57th ASH Annual Meeting and Exposition (December 5-8, 2015): 203. Lymphocytes, Lymphocyte Activation and Immunodeficiency, including HIV and Other Infections: Novel Immunodeficiencies and Natural Killer Cell Biology

Lymphocytes, Lymphocyte Activation and Immunodeficiency, including HIV and Other Infections Oral and Poster Abstracts
Oral

W315, Level 3 (Orange County Convention Center)

Moderators:

Jianhua Yu, PhD, The Ohio State University Wexner Medical Center and Todd A Fehniger, MD, PhD, Washington University School of Medicine

Disclosures:

No relevant conflicts of interest to declare.

9:30 AM

205

Impairment of IL-17 Immunity to Candida and IFN-g Immunity to Mycobacterium in Humans with Bi-Allelic Rorc mutations

Satoshi Okada, MD, PhD^1,2^*, Janet Markle, PhD¹^*, Masao Kobayashi, MD, PhD², Jacinta Bustamante, MD, PhD^3,4,5,6^* and Jean-Laurent Casanova, MD, PhD^1,3,4,5

¹St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY
²Pediatrics, Hiroshima University Graduate School of Biomedical & Health Sciences, Hiroshima, Japan
³Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Imagine Institute, Paris, France
⁴Paris Descartes University, Imagine Institute, Paris, France
⁵Pediatric Hematology-Immunology Unit, Necker Hospital for Sick Children, Paris, France
⁶Center for the Study of Primary Immunodeficiencies, Paris AP-HP, Necker Hospital for Sick Children, Paris, France

9:45 AM

206

Dominant NFKB1 Mutations Cause Antibody Deficiency and Autoinflammatory Episodes

Emma M Haapaniemi, MD, PhD¹^*, Meri Kaustio, M.Sc.²^*, Helka Nurkkala, M.Sc.³^*, Merja Helminen, MD, PhD⁴^*, Satu Mustjoki, MD, PhD^5,6, Einarsdottir Elisabet¹^*, Sahu Biswajyoti⁷^*, Sanna Kilpinen, MD, PhD⁴^*, Jaana Syrjänen, MD, PhD⁴^*, Samuli Rounioja, MD, PhD⁴^*, Christopher Fogarty, M.Sc.⁸^*, Virpi Glumoff, PhD⁹^*, Petri Kulmala, MD, PhD¹⁰^*, Shintaro Katayama, PhD¹^*, Fitsum Tamene, M.Sc.³^*, Timi Martelius, MD, PhD¹¹^*, Luca Trotta, MSc¹²^*, Ekaterina Morungova, PhD¹^*, Jussi Taipale, PhD¹^*, Janna Saarela, MD, PhD¹³^*, Juha Kere, MD, PhD¹^*, Markku Varjosalo³^* and Mikko Seppänen, MD, PhD¹¹^*

¹Karolinska Institute, Department of Biosciences and Nutrition, Stockholm, Sweden
²University of Helsinki, Institute for Molecular Medicine Finland, Helsinki, Finland
³University of Helsinki, Institute of Biotechnology, Helsinki, Finland
⁴Tampere University Hospital, Tampere, Finland
⁵Hematology Research Unit Helsinki (HRUH), Department of Hematology, University of Helsinki and Helsinki University Central Hospital Comprehensive Cancer Center, Helsinki, Finland
⁶Hematology Research Unit Helsinki, University of Helsinki and Department of Hematology, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland
⁷Genome Scale Biology Program, Helsinki, Finland
⁸University of Helsinki, Folkhälsan Institute of Genetics, Helsinki, Finland
⁹University of Oulu, Oulu, Finland
¹⁰Oulu University Hospital, Oulu, Finland
¹¹Helsinki University Central Hospital, Helsinki, Finland
¹²Institute for Molecular Medicine Finland, Helsinki, Finland
¹³Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland

10:00 AM

207

Microrna 29b Mediates Immune Evasion of Natural Killer Cells in Acute Myeloid Leukemia

Steven Scoville, BS¹, Bethany Mundy-Bosse, PhD²^*, Michael Zhang³^*, Li Chen⁴^*, Ryan Sanderson³^*, Tiffany Hughes, BS, PhD⁵^*, Ramiro Garzon, MD², Anjali Mishra, Ph.D.⁶, Stefan Costinean⁷^*, Carlo M. Croce, MD⁶, Aharon G. Freud, MD, PhD¹^* and Michael A. Caligiuri, MD⁶

¹The Ohio State University, Columbus, OH
²Comprehensive Cancer Center, The Ohio State University, Columbus, OH
³the ohio state university, columbus
⁴The Ohio State University, columbus, OH
⁵Ohio State University, Columbus, OH
⁶The Ohio State University Comprehensive Cancer Center, Columbus, OH
⁷University of Nebraska Medical Center, Omaha, NE

10:15 AM

208

Impact of Kindlin-3 in NK Cell-Mediated Anti-Tumor Cytotoxicity and Inflammatory Cytokine Production

Nathan J. Schloemer, MD^1,2^*, Alex M Abel, MS^1,3^*, Monica S Thakar, MD^1,2, Yan-Qing Ma, PhD^3,4^* and Subramaniam Malarkannan, PhD^1,5,6,7^*

¹Laboratory of Molecular Immunology and Immunotherapy, Blood Research Institute, Milwaukee, WI
²MACC Fund Center, Division of Pediatric Hematology/Oncology/Blood and Marrow Transplant, Medical College of Wisconsin, Milwaukee, WI
³Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI
⁴Laboratory of Integrin Biology, Blood Research Institute, Milwaukee, WI
⁵Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI
⁶Department of Medicine, Medical College of Wisconsin, Milwaukee, WI
⁷Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI

10:30 AM

209

mTORC1 Signaling and Metabolism Are Dynamically Regulated during Human NK Cell Maturation and in Adaptive NK Cell Responses to Viral Infection

Cichocki Frank¹^*, Bin Zhang¹^*, Martin Felice¹^*, Bruce R. Blazar, MD^1,2 and Jeffrey S. Miller, MD¹

¹Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN
²Division of Pediatrics, Department of Medicine, University of Minnesota Cancer Center, Minneapolis, MN

10:45 AM

210

Modulation of Natural Killer Cell Activity in the Setting of Oncolytic Virotherapy and with a Chimeric Antigen Receptor

Chen Xilin¹^*, Jianfeng Han¹^*, Chu Jianhong¹^*, Walter Meisen¹^*, Zhang Jianying¹^*, E. Antonio Chiocca²^*, Balveen Kaur¹^*, Michael A. Caligiuri, MD¹ and Jianhua Yu, PhD¹

¹The Ohio State University Comprehensive Cancer Center, Columbus, OH
²Harvard Medical School, Boston, MA

See more of: Lymphocytes, Lymphocyte Activation and Immunodeficiency, including HIV and Other Infections
See more of: Oral and Poster Abstracts

<< Previous Session | Next Session >>

^*signifies non-member of ASH

203.O1.6 203. Lymphocytes, Lymphocyte Activation and Immunodeficiency, including HIV and Other Infections: Novel Immunodeficiencies and Natural Killer Cell Biology