhejiang University, Hangzhou, China

Shohei Yamamoto, MD, PhD^1*, Hui Shi, MD, PhD^2,3*, Shi Chen, MD, PhD^3*, Peng Zhang, PhD^3*, Yuan Zhou, PhD^2*, Mingjiang Xu, MD, PhD³ and Feng-Chun Yang, MD, PhD³

¹Showa University Fujigaoka Hospital, Yokohama, Japan
²State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Center for Stem Cell Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
³Department of Biochemistry and Molecular Biology & Sylvester Comprehensive Cancer Center, University of Miami Leonard M. Miller School of Medicine, Miami, FL

Alessandra Trojani, PhD^1*, Ester Pungolino, MD^2*, Milena Lodola^3*, Barbara Di Camillo^4*, Mariella D'Adda, MD^5*, Alessandra Perego, MD^6*, Mauro Turrini, MD^7*, Chiara Elena, MD^8*, Alessandra Iurlo, MD, PhD^9*, Cristina Buccelli^9*, Simona Malato, MD^10*, Francesco Spina, MD^11*, Maria Luisa Latargia^12*, Francesco Lanza^13*, Sergio Pauli, MD^14*, Michela Anghilieri, MD^15*, Maria Cristina Carraro^16*, Enrica Morra, MD¹⁷ and Roberto Cairoli, MD^17*

¹Division of Hematology, Niguarda Cà Granda Hospital, Milan, Italy
²Niguarda Cà Granda Hospital, Milan, Italy
³Division of Hematology, Niguarda Hospital, Milano, Italy
⁴Department of Information Engineering, University of Padova, Padova, Italy
⁵Division of Hematology, A.O. Spedali Civili of Brescia, Brescia, Italy
⁶Internal medicine-Haematology, Desio Hospital, Desio, Italy
⁷Division of Hematology, Valduce Hospital, Como, Italy
⁸Dept Oncology-Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
⁹Division of Hematology, IRCCS Maggiore Policlinico Hospital Foundation, Milano, Italy
¹⁰Hematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, Milano, Italy
¹¹Division of Hematology, IRCCS Istituto Nazionale dei Tumori, University of Milano, Milano, Italy
¹²Ospedale di Circolo, Busto Arsizio, Italy
¹³Division of Hematology, Hospital of Cremona, Cremona, Italy
¹⁴Azienda Ospedaliera Sant'Antonio Abate, Gallarate, Italy
¹⁵Manzoni Hospital, Lecco, Italy
¹⁶Hematology & Transfusion Medicine, Sacco University Hospital & School of Medicine, Milano, Italy
¹⁷Division of Hematology, Niguarda Ca' Granda Hospital, Milan, Italy

Saara Laukkanen^1*, Thomas Liuksiala^2*, Matti Nykter^2,3*, Merja Heinäniemi^4* and Olli Lohi¹

¹Tampere Center for Child Health Research, University of Tampere and Tampere University Hospital, Tampere, Finland
²Institute of Biosciences and Medical Technology, University of Tampere, Tampere, Finland
³Department of Signal Processing, Tampere University of Technology, Tampere, Finland
⁴A.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland

Guopan Yu^1*, Ling Jiang^2*, Changxin Yin^1*, Zhixiang Wang^1*, Hongsheng Zhou^1*, Xuejie Jiang^3*, Qifa Liu, MD⁴ and Fanyi Meng¹

¹Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China
²hematology department, Nanfang Hospital, Guangzhou, China
³Nanfang hospital, Guangzhou, China
⁴Department of Hematology, NanFang Hospital, Southern Medical University, Guangzhou, China

Marilynn Chow, MS, BS¹, Jason D. MacManiman^1*, Vincent T. Bicocca, PhD^1*, Lina Gao, PhD^1*, Joshi A. Alumkal, MD^1*, Bill H. Chang, MD, PhD² and Jeffrey W. Tyner, PhD³

¹Oregon Health and Science University, Portland, OR
²Oregon Health & Science University Knight Cancer Institute, Portland, OR
³Knight Cancer Institute, Department of Cell, Developmental & Cancer Biology, Oregon Health and Science University, Portland, OR

Wayne A. Warner, BS, David Spencer, MD/PhD, Maria Trissal, BS^*, Nichole Helton, BS^*, Timothy J. Ley, MD and Daniel C. Link, MD

Division of Oncology, Department of Internal Medicine, Washington University in St. Louis School of Medicine, St. Louis, MO