57th ASH Annual Meeting and Exposition (December 5-8, 2015): 602. Disordered Gene Expression in Hematologic Malignancy, including Disordered Epigenetic Regulation: Poster II

Disordered Gene Expression in Hematologic Malignancy, including Disordered Epigenetic Regulation Oral and Poster Abstracts
Poster

Hall A, Level 2 (Orange County Convention Center)

2423

Constitutive Expression of MEF2C, LYL1, or LMO2 in CD34⁺ HSCs Blocks the in Vitro Differentiation before the T-Cell Commitment Point and Could be Oncogenic in Early T-Cell Progenitor ALL

Kirsten Canté-Barrett, PhD¹, Rui D Mendes¹^*, Wilco K Smits¹^*, Rob Pieters, MD, PhD^1,2 and Jules PP Meijerink, PhD¹

¹Department of Pediatric Oncology/Hematology, Erasmus MC - Sophia Children's Hospital, Rotterdam, Netherlands
²Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands

2424

Functional and Molecular Consequences of the Dnmt3aR882H Mutation in Acute Myeloid Leukaemia

Malgorzata Gozdecka, PhD¹^*, Milena M. Mazan, PhD¹^*, Vivek Iyer¹^*, Anna Farne¹^*, Eshwar Meduri²^*, Ruben Bautista¹^*, Nicolas Walker³^*, Anne C Ferguson-Smith, PhD³^*, George S. Vassiliou, MD, PhD¹^* and Brian J.P Huntly, MD, PhD⁴^*

¹Wellcome Trust Sanger Institute, Cambridge, United Kingdom
²Cambridge Institute for Medical Research, Cambridge, United Kingdom
³Department of Genetics, University of Cambridge, Cambridge, United Kingdom
⁴Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom

2425

Regulation of CD19 Exon 2 Inclusion in B-Lymphoid Cells By Splicing Factors and Epigenetic Marks

Kathryn Black, PhD¹^*, Elena Sotillo, PhD¹^*, Nicole Martinez²^*, Matthew Gazzara²^*, Alejandro Barrera³^*, Yoseph Barash, PhD³^*, Kristen Lynch, PhD²^* and Andrei Thomas-Tikhonenko, PhD⁴

¹Cancer Pathobiology, The Children's Hospital of Philadelphia, Philadelphia, PA
²Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA
³Genetics, University of Pennsylvania, Philadelphia, PA
⁴Division of Cancer Pathobiology, Children's Hospital of Philadelphia, Philadelphia, PA

2426

Son and Its Alternatively Spliced Isoforms Control MLL Complex-Mediated H3K4me3 and Transcription of Leukemia-Associated Genes

Jung-Hyun Kim, Ph.D.^*, Thomas W. Butler, MD and Eun-Young Erin Ahn, PhD

Mitchell Cancer Institute, University of South Alabama, Mobile, AL

2427

Transcriptome Sequencing Reveals Thousands of Novel Long Non-Coding RNAs in B-Cell Lymphoma

Akanksha Verma¹^*, Yanwen Jiang, PhD^1,2^*, Lauren Fairchild¹^*, Wei Du, BS¹^*, Ari M. Melnick, MD³ and Olivier Elemento⁴^*

¹Institute for Computational Biomedicine, Weill Cornell Medical College, New York, NY
²Department of Medicine, Weill Cornell Medical College, New York, NY
³Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medical College, New York, NY
⁴Department of Physiology and Biophysics, Weill Cornell Medical College, New York, NY

2428

Meningeoma-1 Cooperates with MLL and DOT1L to Induce Leukemia

Simone Riedel, Ph.D.¹^*, Jessica Haladyna, BA²^*, Brett Stevens³^*, Craig T Jordan, PhD⁴, Daniel Pollyea, MD, MS⁴, Scott A. Armstrong, MD, PhD⁵, Qi Wei, PhD⁶^*, Patricia Ernst, PhD⁷, Tobias Neff, MD¹ and Kathrin M Bernt, MD⁸

¹Center for Cancer and Blood Disorders, Children's Hospital Colorado, Aurora, CO
²Department of Pediatrics, Hematology/Oncology/BMT, University of Colorado Denver, Aurora, CO
³University of Colorado, Aurora, CO
⁴Division of Hematology, University of Colorado School of Medicine, Aurora, CO
⁵Memorial Sloan-Kettering Cancer Center, New York, NY
⁶UC Denver, Aurora, CO
⁷Anschutz Medical Campus-Pediatrics, University of Colorado, Denver, Aurora, CO
⁸Pediatrics, University of Colorado Denver, Aurora, CO

2429

Next-Generation Bisulfite Sequencing of Aml Reveals Widespread Acquisition of Epigenetic Abnormalities in Leukemic Stem Cells That Are Stably Retained in More Mature Leukemic Cell Fractions

Lauren Suarez¹^*, Tingting Qin, PhD²^*, Kristen Meldi, PhD²^*, Manjusha Thakar¹^*, Sarah Sakoian³^*, Jonathan M. Gerber, MD⁴, Gabriel Ghiaur, MD, PhD¹, Hetty E. Carraway, MD, MBA⁵, Maria E Figueroa, MD⁶ and Steven D. Gore, MD⁷

¹Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD
²Department of Pathology, University of Michigan Medical School, Ann Arbor, MI
³Johns Hopkins University School of Medicine, Baltimore, MD
⁴Department of Hematologic Oncology and Blood Disorders, The Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC
⁵Leukemia Program, Cleveland Clinic, Cleveland, OH
⁶Pathology, University of Michigan, Ann Arbor, MI
⁷Yale University School of Medicine, New Haven, CT

2430

Epigenetic Reprogramming of Cis-Regulatory Sites By R882-Mutated DNMT3A Potentiates Aberrant Stem Cell Gene Program and Acute Leukemia Development

Rui Lu, PHD¹^*, Ping Wang, PHD²^*, Trevor Parton¹^*, Deyou Zheng, PHD²^* and Gang Greg Wang, PhD¹

¹Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
²Departments of Genetics and Neuroscience, Albert Einstein College of Medicine, Bronx, NY

2431

Identification of a Meta-Gene Network Associated with Metformin Sensitivity and Clinical Outcomes in Double Hit and Double Expressor Lymphomas

Reem Karmali, MD, MS¹, Annesha Basu²^*, Jeffrey A Borgia³^*, Leo I. Gordon, MD⁴, Parameswaran Venugopal, MD¹ and Casey A Frankenberger³^*

¹Division of Hematology, Oncology and Cell Therapy, Rush University Medical Center, Chicago, IL
²Rush University Medical Center, Chicago, IL
³Departments of Pathology and Biochemistry, Rush University Medical Center, Chicago, IL
⁴Department of Medicine, Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL

2432

Combination Treatment of AML Cells with Dnmt and HDAC Inhibitors: Synergistic Target Gene Downregulation Associated with Gene Body Demethylation

Nadja Blagitko-Dorfs¹^*, Pascal Schlosser²^*, Dietmar Pfeifer¹^* and Michael Lübbert¹

¹Department of Hematology, Oncology and Stem Cell Transplantation, University Medical Center Freiburg, Freiburg, Germany
²Institute for Medical Biometry and Statistics, University Medical Center Freiburg, Freiburg Im Breisgau, Germany

2433

Loss of BCOR Protein in Development of Acute Myeloid Leukaemia

Milena M. Mazan, PhD¹^*, Malgorzata Gozdecka, PhD¹^*, Emmanouil Metzakopian, PhD¹^*, Konstantinos Tzelepis, MSc¹^*, Brian J.P Huntly, MD, PhD^2,3,4^* and George S. Vassiliou, MD, PhD¹^*

¹Wellcome Trust Sanger Institute, Cambridge, United Kingdom
²Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
³Cambridge Institute for Medical Research, Cambridge, United Kingdom
⁴Haematology, University of Cambridge, Cambridge, United Kingdom

2434

Methylation of DNMT3B Strongly Associates with the Methylome, Cytogenetic Risk Groups, and Prognosis of Pediatric Acute Myeloid Leukemia

Jatinder K Lamba, Ph.D¹, Stanley Pounds²^*, Xueyuan Cao²^*, Susana C. Raimondi, PhD³, James R. Downing, MD³, Raul C Ribeiro⁴ and Jeffrey Rubnitz⁴

¹Department of Pharmacotherapy and Translational Research College of Pharmacy, University of Florida, Gainesville
²Biostatistics, St Jude Children's Research Hospital, Memphis, TN
³Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN
⁴Hematology-Oncology, St. Jude Children's Research Hospital, Memphis, TN

2435

The Molecular Mechanism of Transcriptional Activation By MLL-AEP Fusion Proteins

Akihiko Yokoyama, PhD and Hiroshi Okuda, Ph.D.^*

Kyoto University Graduate School of Medicine, Kyoto, Japan

2436

Progressive Epigenetic Programming during B Cell Maturation Is Reflected in a Continuum of Epigenetic Disease Phenotypes in Chronic Lymphocytic Leukemia

Christopher C. Oakes, PhD^1,2^*, Marc Seifert³^*, Yassen Assenov⁴^*, Lei Gu⁵^*, Martina Przekopowitz³^*, Amy S. Ruppert, MAS⁶^*, Qi Wang⁴^*, Charles Imbusch⁴^*, Andrius Serva⁴^*, Sandra Koser⁴^*, David Brocks⁴^*, Daniel B Lipka⁷^*, Olga Bogatyrova⁴^*, Benedikt Brors⁴^*, Dieter Weichenhan⁴^*, Laura Z. Rassenti, PhD⁸, Thomas J. Kipps, MD, PhD⁹, Daniel Mertens, PhD¹⁰^*, Marc Zapatka⁴^*, Peter Lichter⁴^*, Hartmut Döhner, MD¹¹, Ralf Kueppers³^*, Thorsten Zenz¹²^*, Stephan Stilgenbauer, MD¹³, John C Byrd, MD¹⁴ and Christoph Plass, PhD²^*

¹The Ohio State University, Columbus, OH
²Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany
³The University of Duisburg-Essen, Essen, Germany
⁴The German Cancer Research Center (DKFZ), Heidelberg, Germany
⁵Harvard University, Boston
⁶Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH
⁷Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center, Heidelberg, Germany
⁸Moores UCSD Cancer Center, CLL Research Consortium, La Jolla, CA
⁹University of California, San Diego, La Jolla, CA
¹⁰Department of Internal Medicine III, University of Ulm, Ulm, Germany
¹¹Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany
¹²NCT/ German Cancer Research Center, Heidelberg, Germany
¹³Department of Internal Medicine III, University Hospital, Ulm, Germany
¹⁴Division of Hematology, Department of Medicine, The Ohio State University, Columbus, OH

2437

Epigenetic Upregulation of the O-Linked Beta-N-Acetylglucosamine Transferase (OGT) in Response to Dronabinol Results in Antileukemic Efficacy In Vivo

Kerstin Maria Kampa-Schittenhelm, MD¹^*, Hans-Joerg Buehring²^*, Michael Bonin²^*, Wichard Vogel, MD³^*, Lothar Kanz, Prof. Dr. med.⁴, Thomas Haverkamp⁵^* and Marcus M Schittenhelm, MD⁶

¹Department of Oncology, Hematology, Rheumatology, Immunology and Pulmology, University of Tuebingen, Tuebingen, Germany
²University of Tuebingen, Tuebingen, Germany
³Department of Hematology and Oncology, University of Tuebingen, Tuebingen, Germany
⁴Department of Oncology, Hematology, Immunology, Rheumatology and Pulmonology, University Hospital Tuebingen, Tuebingen, Germany
⁵MVZ, Dortmund, Germany
⁶Dept. of Oncology, Hematology, Rheumatology, Immunology and Pulmology, University of Tuebingen, Tuebingen, Germany

2438

Next Generation Sequencing and Functional Analysis of Mirna Expression in Acute Myeloid Leukemia Patients with Different FLT3 Mutations: Block of MiR-155 in FLT3-ITD Driven AML Leads to Downregulation of Myeloid Blasts in Vivo

Dennis Gerloff¹^*, Alexander Arthur Wurm¹^*, Jens-Uwe Hartmann¹^*, Nadja Hilger²^*, Anne-Marie Müller²^*, Christiane Katzerke, PhD¹^*, Daniela Bräuer-Hartmann¹^*, Carolina Yaeko Namasu, MSc¹^*, Michael Cross, PhD¹^*, Sebastian Schwind, MD¹, Knut Krohn, PhD³^*, Stephan Fricke, MD²^*, Dietger Niederwieser, MD⁴ and Gerhard Behre, MD⁵^*

¹Division of Hematology and Clinical Oncology, University Hospital Leipzig, Leipzig, Germany
²Fraunhofer Institute for Cell Therapy and Immunology (IZI), Leipzig, Germany
³Interdisciplinary Center for Clinical Research (IZKF), University Hospital Leipzig, Leipzig, Germany
⁴University Hospital of Leipzig, Leipzig, Germany
⁵Hematology and Oncology, University of Leipzig, Leipzig, Germany

2439

CDKN2 Gene Deletion Impair Prognosis in Adult Ph+ Acute Lymphoblastic Leukemia Even in Tyrosine Kinase Inhibitors Era

Na Xu, MD¹^*, Yuling Li¹^*, Xuan Zhou, MD¹^*, Hongqian Zhu, MD²^*, Lin Li¹^*, Qisi Lu¹^*, Rui Cao¹^*, Huan Li¹^*, Qifa Liu, MD¹ and Liu Xiaoli, MD¹

¹Department of Hematology, NanFang Hospital, Southern Medical University, Guangzhou, China
²Department of Hematology, The People's Hospital of Guizhou Province, Guiyang, China

2440

Down-Regulation of Mir-26b and Its Inhibition on the Growth of T Cell Acute Lymphoblastic Leukemia

Tian Yuan, PhD^1,2^*, Yaling Yang, PhD¹^*, Jeffrey You^3,4^*, Daniel Lin, BS^1,5^*, Kefeng Lin^1,6^*, Yizhuo Zhang, MD²^* and M. James You, MD, PhD¹

¹Department of Hematopathology, UT MD Anderson Cancer Center, Houston, TX
²Department of Hematology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
³Department of Molecular and Cellular Oncology, UT MD Anderson Cancer Center, Houston, TX
⁴Texas A & M University, College Station, TX
⁵Washtington University at St. Louis, St. Louis, MO
⁶Chongqing Medical University, Chongqing, China

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^*signifies non-member of ASH