57th ASH Annual Meeting and Exposition (December 5-8, 2015): 302. Vascular Wall Biology, Endothelial Progenitor Cells and Platelet Adhesion

Vascular Wall Biology, Endothelial Progenitor Cells and Platelet Adhesion Oral and Poster Abstracts
Oral

W307, Level 3 (Orange County Convention Center)

Moderators:

George M. Rodgers, MD, PhD, University of Utah Hospital and Florea Lupu,

Disclosures:

No relevant conflicts of interest to declare.

12:00 PM

Platelet Surface PDI Controls the Ligand-Binding Function of Glycoprotein Ibalpha and Platelet-Neutrophil Interactions Under Thromboinflammatory Conditions

Kyungho Kim, Ph.D.¹^*, Jing Li, Ph.D.¹, Robert K Andrews, Ph.D.², Joyce Chiu, Ph.D.³^*, Philip Hogg, Ph.D.³^* and Jaehyung Cho, Ph.D.¹

¹Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL
²ACBD, Australian Centre for Blood Diseases, Alfred Health / Monash University, Central Clinical School, Melbourne, Australia
³Lowy Cancer Research Centre, University of New South Wales, Sydney, Australia

12:15 PM

236

FAM20c-Mediated Serine 1613 Phosphorylation in the A2 Domain of Von Willebrand Factor Regulates ADAMTS13 Activity and Thrombus Formation

Qi Da, Ph.D¹^*, Jennifer Nolasco, B.S.¹^*, Tanvir Khatlani, PhD¹^*, Fernandez Maria, B, S.¹^*, Miguel A. Cruz, PhD^1,2 and K. Vinod Vijayan, PhD^1,2

¹Medicine, Baylor College of Medicine, Houston, TX
²Center for Translational Research on Inflammatory Diseases, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX

12:30 PM

237

Identification and Characterization of Integrin alphaIIbbeta3 Intermediate Affinity State Induced By Gpibalpha Mechanotransduction

Yunfeng Chen, BS¹, Lining Ju, PhD^2,3^* and Cheng Zhu, PhD⁴^*

¹Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA
²Heart Research Institute and Charles Perkins Centre, The University of Sydney, Camperdown, Sydney, Australia
³Coulter Department of Biomedical Engineering, Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA
⁴Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA

12:45 PM

238

Leukocyte XII Regulates Venous Thrombosis Risk

Evi X. Stavrou, MD^1,2, Chao Fang, PhD³^*, Alona A. Merkulova, M.S.²^*, Lalitha V. Nayak, MD⁴, Howard Meyerson, MD⁵^* and Alvin H. Schmaier, MD²

¹Louis Stokes Cleveland VA Medical Center, Cleveland, OH
²Department of Medicine, Division of Hematology-Oncology, Case Western Reserve University, Cleveland, OH
³Department of Medicine, Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Boston, MA
⁴University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH
⁵Department of Pathology, University Hospitals Case Medical Center/ Case Western Reserve University School of Medicine, Cleveland, OH

1:00 PM

239

N-Acetylcysteine Treatment in Two Patients with Relapsed Thrombotic Thrombocytopenic Purpura Increased ADAMTS13 Activity, Free Thiol Concentration in Plasma, and Inhibited Platelet Activation

Junmei Chen, PhD, Tahsin Özpolat, MD^*, Colette Norby, MS^*, Jennie Le, BS^*, Minhua Ling, PhD^*, Shelby A Cate, BS^*, Dominic W Chung, PhD^*, Xiaoyun Fu, PhD, Barbara Konkle, MD^* and Jose A. Lopez, MD

BloodworksNW Research Institute, Seattle, WA

1:15 PM

240

Engineering a "Self-Healing"ť Hydrogel-Based Microvasculature-on-a-Chip for Investigating the Effects of Cellular and Biomolecular Interactions on Endothelial Permeability in Sickle Cell Disease

Yongzhi Qiu, PhD^1,2^*, Byungwook Ahn, PhD²^*, Yumiko Sakurai, MSc^1,2^*, Caroline Hansen, BS³^*, Clinton H. Joiner, MD, PhD⁴, Solomon Fiifi Ofori-Acquah, PhD⁵ and Wilbur A Lam, MD, PhD^1,2

¹Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA
²Department of Pediatrics, Aflac Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta and Emory University School of Medicine, Atlanta, GA
³Georgia Institute of Technology, Atlanta, GA
⁴Aflac Cancer and Blood Disorder Center, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA
⁵Division of Hematology/Oncology, Department of Medicine, Center for Translational and International Hematology, University of Pittsburgh, Pittsburgh, PA

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^*signifies non-member of ASH

302.O1.6 302. Vascular Wall Biology, Endothelial Progenitor Cells and Platelet Adhesion