Naoya Uchida¹, Fujita Atsushi^1*, Haro-Mora J Juan^1*, Thomas Winkler, MD^2* and John F Tisdale, MD¹

¹Molecular and Clinical Hematology Branch, NHLBI/NIDDK, National Institutes of Health, Bethesda, MD
²Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD

Kyung-Rok Yu, PhD^1*, Chuanfeng Wu, PhD^2*, Diego Espinoza^1*, Idalia Yabe^1*, Sandhya R. Panch, MD, MPH¹, So Gun Hong, PhD^1*, Samson Jonathan Koelle, BA^1*, Rong Lu^3*, Aylin Bonifacino^1*, Alan Krouse^1*, Mark Metzger^1*, Robert Donahue, VMD¹ and Cynthia E. Dunbar, MD⁴

¹Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD
²National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD
³Department of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine, University of Southern California, Los Angeles, CA
⁴Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD

Keisuke Sumide, Phar.B.^1*, Yoshikazu Matsuoka, Ph.D.^1*, Ryusuke Nakatsuka, Ph.D.^1*, Hiroshi Kawamura, M.D.^1*, Tatsuya Fujioka, M.D., Ph.D.^1*, Yutaka Sasaki, M.D., Ph.D.^1*, Hiroaki Asano, Ph.D.^2* and Yoshiaki Sonoda, M.D., Ph.D.¹

¹Department of Stem Cell Biology and Regenerative Medicine, Kansai Medical University, Hirakata, Japan
²School of Nursing, Kyoto Prefectural University of Medicine, Kyoto, Japan

Yurino Ayano, MD^1*, Takuji Yamauchi, MD, PhD^2*, Takuya Nunomura, MD^1*, Yasufumi Uehara, MD^1*, Fumiaki Jinnouchi, MD^1*, Shinya Daitoku, MD^1*, Yuya Kunisaki, MD, PhD^3*, Katsuto Takenaka, MD, PhD³ and Koichi Akashi, MD, PhD¹

¹Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
²Department of stem cell biology and medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
³Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan

Tomohiko Ishibashi, MD^1*, Takafumi Yokota, MD, PhD¹, Hirokazu Tanaka, MD, PhD², Michiko Ichii, MD, PhD^1*, Takao Sudo, MD, PhD^1*, Yusuke Satoh, MD, PhD³, Yukiko Doi, MD^1*, Akira Tanimura, MD, PhD^1*, Yuri Hamanaka, MD^1*, Sachiko Ezoe, MD, PhD^1*, Hirohiko Shibayama, MD, PhD¹, Kenji Oritani, MD, PhD^1* and Yuzuru Kanakura, MD, PhD¹

¹Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita, Japan
²Department of Hematology and Rheumatology, Kinki University Faculty of Medicine, Osaka-Sayama, Osaka, Japan
³Department of Lifestyle Studies, Kobe Shoin Women's University, Kobe, Japan

Stefanie Kreutmair^1*, Rouzanna Istvanffy, PhD^2*, Cathrin Klingeberg, PhD^3*, Christine Dierks, MD^3*, Christian Peschel, MD², Robert A.J. Oostendorp, BSc, MSc, PhD^2*, Justus Duyster, MD, PhD^4* and Anna Lena Illert, MD^3*

¹Dept. of Hematology, Oncology and Stem Cell Transplantation, University Medical Center, Freiburg, Germany
²Hematology/ Oncology, Klinikum r. d. Isar, Technical University of Munich, Munich, Germany
³Department of Hematology, Oncology and Stem Cell Transplantation, University Medical Center Freiburg, Freiburg im Breisgau, Germany
⁴Department of Hematology&Oncology+Comprehensive Cancer Center Freiburg (CCCF), University of Freiburg Medical Center, Freiburg, Germany

Matteo Marchesini, PhD^1*, Yamini Ogoti^1*, Irene Ganan-Gomez, PhD, MSc^1*, Yue Wei, PhD¹, Carlos E. Bueso-Ramos², Guillermo Garcia-Manero, MD³, Ronald A. DePinho^4* and Simona Colla, PhD^1*

¹Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX
²Department of Leukemia, MDACC, Houston, TX
³Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, Houston, TX
⁴Department of Cancer Biology, MDACC, Houston, TX

Ying Xie, PhD^1*, Xin Hu, PhD^1,2* and Zhe Li, PhD³

¹Department of Medicine, Division of Genetics, Brigham & Women's Hospital, Harvard Medical School, Boston, MA
²School of Life Sciences, Jilin University, Changchun, China
³Department of Medicine, Division of Genetics, Brigham & Women’s Hospital, Harvard Medical School, Boston, MA

Ling Tian, PhD^* and Lukas D. Wartman, MD

Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO

Kutay Karatepe, MS^1,2* and Hongbo R. Luo, PhD^1,3

¹Boston Children's Hospital, Boston, MA
²Harvard University, Cambridge, MA
³Harvard Medical School, Boston, MA

Xiao Yan^1,2, Heather A Himburg, PhD^2*, Phuong L Doan, MD³, Mamle Quarmyne, PhD^2*, Evelyn Tran^2*, Liman Zhao^2*, Nelson J. Chao, MD³ and John P Chute, MD^2,4,5

¹Department of Pharmacology and Cancer Biology, Duke University, Durham, NC
²Division of Hematology/Oncology, Department of Medicine, UCLA, Los Angeles, CA
³Dept. of Medicine, Div. of Hematological Malignancies & Cellular Therapy, Duke University Medical Center, Durham, NC
⁴CA Broad Center for Regenerative Medicine and Stem Cell Research, UCLA, Los Angeles, CA
⁵Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA

David E. Muench, MEng, Chinavenmeni S. Velu, PhD, Andre Olsson, Ph.D.^*, Sara E. Meyer, PhD and H. Leighton Grimes, PhD

Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

Kellie R Machlus, PhD^1*, Kelly Elizabeth Johnson, PhD^2*, Rajesh Kulenthirarajan^3*, Saleh El-Husayni^4*, Jodi A Forward^4*, Stephen K Wu^3*, Joseph E Italiano Jr., PhD¹ and Elisabeth M. Battinelli, MD, PhD³

¹Brigham and Women's Hospital/Harvard Medical School, Boston, MA
²Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
³Brigham and Women's Hospital, Boston, MA
⁴Hematology, Brigham and Women's Hospital, Boston, MA

Kathryn Matthews, MSc^*, Irina Eberle-Ayres, PhD^*, Katherine Lu, PhD, MD^*, Nishi Singh, PhD^*, Murray J Cutler, PhD^* and David Bell, PhD

Drug Development, Therapure Biopharma Inc., Mississauga, ON, Canada

Hiroki Kato, MD^1,2*, Ari Itoh-Nakadai, PhD^1*, Risa Ebina-Shibuya, MD^1*, Masahiro Kobayashi, MD, PhD^2*, Mitsuyo Matsumoto, PhD^1*, Akihiko Muto, PhD^1*, Tohru Fujiwara, MD, PhD^2*, Hideo Harigae, MD, PhD² and Kazuhiko Igarashi, MD, PhD^1*

¹Department of Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan
²Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan

Heidi Anderson^1*, Taylor Patch^2*, Pavan Reddy^3*, Elliott Hagedorn^3*, Owen J. Tamplin, PhD⁴, Daniel E. Bauer, M.D., Ph.D.⁵, Barry H. Paw, M.D., Ph.D.⁶, Dietmar Vestweber^7*, Leonard I. Zon, M.D⁸, Stuart H. Orkin, M.D.⁹, George Q. Daley, MD, PhD¹⁰ and Dhvanit I. Shah, Ph.D.^11,12

¹Brigham and Women's Hospital, Harvard Medical School, Boston, MA
²Brigham and Women's Hospital, Boston, MA
³Boston Children's Hospital, Boston, MA
⁴Stem Cell Program and Division of Hematology/Oncology, Children's Hospital Boston, Boston, MA
⁵Pediatric Hematology-Oncology, Boston Children's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
⁶Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
⁷Max Plank Institute for Molecular Biomedicine, Muenster, Germany
⁸Stem Cell Program and Division of Hematology/Oncology, Howard Hughes Medical Institute, Boston Children's Hospital/Harvard Medical School, Boston, MA
⁹Department of Pediatric Oncology, Boston Children's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, HHMI, Boston, MA
¹⁰Hematology/Oncology, Boston Children's Hospital, Boston, MA
¹¹Hematology Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
¹²Harvard Stem Cell Institute, Cambridge, MA

Zhenrui Li, MS¹, Keiyo Takubo, MD, PhD^2*, Pengxu Qian, PhD¹, Toshio Suda, MD, PhD³ and Linheng Li, PhD¹

¹Stowers Institute for Medical Research, Kansas City, MO
²Department of Stem Cell Biology, National Center for Global Health and Medicine, Tokyo, Japan
³Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, Tokyo, Japan

Bin-Kuan Chou, PhD^1*, Hao Bai, PhD^2*, Yongxing Gao^1*, Ying Wang^1*, Zhaohui Ye, PhD¹, Erika Mijin Kwon, PhD^3*, Pu Paul Liu, MD, PhD⁴, Alan D. Friedman, MD⁵, Zack Z. Wang, PhD² and Linzhao Cheng, PhD⁶

¹Division of Hematology and Stem Cell Program in the Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD
²Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD
³Translational and Functional Genomics Branch, NIH, NHGRI, Bethesda, MD
⁴Oncogenesis and Development Section/NHGRI, National Institutes of Health, Bethesda, MD
⁵Pediatric Oncology, Johns Hopkins University School of Medicine, Baltimore, MD
⁶Division of Hematology and Stem Cell Program in the Institute for Cell Egineering, Johns Hopkins University School of Medicine, Baltimore, MD

Tatsuya Imi^1*, Hiroyuki Maruyama, MD^1*, Takamasa Katagiri, PhD^1*, Yoshitaka Zaimoku, MD^1*, Kana Maruyama, MD^1*, Noriharu Nakagawa, MD^1*, Kohei Hosokawa, MD, PhD^1*, Ken Ishiyama^1*, Hirohito Yamazaki, MD, PhD^1*, Koichi Kashiwase, MD, PhD^2* and Shinji Nakao, MD, PhD¹

¹Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
²Japanese Red Cross Kanto-Koshinetsu Block Blood Center, Tokyo, Japan

Kam Tong Leung, PhD^1*, Karen Li, PhD^1*, Yorky Tsin Sik Wong, BSc^1*, Kathy Yuen Yee Chan, PhD^1*, Xiao-Bing Zhang, PhD^2*, Alex Wing Kwan Leung, MRCPCH^1*, Tak Yeung Leung, MD^3*, Kam Sze Tsang, PhD^4*, Pak Cheung Ng, MD, FRCPCH^1* and Chi Kong Li, MD¹

¹Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong, Hong Kong
²Department of Medicine, Loma Linda University, Loma Linda, CA
³Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong, Hong Kong
⁴Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children’s Research Hospital, Memphis, TN

Orna Steinberg Shemer, MD, MSc^1*, Marta Byrska-Bishop, PhD^2*, Jacob C Ulirsch^3,4*, Osheiza Abdulmalik, DVM, MS⁵, Yu Yao, MD^6*, Ah Ram Kim, PhD^3,4*, Paul Gadue, PhD^5*, Paul D. Kingsley, PhD⁷, Deborah French, PhD^5*, Ross C. Hardison, PhD^2*, James Palis, MD⁷, Vijay G Sankaran, MD, PhD^3,4 and Mitchell J Weiss, MD, PhD^1,6*

¹Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA
²Penn State University, State College, PA
³Division of Hematology/Oncology, Boston Children’s Hospital, Boston, MA
⁴Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
⁵Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA
⁶Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN
⁷Pediatrics, University of Rochester, Rochester, NY

Zhi-Jian Liu, Ph.D.¹, Ioana Nitulescu^2*, Henry Pelish, Ph.D.^2*, Matthew Shair, Ph.D.^2* and Martha Sola-Visner, MD³

¹Division of Newborn Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA
²Department of Chemistry and Chemical Biology, Harvard University, Cambridge
³Division of Newborn Medicine, Boston Children's Hospital, Boston, MA

Avishek Ganguly, PhD^1*, Omar S. Aljitawi, MD² and Soumen Paul, PhD^3*

¹Pathology & Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS
²Division of Hematology/Oncology, University of Kansas Medical Center, Kansas City, KS
³University of Kansas Medical Center, Kansas City, KS

Lei Sun, Ph.D.

Mouse Cancer Genetics Program, National Cancer Institute, National Institutes of Health, Frederick, MD

Darlene Monlish, PhD^*, Angela Herman, MD^*, Molly Romine^*, Sima Bhatt, MD^* and Laura G. Schuettpelz, MD, PhD

Washington University School of Medicine, St. Louis, MO