-Author name in bold denotes the presenting author
-Asterisk * with author name denotes a Non-ASH member
Clinically Relevant Abstract denotes an abstract that is clinically relevant.

PhD Trainee denotes that this is a recommended PHD Trainee Session.

Ticketed Session denotes that this is a ticketed session.

601. Chromosomal Rearrangements and DNA Repair: Poster II

Chromosomal Rearrangements and DNA Repair Program: Oral and Poster Abstracts
Type: Poster
Sunday, December 6, 2015: 6:00 PM-8:00 PM
Hall A, Level 2 (Orange County Convention Center)
2419
Targeting Replicative Stress to Treat Hematological DisordersClinically Relevant Abstract

Francesca Cottini, MD1,2, Giovanni Tonon, MD, PhD3*, Teru Hideshima, M.D., Ph.D.4, Paul G. Richardson, MD5 and Kenneth C Anderson6

1Internal Medicine department, Ohio State University, Columbus, OH
2Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
3Ospedale San Raffaele, Milan, Italy
4Jerome Lipper Multiple Myeloma Disease Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
5Division of Hematologic Malignancy, Department of Medical Oncology, Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
6The Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
2420
Nuclease Activity Is Associated with Genomic Instability As Well As Survival in Myeloma; Underlying Mechanisms and SignificanceClinically Relevant Abstract

Masood A Shammas, PhD1,2, Leutz Buon3*, Jianhong Lin, M.D, M.Sc4*, Mehmet K Samur, Ph.D5*, Jaymin M. Patel, MD6*, Ankit Vahia1*, Purushothama Nanjappa1*, Subodh Kumar, PhD1,2*, Ahsun Bajwa1*, Humza Ahmad1*, David Alagpulinsa, BPham1,6, Giovanni Parmigiani, PhD5*, Florence Magrangeas7*, Stephane Minvielle7*, Herve Avet-Loiseau8* and Nikhil C. Munshi, MD1,6

1The Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
2VA Boston Healthcare System, West Roxbury, MA
3Medical oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
4Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
5Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA
6VA Boston Healthcare System, west roxbury, MA
7Centre de Recherche en Cancérologie Nantes-Angers UMR Inserm 892—CNRS 6299 and Institut de Recherche Thérapeutique de l’Université de Nantes (IRT-UN), Nantes, France
8Unité de Génomique du Myélome, CHU Rangueil, Toulouse, France
2421
A Double Strand Break during Telophase Is Repaired with Homologous Recombination Despite the Absence of an Available Sister Chromatid

Amit Patel, MBBS, PhD, MRCP, MRCS, FRCPath1* and Luis Alcaide Aragon, PhD2*

1Targeted Therapy, Division of Cancer Biology, Institute of Cancer Research, London, United Kingdom
2Cell Cycle Group, Section of Epigenetics, MRC Clinical Sciences Centre, Imperial College London, London, United Kingdom
2422
FOXR1 Activation in B-Cell Lymphoma

Hilmar Quentmeier, PhD1*, Claudia Pommerenke, PhD1*, Stefan Nagel, PhD2*, Vivien Hauer1*, Margarete Zaborski1*, Rose Marie Amini, PhD3*, Mattias Berglund, PhD4*, Robert Geffers, PhD5* and Hans G Drexler, Prof. MD1

1Leibniz-Institute DSMZ-German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
2Human and Animal Cell Lines, Leibniz-Institute DSMZ-German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
3Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
4Department of Immunology, Genetics and Pathology, Uppsala University and Uppsala University Hospital, Uppsala, Sweden
5Genome Analysis Research Group, Helmholtz Centre for Infection Research, Braunschweig, Germany
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*signifies non-member of ASH