57th ASH Annual Meeting and Exposition (December 5-8, 2015): 203. Lymphocytes, Lymphocyte Activation and Immunodeficiency, including HIV and Other Infections: T and B Lymphocyte Biology

Lymphocytes, Lymphocyte Activation and Immunodeficiency, including HIV and Other Infections Oral and Poster Abstracts
Oral

W315, Level 3 (Orange County Convention Center)

Moderators:

Vicki A Boussiotis, MD, PhD, Harvard Institutes of Medicine, Beth Israel Deaconess Medical Center and Taku Kambayashi, MD/PhD, University of Pennsylvania

Disclosures:

No relevant conflicts of interest to declare.

4:30 PM

283

PD-1 Inhibits TCR Proximal Signaling By Sequestering SHP-2 Phosphatase and Facilitating Csk-Mediated Inhibitory Phosphorylation of Lck

Kankana Bardhan, PhD¹^*, Nikolaos Patsoukis, PhD¹^*, Duygu Sari¹^*, Theodore Anagnostou²^*, Pranam Chatterjee¹^*, Gordon J. Freeman, PhD³^*, Lequn Li, MD, PhD¹^* and Vassiliki A. Boussiotis, MD, PhD¹

¹Hematology-Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
²Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
³Dana-Farber Cancer Institute, Boston, MA

4:45 PM

284

Kras Is Critical for CD8 T Cell Antiviral Function

Yuhong Chen, Ph.D.¹^*, Yongwei Zheng, Ph.D.²^*, Xiaona You, Ph.D.³^*, Gang Xin, Ph.D.¹^*, Mei Yu, Ph.D.¹^*, Guoping Fu, Ph.D.¹^*, Fen Zhou⁴^*, Wen Zhu¹^*, Weiguo Cui, Ph.D.¹^*, Jing Zhang, PhD³, Renren Wen, PhD¹^* and Demin Wang, PhD¹

¹Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI
²Blood Research Institute, Bloodcenter of Wisconsin, Milwaukee, WI
³McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, WI
⁴Department of Pediatrics, Union Hospital, Tongji Medical College, Wuhan, China

5:00 PM

285

Blocking Specific CD44 Splicing Variant Isoform Inhibits the Differentiation of Th-2 Cells through Interfering with IL-4/IL-4R Signaling Pathway

Chun Yang, M.D. Ph.D.^1,2^*, Jianhong Lin, M.D, M.Sc¹^*, Hongyan Liang, M.D. Ph.D.²^*, Ariel Kwart, B.S.¹^*, Meng Jiang, M.D¹^*, Jianjun Zhao, M.D. Ph.D.¹, Xiaofeng Jiang, M.D. Ph.D.²^* and Nikhil C. Munshi, MD^3,4

¹Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
²Department of Clinical Laboratory, the 4th Hospital of Harbin Medical University, Harbin, China
³Jerome Lipper Multiple Myeloma Center, Dana Farber Cancer Institute, Boston, MA
⁴VA Boston Healthcare System, West Roxbury, MA

5:15 PM

286

Cereblon Deficiency Leads to Alteration in c-Myc Regulated Genes, Increased Glucose Uptake and Resistance to JQ1 Bromodomain Inhibition

Matthew S Beatty, PhD¹^*, Rebecca S Hesterberg, BA², Ying Han, MD³^*, Eric Padron, M.D.^1,4, Adam W Mailloux, PhD¹^*, Sean Yoder, M.S⁵^*, Anjali M Rajadhyaksha, PhD⁶^*, Alan F. List, MD^7,8 and Pearlie K Epling-Burnette, PhD¹

¹Department of Immunology, Moffitt Cancer Center and Research Institute, Tampa, FL
²Immunology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
³Biotherapy Department, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
⁴Division of Hematologic Malignancies, Moffitt Cancer Center and Research Institute, Tampa, FL
⁵Molecular Genomics Core Facility, Moffit Cancer Center and Research Institute, Tampa, FL
⁶Pediatric Neurology, Weill Cornell Medical College, New York, NY
⁷Department of Hematologic Malignancies, Moffitt Cancer Center and Research Institute, Tampa, FL
⁸Division of Clinical Science, Moffitt Cancer Center and Research Institute, Tampa, FL

5:30 PM

287

Regulation of Transcription Factors Foxp1, E2A and Egr-1 By microRNA-191 Constrains B Lymphocyte Development and Suppresses Development of Diffuse Large B Cell Lymphoma

Marcin Lyszkiewicz, PhD^1,2^*, Jonas Blume, PhD¹^*, Natalia Zietara, PhD^1,2^*, Katrin Witzlau¹^*, Jacek Puchalka, PhD²^*, Namita Saran, PhD^3,4^*, Sandra Duber, PhD⁵^*, Roy Bishnudeo, PhD^5,6^*, Siegfried Weiss, PhD⁷^* and Andreas Krueger, PhD, Prof.¹^*

¹Institute of Immunology, Hannover Medical School, Hannover, Germany
²Dr. von Hauner Children's Hospital, Ludwig Maximilians University, Munich, Germany
³Hannover Medical School, Hannover, Germany
⁴Immunobiology, King's College London, London, United Kingdom
⁵Molecular Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
⁶Centre for Immune Regulation and Department of Immunology, University of Oslo and Oslo University Hospital, Oslo, Norway
⁷Molecular Immunology, Helmholtz Centre for Infection Research, HZI, Braunschweig, Germany

5:45 PM

288

CD28 Induces Mitochondrial Respiration through Slp-76 in Long-Lived Plasma Cells for Reactive Oxygen Species-Dependent Survival

Adam T. Utley, BS, BA¹^*, Daniela Ventro, PhD¹^*, Megan Murray, MD, PhD²^*, Amin Mahpour, BS, MS³^* and Kelvin P. Lee, MD⁴

¹Immunology, Roswell Park Cancer Institute, Buffalo, NY
²Duke University, Durham, NC
³Roswell Park Cancer Institute, Buffalo, NY
⁴Departments of Medicine and Immunology, Roswell Park Cancer Institute, Buffalo, NY

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^*signifies non-member of ASH

203.O2.6 203. Lymphocytes, Lymphocyte Activation and Immunodeficiency, including HIV and Other Infections: T and B Lymphocyte Biology