57th ASH Annual Meeting and Exposition (December 5-8, 2015): 506. Hematopoiesis and Stem Cells: Microenvironment, Cell Adhesion and Stromal Stem Cells: Hematopoietic Stem Cell Niche

Hematopoiesis and Stem Cells: Microenvironment, Cell Adhesion and Stromal Stem Cells Oral and Poster Abstracts
Oral

W304EFGH, Level 3 (Orange County Convention Center)

Moderators:

Jonathan Hoggatt, PhD, Massachusetts General Hospital and Louis M. Pelus, PhD, Indiana University School of Medicine

Disclosures:

No relevant conflicts of interest to declare.

2:45 PM

661

Distinct Contributions By Perivascular Niche Cells in Hematopoietic Stem Cell Maintenance

Noboru Asada, MD, PhD¹^*, Yuya Kunisaki, MD, PhD²^*, Takashi Nagasawa, MD, PhD³^* and Paul S. Frenette, MD²

¹Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, New York, NY
²Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY
³Department of Immunobiology and Hematology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan

3:00 PM

662

Spatiotemporal Regulation of Hematopoietic Stem Cell Niches By Dual Cholinergic Signaling

Andres Garcia-Garcia, BSc^1,2^* and Simon Mendez-Ferrer, PhD^2,3

¹Stem Cell Niche Pathophysiology Group. Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain
²Stem Cell Institute and Department of Haematology, University of Cambridge, and National Health Service Blood and Transplant, Cambridge, United Kingdom
³Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain

3:15 PM

663

Embigin Regulates HSPC Homing and Quiescence and Acts As a Cell Surface Marker for a Niche Factor-Enriched Subset of Osteolineage Cells

Lev Silberstein, MD PhD^1,2, Peter V. Kharchenko, Ph.D.³^*, Youmna Sami Kfoury, PhD,¹^*, Francois Mercier, MD, FRCPC⁴, Raphael Turcotte, PhD⁵^*, Charles P. Lin²^*, Ninib Baryawno, PhD¹^*, Nicolas Severe^1,2^*, Tiffany Tate, BS⁶^*, Jonathan Hoggatt, PhD^1,2 and David T. Scadden, MD^6,7

¹Harvard Stem Cell Institute, Cambridge
²Massachusetts General Hospital, Boston
³Department of Biomedical Informatics, Harvard Medical School, Boston, MA
⁴Harvard Stem Cell Institute, Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA
⁵Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA
⁶Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA
⁷Harvard Stem Cell Institute, Cambridge, MA

3:30 PM

664

Distinct Bone Marrow Blood Vessels Differentially Regulate Normal and Malignant Hematopoietic Stem and Progenitor Cells

Tomer Itkin, PhD¹^*, Shiri Gur Cohen, PhD¹^*, Joel A. Spencer, PhD²^*, Amir Schajnovitz³^*, Saravana K. Ramasamy, PhD⁴^*, Anjali P. Kusumbe, PhD⁴^*, Yookyung Jung, PhD⁵^*, Guy Ledergor, MD¹^*, Idan Milo, PhD¹^*, Michael Gustave Poulos, PhD⁶^*, Maria Garcia Fernandez, PhD⁷^*, Alexander Kalinkovich, MD PhD¹^*, Aya Ludin¹^*, Orit Kollet, Ph.D¹, Guy Shakhar, PhD⁸^*, Simon Mendez-Ferrer, PhD^9,10, Jason M. Butler, PhD¹¹, Shahin Rafii, MD¹², Ralf H. Adams, PhD⁴^*, David T. Scadden, MD^3,13,14, Charles P. Lin⁵^* and Tsvee Lapidot, PhD¹

¹Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
²Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA
³Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA
⁴Max Planck Institute for Molecular Biomedicine, Munster, Germany
⁵Massachusetts General Hospital, Boston
⁶Ansary Stem Cell Institute/Genetic Medicine, Weill Cornell Medical College, New York, NY
⁷Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain
⁸The Weizmann Institute of Science, Rehovot, Israel
⁹Stem Cell Institute and Department of Haematology, University of Cambridge, and National Health Service Blood and Transplant, Cambridge, United Kingdom
¹⁰Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain
¹¹Ansary Stem Cell Institute, Weill Cornell Medical College, New York, NY
¹²Department of Medicine, Weill Cornell Medical College, New York, NY
¹³Harvard Stem Cell Institute, Cambridge, MA
¹⁴Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA

3:45 PM

665

EGFR Signaling in Osteoblasts Regulates Circadian Rhythm of HSPC in Circulation

Sachin Kumar, PhD¹^*, Jeff Vassallo, PhD¹^*, Kalpana Nattamai, MSc¹^*, Jose A Cancelas, MD, PhD¹ and Hartmut Geiger, PhD^2,3

¹Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center, cincinnati, OH
²Institute of Molecular Medicine, Ulm University, Ulm, Germany
³Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

4:00 PM

666

Loss of TGF-β Signaling in Bone Marrow Mesenchymal Progenitors Promotes Adipocyte over Osteoblast Differentiation but Does Not Disrupt the HSC Niche

Grazia Abou Ezzi, PhD¹^*, Teerawit Suparkorndej²^*, Bryan Anthony²^*, Jingzhu Zhang, BS³, Shilpi Ganguly⁴^*, Roberto Civitelli⁵^* and Daniel C. Link²

¹Department of Medicine, Division of Oncology, Section of Stem Cell Biology, Washington University School of medicine, Saint Louis, MO
²Department of Medicine, Division of Oncology, Section of Stem Cell Biology, Washington University School of Medicine, Saint Louis, MO
³Department of Internal Medicine, Division of Oncology, Section of Stem Cell Biology, Washington University School of Medicine, St Louis, MO
⁴Washington University School of Medicine, Saint Louis, MO
⁵Int Med - Bone & Mineral Diseases, Washington University School of Medicine, Saint Louis, MO

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^*signifies non-member of ASH

506.O1.6 506. Hematopoiesis and Stem Cells: Microenvironment, Cell Adhesion and Stromal Stem Cells: Hematopoietic Stem Cell Niche