57th ASH Annual Meeting and Exposition (December 5-8, 2015): 321. Blood Coagulation and Fibrinolytic Factors: Coagulation Proteins and Blood Vessels

Blood Coagulation and Fibrinolytic Factors Oral and Poster Abstracts
Oral

W314, Level 3 (Orange County Convention Center)

Moderators:

Christopher B Doering, PhD, Emory University School of Medicine and Usha R. Pendurthi, Ph.D., University of Texas Health Science Center At Tyler

Disclosures:

Doering: Expression Therapeutics: Equity Ownership ; Bayer Healthcare: Consultancy , Honoraria , Research Funding .

9:30 AM

211

Bleeding Phenotype Observed in Murine Defect of VWF-Collagen 4 Interactions

Veronica H Flood, MD¹, Tricia L Slobodianuk²^*, Ashley Doruelo^2,3^*, Derek Adams²^*, Jamie Foeckler^2,4^*, Shawn Kalloway^2,4^*, Hartmut Weiler⁵ and Robert R Montgomery²

¹BloodCenter of Wisconsin, Medical College of Wisconsin, Department of Pediatrics, Milwaukee, WI
²Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI
³Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI
⁴Transgenic Core Facility, Medical College of Wisconsin, Milwaukee, WI
⁵BloodCenter of Wisconsin, Medical College of Wisconsin, Children's Research Institute, Milwaukee, WI

9:45 AM

212

A Targeted Photochemical Microfluidic Vascular Injury Model for in Vitro Thrombosis Studies: Usage in Heparin-Induced Thrombocytopenia (HIT)

Ian Johnston, BS¹, Vincent M Hayes, BS²^*, Douglas B. Cines³ and Mortimer Poncz, MD²

¹Children's Hospital of Philadelphia, Philadelphia, PA
²Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA
³University of Pennsylvania, Philadelphia, PA

10:00 AM

213

The Role of Putative Phosphatidylserine-Interactive Residues of Tissue Factor on Its Coagulant Activity at the Cell Surface

Shabbir Ansari^*, Usha R. Pendurthi, PhD and L. Vijaya Mohan Rao, Ph.D.

Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX

10:15 AM

214

Von Willebrand Factor Protects Factor VIII from Rapid Endocytosis Via LDL Receptor-Related Protein By Blocking the Initial Rate-Limiting Cell Surface Binding Step of Factor VIII

Henriet Meems, PhD^*, Carmen van der Zwaan^*, Koen Mertens, PhD and Alexander Meijer, PhD^*

Department of Plasma Proteins, Sanquin Blood Supply, Amsterdam, Netherlands

10:30 AM

215

Clot Contraction-Mediated Erythrocyte Packing Is Significantly Altered in Sickle Cell Disease

Hunter Strauss¹^*, David R Myers, PhD^2,3, Margo Renee Rollins, MD⁴, John W. Weisel, PhD⁵ and Wilbur A Lam, MD, PhD^2,3

¹Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA
²Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA
³Department of Pediatrics, Aflac Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta and Emory University School of Medicine, Atlanta, GA
⁴Department of Pediatric Hematology Oncology, Aflac Cancer and Blood Disorder Service of Children's Healthcare of Atlanta, Atlanta, GA
⁵Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA

10:45 AM

216

Coagulation Factor V Mediates Inhibition of Tissue Factor Signaling By Activated Protein C

Hartmut Weiler¹, Hai-Po Liang, PhD²^*, Edward J Kerschen, PhD³^*, Alireza Rezaie, PhD⁴, Jose A. Fernandez, MD, PhD⁵, Rodney M. Camire, PhD⁶, Wolfram Ruf, MD⁷, John H. Griffin, PhD⁸ and Raffaele Toso, PhD⁹^*

¹BloodCenter of Wisconsin, Medical College of Wisconsin, Children's Research Institute, Milwaukee, WI
²BloodCenter of Wisconsin, Milwaukee
³BloodCenter of Wisconsin, Milwaukee, WI
⁴St. Louis Univ. School of Med., Saint Louis, MO
⁵Scripps Research Institute, La Jolla
⁶Hematology, Children's Hospital of Philadelphia, Philadelphia, PA
⁷SP258, The Scripps Research Institute, La Jolla, CA
⁸The Scripps Research Institute, La Jolla, CA
⁹University of Pennsylvania, Philadelphia

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^*signifies non-member of ASH

321.O3.6 321. Blood Coagulation and Fibrinolytic Factors: Coagulation Proteins and Blood Vessels