Yiwei Zhou^*, Zhiyuan Ma, PhD^*, Shiang Huang, MD, Zhenhui Li^*, Beining Lei^*, Fang Zou^*, Qijiao Li^*, Liang Liang^*, Li Sun^* and Jie Zhang, MS^*

Wuhan Kindstar Biotech Technology Co., Ltd, Wuhan, China

Jamin Wu, MD^1*, Alec Chu, BS^2*, Jang Cho, MD^2*, Misha Movahed-Ezazi, MD^1*, Kristyn Galbraith, MD^1*, Chanel Schroff, BA^1*, Yiying Yang, MS^1*, Jon-Matthew Belton, PhD^3*, Valentina Nardi, MD^4*, Abner Louissaint, MD, PhD^4*, Dennis Shasha, PhD^5*, Tatyana Gindin, MD, PhD^1*, Minji Kim, PhD^6*, Marcin P Cieslik, PhD^2*, Anthony Schmitt, PhD^3*, Matija Snuderl, MD^1* and Russell J. H. Ryan, MD²

¹Department of Pathology, NYU Langone Health, New York, NY
²Department of Pathology, University of Michigan Medical School, Ann Arbor, MI
³Arima Genomics, Carlsbad, CA
⁴Massachusetts General Hospital, Boston, MA
⁵Courant Institute of Mathematical Sciences, New York University, New York, NY
⁶Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI

Yuqing Wang^1,2*, Shuo Wang^1*, Hongmei Yi^3*, Yue Wang^1*, Haimin Xu^3*, Shuang Tian^1*, Yan Dong^1*, Jing Zhao^1*, Di Fu^1*, Rongji Mu^4*, Shuye Wang^2*, Li Wang^1*, Pengpeng Xu, MD¹ and Wei Li Zhao, MD¹

¹Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics; National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China, Shanghai, China
²Department of Hematology, The First Affiliated Hospital of Harbin Medical University, Harbin, China, Harbin, China
³Department of Pathology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China, Shanghai, China
⁴Department of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Shanghai, China

Dante Adami^1*, Sebastian Riechert^1*, Tim Schmittmann^1*, Markus Badstübner, MSc^1*, Karsten Wendt, PhD^1,2,3*, Stefani Barbara Parmentier, MD⁴, Katja Sockel, MD^5*, Frank P. Kroschinsky, MD, MBA⁵, Martin Bornhäuser, MD^5,6,7*, Jan Moritz Middeke, MD^1,2,5* and Jan-Niklas Eckardt^1,8,9*

¹Cancilico GmbH, Dresden, Germany
²Else Kroener Fresenius Center for Digital Health, Technical University Dresden, Dresden, Germany
³Chair of Software Technology, Technical University Dresden, Dresden, Germany
⁴Tumorzentrum, St. Claraspital, Basel, Switzerland
⁵Department of Internal Medicine I, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany
⁶National Center for Tumor Diseases Dresden (NCT/UCC), Technical University Dresden, Dresden, Germany
⁷German Consortium for Translational Cancer Research DKFZ, Heidelberg, Germany
⁸Else Kroener Fresenius Center for Digital Health, TUD Dresden University of Technology, Dresden, Germany
⁹Department of Internal Medicine I, University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany

Connor Kunihiro^*, Dagmar Walter, PhD^*, Yinzhou Zhu, PhD^*, Kelly Martin, PhD^*, Jawad Abousoud^*, Tingsheng Drennon, PhD^*, Nandhini Raman^*, Veronica Rodriguez^*, Yina Li^*, Jill Herschleb, PhD^* and Josephine Lee, PhD^*

10x Genomics, Pleasanton, CA

Ka Young Kim, MD^1*, Sung-Soo Park, MD, PhD^1,2*, Na Yung Kim^3*, Ji-Young Lim^1,2*, Jung Yeon Lee^1,2*, Sujin Yun^3*, Yeun-Jun Chung^3,4,5*, Seung-Hyun Jung^3,5,6*, Jae-Ho Yoon, MD, PhD¹, Hee-Je Kim¹ and Chang-Ki Min^1,2,3*

¹Department of Hematology, Seoul St. Mary’s Hematology Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)
²Catholic Research Network for Multiple Myeloma, Catholic Hematology Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)
³Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)
⁴Department of Microbiology, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)
⁵Integrated Research Center for Genome Polymorphism, Precision Medicine Research Center, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)
⁶Department of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)

Szu-Ying Chen, PhD^1*, Martin Cienciala^2*, Tasfia Rashid^1*, Bonell Patino Escobar^3*, Laura Berne^2*, Daniel Georgiev^2* and Arun P Wiita, MD, PhD^4,5,6,7

¹Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA
²Department of Research & Development, Sampling Human, Berkeley, CA
³University of California San Francisco, San Francisco, CA
⁴Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA
⁵Chan Zuckerberg Biohub, San Francisco, CA
⁶Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA
⁷Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA

Curtis Gravenmier, MD^1*, Sadegh Marzban^2*, Ling Zhang, MD^3*, Lynn C. Moscinski, MD⁴ and Jeffrey West, PhD^2*

¹Department of Hematopathology and Laboratory Medicine, Moffitt Cancer Center & Research Institute, Tampa
²Integrated Mathematical Oncology Department, Moffitt Cancer Center & Research Institute, Tampa, FL
³Hematopathology and Laboratory Medicine, Moffitt Cancer Center & Research Institute, Tampa, FL
⁴Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL

Arda Durmaz, PhD^1*, Carlos Bravo-Perez, MD^1,2*, Zachary Brady^1*, Matteo D'Addona^1,3*, Luca Guarnera, MD^1,4*, Serhan Unlu, MD¹, Hussein Awada¹, Praveena Thiagarajan, MD, PhD^1*, Yuriy Fedorov^5*, Drew Adams^6*, Carmelo Gurnari, MD, PhD^4,7, Jacob G. Scott, MD, DPhil^1*, Jaroslaw Maciejewski¹ and Valeria Visconte, PhD⁸

¹Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
²Department of Hematology and Medical Oncology, Hospital Universitario Morales Meseguer, University of Murcia, IMIB-Pascual Parrilla, CIBERER - Instituto de Salud Carlos III, Murcia, Spain
³Hematology and Transplant Center, University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, Ercolano, Italy
⁴Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy
⁵Small Molecule Drug Development Core Facility, Case Western Reserve University School of Medicine, Cleveland
⁶Department of Genetics and Genome Sciences and Chemical Biology Program, Case Western Reserve University School of Medicine, Cleveland
⁷Cleveland Clinic Foundation, Cleveland, OH
⁸Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH

Saverio D'Amico, MSc^1,2*, Mattia Delleani^2*, Elisabetta Sauta, PhD^2*, Gianluca Asti, MSc^2*, Elena Zazzetti, MSc^2*, Alessia Campagna^2*, Luca Lanino, MD³, Giulia Maggioni, MD^2*, Marta Ubezio, MD^2*, Gabriele Todisco, MD^4*, Antonio Russo, MD^2*, Cristina Astrid Tentori, MD^2*, Alessandro Buizza, MD^2*, Marilena Bicchieri, PhD^2*, Matteo Zampini, PhD^3*, Matteo Brindisi^3*, Francesca Ficara, PhD^2*, Elena Riva, PhD^3*, Denise Ventura, MSc^3*, Laura Crisafulli, PhD^3*, Nicole Pinocchio, MSc^3*, Flavia Jacobs, MD^2*, Alberto Zambelli, MD^2*, Victor Savevski, MEng^2*, Armando Santoro, MD^5*, Tiziana Sanavia, PhD^6*, Cesare Rollo, PhD^6*, Flavio Sartori, MSc^6*, Piero Fariselli, PhD^6*, Guillermo Sanz, MD, PhD⁷, Valeria Santini, MD⁸, Francesc Sole, PhD⁹, Uwe Platzbecker, MD¹⁰, Pierre Fenaux, MD¹¹, Maria Diez-Campelo, MD, PhD^12*, Shahram Kordasti, MD, PhD^13,14, Rami S. Komrokji, MD¹⁵, Guillermo Garcia-Manero, MD¹⁶, Torsten Haferlach, MD¹⁷, Amer M. Zeidan, MD¹⁸, Gastone Castellani, PhD^19* and Matteo Giovanni Della Porta, MD^2,20*

¹Train s.r.l., Milan, Italy
²IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
³IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy
⁴IRCCS Humanitas Research Hospital, Houston, TX
⁵IRCCS Humanitas Research Hospital, Rozzano, Italy
⁶Computational Biomedicine Unit, Department of Medical Sciences, University of Torino, Turin, Italy
⁷Hospital Universitario y Politécnico e Instituto de Investigación Sanitaria La Fe, Valencia, Spain
⁸MDS Unit, Hematology, AOUC, University of Florence, Florence, Italy
⁹Myelodysplastic Syndromes Research Group, Institut De Recerca Josep Carreras, Badalona, Barcelona, Spain
¹⁰Department for Hematology, Cell Therapy, Hemostaseology and Infectious Diseases, University of Leipzig Medical Center, Leipzig, Germany
¹¹Hôpital Saint-Louis, Université de Paris 7, Paris, France
¹²Hospital Clínico Universitario de Salamanca, Salamanca, Spain
¹³Hematology Unit, Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Ancona, Italy
¹⁴Kings College London, London, United Kingdom
¹⁵Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL
¹⁶Department of Leukemia, MD Anderson Cancer Center, Houston, TX
¹⁷MLL Munich Leukemia Laboratory, Munich, Germany
¹⁸Yale School of Medicine and Yale Comprehensive Cancer Center, Yale University, New Haven, CT
¹⁹Dipartimento di Scienze Mediche e Chirurgiche, Università di Bologna, Bologna, Italy
²⁰Department of Biomedical Sciences, Humanitas University, Milan, Italy

Erik R Sampson, PhD^1*, Yi-Chien Chang, PhD^1*, Kuan-Chun Huang, PhD^1*, Tom Lin, MS^1*, Prasanna Baskar, MS^1*, Mei-Ling Yang, PhD^1*, Ali Sepahi, PhD^1*, Dobeen Hwang, PhD^1*, Jack Huck, PhD^1*, Ming-Tang Chen, PhD^1*, Emily Huang^1*, Ivana Grbesa, PhD^2*, Francesco Lamanna, PhD^2*, Andreas Kramer, PhD^2*, Andrew Srisuwananukorn, MD³ and Lih-Ling Lin, PhD^1*

¹PharmaEssentia Innovation Research Center, Bedford, MA
²QIAGEN, LLC, Germantown, MD
³The Ohio State University, Columbus, OH

Paraic Behan^1*, Sahin Sarihan, BSc^1*, Megan Chiasson^1*, Pir Zainulabdeen Jan Sarhandi^1*, Joanna Fay^2*, John P Quinn^3*, Philip T Murphy^3*, Katherine M Sheehan^2* and Siobhan V Glavey¹

¹Departments of Haematology and Pathology, Beaumont RCSI Cancer Centre, Dublin, Ireland
²Department of Pathology, Beaumont RCSI Cancer Centre, Dublin, Ireland
³Department of Haematology, Beaumont RCSI Cancer Centre, Dublin, Ireland

Floris Chabrun, PhD, PharmD^1*, Jean-Baptiste Alberge, PhD¹, Sabine Allam, MD^1*, Jacqueline F Perry^1*, Habib El-Khoury, MD^1*, David J Lee, MD^1*, Michael Timonian, MD^1*, Luca Bertamini, MD^1*, Hadley Barr, BSc^1*, Grace Fleming, BSc^1*, Joseph Casey Flinn^1*, Ciara Murphy^1*, Sofia Wallin^1*, Hiba Hussain^2*, Elizabeth D. Lightbody, PhD¹, Sungjae Kim, PhD^3*, Mark C Perkins, PhD^4*, Stephen J. Harding, PhD⁵, Dhananjay Sakrikar, PhD^4*, Romanos Sklavenitis Pistofidis, MD, PhD^1*, Kenneth C. Anderson, MD⁶, Omar Nadeem, MD⁷, Elizabeth K. O'Donnell^8*, Yuxin Liu, MD⁹, Wenlong Chen^10*, Maureen Joffe^11*, Benjamin Levine Ebert, MD, PhD¹, Catherine R. Marinac, PhD¹, Gad Getz, PhD^3* and Irene Ghobrial, MD¹²

¹Dana-Farber Cancer Institute, Boston, MA
²Dana Farber Cancer Institute, Boston, MA
³Broad Institute of MIT and Harvard, Cambridge, MA
⁴Thermo Fisher Scientific, Waltham, MA
⁵The Binding Site Inc., Birmingham, United Kingdom
⁶Dana-Farber/Boston Children's Cancer and Blood Disorders Ctr, Boston, MA
⁷Center for Early Detection and Interception of Blood Cancers, Dana-Farber Cancer Institute, Boston, MA
⁸Dana Farber Cancer Institute, Boston
⁹Department of Internal Medicine, Section of Hematology, Yale University School of Medicine and Yale Cancer Center, New Haven, CT
¹⁰University of the Witwatersrand, Johannesburg, ZAF
¹¹University of the Witwatersrand, Johannesburg, South Africa
¹²Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA

Enayetur Raheem^1*, Zheng Lu^1*, Fred Zheng, MD^2*, Limei Cheng^1*, Peter Langmuir, MD^2* and Jennifer Sheng, PhD^1*

¹Incyte Research Institute, Wilmington, DE
²Incyte Corporation, Wilmington, DE

Carlos Pérez Míguez^1*, Adrian Mosquera Orgueira, MD, PhD^2*, Manuel Perez Encinas, MD^3*, Rebeca Rodriguez Veiga, MD, PhD^4*, Juan Miguel Bergua Burgues, MD^5*, Jesus Lorenzo Algarra^6*, Carmen Botella^7*, Jose Antonio Perez Simon^8*, Teresa Bernal^9,10,11*, Mar Tormo, MD^12*, Maria Calbacho, MD^13*, Olga Salamero, MD^14,15*, Josefina Serrano, MD^16*, Victor Noriega^17*, Juan Antonio Lopez Lopez^18*, Susana Vives, MD^19*, Mercedes Colorado, MD^20*, Jose Luis Lopez Lorenzo, MD^21*, Maria Vidriales Vicente^22*, Raimundo Garcia Boyero, MD^23*, Maria Teresa Olave Rubio^24*, Pilar Herrera Puente^25*, Olga Arce, MD^26*, Manuel Barrios Garcia^27*, Maria Jose Sayas Lloris, MD^28*, Marta Polo, MD^29*, Maria Isabel Gomez Roncero^30*, Eva Barragán, PhD^31*, Rosa Ayala, MD, PhD^32*, Carmen Chillon, MD^33*, Maria Jose Calasanz, PhD^34*, Blanca Boluda^35*, Andres Peleteiro Raindo^36*, Raquel Amigo^37*, David Martinez-Cuadron, PhD³⁸, Jorge Labrador, MD^39* and Pau Montesinos, PhD, MD^40*

¹University Hospital of Santiago de Compostela, Department of Hematology, Santiago de Compostela, Spain, Santiago de Compostela, Spain
²University Hospital of Santiago de Compostela, Department of Hematology, IDIS, SANTIAGO DE COMPOSTELA, Spain
³Department of Hematology, Hospital Unviersitario de Santiago de Compostela, IDIS, Santiago de Compostela, ESP
⁴Hospital Universitary i Politecnic La Fe, Valencia, ESP
⁵Hospital San Pedro de Alcántara, Caceres, Spain
⁶6. Hospital General de Albacete, Albacete, Spain
⁷Hospital General Universitario de Alicante, Alicante, Spain
⁸University Hospital Virgen del Rocío, Sevilla, Spain
⁹Hospital Universitario Central de Asturias, Oviedo, Spain
¹⁰Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Asturias, Spain
¹¹Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Asturias, Spain
¹²Department of Hematology, Hospital Clínico de Valencia, Valencia, Spain
¹³Hematology Department, Hospital Universitario 12 de Octubre, Madrid, Madrid, Spain
¹⁴Hematology Department, University Hospital Vall d’Hebron, Barcelona, Spain
¹⁵Experimental Hematology, Vall d’Hebron Institute of Oncology, Barcelona, Spain
¹⁶Department of Hematology, Hospital Universitario Reina Sofía, IMIBIC.UCO, Cordoba, ESP
¹⁷Hospital Clínico de A Coruña, A Coruña, Spain
¹⁸Hospital Universitario de Jaen, Jaen, Spain
¹⁹Hematology Department, Institut Catala d'Oncologia - Hospital Germans Trias i Pujol, Badalona, Spain
²⁰Hematology Department, University Hospital Marques de Valdecilla, Santander, Spain
²¹Fundacion Jimenez Diaz, Madrid, ESP
²²Hospital Universitario de Salamanca, Salamanca, Spain
²³Hospital General Universitario de Castellon, Castellon, Spain
²⁴Hospital Clinico Universitario Lorenzo Blesa, Zaragoza, ESP
²⁵Hospital Universitario Ramón y Cajal (IRYCIS), Madrid, Spain
²⁶Hospital Universitario de Basurto, Bilbao, Spain
²⁷Hospital Universitario Regional de Malaga, Malaga, Spain
²⁸Hospital Dr. Peset, Valencia, Spain
²⁹Department of Hematology, Hospital Universitario Clinico San Carlos, Madrid, Spain
³⁰Hospital Virgen de la Salud, Toledo, Spain
³¹Hospital Universitary i Politecnic La Fe, Valencia, Spain
³²Department of Hematology, Hospital Universitario 12 de Octubre, Madrid, Spain
³³Haematology Department, University Hospital of Salamanca, Research Biomedical Institute of Salamanca (IBSAL), CIBERONC and Center for Cancer Research-IBMCC (USAL-CSIC), Salamanca, Spain
³⁴Department of Hematology, Centre for Applied Medical Research, Cancer Center Clinica Universidad de Navarra, University of Navarra, IdiSNA, CIBERONC, Pamplona, Spain
³⁵Hospital Universitari I Politècnic La Fe, Valencia, ESP
³⁶University Hospital of Santiago De Compostela, Department of Hematology, IDIS, SANTIAGO DE COMPOSTELA, ESP
³⁷Instituto de Investigaciones Santiarias La Fe, Valencia, Spain
³⁸Hematology, Instituto de Investigación Sanitaria La Fe, Valencia, Spain
³⁹Department of Hematology, Hospital Universitario de Burgos, Universidad Isabel I, Burgos, Spain
⁴⁰Hematology, Hospital Universitari I Politécnic La Fe and Programa Español de Tratamientos en Hematología (PETHEMA) Group, Valencia, Spain

Xinhua Wang^1*, Zhiming Li, PhD, MD², Yu Chang, MD^3*, Shiyong Li^4*, Wei Wu^5*, Fangyuan Chang^6*, Yinyin Chang^7*, Dandan Zhu^7*, Mingzhi Zhang, MD³ and Mao Mao, MD, PhD⁸

¹The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China
²Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China
³The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
⁴"Research & Development, SeekIn Inc 11F, Building 2, DBH Life Sciences & Health Indust，518000", China, China
⁵Research & Development, SeekIn Inc 11F, Building 2, DBH Life Sciences & Health Indust，518000, Shenzhen, China
⁶Clinical Laboratories, Shenyou Bio, Zhengzhou, China
⁷Clinical Laboratories, Shenyou Bio, China, China
⁸Seekin, Shenzhen, China

Ai Guan, MD^1*, Kaini Shen, MD^2*, Wei Su^3*, Bing Wang^4*, Bin Ma, PhD⁵ and Jian Li, MD⁶

¹Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
²Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, CHN
³Department of Laboratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⁴Shanghai Kuaixu Biotechnology Co., Ltd, Shanghai, China
⁵Rapid Novor Inc., Kitchener, ON, Canada
⁶Department of Hematology, Peking Union Medical College Hospital, Beijing, China

Gianluca Asti, MSc^1*, Saverio D'Amico, MSc^1,2*, Luciana Carota, PhD^3*, Davide Piscia, MSc^4*, Francesco Casadei, MSc^5*, Nono Saha Cyrille Merleau, PhD^6,7*, Patricia Alonso de Apellániz, MSc^8*, Anne Sophie Kubasch, MD⁹, Silke Gloaguen, MSc^9*, Nicole Modler, MSc^9*, Catalina Gonzalez Martin, MSc^10*, Cesare Rollo, PhD^11*, Juan Parras, PhD^8*, Mattia Delleani^1*, Elena Zazzetti, MSc^1*, Elisabetta Sauta, PhD^1*, Nico Curti, PhD^12*, Nicolas Riccardo Derus, PhD^12*, Gianluca Carlini, PhD^5*, Daniele Dall'Olio, PhD^13*, Claudia Sala, PhD^3*, Lorenzo Dall'Olio, PhD^5,12*, Luca Lanino, MD¹⁴, Giulia Maggioni, MD^1*, Alessia Campagna, MD^1*, Marilena Bicchieri, PhD^1*, Arturo Bonometti, MD^1*, Cesare Lancellotti, MD^15*, Daoud Rahal, MD^1*, Luca Di Tommaso, MD^1,16*, Tiziana Sanavia, PhD^11*, Piero Fariselli, PhD^11*, Matteo Zampini, PhD^17*, Matteo Brindisi^14*, Victor Savevski, MEng^1*, Uwe Platzbecker, MD¹⁸, Maria Diez-Campelo, MD, PhD^19*, Lin Pierre Zhao, MD, PhD^20*, Pierre Fenaux, MD²⁰, Torsten Haferlach, MD²¹, Vincent Planat, PhD^10*, Raffaella Colombatti, MD, PhD²², Maria del Mar Mañú-Pereira, PhD^23*, Anders Krogh, PhD^24*, Silvia Uribe, PhD^25*, Santiago Zazo, Prof., PhD^8*, Enrico Giampieri, PhD^3*, Gastone Castellani, PhD^26*, Matteo Giovanni Della Porta, MD^1,16* and Federico Alvarez, Prof, PhD^8*

¹IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
²Train s.r.l., Rozzano, Milan, Italy
³University of Bologna, Bologna, Italy
⁴Centro Nacional de Análisis Genómico - CNAG, Barcelona, Spain
⁵Data Science and Bioinformatics Laboratory, IRCCS Institute of Neurological Sciences of Bologna, Bologna, Italy
⁶Max Planck Institute for Mathematics in the Sciences, Leipzig, Germany
⁷Center for Scalable Data Analytics and Artificial Intelligence, University of Leipzig, Leipzig, Germany
⁸Information Processing and Telecommunications Center, Universidad Politécnica de Madrid, Madrid, Spain
⁹Medical Clinic and Policlinic 1, Hematology and Cellular Therapy, Leipzig, Germany
¹⁰Dedalus Spain, Madrid, Spain
¹¹Computational Biomedicine Unit, Department of Medical Sciences, University of Torino, Turin, Italy
¹²Department of Physics and Astronomy, University of Bologna, Bologna, Italy
¹³IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy
¹⁴IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy
¹⁵Struttura Complessa di Anatomia Patologica, Policlinico di Modena, Modena, Italy
¹⁶Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy
¹⁷IRCCS Humanitas Research Hospital & Humanitas University, Rozzano - Milan, Italy
¹⁸Department for Hematology, Cell Therapy, Hemostaseology and Infectious Diseases, University of Leipzig Medical Center, Leipzig, Germany
¹⁹Hospital Clínico Universitario de Salamanca, Salamanca, Spain
²⁰Hôpital Saint-Louis, Université de Paris 7, Paris, France
²¹MLL Munich Leukemia Laboratory, Munich, Germany
²²Department for Woman's and Child's Health, University of Padova, Padova, Italy
²³Translational Research in Cancer and Blood disorders in Children, Valll d'Hebron Research Institution, Barcelona, Spain
²⁴University of Copenhagen, Copenhagen, DNK
²⁵Escuela Técnica Superior de Ingeniería de Sistemas Informáticos, Universidad Politécnica de Madrid, Madrid, Spain
²⁶Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy

Byungsan Choi, PhD^1*, Minsoo Kang, PhD^1* and Janghee Woo, MD, PhD²

¹PROTEINA Co., Ltd., Seoul, Korea, Republic of (South)
²Winship Cancer Institute of Emory University, Atlanta, GA

Palak Dave^1*, Jordan Rai^2*, Ling Zhang, MD³, Mohammad Omar Hussaini, MD^4*, Mary Ellen Walker^5*, Nancy Gillis, PhD^6,7, Mikkael A. Sekeres, MD⁸, Amy E. DeZern, MD, MHS⁹, Eric Padron, MD¹⁰, Rami S. Komrokji, MD¹⁰ and Issam El Naqa^11*

¹Department of Machine Learning, H. Lee Moffitt Cancer and Research Institute, Wesley Chapel, FL
²Department of Machine Learning, H. Lee Moffitt Cancer and Research Institute, Tampa, FL
³Department of Pathology and Laboratory Medicine, H. Lee Moffitt Cancer and Research Institute, Tampa, FL
⁴Department of Pathology and Laboratory Medicine, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
⁵Department of Cancer Epidemiology, H. Lee Moffitt Cancer and Research Institute, tampa, FL
⁶Department of Cancer Epidemiology, Moffitt Cancer Center and Research Institute, Tampa, FL
⁷Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
⁸Division of Hematology, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL
⁹Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD
¹⁰Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
¹¹Department of Machine Learning, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL

Dylan C. Webb, BS^1,2*, Cesar Colorado-Jimenez, MS^1*, Maly Fenelus, MD, MPH^1*, Siddharth Singi, MS^3*, Zhanghan Yin, BS^1,2*, Sean Paulsen, PhD^1*, K. Hasan Bilal, MD^4*, A. Zara Herskovitz, MD, PhD^4*, Samuel McCash, MD^1*, Linlin Wang, MD, PhD^5*, Mikhail Roshal, MD, PhD^1*, Lauren McVoy, MD, PhD¹, Chad Vanderbilt, MD^1*, Ahmet Dogan, MD, PhD³ and Gregory Mark Goldgof, MD, PhD^1*

¹Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
²Department of Statistics, University of California, Berkeley, CA
³Memorial Sloan Kettering Cancer Center, New York, NY
⁴Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York
⁵Department of Laboratory Medicine, University of California-San Francisco, San Francisco

Shouvik Mani, MS^1*, Fabian Grubert, MD, PhD^2*, Dita Gratzinger, MD, PhD^2*, Anshul Kundaje, PhD^1,3* and Maya Kasowski, MD, PhD^2,4*

¹Department of Computer Science, Stanford University, Stanford, CA
²Department of Pathology, Stanford University School of Medicine, Stanford, CA
³Department of Genetics, Stanford University, Stanford, CA
⁴Sean N. Parker Center for Allergy and Asthma Research, Stanford University School of Medicine, Stanford, CA

Borhan R. R Saeed, PhD^1,2*, Anastasia Saboli, MSc^1,3*, Anna Rehammar, PhD^4*, Adam Molnar, MSc^1*, Erik Delsing Malmberg, MD, PhD^5*, Barbara Depreter, PhD^6*, Giti Shah Barkhordar, MSc^1,7*, Barbara De Moerloose, MD, PhD^6,8,9*, Tim Lammens, PhD^6,8,9*, Lars Palmqvist, MD, Professor^10,11, Jonas Abrahamsson, MD, PhD, Professor^3,12* and Linda Fogelstrand, MD^1,3

¹Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
²Department of Pathology and Neuropathology and Comprehensive Cancer Center, Tübingen University Hospital, Tuebingen, CA, Germany
³Region Vastra Gotaland, Sahlgrenska University Hospital, Gothenburg, Sweden
⁴School of Public Health and Community Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
⁵Department of Pathology, Region Vastra Gotaland, Sahlgrenska University Hospital, Gothenburg, Sweden
⁶Department of Internal Medicine and Pediatrics, University of Ghent, Ghent, Belgium
⁷Department of Clinical Genetics and Genomics, Region Vastra Gotaland, Sahlgrenska University Hospital, Gothenburg, Sweden
⁸Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium
⁹Cancer Research Institute Ghent (CRIG), Ghent, Belgium
¹⁰Department of Clinical Chemistry, Region Vastra Gotaland, Sahlgrenska University Hospital, Gothenburg, Sweden
¹¹Department of Laboratory Medicine, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden
¹²Department of Pediatrics, Institute for Clinical Sciences, University of Gothenburg, Gothenburg, Sweden

Alex Liu, BSc^1*, Severine Cathelin, PhD^2*, Yitong Yang^1*, Farzaneh Aboualizadeh^3*, Amina Abow^3*, Gurbaksh Basi^3*, Lance Li^1*, David L Dai^1*, Abdula Maher^4*, Eric Grignano, MD, PhD^3*, Mohsen Hosseini, PhD^2*, Dhanoop Manikoth Ayyathan, PhD^2*, Vivian Wang^1*, Troy Ketela, PhD^3*, Dylan Marchione, PhD^5*, Adriana Tron, PhD^5*, Andrea Arruda^3*, Mark D. Minden, MD, PhD^1,3* and Steven M. Chan, MD, PhD^1,6

¹Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
²Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada
³Princess Margaret Cancer Centre / University Health Network, Toronto, ON, Canada
⁴Institute of Medical Science, University of Toronto, Toronto, ON, Canada
⁵Servier Pharmaceuticals LLC, Boston, MA
⁶Princess Margaret Cancer Centre, Toronto, ON, Canada

Lydian A. De Ligt, MD^1,2,3*, Eelke Brandsma^2*, Aafke E. Gaartman^2,4*, Guusje Van Gameren^2*, Colin Blans^2*, Martijn Veldthuis^2*, Hanke Matlung^2*, Bart J. Biemond⁴, Erfan Nur^2,4*, Emile Van Den Akker^2* and Robin van Bruggen^2*

¹Department of Hematology, Amsterdam University Medical Centers, Amsterdam, AL, Netherlands
²Department of Molecular Hematology, Sanquin Research and Landsteiner Laboratory, Amsterdam, Netherlands
³Department of Pediatric Hematology, Emma Children's Hospital, Amsterdam University Medical Centers, Amsterdam, Netherlands
⁴Department of Hematology, Amsterdam University Medical Centers, Amsterdam, Netherlands