57th ASH Annual Meeting and Exposition (December 5-8, 2015): 401. Basic Science and Clinical Practice in Blood Transfusion: Outcomes with Transfusion and Infusion Therapies Across Diverse Clinical Settings

Basic Science and Clinical Practice in Blood Transfusion Oral and Poster Abstracts
Oral

W308, Level 3 (Orange County Convention Center)

Moderators:

Christopher A Tormey, MD, Yale University School of Medicine and Jeffrey L. Winters, MD, Mayo Clinic

Disclosures:

No relevant conflicts of interest to declare.

4:30 PM

Tissue Oxygenation By Transfusion in Severe Anemia with Lactic Acidosis (TOTAL): A Prospective, Randomized, Non-Inferiority Trial of Blood Storage Duration

Aggrey Dhabangi, MD¹^*, Brenda Ainomugisha, MD²^*, Christine M. Cserti-Gazdewich, MD³, Henry Ddungu, MBCHB, M.MED (Int. Med)⁴^*, Dorothy Kyeyune, MD⁵^*, Ezra Musisi⁵^*, Robert Opoka, MD⁶^*, Christopher P. Stowell, MD, PhD⁷^* and Walter H. Dzik, MD⁸

¹Child Health and Development Centre, Makerere University, Kampala, Uganda
²Mulago Hospital, Kampala, Uganda
³Department of Medicine, Division of Hematology / Medical Oncology, University Health Network, Toronto, ON, Canada
⁴Mulago Hospital Complex, Kampala, Uganda
⁵Uganda National Blood Transfusion Service, Kampala, Uganda
⁶Department of Pediatrics, Makerere University, Kampala, Uganda
⁷Blood Transfusion Service, Massachusetts General Hospital, Boston, MA
⁸Massachusetts General Hospital, Boston, MA

4:45 PM

770

Prevention of Transfusion-Transmitted Malaria By Treatment of Whole Blood with the Mirasol^Ž PRT System

Jean-Pierre Allain, MD, PhD¹^*, Alex Owusu-Ofori, PhD²^*, Sonny Michael Assennato, MS¹^*, Susanne Marschner, PhD³^*, Raymond P Goodrich, PhD³^* and Shirley Owusu-Ofori, MBChB²^*

¹University of Cambridge, Cambridge, United Kingdom
²Komfo Anokye Teaching Hospital, Kumasi, Ghana
³Terumo BCT, Inc., Lakewood, CO

5:00 PM

771

Liberal Vs. Restrictive Transfusion Thresholds in Leukemia Patients: A Feasibility Pilot Study

Amy E. DeZern, MD, MHS¹, Katherine Williams²^*, Karen E. King, MD³, Wesley Hand¹^*, Mark J. Levis, MD, PhD⁴, B Doug Smith, MD⁵^*, Ivana Gojo, MD⁶, Keith W. Pratz, MD⁶, Lukasz P Gondek, MD, PhD¹, Gabrielle T. Prince, MD⁶, Gabriel Ghiaur, MD, PhD¹, Margaret M. Showel, MD⁶^*, Douglas Gladstone, MD⁷, Steve Frank⁸^* and Paul M. Ness, MD⁹

¹Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD
²The Johns Hopkins University School Of Medicine, Baltimore, MD
³Johns Hopkins Hospital, Baltimore, MD
⁴Johns Hopkins University School of Medicine, Baltimore, MD
⁵The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimre, MD
⁶Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD
⁷CRB1-287, The Sidney Kimmel Comphrensive Cancer Center at Johns Hopkins, Baltimore, MD
⁸Johns Hopkins, Baltimore, MD
⁹Johns Hopkins Hospital, Johns Hopkins Medical Institute, Baltimore, MD

5:15 PM

772

Cold-Stored Platelets in PAS Exhibit Superior Hemostatic Potential

Prajeeda M Nair, MS^1,2^*, Shatha Dallo, PhD³^*, Andrew P Cap, MD, PhD⁴ and Anand K Ramasubramanian, PhD⁵^*

¹Department of Biomedical engineering, The University of Texas at San Antonio, San Antonio, TX
²Department of Biomedical engineering, The University of Texas Health science center at San Antonio, San Antonio, TX
³University of Texas at San Antonio, San Antonio, TX
⁴Coagulation and Blood Research, US Army Institute of Surgical Research, JBSA Fort Sam Houston, TX
⁵Biomedical Engineering, University of Texas at San Antonio, San Antonio, TX

5:30 PM

773

Therapeutic Efficacy of Semisynthetic Supra Perfusion Resuscitation Fluids, EAF Peg Alb and EAF Peg Hb, Are Differentiated By Their Cerebral Effects in Animal Models of Sickle Cell Disease

Craig A Branch, MS, PhD¹^*, Min-Hui Cui, Ph.D.¹^*, Sangeetha Thangaswamy, PhD²^*, Nicholas Branch³^* and Seetharama Acharya¹^*

¹Albert Einstein College of Medicine, Bronx, NY
²Hematology-Oncology, Albert Einstein College of Medicine, Bronx, NY
³Aerospace, Georgia Technicial University, Atlanta, GA

5:45 PM

774

The Donation Interval of 56 Days Requires Extension to 180 Days for Whole Blood Donors to Recover from Disturbances in Iron Homeostasis

Nienke N.Schotten, MSc¹^*, Pieternel C Pasker- de Jong, PhD²^*, Diego Moretti, PhD³^*, Michael Bruce Zimmermann, MD³^*, Marian G Kraaij, MD, PhD⁴^* and Dorine W. Swinkels, MD, PhD⁵

¹Donor studies, Sanquin research, Amsterdam, Netherlands
²Donor studies, Sanquin Research, Amsterdam, Netherlands
³Laboratory for Human Nutrition, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland
⁴Department of Transfusion Medicine, Sanquin Blood Bank, Amsterdam, Netherlands
⁵Dep. of Laboratory Medicine, Radboudumc, Nijmegen, Netherlands

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^*signifies non-member of ASH

401.O1.6 401. Basic Science and Clinical Practice in Blood Transfusion: Outcomes with Transfusion and Infusion Therapies Across Diverse Clinical Settings