57th ASH Annual Meeting and Exposition (December 5-8, 2015): 322. Disorders of Coagulation or Fibrinolysis: Clinical Aspects of Bleeding Disorders

Disorders of Coagulation or Fibrinolysis Oral and Poster Abstracts
Oral

W314, Level 3 (Orange County Convention Center)

Moderators:

Anne T. Neff, MD, CLEVELAND CLINIC and Tyler W. Buckner, MD, MSc, University of Colorado School of Medicine

Disclosures:

Neff: CSL Behring: Membership on an entity’s Board of Directors or advisory committees ; American Board of Internal Medicine: Membership on an entity’s Board of Directors or advisory committees ; Alexion: Membership on an entity’s Board of Directors or advisory committees ; Kedrion: Membership on an entity’s Board of Directors or advisory committees ; Baxalta: Membership on an entity’s Board of Directors or advisory committees ; NovoNordisk: Membership on an entity’s Board of Directors or advisory committees , Research Funding . Buckner: Novo Nordisk: Consultancy ; Baxalta, Inc. US: Consultancy .

4:30 PM

757

Gene Analysis of 45 FXIII Deficient Patients in the US: An in Depth Whole Gene NGS Sequencing Analysis of FXIII a and B Subunit Mutations

Diane J. Nugent, MD^1,2, Leiquian Tai, Pharm D³^*, Shirley Williams, PhD⁴^*, Suman Verma, PhD⁵^*, Moore Mathew, PhD⁶^* and Michael Tai, PhD⁶^*

¹University of California, Irvine, CA
²Department of Hematology, CHOC Children's Hospital, Orange, CA
³CHOC Chidrens Hospital / UC Irvine, Orange, CA
⁴CHOC Childrens Hospital/ UC Irvine, Orange, CA
⁵Research Dx, Irvine, CA
⁶Research DX, Irvine, CA

4:45 PM

758

Domain Distribution of Type 1 VWD Sequence Variants and Impact on Clinical and Laboratory Phenotype in the Zimmerman Program

Pamela A Christopherson¹^*, Veronica H Flood, MD², Sandra L Haberichter, PhD¹, Daniel B Bellissimo, PhD³, Kenneth D Friedman, MD¹, Joan Cox Gill, MD², Rupa A Udani, PhD⁴, Robert R Montgomery, MD¹ and Zimmerman Program Investigators¹^*

¹Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI
²Blood Research Institute, BloodCenter of Wisconsin, Medical College of Wisconsin, Children's Research Institute, Milwaukee, WI
³Magee Women’s Hospital, University of Pittsburgh, Pittsburgh, PA
⁴BloodCenter of Wisconsin, Milwaukee, WI

5:00 PM

759

Safety and Effectiveness of Desmopressin for the Management of Delivery and Major Surgery in Patients with Mild-Moderate Von Willebrand Disease: Final Analysis of the Prodeswil Study

Augusto Bramante Federici, MD¹^*, Giancarlo Castaman, MD²^*, Alfonso Iorio, MD, PhD³, Emily Oliovecchio⁴^* and Prodeswil Investigators⁵^*

¹Hematology and Transfusion Medicine, L.Sacco University Hospital, Milano, Italy
²Center for Bleeding Disorders, University of Florence, Florence, Italy
³McMaster University, Hamilton, ON, Canada
⁴Hemophilia Center, Perugia Hospital, Perugia, Italy
⁵Department of Clinical Sciences and Community Health, University of Milan, Milano, Italy

5:15 PM

760

Bleeding and Liver Transplant Outcomes in Hemophilia

Kathan Dilipbhai Mehta, MBBS, MPH¹ and Margaret V. Ragni, MD, MPH²

¹University of Pittsburgh Medical Center, Pittsburgh, PA
²Department of Medicine, Division Hematology/Oncology, University of Pittsburgh and Hemophilia Center of Western PA, Pittsburgh, PA

5:30 PM

761

A Cross-Sectional Analysis of Cardiovascular Disease in the Hemophilia Population

Suman L. Sood, MD¹, Dunlei Cheng, PhD²^*, Margaret V Ragni³, Craig M. Kessler, MD⁴, Doris Quon, MD, PhD⁵, Amy D Shapiro, MD⁶, Nigel S. Key, MBChB⁷, Marilyn J. Manco-Johnson, MD⁸, Adam Cuker, MD, MS⁹, Christine Kempton, MD¹⁰, Tzu-Fei Wang, MD¹¹, M. Elaine Eyster, MD¹², Philip Kuriakose, MD¹³, Annette von Drygalski, MD, PharmD¹⁴, Joan Cox Gill, MD¹⁵, Allison Paroskie, MD¹⁶^*, Peter A. Kouides¹⁷, Miguel Antonio Escobar, MD¹⁸, Cindy A. Leissinger, MD¹⁹, Sarah Galdzicka²⁰^*, Diane Aschman²^* and Barbara Konkle, MD²¹^*

¹Department of Medicine; Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI
²American Thrombosis and Hemostasis Network, Riverwoods, IL
³Department of Medicine, Division Hematology/Oncology, University of Pittsburgh and Hemophilia Center of Western PA, Pittsburgh, PA
⁴Lombardi Cancer Center, Washington, DC
⁵Orthopaedic Hemophilia Treatment Center, Los Angeles, CA
⁶Indiana Hemophilia & Thrombosis Center, Indianapolis, IN
⁷Medicine, University of North Carolina, Chapel Hill, NC
⁸Mountain State Regional Hemophilia and Thrombosis Center, University of Colorado Denver, Aurora, CO
⁹Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
¹⁰Department of Hematology and Medical Oncology, and Department of Pediatrics, Emory University School of Medicine, Atlanta, GA
¹¹The Ohio State University, Columbus, OH
¹²Department of Hematology, Penn State Hershey Medical Center, Hershey, PA
¹³Hematology/Oncology, Henry Ford Hospital, Detroit, MI
¹⁴Medicine; Division of Hematology/Oncology, UCSD, San Diego, CA
¹⁵Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI
¹⁶The Vanderbilt Hemostasis/Hemophilia Clinic, Nashville, TN
¹⁷Department of Medicine, Rochester General Hospital, Rochester, NY
¹⁸Department of Pediatrics and Gulf States Hemophilia and Thrombophilia Center, University of Texas-Houston Medical school, Houston, TX
¹⁹Tulane University School of Medicine, New Orleans, LA
²⁰Bloodworks Northwest, Seattle, WA
²¹BloodworksNW Research Institute, Seattle, WA

5:45 PM

762

The Hypertension of Hemophilia Is Associated with Vascular Joint Remodeling and Cannot be Explained By the Usual Cardiovascular Risk Factors

Richard FW Barnes, PhD, MPH¹^*, Thomas J Cramer, PhD²^*, Afrah S Sait, MD³^*, Rebecca Kruse-Jarres, MD, MPH⁴, Doris V. Quon, MD, PhD⁵ and Annette von Drygalski, MD, PharmD⁶

¹University of California San Diego, San Diego, CA
²Medicine; Div of Hematology/Oncology, UCSD, San Diego, CA
³Department of Medicine, University of British Columbia, Vancouver, BC, Canada
⁴Washington Center for Bleeding Disorders at BloodWorks NW, University of Washington, Seattle, WA
⁵Orthopaedic Hemophilia Treatment Center, Los Angeles, CA
⁶Medicine; Division of Hematology/Oncology, UCSD, San Diego, CA

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^*signifies non-member of ASH

322.O3.6 322. Disorders of Coagulation or Fibrinolysis: Clinical Aspects of Bleeding Disorders