57th ASH Annual Meeting and Exposition (December 5-8, 2015): 506. Hematopoiesis and Stem Cells: Microenvironment, Cell Adhesion and Stromal Stem Cells: Hematopoietic Stem Cells on Stress

Hematopoiesis and Stem Cells: Microenvironment, Cell Adhesion and Stromal Stem Cells Oral and Poster Abstracts
Oral

W304EFGH, Level 3 (Orange County Convention Center)

Moderators:

Benjamin J. Frisch, PhD, University of Rochester Medical Center and Daniel Lucas, Ph.D.,

Disclosures:

No relevant conflicts of interest to declare.

4:30 PM

781

Rejuvenation of Aged Vascular Niches to Enhance Hematopoietic Function

Michael Gustave Poulos, PhD¹^*, Michael Gutkin, M.S.¹^*, Christopher Y. Park, M.D., Ph.D.² and Jason M. Butler, PhD³

¹Ansary Stem Cell Institute/Genetic Medicine, Weill Cornell Medical College, New York, NY
²Pathology and Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY
³Ansary Stem Cell Institute, Weill Cornell Medical College, New York, NY

4:45 PM

782

Adipogenic Chemokine Inhibition of Hematopoietic Cell Adherence and Transmigration, a Hurdle to Homing

Troy C Lund, MD, PhD¹, Ashley C. Kramer²^*, Paul Stadem, BS²^*, Michael Lehrke, MS²^* and Taylour Hanson, MS²^*

¹Pediatric Blood and Marrow Transplant, University of Minnesota, Minneapolis
²Pediatric Blood and Marrow Transplant, University of Minnesota, Minneapolis, MN

5:00 PM

783

IL-8 and CXCR1 Remodel the Vascular Niche to Promote Hematopoietic Stem and Progenitor Cell Engraftment

Bradley Wayne Blaser, MD, PhD^1,2, Jessica Moore²^*, Brian LI²^*, Owen J. Tamplin, PhD³, Vera Binder, MD^4,5^* and Leonard I. Zon, M.D⁴

¹Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Boston, MA
²Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA
³Boston Children's Hospital, Howard Hughes Medical Institute, Harvard Medical School, Hematology/Oncology, Boston, MA, Boston, MA
⁴Stem Cell Program and Division of Hematology/Oncology, Howard Hughes Medical Institute, Boston Children's Hospital/Harvard Medical School, Boston, MA
⁵Department of Hematology and Oncology, Dr. von Hauner Children's Hospital, Ludwig-Maximilians University, Munich, Germany

5:15 PM

784

Prostaglandin E2 Signaling through EP4 Receptor Promotes Hematopoietic Stem Cell Niche Regeneration and Enhances Hematopoietic Recovery

Pratibha Singh, PhD¹, Christie M. Orschell, PhD² and Louis M. Pelus, PhD¹

¹Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN
²Department of Medicine, Indiana University School of Medicine, Indianapolis

5:30 PM

785

Systemic Inflammation Recruits Ccr7⁺ Dendritric-Biased Granulocyte-Macrophage Progenitors to Lymphatic Circulation in a Non-Canonical Traf6-Dependent Manner

Juana Serrano-Lopez, PhD¹^*, Josefina Serrano²^*, Cuiping Zhang, MD, PhD¹^*, Ashley Wellendorf¹^*, Jing Fang, MD, PhD¹^*, Joaquin Sanchez-Garcia³^*, H. Leighton Grimes, PhD⁴, Daniel T Starczynowski, PhD⁵ and Jose A Cancelas, MD, PhD⁶

¹Cincinnati Children's Hospital Medical Center, Cincinnati, OH
²Hospital Universitario Reina Sofía, Cordoba, Spain
³Hospital Reina Sofia, Cordoba, Spain
⁴Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁵Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
⁶Stem Cell Program, Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

5:45 PM

786

Bortezomib Attenuates Adhesion of B Cell Precursor Acute Lymphoblastic Lleukemia Cells to Bone Marrow Mesenchymal Stromal/Stem Cells Via Regulating SPARC Expression

Masaki Iwasa, MD^1,2^*, Yasuo Miura, MD, PhD¹, Aya Fujishiro, MD^1,2^*, Sumie Fujii, MD^1,3^*, Noriko Sugino, MD³^*, Satoshi Yoshioka, M.D., Ph.D.^1,3,4, Akihiro Tamura, MD¹^*, Atsushi Sato, MD¹^*, Asumi Yokota, PhD¹^*, Katsuyuki Kito, MD, PhD²^*, Akira Ando, MD, PhD²^*, Hideyo Hirai, MD, PhD¹, Akifumi Takaori-Kondo, MD, PhD³, Tatsuo Ichinohe, MD, Ph.D⁵ and Taira Maekawa, MD, PhD¹

¹Department of Transfusion Medicine and Cell Therapy, Kyoto University Hospital, Kyoto, Japan
²Division of Gastroenterology and Hematology, Shiga University of Medical Science, Shiga, Japan
³Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
⁴Department of Hematology, Kobe City Medical Center General Hospital, Kobe, Japan
⁵Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan

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^*signifies non-member of ASH

506.O2.6 506. Hematopoiesis and Stem Cells: Microenvironment, Cell Adhesion and Stromal Stem Cells: Hematopoietic Stem Cells on Stress