57th ASH Annual Meeting and Exposition (December 5-8, 2015): 636. Myelodysplastic Syndromes – Basic and Translational Studies: Emerging Paradigms in MDS Pathobiology

Myelodysplastic Syndromes – Basic and Translational Studies Oral and Poster Abstracts
Oral

Valencia D (W415D), Level 4 (Orange County Convention Center)

Moderators:

Maria Figueroa, MD, University of Michigan Medical School and Alan F. List, MD, H Lee Moffitt Cancer Center & Research Institute

Disclosures:

No relevant conflicts of interest to declare.

4:30 PM

355

The Proinflammatory Protein S100A9 Suppresses Erythropoietin Elaboration in Patients with Myelodysplastic Syndromes

Thomas Cluzeau, MD, PhD^1,2,3^*, Kathy L McGraw, Ph.D.⁴, Brittany Irvine⁵^*, Erico Masala⁶^*, Lionel Ades, MD, PhD^7,8, Ashley A Basiorka⁹, Ghulam J Mufti, FRCP, FRCPath¹⁰, Jaroslaw P. Maciejewski, MD, Ph.D.¹¹, Sheng Wei, MD¹², Pierre Fenaux, MD, PhD^13,14, Valeria Santini, MD¹⁵ and Alan F. List, MD¹⁶

¹H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
²INSERM U1065, Centre Mediterraneen de Medecine Moleculaire, Nice, France
³French Group of Myelodysplasia, Paris, France
⁴H Lee Moffitt Cancer Center & Research Institute, Tampa, FL
⁵H. Lee Moffitt Cancer Center, Tampa, FL
⁶Hematology Unit, AOU Careggi, Firenze, Italy
⁷Service d’Hématologie Séniors, St Louis hospital, University Paris 7, Paris, France
⁸GFM, Hôpital Saint Louis, Paris, France
⁹H. Lee Moffitt Cancer Center and University of South Florida Cancer Biology PhD Program, Tampa, FL
¹⁰Department of Haematological Medicine, King’s College London, London, United Kingdom
¹¹Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
¹²Department of Immunology, Moffitt Cancer Center and Research Institute, Tampa, FL
¹³Service d'Hématologie Séniors, Hôpital Saint-Louis, Université Paris 7, Paris, France
¹⁴Groupe Francais des myélodysplasies (GFM), Paris, France
¹⁵AOU Careggi, University of Florence, Florence, Italy
¹⁶Department of Hematologic Malignancies, Moffitt Cancer Center and Research Institute, Tampa, FL

4:45 PM

356

Cooperating Effect of Rps14, Csnk1a1 and miRNA145/miRNA146a Haploinsufficiency in the Activation of the Innate Immune System in Del(5q) MDS

Schneider K. Rebekka, MD¹^*, Monica Schenone, PhD²^*, Monica Ferreira Ventura, PhD³^*, Fabian Beier, MD⁴^*, Tim H. Bruemmendorf, MD⁵, Ulrich Germing, MD⁶^*, Uwe Platzbecker, MD⁷, Guntram Büsche, MD⁸^*, Marie E. McConkey, PhD⁹^*, Christopher S Waters¹⁰^*, R. Coleman Lindsley, MD, PhD¹¹ and Benjamin L. Ebert, MD⁹

¹Department of Hematology, University Hospital RWTH Aachen, Aachen, Germany
²Broad Institute, Boston
³Hematology, RWTH Aachen University, Aachen, Germany
⁴University Hospital Aachen, Aachen, Germany
⁵Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, RWTH Aachen University, Aachen, Germany
⁶Department of Hematology, Oncology, and Clinical Immunology, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany
⁷Carl Gustav Carus an der Technischen Universität, Universitätsklinikum, Dresden, Germany
⁸Pathology, Hannover Medical School, Hannover, Germany
⁹Division of Hematology, Brigham and Women's Hospital, Boston, MA
¹⁰Hematology, Brigham and Women's Hospital, Boston, MA
¹¹Dana-Farber Cancer Institute, Boston, MA

5:00 PM

357

Cytotoxic Exposure to Both Hematopoietic Stem and Progenitor Cells and the Bone Marrow Niche Cooperate to Promote Leukemogenesis in a Mouse Model of Therapy-Related Myeloid Neoplasms with a Del(5q)

Angela Stoddart, PhD¹, Jianghong Wang, MD²^*, Chunmei Hu, MD³^*, Anthony A. Fernald, BS²^*, Elizabeth M. Davis, BS²^*, Jason X. Cheng, MD, PhD⁴ and Michelle M. Le Beau, PhD^1,5

¹Medicine, University of Chicago, Chicago, IL
²University of Chicago, Chicago, IL
³The Second Hospital of Jilin University, Changchun, China
⁴Department of Pathology, University of Chicago, Chicago, IL
⁵Comprehensive Cancer Center, Chicago, IL

5:15 PM

358

Restoration of the Bone Marrow Microenvironment Improves Hematopoietic Function in a Murine Model of Myelodysplastic Syndrome

Allison J. Li, BA¹^*, Sophia R. Balderman, MD², Benjamin J. Frisch, PhD³^*, Mark W. LaMere, BA⁴^*, Michael W. Becker, MD⁴ and Laura M. Calvi, MD⁴

¹Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY
²Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY
³Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY
⁴James P. Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY

5:30 PM

359

Myelodysplastic Syndrome Caused By Activating Kras Mutation in the Non-Hematopoietic Bone Marrow Microenvironment

Lena Osswald¹^*, Cornelius Miething, MD¹^*, Justus Duyster, MD, PhD¹^*, Tilman Brummer, PhD²^* and Robert Zeiser, MD³

¹Department of Hematology, Oncology and Stem Cell Transplantation, Freiburg University Medical Center, Albert Ludwigs University (ALU) Freiburg, Freiburg, Germany
²BIOSS Centre for Biological Signalling Studies, University of Freiburg, Freiburg, Germany
³Department of Hematology, Oncology and Stem Cell Transplantation, University Medical Center Freiburg, Freiburg, Germany

5:45 PM

360

Inhibition of Akt Signaling Alleviates MDS/MPN Driven By Kras^D12 or Nf1 Loss

Tannie Huang, MD^*, Jon Akutagawa^*, Inbal Epstein^*, Charisa Cottonham, PhD^*, Maricel Quirindongo-Crespo^* and Benjamin S. Braun, MD, PhD

Dept. of Pediatrics and the Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA

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^*signifies non-member of ASH

636.O3.6 636. Myelodysplastic Syndromes – Basic and Translational Studies: Emerging Paradigms in MDS Pathobiology