57th ASH Annual Meeting and Exposition (December 5-8, 2015): 504. Hematopoiesis: Cytokines, Signal Transduction, Apoptosis and Cell Cycle Regulation: Hematopoietic Stem Cell Regulation By Cytokine Signaling

Hematopoiesis: Cytokines, Signal Transduction, Apoptosis and Cell Cycle Regulation Oral and Poster Abstracts
Oral

W312, Level 3 (Orange County Convention Center)

Moderators:

Nadia Carlesso, MD, PhD, Cancer Research Institute and Peng Ji, MD, PhD, Northwestern University Medical School

Disclosures:

No relevant conflicts of interest to declare.

4:30 PM

775

Novel Functional Roles for Ten-Eleven-Translocation 2 (Tet2) in Normal and Leukemic Growth of Mast Cells

Raghuveer Mali, PhD¹^*, Holly Rene Martin, Ph.D.²^*, Baskar Ramdas, Ph.D.³^*, Lakshmi Palam, Ph.D.²^*, Valeria Visconte, PhD⁴^*, Tiu Ramon, M.D.⁵^*, Helmut Hanenberg, MD², Mingjiang Xu, MD, PhD⁶ and Reuben Kapur, Ph.D.²

¹Indiana University School of Medicine Herman B Wells Center for Pediatric Resear, Indianapolis, IN
²Indiana University School of Medicine, Indianapolis, IN
³Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN
⁴Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
⁵Translational Oncology and Hematology Research, Cleveland, OH
⁶Sylvester Comprehensive Cancer Center,, University of Miami Leonard M. Miller School of Medicine, Miami

4:45 PM

776

p38α Activates Purine Metabolism to Initiate Hematopoietic Stem Cell Cycling

Daiki Karigane, MD^1,2^*, Shinichiro Okamoto¹, Toshio Suda, MD, PhD³ and Keiyo Takubo, MD, PhD²^*

¹Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
²Department of Stem Cell Biology, National Center for Global Health and Medicine, Tokyo, Japan
³Cancer Science institute, National University of Singarore, 14 Medical Dr, Singapore

5:00 PM

777

Adipocyte-Derived Adiponectin Positively Regulates Exit from Quiescence of Hematopoietic Stem Cells By Potentiating mTORC1 Activation after Myelotoxic Injury

Yosuke Masamoto, MD, PhD¹^*, Shunya Arai, M.D., Ph.D.²^*, Tomohiko Sato, MD, PhD³^*, Iseki Takamoto, MD, PhD⁴^*, Naoto Kubota, MD, PhD⁴^*, Takashi Kadowaki, MD, PhD⁴^* and Mineo Kurokawa, MD, PhD¹

¹Department of Hematology & Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
²Department of Hematology and Oncology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan
³Department of Hematology & Oncology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan
⁴Department of Diabetes & Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

5:15 PM

778

Interleukin-1 Drives Precocious Myeloid Differentiation of Hematopoietic Stem Cells at the Expense of Self-Renewal

Eric Martin Pietras, PhD¹^*, Cristina Mirantes-Barbeito, PhD²^*, Sarah Fong³^*, Dirk Loffler, PhD⁴^*, Larisa Vladimirovna Kovtonyuk⁵^*, Ranjani Lakshminarashimhan²^*, Chih Peng Chin²^*, Jose-Marc Techner²^*, Britta Will, PhD⁶, Claus Nerlov, PhD⁷^*, Ulrich Steidl, MD, PhD⁸, Markus Manz, MD⁹, Timm Schroeder, PhD⁴^* and Emmanuelle Passegue, PhD²

¹Division of Hematology, University of Colorado - Denver, Aurora, CO
²The Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of California - San Francisco, San Francisco, CA
³The Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of California - San Francisco, San Francisco
⁴Department of Biosystems Science and Engineering (D-BSSE), Swiss Federal Institute of Technology (ETH) Zürich, Basel, Switzerland
⁵Division of Hematology, Zürich University Hospital, Zurich, Switzerland
⁶Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY
⁷Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
⁸Department of Cell Biology, Albert Einstein College of Medicine, New York, NY
⁹Division of Hematology, University Hospital Zurich, Zurich, Switzerland

5:30 PM

779

Recombinant DEK Enhances Ex Vivo expansion of Human Cord Blood and Mouse Bone Marrow Hematopoietic Stem Cells in a CXCR2- and Hspg-Dependent Manner

Maegan L. Capitano, Ph.D.¹, Nirit Mor-Vaknin²^*, Maureen Legendre²^*, Scott Cooper, MAS¹^*, David Markovitz, M.D.²^* and Hal E. Broxmeyer, Ph.D.³

¹Department of Microbiology/Immunology, Indiana University School of Medicine, Indianapolis, IN
²University of Michigan Medical Center, Ann Arbor, MI
³Indiana University School of Medicine, Indianapolis, IN

5:45 PM

780

Role for Megakaryocyte Phosphatidylinositol Transfer Proteins -Alpha and -Beta in TGF Beta-Mediated Regulation of Hematopoietic Homeostasis

Hal E. Broxmeyer, Ph.D.¹, Maegan L. Capitano, Ph.D.¹, Liang Zhao, PhD²^*, Scott Cooper, MAS¹^* and Charles S. Abrams, MD²

¹Department of Microbiology/Immunology, Indiana University School of Medicine, Indianapolis, IN
²School of Medicine, University of Pennsylvania, Philadelphia, PA

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^*signifies non-member of ASH

504.O1.6 504. Hematopoiesis: Cytokines, Signal Transduction, Apoptosis and Cell Cycle Regulation: Hematopoietic Stem Cell Regulation By Cytokine Signaling