57th ASH Annual Meeting and Exposition (December 5-8, 2015): 331. Pathophysiology of Thrombosis: Procoagulant States

Pathophysiology of Thrombosis Oral and Poster Abstracts
Oral

W311ABCD, Level 3 (Orange County Convention Center)

Moderators:

Jeffrey I Zwicker, MD, Beth Israel Deaconess Medical Center, Harvard Medical School and Agnes Y. Y. Lee, MD, MSc, British Columbia Cancer Agency

Disclosures:

No relevant conflicts of interest to declare.

4:30 PM

763

Exome Genotyping Links Venous Thrombosis Risk with the Skeletal Muscle Myosin Gene Cluster and Leads to Discovery of New Family of Procoagulant Factors

Hiroshi Deguchi, MD, PhD^*, Ranjeet Kumar Sinha, PhD, MSc, Darlene J. Elias, MD^* and John H. Griffin, PhD

The Scripps Research Institute, La Jolla, CA

4:45 PM

764

A Novel PF4-Dependent Platelet Activation Assay Identifies Patients Likely to Have Heparin-Induced Thrombocytopenia/Thrombosis (HIT)

Anand Padmanabhan, MBBS, MA, PhD¹, Curtis Jones²^*, Brian R Curtis, MS, MT(ASCP)SBB³^*, Daniel W. Bougie, PhD⁴, Mia Sullivan²^*, Namrata Peswani, MD, MBBS⁵^*, Janice McFarland, MD⁶, Daniel Eastwood⁷^*, Demin Wang, PhD² and Richard H. Aster, MD⁸

¹Medical Sciences Institute, BloodCenter of Wisconsin, Milwaukee, WI
²BLOODCENTER OF WISCONSIN, MILWAUKEE, WI
³Platelet & Neutrophil Immunology Lab, BloodCenter of Wisconsin, Milwaukee, WI
⁴BloodCenter of Wisconsin, Milwaukee, WI
⁵Department of Hematology/Oncology, Medical College of Wisconsin, Milwaukee, WI
⁶Platelet and Neutrophil Immunology Laboratory, BloodCenter of Wisconsin, Milwaukee, WI
⁷MEDICAL COLLEGE OF WISCONSIN, MILWAUKEE, WI
⁸Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI

5:00 PM

765

Complement C5 Inhibition Blocks the Cytokine Storm and Consumptive Coagulopathy By Decreasing Lipopolysaccharide (LPS) Release in E. coli Sepsis

Ravi Shankar Keshari, PhD¹^*, Robert Silasi-Mansat, Ph.D.¹^*, Narcis I. Popescu, PhD², Marybeth Langer, Ph.D.²^*, Hala Chaaban, MD³^*, Cristina Lupu, Ph.D.¹^*, Mark K. Coggeshall²^*, Steven DeMarco, PhD⁴^* and Florea Lupu, PhD¹

¹Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK
²Immunobiology and Cancer Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK
³Department of Pediatrics, Oklahoma University Health Sciences Center, Oklahoma City, OK
⁴Ra Pharmaceuticals, Cambridge, MA

5:15 PM

766

Platelet Adhesion Under Flow Condition in Patients with Essential Thrombocythemia (ET) and Polycythemia Vera (PV): Analysis According to the Mutational Status

Alfonso Vignoli, MSc¹^*, Serena Tessarolo, MSc¹^*, Marina Marchetti, MSc, PhD¹^*, Sara Gamba, MSc¹^*, Francesca Piras, MSc¹^*, Guido Finazzi, MD²^*, Paola van der Meijden, PhD³^*, Frauke Swieringa, PhD³^*, Hugo ten Cate, MD, PhD⁴, Johan Heemskerk, PhD³^*, Alessandro Rambaldi, MD² and Anna Falanga, MD^1,5

¹Division of Immunohematology and Transfusion Medicine, Hospital Papa Giovanni XXIII, Bergamo, Italy
²Department of Hematology, Hospital Papa Giovanni XXIII, Bergamo, Italy
³Department of Biochemistry, CARIM, Maastricht University, Maastricht, Netherlands
⁴Department of Internal Medicine, Cardiovascular Research Institute Maastricht, The Netherlands, Maastricht University, Maastricht, Netherlands
⁵Immunohematology and Transfusion Medicine, Hospital Papa Giovanni XXIII, Bergamo, Italy

5:30 PM

767

Purified DNA, but Not Neutrophil Extracellular Traps (NETs), Promotes Contact Activation of Coagulation

Denis Noubouossie, MD, PhD^*, Matthew F Whelihan, PhD, Dougald M. Monroe III, PhD and Nigel S. Key, MB, ChB

Division of Hematology/Oncology, Department of Medicine, University of North Carolina, Chapel Hill, NC

5:45 PM

768

Antibodies Directed Against the Domain 1 of Beta2-Glicoprotein 1 May be Associated with Secondary Antiphospholipid Syndrome

Silmara Aparecida De Lima Montalvao¹^*, Priscila Elidio Soares¹^*, Sabrina Saraiva, MD¹^*, Bruna Moraes Mazetto, MSc²^*, Marina Pereira Colella, MD, PhD³^*, Erich Vinicius De Paula, MD, PhD³, Simone Appenzeller, MD PhD⁴^*, Joyce Maria Annichino-Bizzacchi, MD, PhD³^* and Fernanda Andrade Orsi, MD PhD^5,6

¹Hematology and Hemotherapy Center, University of Campinas, Campinas, Brazil
²Hematology and Hemoterapy Center, University of Campinas, Campinas, Brazil
³Hematology and Hemotherapy Center, University of Campinas, Campinas, SP, Brazil
⁴Department of Rheumatology, University of Campinas, Campinas, Brazil
⁵Faculty of Medical Sciences, Department of Clinical Pathology, University of Campinas, Campinas, SP, Brazil
⁶University of Campinas, Hematology and Hemotherapy Center, Campinas, Brazil

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^*signifies non-member of ASH

331.O2.6 331. Pathophysiology of Thrombosis: Procoagulant States – Assessment and Risks