57th ASH Annual Meeting and Exposition (December 5-8, 2015): 302. Vascular Wall Biology, Endothelial Progenitor Cells and Platelet Adhesion: Poster II

Vascular Wall Biology, Endothelial Progenitor Cells and Platelet Adhesion Oral and Poster Abstracts
Poster

Hall A, Level 2 (Orange County Convention Center)

Non-Proteolytic Regulation of the Multimerization of Von Willebrand Factor By ADAMTS13 Based on a Novel Cysteine Thiol Redundancy

Hanspeter Rottensteiner, PhD¹^*, Susanna Skalicky¹^*, Birgit Seyfried, PhD²^*, Stefan Kaufmann¹^*, Christian Fiedler³^*, Meinhard Hasslacher, PhD³^*, Jing-fei Dong, MD, PhD⁴, X. Long Zheng, MD, PhD⁵, Barbara Plaimauer, PhD¹^* and Friedrich Scheiflinger, PhD¹

¹Research & Innovation, Baxalta Innovations GmbH, Vienna, Austria
²Analytical Science, Baxalta Innovations GmbH, Vienna, Austria
³Downstream Process Science, Baxalta Innovations GmbH, Vienna, Austria
⁴BloodWorks Research Institute, University of Washington, Seattle, WA
⁵Division of Laboratory Medicine, Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL

2237

Vimentin Is a Novel Molecule Required for the Formation of Von Willebrand Factor Strings from the Vascular Endothelium

Titilope Ishola, MD, PhD¹, Qi Da, Ph.D²^*, Sean P Marrelli, PhD³^* and Miguel A. Cruz, PhD^2,4

¹Baylor College of Medicine, Texas Children's Cancer and Hematology Centers, Houston, TX
²Medicine, Baylor College of Medicine, Houston, TX
³Anesthesiology, Baylor College of Medicine, Houston, TX
⁴Center for Translational Research on Inflammatory Diseases, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX

2238

Temperature-Dependent Irreversible Conformational Change of ADAMTS13 upon Metal Ion Chelation

Rana Grillberger, PhD¹^*, Stefan Kaufmann¹^*, Barbara Kink²^*, Peter Matthiessen, PhD²^*, Barbara Plaimauer, PhD¹^*, Friedrich Scheiflinger, PhD¹ and Hanspeter Rottensteiner, PhD¹^*

¹Research & Innovation, Baxalta Innovations GmbH, Vienna, Austria
²Formulation Fill Finish, Baxalta Innovations GmbH, Vienna, Austria

2239

Genetic Deletion of CCRL2 Impairs Macrophage Accumulation in Arterial Intima and Attenuates Atherosclerotic Plaque Development

Yiren Cao, MD¹^*, Fei Yang, MS¹^*, Chaojun Tang, PhD¹^*, Shuhong Hu, MS¹^*, Brian Anthony Zabel, PhD²^* and Li Zhu, MD, PhD¹

¹Soochow University, Suzhou, China
²Stanford University, Palo Alto

2240

ADAMTS13/ VWF Axis Potentially Contributes to Diabetic Nephropathy By Regulating PAI-1 Levels

Nirav Dhanesha, Ph.D.^* and Anil K. Chauhan, PhD

Department of Internal Medicine, University of Iowa, Iowa, IA

2241

Endothelial Cell Protein C Receptor Promotes Apoptosis in Malignant Pleural Mesothelioma Cells

Shiva Keshava, Ph.D.^*, L. Vijaya Mohan Rao, Ph.D. and Usha R. Pendurthi, PhD

Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX

2242

Complex Relationship of Blood Group H, ABO Glycans, and Von Willebrand Factor Levels

Andy Itsara, MD, PhD¹^*, Jill M. Johnsen, MD^1,2, Kerry W Lannert²^*, Katherine Odem-Davis, PhD²^*, Ayse Bilge Ozel, PhD³^*, Karl C. Desch, MD⁴ and Thomas Walsh, BS²^*

¹Department of Medicine, University of Washington, Seattle, WA
²Research Institute - Puget Sound, Bloodworks NW, Seattle, WA
³Department of Human Genetics, University of Michigan, Ann Arbor, MI
⁴Pediatrics and Communicable Disease, University of Michigan, Ann Arbor, MI

2243

Relevant Role of Von Willebrand Factor in Ischemia-Reperfusion Model of Acute Kidney Injury in Mice

Shiro Ono¹^*, Hideto Matsui, MD, PhD², Masashi Noda²^*, Shogo Kasuda³^*, Yasunori Matsunari, MD²^*, Noritaka Yada¹^*, Kenji Nishio¹^* and Mitsuhiko Sugimoto, MD, Ph.D²^*

¹General Medicine, Nara Medical University, Kashihara, Japan
²Regulatory Medicine for Thrombosis, Nara Medical University, Kashihara, Japan
³Legal Medicine, Nara Medical University, Kashihara, Japan

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^*signifies non-member of ASH