57th ASH Annual Meeting and Exposition (December 5-8, 2015): 603. Oncogenes and Tumor Suppressors: Transcriptional Control and Dysregulation in Hematopoiesis and Leukemia

Oncogenes and Tumor Suppressors Oral and Poster Abstracts
Oral

W308, Level 3 (Orange County Convention Center)

Moderators:

Ann-Kathrin Eisfeld, MD, The Ohio State University Comprehensive Cancer Center and Yong-Mi Kim, MD PhD MPH, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California

Disclosures:

No relevant conflicts of interest to declare.

10:30 AM

553

LMO2 Regulates DNA Replication in Hematopoietic Cells

Marie-Claude Sincennes¹^*, Magali Humbert¹^*, Benoit Grondin¹^*, Christophe Cazaux²^*, Veronique Lisi¹^*, Nazar Mashtalir³^*, EL Bachir Affar³^*, Alain Verreault¹^* and Trang Hoang¹

¹Institute for Research in Immunology and Cancer, University of Montreal, Montreal, QC, Canada
²Cancer Research Center of Toulouse, Toulouse, France
³Department of Medicine, Maisonneuve-Rosemont Hospital Research Center, Montreal, QC, Canada

10:45 AM

554

A Crispr/Cas9 Drop-out Screen Identifies Genome-Wide Genetic Valnerubilities in Acute Myeloid Leukaemia

Konstantinos Tzelepis, MSc¹^*, Hiroko Koike-Yusa, MD¹^*, Etienne De Braekeleer, PhD¹^*, Yilong Li¹^*, Emmanouil Metzakopian, PhD¹^*, Oliver M. Dovey, PhD¹^*, Annalisa Mupo, PhD¹^*, Vera Grinkevich, PhD¹^*, Milena M. Mazan, PhD¹^*, Malgorzata Gozdecka, PhD¹^*, Jonathan L. Cooper¹^*, Miten Patel, MD¹^*, Thomas David Hardman McKerrell, MD¹^*, Bin Chen¹^*, Hannes Ponstingl, PhD¹^*, Brian J.P Huntly, MD, PhD²^*, Ultan McDermott, MD, PhD¹^*, Julio Saez-Rodriguez, PhD³^*, Francesco Iorio, PhD³^*, Kosuke Yusa, PhD¹^* and George S. Vassiliou, MD, PhD¹^*

¹Wellcome Trust Sanger Institute, Cambridge, United Kingdom
²Cambridge Institute for Medical Research, Cambridge, United Kingdom
³EMBL European Bioinformatics Institute, Cambridge, United Kingdom

11:00 AM

555

Two Novel Knock-in and Knock-out of Setd2 Alleles Cooperate with Mll-Af9 Knock-in Allele to Accelerate Leukemia Development

Yunzhu Dong^1,2^*, Yoshihiro Hayashi, MD, PhD¹, Xiaomei Yan, MD, PhD¹^*, Feng Xue, PhD¹^*, Wei Chen, PhD²^* and Gang Huang, PhD¹

¹Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
²Beijing Institute of Biotechnology, Beijing, China

11:15 AM

556

Identification of BCL6 As a Therapeutic Target in RAS-Driven Acute Lymphoblastic Leukemia

Qiang Li, PhD¹^*, Christian Hurtz, PhD¹^*, Seyedmehdi Shojaee, PhD¹^*, Zhengshan Chen, MD PhD¹^*, Huimin Geng, PhD¹^*, Gang Xiao, PhD¹^*, Mignon L. Loh, MD², B. Hilda Ye, PhD³, Ari Melnick, MD⁴ and Markus Muschen, MD PhD¹

¹Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA
²Department of Pediatrics, Benioff Children’s Hospital, University of California San Francisco, San Francisco, CA
³Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY
⁴Department of Medicine, Weill Cornell Medical College, New York, NY

11:30 AM

557

Cdx2 Cooperates with Flt3-ITD to Induce Acute Myeloid Leukaemia in Mice

Therese Vu, BSc¹^*, Claudia Bruedigam¹^*, Axia Song¹^*, Solene Guignes¹^*, Rebecca Austin¹^*, Sebastien Jacquelin¹^*, Alistair Chalk²^*, Carl Walkley, PhD, BPharm², Claudia Scholl³, Stefan Fröhling, MD³ and Steven W. Lane, MD¹

¹QIMR Berghofer Medical Research Institute, Brisbane, Australia
²Stem Cell Regulation Unit, St. Vincent's Institute, Melbourne, Australia
³National Center for Tumor Diseases, Heidelberg, Germany

11:45 AM

558

Recurrent Mutations in Focal Adhesion Genes Including the RhoA Signaling Axis Are a Defining Feature of Germinal Center (GC) Derived B Cell Lymphomas and Promote Aberrant Migration and Cellular Adhesion within the GC Niche

Jane Healy, MD, PhD¹, Rachel E Rempel, PhD²^*, Andrea B. Moffitt²^*, Nicholas Davis²^*, Jenny Zhang²^*, Cassandra Love²^*, Jennifer R Shingleton, PhD²^* and Sandeep Dave, MD³

¹Department of Medicine, Division of Hematologic Malignancies, Duke University Medical Center, Durham, NC
²Duke University, Durham, NC
³Duke University Medical Center, Durham, NC

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^*signifies non-member of ASH

603.O2.6 603. Oncogenes and Tumor Suppressors: Transcriptional Control and Dysregulation in Hematopoiesis and Leukemia