Doreen te Raa^1*, Mark Lanasa, MD, PhD², Sallie Allgood^3*, Paula Scotland^3*, Cassie Love^3*, Arend Jan van Houte^4*, Douwe Biesma^4*, Arnon P. Kater, MD, PhD⁵ and Sandeep Dave, MD²

¹Academic Medical Center, Amsterdam, Netherlands
²Duke University Medical Center, Durham, NC
³Duke University Medical Center, Durham
⁴St Antonius Hospital, Nieuwegein, Netherlands
⁵Department of Hematology, Academic Medical Center, Amsterdam, Netherlands

Dan A. Landau, MD, PhD^1,2, Eugen Tausch, MD^3*, Sebastian Böttcher, MD, PD^4*, Chip Stewart, PhD^1*, Ivana Bozic^5*, Iganty Leischner^1*, Daniel Rosebrock^1*, Amaro Taylor-Weiner, BS^1*, Daniel Mertens, PhD^6,7*, Carrie Sougnez^1*, Sabrina Kless^8*, Michael Kneba⁹, Matthias Ritgen^10*, Sandra Kluth^11*, Jasmin Bahlo^12*, Anna-Maria Fink, MD^11*, Kirsten Fischer, MD^13*, Stacey Gabriel^1*, Eric Lander, PhD^14*, Hartmut Dohner, MD¹⁵, Michael Hallek, MD¹⁶, Donna S Neuberg, ScD¹⁷, Martin Nowak^5*, Gad Getz, PhD^1*, Stephan Stilgenbauer¹⁸ and Catherine J. Wu, MD¹⁹

¹Broad Institute, Cambridge, MA
²Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
³Department of Internal Medicine III, Ulm University Medical Center, Ulm, Germany
⁴Second Department of Medicine, University Hospital of Schleswig-Holstein, Kiel, Germany
⁵Harvard University, Program for Evolutionary Dynamics, Cambridge, MA
⁶Mechanisms of Leukemogenesis, German Cancer Research Center (DKFZ), Heidelberg, Germany
⁷Department of Internal Medicine III, University of Ulm, Ulm, Germany
⁸Department of Internal Medicine III, Ulm University, Ulm, Germany
⁹Department of Hematology, University Hospital Schleswig-Holstein, Kiel, Germany
¹⁰Internal Medicine II, University Hospital of Schleswig-Holstein, Campus Kiel, Kiel, Germany
¹¹Department I of Internal Medicine and Center of Integrated Oncology Cologne-Bonn, German CLL Study Group, University of Cologne, Cologne, Germany
¹²Department I of Internal Medicine, Center of Integrated Oncology Cologne-Bonn, University Hospital Cologne, Cologne, Germany
¹³University Hospital Cologne, Cologne, Germany
¹⁴Broad Institute of Harvard and MIT, Cambridge, MA
¹⁵University Hospital of Ulm, Ulm, Germany
¹⁶Department of Internal Medicine, University of Cologne, Cologne, Germany
¹⁷Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA
¹⁸University of Ulm, Ulm, Germany
¹⁹Cancer Vaccine Center, Dana-Farber Cancer Institute, Boston, MA

Charles C Chu^1,2, Xiao-Jie Yan, MD, PhD², Arvind Dhayalan^2*, Piers E. Patten, BSc, MRCP, MRCPath, PhD³, Thomas MacCarthy, PhD^4*, Chaohui Yuan, MS^4*, Jacqueline C. Barrientos, MD^1,2, Jonathan E. Kolitz, MD^1,2, Steven L Allen, MD^1,2, Kanti R. Rai, MD^1,2 and Nicholas Chiorazzi, MD.^1,2

¹Hofstra North Shore-LIJ School of Medicine, Hempstead, NY
²The Feinstein Institute for Medical Research, North Shore-LIJ Health System, Manhasset, NY
³Haematology, King's College Hospital, London, United Kingdom
⁴Department of Applied Mathematics and Statistics, State University of New York, Stony Brook University, Stony Brook, NY

Melanie Märklin, PhD^1*, Jonas Heitmann^1*, Felicia Truckenmüller^1*, Lothar Kanz, MD¹, Sebastian Jonas Saur, MD^1*, Manuela Ganser^1*, Bugl Stefanie, PhD^1*, Hans-Georg Kopp, MD^1*, Michael Haap, MD^2*, Anjana Rao, PhD³, Stefan Wirths, MD^4* and Martin R Mueller, MD, PhD¹

¹Dept. of Hematology, Oncology and Immunology, University of Tuebingen, Tuebingen, Germany
²Dept. of Endocrinology, Diabetology, Clinical Chemistry and Metabolism, University of Tuebingen, Tuebingen, Germany
³La Jolla Institute For Allergy and Immunology, La Jolla, CA
⁴Department of Hematology and Oncology, University of Tuebingen, Tuebingen, Germany

Matthew John Jerome Rose-Zerilli, PhD^1*, Helen Parker^1*, Marta Larrayoz, PhD^2*, Ruth Clifford^3*, Stuart Blakemore^4*, Jennifer Edelmann, MD^5*, Jane Gibson^1*, Jun Wang^6*, Viktor Ljungstrom^7*, Tracy Chaplin^6*, Ali Roghanian^1*, Zadie Davis^8*, Anton Parker, BSc^9*, Eugen Tausch, MD^10*, Stavroula Ntoufa^11*, Sara Ramos^12*, Pauline Robbe, MSc^13*, Andrew J Steele, PhD², Graham Packham, PhD^2*, Ana E. Rodriguez^14*, Lee Brown^15*, Feargal McNicholl^16*, Francesco Forconi, MD, DM, PhD, FRCPath^17*, Andrew R Pettitt, MRCP PhD^18*, Peter Hillmen¹⁹, Martin J.S. Dyer, Prof.²⁰, Mark S Cragg, PhD^21*, Bryan D Young, BSc, PhD²², Claude Chelala^6*, Richard Rosenquist⁷, Kostas Stamatopoulos, MD^23*, Stephan Stilgenbauer²⁴, Samantha Knight^3*, Anna Schuh, MD, PhD^3*, David Oscier²⁵ and Jonathan C Strefford, PhD²

¹University of Southampton, Southampton, United Kingdom
²Cancer Sciences Unit, University of Southampton, Southampton, United Kingdom
³Oxford National Institute for Health Research Biomedical Research Centre/Molecular Diagnostic Centre, University of Oxford, Oxford, United Kingdom
⁴Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
⁵University of Ulm, Ulm, Germany
⁶Barts Cancer Institute, London, United Kingdom
⁷Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
⁸Department of Molecular Pathology, Royal Bournemouth Hospital, Bournemouth, United Kingdom
⁹Department of Pathology, Royal Bournemouth Hospital, Bournemouth, United Kingdom
¹⁰Department of Internal Medicine III, Ulm University Medical Center, Ulm, Germany
¹¹Institute of Applied Biosciences, CERTH, Thessaloniki, Greece
¹²University of Oxford, Oxford, United Kingdom
¹³Nuffield Department of Laboratory Sciences, University of Oxford, Oxford, United Kingdom
¹⁴Centro De Investigacion Del Cancer-Universidad, Salamanca, Spain
¹⁵University of Southampton, southampton, United Kingdom
¹⁶Western Health and Social Care Trust, Londonderry, United Kingdom
¹⁷Cancer Sciences Unit, Haematological Oncology Group, University of Southampton, Southampton, United Kingdom
¹⁸Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, United Kingdom
¹⁹St. James's Institute of Oncology, Leeds, United Kingdom
²⁰Ernest and Helen Scott Haematological Research Institute, University of Leicester, Leicester, United Kingdom
²¹Cancer Sciences Unit, Faculty of Medicine, Southampton General Hospital, University of Southampton, Southampton, United Kingdom
²²Medical Oncology, Barts and the London School of Medicine and Dentistry, QMUL, London, England
²³G. Papanicolaou Hospital, Thessaloniki, Greece
²⁴Department of Internal Medicine III, Ulm University, Ulm, Germany
²⁵Department of Haematology, Royal Bournemouth Hospital, Bournemouth, United Kingdom

Lili Wang, MD, PhD^1,2,3*, Rutendo Gambe, BS^1*, Jean Fan, BS^4*, Youzhong Wan, PhD^1,5*, Angela N Brooks, PhD^6,7*, Jing Sun, PhD^1*, Esther A. Obeng, MD, PhD^3,8,9, Donna S Neuberg, ScD¹⁰, Matthew Meyerson, MD, PhD^1,6*, Mark D. Fleming, MD, DPhil¹¹, Benjamin L. Ebert, MD^3,8, Ruben D. Carrasco, MD, PhD¹² and Catherine J Wu, MD^1,2,3,13

¹Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
²Cancer Vaccine Center, Dana-Farber Cancer Institute, Boston, MA
³Harvard Medical School, Boston, MA
⁴Department of Biomedical Informatics, Harvard Medical School, Boston, MA
⁵School of Life Sciences, Jilin University, Changchun, China
⁶Broad Institute, Cambridge, MA
⁷University of California, Santa Cruz
⁸Division of Hematology, Brigham and Women's Hospital, Boston, MA
⁹Pediatric Hematology/Oncology, Boston Children's Hospital, Boston, MA
¹⁰Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA
¹¹Department of Pathology, Boston Children's Hospital, Boston, MA
¹²Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA
¹³Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA