57th ASH Annual Meeting and Exposition (December 5-8, 2015): 501. Hematopoietic Stem and Progenitor Biology: The Clone Wars

Hematopoietic Stem and Progenitor Biology Oral and Poster Abstracts
Oral

W308, Level 3 (Orange County Convention Center)

Moderators:

Jeff A. Magee, MD, PhD, Washington University School of Medicine and Florian H. Heidel, MD, Otto-von-Guericke-University Magdeburg

Disclosures:

No relevant conflicts of interest to declare.

12:00 PM

241

Clonal Tracking of the Geographic Distribution of Hematopoiesis in Nonhuman Primates Provides New Insights into HSPC Migration and Differentiation

Chuanfeng Wu, PhD¹^*, Samson J Koelle²^*, Brian Li², Diego Espinoza³^*, Rong Lu⁴^*, Allen E Krouse²^*, Mark Metzger³^*, Robert Donahue, VMD³ and Cynthia E. Dunbar, MD⁵

¹National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD
²National Heart, Lung, and Blood Institute, Hematology Branch, National Institutes of Health, Bethesda, MD
³Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD
⁴Department of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine, University of Southern California, Los Angeles, CA
⁵Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD

12:15 PM

242

In Vivo Selection Unmasks a Dormant Pool of Repopulating Hematopoietic Clones

Jennifer E Adair, PhD^1,2^*, Lauren E Schefter, B.A.³^*, Daniel R Humphrys, B.S.¹^*, Kevin G Haworth, PhD¹^*, Jonah D Hocum, B.S.⁴^*, Grant D. Trobridge, PhD⁵^* and Hans-Peter Kiem, MD^1,2

¹Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA
²University of Washington, Seattle, WA
³Clinical Research Division, Fred Hutch Cancer Research Center, Seattle, WA
⁴Department of Pharmacy, Washington State University, Pullman, WA
⁵Washington State University, Pullman, WA

12:30 PM

243

Clonal Features of Hematopoietic Stem and Progenitor Cells in Aging

Jianlong Sun, PhD^1,2 and Fernando D. Camargo, PhD^1,2^*

¹Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA
²Stem Cell Program, Boston Children's Hospital, Boston, MA

12:45 PM

244

Single-Cell Analysis of Lymphoid-Primed Multipotent Progenitors (LMPPs) Reveal Alterations in Lineage Commitment during Aging

Sneha Borikar^1,2, Vivek Philip, PhD¹^* and Jennifer J. Trowbridge, PhD^1,2

¹The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME
²Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA

1:00 PM

245

Long-Lasting Dysregulation of the Hematopoietic Stem Cell Compartment in Obesity

Jung-Mi Lee, PhD¹^*, Bryan Goddard¹^*, Ashwini S. Hinge, PhD¹^*, Bruce J. Aronow, Ph.D.²^*, Nathan Salomonis, Ph.D.²^*, Marie-Dominique Filippi, PhD¹, H. Leighton Grimes, PhD³, Jose A Cancelas, MD, PhD¹ and Damien Reynaud, PhD¹

¹Stem Cell Program, Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
²Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
³Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

1:15 PM

246

A Short Pulse of Prostaglandin E2 (PGE2) Induces Long Term Chromatin Changes in Hematopoietic Stem Cells Leading to Increased Self-Renewal and Engraftment

Eva M Fast, PhD^1,2^*, Ellen M Durand, PhD²^*, Audrey Sporrij¹^*, Leslie Ojeaburu¹^*, Rebecca Maher²^*, Vera Binder, MD^2,3^*, Song Yang, PhD²^*, Yi Zhou, Ph.D²^* and Leonard I. Zon, M.D^1,2

¹Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA
²Stem Cell Program and Division of Hematology/Oncology, Howard Hughes Medical Institute, Boston Children's Hospital/Harvard Medical School, Boston, MA
³Department of Hematology and Oncology, Dr. von Hauner Children's Hospital, Ludwig-Maximilians University, Munich, Germany

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^*signifies non-member of ASH

501.O1.6 501. Hematopoietic Stem and Progenitor Biology: The Clone Wars