57th ASH Annual Meeting and Exposition (December 5-8, 2015): 401. Basic Science and Clinical Practice in Blood Transfusion: Immunology of RBC Alloimmunization and Novel Therapies for Platelet Disorders

Basic Science and Clinical Practice in Blood Transfusion Oral and Poster Abstracts
Oral

W308, Level 3 (Orange County Convention Center)

Moderators:

Stephanie C. Eisenbarth, MD, PhD, Yale School of Medicine and Sean R. Stowell, MD, PhD, Emory University

Disclosures:

No relevant conflicts of interest to declare.

2:45 PM

655

Altered Heme-Mediated Modulation of Dendritic Cell Function in Sickle Cell Alloimmunization

Emmanuelle Godefroy, PhD¹^*, Yunfeng Liu, PhD¹^*, Patricia A Shi, MD², W. Beau Mitchell, MD³, Devin Cohen, BSc⁴^*, Stella T. Chou, MD⁴, Deepa Manwani, MD⁵ and Karina Yazdanbakhsh, PhD²

¹Laboratory of Complement Biology, New York Blood Center, New York, NY
²New York Blood Center, New York, NY
³Platelet Biology Laboratory, New York Blood Center, New York, NY
⁴Div of Hematology/Dept of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA
⁵Department of Pediatrics, Albert Einstein College of Medicine, Children's Hospital at Montefiore, Bronx, NY

3:00 PM

656

Establishment of Human Adipose Tissue-Derived Stromal Cell Lines: A Culture System to Manufacture Megakaryocytes Releasing Functional Platelets

Keiichi Tozawa, MD^1,2^*, Yukako Ono-Uruga, MD, PhD^1,2^*, Noriko Takizawa^1,2^*, Tadashi Horiuchi^1,2^*, Shin-ichiro Okamoto, MD, PhD¹, Mitsuru Murata, MD, PhD¹, Yasuo Ikeda, MD, PhD^1,3 and Yumiko Matsubara, PhD^1,2

¹Keio University School of Medicine, Tokyo, Japan
²Kanagawa Academy of Science and Technology, Kanagawa, Japan
³Graduate School of Advanced Science and Engineering,Waseda University, Tokyo, Japan

3:15 PM

657

Longer Duration of Red Blood Cell Storage Induces Progressively Increased Markers of Extravascular Hemolysis and Hepcidin in Autologously Transfused Healthy Volunteers

Francesca Rapido, MD^1,2^*, Sheila Bandyopadhyay, BA²^*, Richard O. Francis, MD, PhD³, Mark Soffing, MD⁴^*, Chaitanya R Divgi, MD⁵^*, Donald J. McMahon, MS⁶^*, Gary M. Brittenham, MD⁷, Steven L Spitalnik, MD⁸ and Eldad A. Hod, MD²

¹Department of Medical-Surgical Pathophysiology and Organ Transplantation, Università degli Studi di Milano, Milan, Italy
²Departments of Pathology and Cell Biology, Columbia University Medical Center, New York, NY
³Laboratory of Transfusion Biology, Pathology & Cell Biology, Columbia University Medical Center, New York, NY
⁴Radiology and Nuclear Medicine, Columbia University Medical Center, New York
⁵Department of Radiology, Columbia University Medical Center, New York
⁶Medicine Endocrinology, Columbia University Medical Center, New York
⁷Department of Pediatrics, Columbia University Medical Center, New York, NY
⁸Department of Pathology & Cell Biology, Columbia University, New York, NY

3:30 PM

658

DOCK8-Deficient Mice Reveal a Crucial Role for Dendritic Cell Activity in the Initiation of the Allogeneic Response to Transfused Red Blood Cells

Stephanie C. Eisenbarth, MD, PhD¹, Jeanne E. Hendrickson, MD², Samuele Calabro, PhD²^* and Antonia Gallman, BS²^*

¹Laboratory Medicine, Yale School of Medicine, New Haven, CT
²Laboratory Medicine, Yale University School of Medicine, New Haven, CT

3:45 PM

659

Therapeutic Efficacy of Anfibatide in a Murine Model of Thrombotic Thrombocytopenic Purpura

Liang Zheng, Ph.D.¹^*, Yingying Mao, Ph.D.¹^*, Mandy Li, Ph.D.²^*, Xiangrong Dai, M.S.³^*, Benjamin Li, Ph.D.²^* and X. Long Zheng, MD, PhD¹

¹Division of Laboratory Medicine, Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL
²Lee’s Pharmaceutical Holdings Limited, Hongkong, China
³Zhaoke Pharmaceutical Co. Limited, Hefei, China

4:00 PM

660

IgG Alloantibodies Against RBC Induced By Pregnancy or Transfusion Have Unique Glycosylation Patterns Which Correlate with Clinical Outcome of Hemolytic Disease of the Fetus or Newborn

Myrthe Elisabeth Sonneveld, MD¹^*, Rosina Plomp²^*, Jon Admiraal¹^*, Carolien Koeleman²^*, Agnes Hipgrave-Ederveen²^*, Joke Koelewijn, PhD³^*, Peter Ligthart³^*, Masja De Haas, Prof, MD³^*, Manfred Wuhrer, Prof²^*, C. Ellen Van der Schoot, Prof, MD¹ and Gestur Vidarsson, PhD¹^*

¹Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, Department of Experimental Immunohematology, Sanquin Research, Amsterdam, Netherlands
²Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, Netherlands
³Erythrocyte Serology, Sanquin Research, Amsterdam, Netherlands

See more of: Basic Science and Clinical Practice in Blood Transfusion
See more of: Oral and Poster Abstracts

<< Previous Session | Next Session >>

^*signifies non-member of ASH

401.O2.6 401. Basic Science and Clinical Practice in Blood Transfusion: Immunology of RBC Alloimmunization and Novel Therapies for Platelet Disorders