Christina K Baumgartner, PhD^*, Jeremy G Mattson^*, Hartmut Weiler, Qizhen Shi and Robert R Montgomery

BloodCenter of Wisconsin, Medical College of Wisconsin, Children's Research Institute, Milwaukee, WI

Nicholas D. Martinez, BS^1*, Susan A Maroney, DVM, PhD¹, Julie A. Peterson, PhD¹, Wes Zwifelhofer, BS^1*, Sinny Delacroix, MD^2*, Shuchong Pan, MD, PhD^2*, Robert Simari, MD^3* and Alan E. Mast, MD, PhD¹

¹Blood Center of Wisconsin, Milwaukee, WI
²Mayo Clinic, Rochester, MN
³University of Kansas School of Medicine, Kansas City, KS

Randolph B Lyde Jr., BS^1,2, Li Zhai, BS^3*, Karen Vo, BS^4*, Danuta Jadwiga Jarocha, PhD^5*, Spencer Sullivan, MD^6*, Valder R Arruda, MD, PhD⁷, Rodney M. Camire, PhD⁸, Deborah French, PhD^9* and Mortimer Poncz, MD¹⁰

¹Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA
²Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA
³Hematology, Children's hospital of philadelphia, Philadelphia
⁴Pharmacology, University of Pennsylvania, Philadelphia, PA
⁵Children's hospital of philadelphia, Philadelphia, PA
⁶Division of Hematology, University of Mississippi Medical Center, Jackson, MS
⁷Perelman School of Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA
⁸Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA
⁹Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA
¹⁰Department of Pediatrics, University of Pennsylvania, Philadelphia, PA

Mikhail Galkin, PhD^1*, Harlan Bradford, BA^2* and Sriram Krishnaswamy, PhD³

¹Children's Hospital of Philadelphia, Philadelphia, PA
²Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA
³Research Insitute, Children's Hospital of Philadelphia, Philadelphia, PA

Shauna D Mason^1*, Jon Kenniston^1*, Stephen R Comeau^1*, Gregory P Conley^1*, Niksa Kastrapeli^1*, Kris J Kopacz^1*, Allison P Lindberg^1*, Janja Cosic^1*, Monicah Kivaa^1*, James A Qiu^1*, Ryan Faucette^1*, Dan Sexton^1*, Christopher Tenhoor^1*, David Gailani², S. Kent Dickeson^2*, Qiufang Cheng^2*, Michael Wallisch^3*, Andras Gruber, MD³, Burt Adelman¹ and Andrew Nixon^1*

¹Dyax Corp., Burlington, MA
²Vanderbilt University, Nashville, TN
³Aronora Inc., Portland, OR

Maria M. Aleman, PhD¹, Elena N. Kistanova^1*, Nancy Moore^1*, Volker Schellenberger, PhD^2*, Robert Peters, PhD¹ and Joe Salas, PhD^1*

¹Hematology Research, Biogen, Cambridge, MA
²Amunix Operating Inc., Mountain View, CA

Hiroaki Minami, MD^1*, Keiji Nogami, MD. PhD^2* and Midori Shima, MD, PhD¹

¹Department of Pediatrics, Nara Medical University, Kashihara, Nara, Japan
²Department of Pediatrics, Nara Medical University, Kashihara, Japan

Arjan van der Flier, PhD^1*, Zhiqian Lucy Liu, PhD^1*, Zhan Liu, MSc^1*, Oblaise Mercury, BS^1*, Ayman Ismail, PhD^1*, Ekta Seth-Chhabra, PhD^1*, John Kulman, PhD^1*, Volker Schellenberger, PhD^2*, David R. Light, PhD³ and Robert Peters, PhD¹

¹Hematology Research, Biogen, Cambridge, MA
²Amunix Operating Inc., Mountain View, CA
³Hematology, Biogen, Cambridge, MA

Noah Kastelowitz, BA¹, Abimbola Jarvis, PhD^2*, Ormacinda R. White, MS^1*, Peter N. Brown, PhD^1*, Gary Brodsky, PhD^2*, Ryo Tamura, BS^1*, Jorge A. Di Paola, MD² and Hang Yin, PhD^1*

¹Department of Chemistry & Biochemistry and BioFrontiers Institute, University of Colorado Boulder, Boulder, CO
²Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO

Fanny Lassalle, PharmD^1*, Antoine Rauch, MD, PhD^1,2*, Benedicte Wibaut, MD, PhD^1*, Christine Vinciguerra, PharmD, PhD^3*, Mathilde Fretigny, PharmD, PhD^3*, Bertrand Vaast^1,2*, Valerie Gomanne^1*, Sophie Susen, MD, PhD^1,2*, Jenny Goudemand, MD, PhD^1,2 and Christophe Zawadzki, PharmD, PhD^1,2*

¹Department of Hematology Transfusion, Lille University Hospital, Lille, France
²Inserm UMR1011, University of Lille, Institut Pasteur de Lille, EGID, Lille, France
³Haemostasis Laboratory, Edouard Herriot Hospital, Lyon, France

William E. Plautz^1*, Satish Sekhar^1*, Rinku Majumder, PhD² and John P. Sheehan, MD³

¹Biophysics and Biochemistry, University of Chapel Hill, Chapel Hill, NC
²Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC
³Dept. of Medicine/Hematology-Oncology, University of Wisconsin, Madison, WI

Oliver Grottke, MD PhD^1*, Markus Honickel, MD^1*, Rolf Rossaint, MD Prof^1* and Till Braunschweig, MD^2*

¹Department of Anesthesiology, RWTH University Hospital Aachen, Aachen, Germany
²Department of Pathology, University Hospital RWTH Aachen, Aachen, Germany

Karl Egan, PhD^1*, Hui Ma, PhD^2*, Barry Kevane, MB^1,3,4*, Áine Lennon, BSc^3*, Elaine Neary, MD^5*, Kieran Wynne^6*, Seamus Allen, PhD^1*, Susan O'Shea, MB, BCH, MHS⁷, Richard O Kennedy^2* and Fionnuala Ní Áinle, MD, PhD^1,3,4

¹School of Medicine and Medical Science, University College Dublin, Dublin, Ireland
²School of Biotechnology and Biomedical Diagnostics Institute, Dublin City University, Dublin, Ireland
³Department of Haematology, Mater Misericordiae University Hospital, Dublin, Ireland
⁴Department of Haematology, Rotunda Hospital, Dublin, Ireland
⁵Department of Neonatology, Rotunda Hospital, Dublin, Ireland
⁶Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland
⁷Department of Haematology, Cork University Hospital, Cork, Ireland

Vijaya Satish Sekhar Pilli, PhD^1*, Willium Plautz, BS^2*, Rinku Majumder, PhD³ and Paolo Simioni, MD, PhD^4*

¹Biochemistry and Biophysics, UNC chapel hill, Chapel Hill, NC
²Biophysics and Biochemistry, UNC chapel hill, Chapel hill, NC
³Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC
⁴Medical & Surgical Sciences, Univ. of Padua, Med. School, Padova, Italy

Sarah C Bassi, M.D.^1* and Eduardo Magalhăes Rego, M.D., Ph.D.²

¹Medical School of Ribeirao Preto of the University of Sao Paulo, Ribeirao Preto, Brazil
²Medical School of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil

Ekta Seth Chhabra, PhD^1*, Nancy Moore^1*, Chris Furcht^2*, Amy M Holthaus, BS, MS^1*, Jiayun Liu, MS^1*, Tongyao Liu^3*, Volker Schellenberger, PhD^4*, John Kulman, PhD^1*, Joe Salas, PhD^1* and Robert Peters, PhD¹

¹Hematology Research, Biogen, Cambridge, MA
²Technical Development, Biogen, Cambridge, MA
³Hematology Research, Biogen Idec, Cambridge, MA
⁴Amunix Operating Inc., Mountain View, CA

Zhiqian Lucy Liu, PhD^1*, Arjan van der Flier, PhD^1*, Sara Bardan^2*, Sheng Ding^3*, Volker Schellenberger, PhD^4*, John Kulman, PhD^1* and Robert Peters, PhD⁵

¹Hematology Research, Biogen, Cambridge, MA
²Hematology research, Biogen, Cambridge, MA
³Amunix, Mountain View, CA
⁴Amunix Operating Inc., Mountain View, CA
⁵Biogen Idec Hemophilia, Cambridge, MA

Amanda Walborn^*, Daniel Kahn^*, Debra Hoppensteadt, PhD^* and Jawed Fareed, PhD

Department of Pathology, Loyola University Medical Center, Maywood, IL