Suganti Shivaram, M.B.B.S^1*, Huihuang Yan, PhD^2*, Hongwei Tang, PhD^1*, Hans M. Anderson^3*, Marcella Kaddoura, M.D.^4*, J Erin Wiedmeier-Nutor, MD, MPH⁵, Shulan Tian, PhD^2*, Michael D Howe^6*, Abiola Bolarinwa, MBBS, FMCPath^7*, Cinthya Zepeda Mendoza, PhD^8*, Vikas A Gupta, MD, PhD^9*, Stacey Lehman^1*, Constantine S Mitsiades, MD¹⁰, P. Leif Bergsagel, MD¹¹, Esteban Braggio, PhD¹², Lawrence H. Boise, PhD¹³, Rafael Fonseca, MD¹⁴, Francesco Maura, MD¹⁵, Shaji Kumar, MD¹⁶ and Linda B. Baughn, PhD¹

¹Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
²Division of Computational Biology, Mayo Clinic, Rochester, MN
³Chemistry Department, Carleton College, Northfield, MN
⁴Myeloma Service, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL
⁵Division of Hematology, Mayo Clinic, Phoenix, AZ
⁶Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN
⁷Mayo Clinic, Rochester, MN
⁸Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester
⁹Winship Cancer Institute, Emory University, Atlanta, GA
¹⁰Ludwig Center, Harvard Medical School, Brookline, MA
¹¹Mayo Clinic Arizona, Phoenix, AZ
¹²Division of Hematology and Oncology, Mayo Clinic, Scottsdale, AZ
¹³Emory University, Atlanta, GA
¹⁴Division of Hematology, Mayo Clinic, Paradise Valley, AZ
¹⁵University of Miami, Coral Gables, FL
¹⁶Division of Hematology, Mayo Clinic, Rochester, MN

Jason I. Avigan, MD^*, Dylan C Gagler^*, Hussein Ghamlouch, PhD^*, Patrick Blaney, MS^*, Di Zhang, MS^*, Faith E Davies, MD and Gareth Morgan, M.D., Ph.D.^*

Perlmutter Cancer Center, Multiple Myeloma Research Program, NYU Langone Health, New York, NY

Junko Tsuji, PhD^1*, Elizabeth D. Lightbody, PhD^1,2, Romanos Sklavenitis-Pistofidis, MD^1,2, Ting Wu, MS^1*, Michael P. Agius, PhD^3*, Danielle T. Firer, BS^1*, Mahshid Rahmat, PhD^2*, Hadley Barr, BSc^2*, Yoshinobu Konishi, MD, PhD^1,4, Ankit K. Dutta, PhD^2*, Jean-Baptiste Alberge, PhD^1,2, Nang Kham Su, MSc^2*, Cody J. Boehner, BSc^2*, Michelle P. Aranha, PhD^1,2*, Laura Hevenor^2*, Katherine Towle^2*, Erica M. Horowitz, BA^2*, Maya Davis, BA^2*, Jacqueline F Perry^2*, Francois Aguet, PhD^5*, Ruitong Li, MS^1*, Sungjae Kim, PhD^1*, Nicholas J. Haradhvala, PhD^1*, Rebecca Boiarsky, MS^6*, Gad Getz, PhD^1,7,8* and Irene Ghobrial, MD^2,7

¹Broad Institute of MIT and Harvard, Cambridge, MA
²Dana-Farber Cancer Institute, Boston, MA
³Dana Farber Cancer Institute, Boston, MA
⁴Dana-Farber Cancer Institute, Brookline, MA
⁵Illumina, San Francisco, CA
⁶Massachusetts Institute of Technology, Cambridge, MA
⁷Harvard Medical School, Boston, MA
⁸Krantz Family Center for Cancer Research and Dept. of Pathology, Massachusetts General Hospital, Boston, MA

Toru Ebina, MD^1,2*, Masaki Ri, MD, PhD^3*, Yoshiko Oshima, MD^3*, Tomoyuki Nakamura^4*, Yoshiaki Marumo, MD^4*, Hirokazu Sasaki, MD^3*, Arisa Asano, MD, PhD^3*, Shiori Kinoshita, MD, PhD^3*, Tomotaka Suzuki^3*, Tomoko Narita, MD, PhD^3*, Ayako Masaki, MD.PhD^5*, Takaomi Sanda, MD, PhD³, Hirokazu Komatsu, MD, PhD^3*, Hirotake Sakuraba, MD, PhD^2* and Shinsuke Iida, MD, PhD⁶

¹Department of Hematology and Oncology, Nagoya City University Graduate School of Medical Sciences, Aomori, Japan
²Department of Gastroenterology, Hematology and Clinical immunology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
³Department of Hematology and Oncology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
⁴Department of Hematology and Oncology, Nagoya City University Graduate School of Medical Sciences, Nagoya, AIC, Japan
⁵Department of Pathology and Molecular Diagnostics, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
⁶Nagoya City University Institute of Medical and Pharmaceutical Sciences, Nagoya, Japan

Jennifer Wing Lam Cheung, MSc^1,2*, Prachurjya Panda^3*, Xiang Zhou, MD, BMBS^4,5, Katrin Sinning^3*, Ankit Agrawal^3*, Andy Shing Fung Chan^3*, Johannes Duell, MD^6,7,8*, Johannes Waldschmidt, MD⁵, Hermann Einsele, MD^{5,7,9,10,11,12}, Martin Väth^3*, Andreas Rosenwald, MD^13*, Dominic Grün^14,15* and Leo Rasche, MD^{16,17,18,19,20*}

¹Würzburg Institute of Systems Immunology, Max Planck Research Group at the Julius‐Maximilians-Universität Würzburg, Würzburg, AL, Germany
²Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany
³Würzburg Institute of Systems Immunology, Max Planck Research Group at the Julius‐Maximilians-Universität Würzburg, Würzburg, Germany
⁴University Hospital Wuerzburg, Wurzburg, Germany
⁵Department of Internal Medicine II, University Hospital Wuerzburg, Wuerzburg, Germany
⁶Department of Internal Medicine II, Hematology and Oncology, University Hospital Wuerzburg, Wurzburg, Germany
⁷Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg, Würzburg, Germany
⁸University of Wurzburg, Wurzburg, Germany
⁹University Hospital of Würzburg, Wurzburg, Germany
¹⁰Division of Hematology, University Hospital of Wurzburg, Wurzburg, Germany, Würzburg, DEU
¹¹Department of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany
¹²Division of Medicine II, University Hospital Würzburg, Würzburg, Germany
¹³Comprehensive Cancer Center Mainfranken, University Hospital Würzburg, Würzburg, Germany
¹⁴Würzburg Institute of Systems Immunology, Würzburg, Germany
¹⁵CAIDAS - Center for Artificial Intelligence and Data Science, Würzburg, Germany
¹⁶Department of Internal Medicine, University Hospital of Würzburg, Würzburg, Germany
¹⁷Mildred Scheel Early Career Center for Cancer Research, University Hospital Wuerzburg, Wuerzburg, Germany
¹⁸University Hospital of Würzburg, Würzburg, Germany
¹⁹Wurzburg University, Würzburg, Germany
²⁰Department of Internal Medicine II, University Hospital Wurzburg, Wurzburg, Germany

Wei Tan^1*, Minghao Dang, PhD^1*, Upasana Ray^1*, Luz Yurany Moreno Rueda, PhD, MSc^1*, Maria Jose Acevedo-Calado, PhD^1*, Hua Wang, PhD^1*, Jun Wei^1*, Li Qin, PhD^1*, Isere Kuiatse, PhD^1* and Robert Z. Orlowski, MD, PhD^1,2

¹Department of Lymphoma & Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX

Jonathan S. Wall, PhD^*, Stephen J. Kennel, PhD^*, Alan Stuckey, CNMT^*, Tina Richey, MS^*, Angela D. Williams, MS^*, Manasi Balachandran, PhD^*, Trevor Hancock, PhD^*, Joseph W. Jackson, PhD^*, D. Craig Wooliver^*, Sallie Macy^*, R. Eric Heidel, PhD^*, Ronald H. Lands, MD and Emily B Martin, PhD^*

University of Tennessee Health Science Center College of Medicine, Knoxville, TN

Noémie Leblay, PhD^1*, Sungwoo Ahn, PhD^1*, Holly Lee, MD¹, Matteo Claudio Da Vià, MD^2*, Mansour Poorebrahim, PhD^1*, Sacha Benaoudia, PhD^1*, David Jung, BSc^1*, Elham Hasheminasabgorji, MSc^1*, Niccolò Bolli, MD, PhD^2*, Nizar J. Bahlis, MD¹ and Paola Neri, MD, PhD¹

¹Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, AB, Canada
²Hematology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy

Li Zhou, MD^1,2*, Xiaotong Song^3* and Zhimin Zhai, MD^1,2

¹Department of Hematology, the Second Affiliated Hospital of Anhui Medical University, Hefei, China
²Anhui Medical University, Hefei, China
³Icell Keleax Therapeutics, Houston, TX

Enze Liu, PhD^1*, Nathan Becker, MS^2*, Parvathi Sudha, MS^1*, Aneta Mikulasova, PhD^3*, Rafat Abonour, MD¹ and Brian A. Walker, PhD^1,4

¹Melvin and Bren Simon Comprehensive Cancer Center, Division of Hematology and Oncology, Indiana University School of Medicine, Indianapolis, IN
²Melvin and Bren Simon Comprehensive Cancer Center, Division of Hematology and Oncology, Indiana University School of Medicine, Fishers, IN
³Centre for Cancer and Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, United Kingdom
⁴Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN

Praneeth Reddy Sudalagunta, PhD^1*, David R. Noyes, MS^2*, Gabriel De Avila^3*, Alexandra Achille^2*, Rafael Renatino-Canevarolo, PhD^1*, Xiaohong Zhao, MD, PhD^2*, Maria Silva^1*, Angel Perez^1*, Mark B. Meads, PhD^4*, Lauren C. Peres, PhD, MPH^5*, Doris K. Hansen, MD^6*, Kenneth H. Shain, MD, PhD⁴ and Ariosto Siqueira Silva, PhD^7*

¹Department of Metabolism and Physiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL
²Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL
³H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
⁴H. Lee Moffitt Cancer Center, Tampa, FL
⁵Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL
⁶Moffitt Cancer Center, Tampa, FL
⁷Department of Metabolism and Physiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL

Bonell Patiño-Escobar, MD^1*, Lucy Perez-Lugo, MD^1,2*, Huimin Geng, PhD^1*, Fernando Salangsang^3*, Paul Phojanakong, BA^3*, Juan Antonio Camara Serrano, PhD^3*, Veronica Steri, PhD^3*, Oscar A Aguilar, PhD^4* and Arun P Wiita, MD, PhD⁵

¹Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA
²Department of Hematology-Oncology, Fundación Valle de Lili, Cali, Colombia
³Preclinical Therapeutics Core, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA
⁴Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA
⁵Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA

Yifan Hou^1*, Jianwei Qu^1*, Enfan Zhang^2* and Zhen Cai^2*

¹Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
²Bone Marrow Transplantation Center, Department of Hematology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China

Ankita Srivastava, M.Tech^1*, Romika Kumari, PhD^2*, Juho J. Miettinen, PhD^2*, Minna H. Suvela^2*, Klara Acs, PhD^3*, Sini Luoma, MD^4* and Caroline A. Heckman, PhD¹

¹Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Helsinki, Finland
²Institute for Molecular Medicine Finland – FIMM, HiLIFE – Helsinki Institute of Life Science, iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Helsinki, Finland
³Oncopeptides AB, Stockholm, Sweden
⁴Department of Hematology, Comprehensive Cancer Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland

Ya-Wei Qiang^1,2*, Michelle Karam, BS^1*, Allyson Schimelman, BS^1,3*, Edward Jachimowicz, MS^1*, Heather Fairfield, MS^1,2* and Michaela R Reagan, PhD^2,4

¹Center for Molecular Medicine, MaineHealth Institute for Research, Scarborough, ME
²Tufts University School of Medicine, Boston, MA
³The Roux Institute at Northeastern University, Portland, ME
⁴Center for Molecular Medicine, MaineHealth Institute for Research, South Portland, ME

Vinidhra Sridharan^1*, Hsiling Chiu^1*, Shirong Li^1*, Chad C. Bjorklund^1*, Anita K. Gandhi, PhD² and Patrick R. Hagner, PhD^1*

¹Bristol Myers Squibb, Summit, NJ
²Hematology, Translational Medicine, Bristol Myers Squibb, Summit, NJ

Holly Lee, MD¹, David Jung, BSc^1*, Mansour Poorebrahim, PhD^1*, Sacha Benaoudia, PhD^1*, Sungwoo Ahn, PhD^1*, Noémie Leblay, PhD^1*, Eric Letouzé, PhD^2*, Philippe Moreau, MD, PhD^3*, Herve Avet-Loiseau, MD, PhD^4*, Leo Rasche, MD^5*, Jonathan J Keats, PhD⁶, Francesco Maura, MD⁷, Paola Neri, MD, PhD¹ and Nizar J. Bahlis, MD¹

¹Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, AB, Canada
²Nantes Université, Nantes, FRA
³Department of Hematology, Nantes University Hospital, Nantes, France
⁴Institut universitaire du cancer de Toulouse Oncopole, Toulouse, France
⁵Department of Internal Medicine, University Hospital of Würzburg, Würzburg, Germany
⁶Translational Genomics Research Institute, Phoenix, AZ
⁷University of Miami, Coral Gables, FL

Alice Cleynen, PhD^1*, Agin Ravindran^2*, Dipti Talaulikar, PhD, FRACP, FRCPA, MBBS³, Eduardo Eyras, PhD^2* and Nikolay Shirokikh, PhD^4*

¹Universite De Montpellier, Montpellier, France
²The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia
³College of Health and Medicine, Australian National University, Red Hill, Australia
⁴ANU, John Curtin School of Public Health, Canberra, Australia

Diana Cortes, PhD^1*, Brendan Paul Hodkinson, PhD, BS^1*, Ashwini Kumar, PhD¹, Sheri Skerget, PhD^1*, Gary E Mason, MD, MS^1*, Elizabeth Shearin, PharmD^2*, Hein Ludlage, MSc^2*, Bas D Koster, MD, PhD³, Colleen Kane, PhD¹, Thomas Renaud, MD⁴, Tobias Kampfenkel, MD, MHBA^5*, Christoph Heuck, MD^1*, Bhoomika Thakkar, MS^4*, Farheen Zishan^6*, Emma Searle, MD, PhD^7*, Hang Quach, MD, FRACP, FRCPA, MBBS⁸, Gayathri Ravi, MD⁹, Cyrille Hulin, MD^10*, Wojciech Janowski, MD^11*, Jesus G Berdeja, MD¹², Sébastien Anguille, MD^13*, Jeffrey V Matous, MD¹⁴, Cyrille Touzeau, MD, PhD^15*, Anne-Sophie Michallet, MD, PhD^16*, Ajay K. Nooka, MD, MPH¹⁷, Tara Cochrane, MBBS, FRCPA, FRACP¹⁸, Anita D'Souza, MD, MS^19*, Peter M. Voorhees, MD²⁰, Karthik Ramasamy, MBBS, PhD^21*, Aurore Perrot, MD, PhD²², Andrew Spencer, MBBS^23*, Gurdeep Parmar, MBBS^24* and Deeksha Vishwamitra¹

¹Janssen Research & Development, Spring House, PA
²Janssen-Cilag Benelux, Leiden, Netherlands
³Janssen Biologics Europe, Leiden, Netherlands
⁴Janssen Research & Development, Raritan, NJ
⁵Janssen Research & Development, Neuss, Germany
⁶Janssen Research & Development, High Wycombe, United Kingdom
⁷The Christie NHS Foundation Trust and University of Manchester, Manchester, United Kingdom
⁸University of Melbourne, St. Vincent’s Hospital, Melbourne, VIC, Australia
⁹University of Alabama at Birmingham, Birmingham, AL
¹⁰Hôpital Haut Leveque, University Hospital, Pessac, France
¹¹Calvary Mater Newcastle, Waratah, NSW, Australia
¹²Tennessee Oncology, Sarah Cannon Research Institute, Nashville, TN
¹³Vaccine and Infectious Disease Institute, University of Antwerp, Center for Cell Therapy and Regenerative Medicine, Antwerp University Hospital, Edegem, Belgium
¹⁴Sarah Cannon Research Institute, Colorado Blood Cancer Institute, Denver, CO
¹⁵Centre Hospitalier Universitaire de Nantes, Nantes, France
¹⁶Hospices Civils, Centre Hospitalier Lyon Sud, Pierre Bénite, France
¹⁷Winship Cancer Institute, Emory University, Atlanta, GA
¹⁸Gold Coast University Hospital and Griffith University, Gold Coast, QLD, Australia
¹⁹Medical College of Wisconsin, Milwaukee, WI
²⁰Atrium Health Levine Cancer Institute, Charlotte, NC
²¹Oxford University Hospitals, NHS Foundation Trust, Oxford, United Kingdom
²²Centre Hospitalier Universitaire de Toulouse, Oncopole, Toulouse, France
²³School of Translational Medicine, Alfred Health-Monash University, Melbourne, VIC, Australia
²⁴lllawarra Cancer Care Centre, Wollongong, NSW, Australia

Junia Vieira, MD, PhD^1*, Alison S Park, BSc^2*, David Melnekoff, PhD^1*, Tarek H. Mouhieddine, MD³, Alessia D'anna, PhD^2*, Adolfo Aleman, Jr.^4*, Meghana Ram, BSc^5*, Katerina Kappes, BSc^4*, Mark Hamilton, MD⁶, George Mulligan, PhD⁶, Arun P Wiita, MD, PhD⁷, Ajai Chari, MD⁸, Thomas Martin, MD⁹, Michael Slade, MD, MS¹⁰, Li Ding, PhD^11*, Ravi Vij, MD, MBA¹², Brian Brown, PhD^5*, Benjamin Tycko, MD, PhD^13*, Rena Feinman, PhD¹⁴, David S. Siegel, MD, PhD¹⁵, Sundar Jagannath, MD¹, Samir Parekh, MD¹ and Alessandro Lagana, PhD¹⁶

¹Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
²Icahn School of Medicine at Mount Sinai, New York
³Department of Medicine, Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
⁴Department of Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY
⁵Icahn School of Medicine at Mount Sinai, New York, NY
⁶Multiple Myeloma Research Foundation, Norwalk, CT
⁷Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA
⁸University of California, San Francisco, San Francisco, CA
⁹Department of Hematology, University of California at San Francisco, San Francisco, CA
¹⁰Division of Oncology, Washington University School of Medicine, Saint Louis, MO
¹¹Washington University, St. Louis, MO
¹²Division of Oncology, Washington University School of Medicine, St. Louis, MO
¹³Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ
¹⁴Center for Discovery & Innovation, Hackensack Meridian Health, Nutley, NJ
¹⁵Hackensack University Medical Center, Hackensack, NJ
¹⁶Department of Medicine, Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York

Patrick Blaney, MS^1,2*, Kylee H Maclachlan, PhD, BSc, FRACP, FRCPA³, Marios Papadimitriou, MD^4*, Aneta Mikulasova, PhD^5*, Dylan C Gagler^1,2*, Marc J Braunstein, MD, PhD¹, Oscar B Lahoud, MD¹, David Kaminetzky, MD^1*, Yubao Wang, PhD^1*, Sanxiong Liu, PhD^1*, Di Zhang, MS^1*, Anthony Cirrincione, PhD^4*, Alexandra Maria Poos, PhD^6*, Bachisio Ziccheddu^4*, Marcella Kaddoura, MD⁷, Monika Chojnacka, B.S.⁴, Benjamin Diamond, MD⁴, Neha Korde, MD³, Alexander M. Lesokhin, MD³, Saad Z. Usmani, MD³, Leo Rasche, MD^8*, Elias K. Mai, MD^6*, Marc S. Raab^6*, Niels Weinhold, PhD⁶, Elizabeth E. Brown, PhD, MPH⁹, Nicolas Robine, PhD^10*, Leif Bergsagel, MD¹¹, Brian A. Walker, PhD¹², Ola Landgren⁴, Francesco Maura, MD¹³, Faith E Davies, MD¹ and Gareth Morgan, M.D., Ph.D.^1*

¹Perlmutter Cancer Center, Multiple Myeloma Research Program, NYU Langone Health, New York, NY
²Applied Bioinformatics Laboratories, NYU Grossman School of Medicine, NYU Langone Health, New York, NY
³Myeloma Service, Division of Hematologic Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
⁴Myeloma Institute, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL
⁵Centre for Cancer and Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, United Kingdom
⁶Heidelberg Myeloma Center, Department of Internal Medicine V, University Hospital Heidelberg, Heidelberg, Germany
⁷Myeloma Institute, Sylvester Comprehensive Cancer Center, University of Miami, Dearborn, MI
⁸Department of Internal Medicine II, University Hospital Wurzburg, Wurzburg, Germany
⁹Department of Pathology, University of Alabama At Birmingham, Birmingham, AL
¹⁰New York Genome Center, New York, NY
¹¹Division of Hematology/Oncology, Department of Internal Medicine, Mayo Clinic, Scottsdale, AZ
¹²Melvin and Bren Simon Comprehensive Cancer Center, Division of Hematology and Oncology, Indiana University School of Medicine, Indianapolis, IN
¹³University of Miami, Coral Gables, FL

Mattia Dessena, PhD^1*, Tommaso Torelli, MSc^2*, Cristina Manferdini, MSc^3*, Denise Toscani, PhD^1*, Alessandro Guidi, MSc^2*, Rosanna Vescovini, PhD^1*, Nicolas Thomas Iannozzi, MSc^1*, Anna Benedetta Dalla Palma, MD, PhD^4*, Vincenzo Raimondi^1*, Oxana Lungu, MSc^1*, Federica Librale, MD^4*, Matia Bernardi, MD^4*, Stefania Ricci, MSc^1*, Laura Pelagatti, MD^4*, Giannalisa Todaro, PhD^4*, Gabriella Sammarelli, PhD^4*, Camilla Sitzia, MSc^1*, Emanuela Aleo^5*, Gina Lisignoli, MSc^3*, Luca Agnelli, PhD^2*, Nicola Giuliani, MD, PhD^1,4 and Paola Storti, PhD^1*

¹Laboratory of Hematology, Department of Medicine and Surgery, University of Parma, Parma, Italy
²Department of Advanced Diagnostic Innovations, IRCCS Istituto Nazionale Tumori, Milano, Italy
³Laboratory of Immunorheumatology and tissue regeneration, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
⁴Azienda Ospedaliero-Universitaria di Parma, Parma, Italy
⁵IGA Technology Services, Udine, Italy

Travis Johnson, PhD¹, Enze Liu, PhD^2*, Ke Yang^3*, Parvathi Sudha, MS^2*, Vivek S. Chopra^4*, Faiza Zafar^4*, Rafat Abonour, MD² and Brian A. Walker, PhD²

¹Department of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, IN
²Melvin and Bren Simon Comprehensive Cancer Center, Division of Hematology and Oncology, Indiana University School of Medicine, Indianapolis, IN
³IU Health, Indianapolis
⁴Genentech, Inc., South San Francisco, CA

Junia Vieira, MD, PhD^1*, Alison S Park, BSc^2*, Edgar Gonzalez-Kozlova, PhD^3*, David Melnekoff, PhD^1*, Sherry Bhalla, PhD^4*, Chaitanya Acharya, PhD^5*, Mark Hamilton, MD⁶, George Mulligan, PhD⁶, Immune Atlas Network^7*, Hearn Jay Cho, MD, PhD⁸, Li Ding, PhD^9*, Sacha Gnjatic, PhD^10*, Ioannis S Vlachos, PhD^11*, Manoj Bhasin, PhD¹², Sundar Jagannath¹³, Samir Parekh, MD¹ and Alessandro Lagana, PhD¹⁴

¹Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
²Icahn School of Medicine at Mount Sinai, New York
³MSSM, New York
⁴Mount Sinai Hospital, New York, NY
⁵MMRF, Norwalk, CT
⁶Multiple Myeloma Research Foundation, Norwalk, CT
⁷MMRF, Norwalk
⁸Department of Medicine, Hematology and Medical Oncology, Tisch Cancer Institute, Tisch Cancer Institute, New York, NY
⁹WUSTL, St Louis
¹⁰Icahn School of Medicine at Mount Sinai, New York, NY
¹¹Beth Israel Deaconess Medical Center, Boston, MA
¹²Department of Biomedical Engineering, Georgia Institute of Technology, Johns Creek, GA
¹³Mount Sinai Medical Center, New York, NY
¹⁴Department of Medicine, Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York

Qun Li^1*, Chi Ma^2*, Liping Zuo^2*, Aoshuang Xu^2*, Fei Zhao^2*, Yu Hu^2* and Chunyan Sun^2*

¹Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong Univer, Wuhan, China
²Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Vincenzo Raimondi, MSc^1*, Paola Storti, PhD^1*, Rosanna Vescovini, PhD^1*, Valentina Franceschi, PhD^2*, Giulia Pozzi, PhD^3*, Denise Toscani, PhD^1*, Nicolas Thomas Iannozzi, MSc^1*, Oxana Lungu, MSc^1*, Anna Benedetta Dalla Palma, MD, PhD^4*, Laura Pelagatti, MD^4*, Federica Librale, MD^4*, Mattia Dessena, PhD^1*, Stefania Ricci, MSc^1*, Prisco Mirandola, PhD^3*, Gaetano Donofrio, VMD, PhD^2* and Nicola Giuliani, MD, PhD^1,4

¹Laboratory of Hematology, Department of Medicine and Surgery, University of Parma, Parma, Italy
²Department of Medical-Veterinary Science, University of Parma, Parma, Italy
³Department of Medicine and Surgery, University of Parma, Parma, Italy
⁴Azienda Ospedaliero-Universitaria di Parma, Parma, Italy

Zijun Zhang^1*, Yan Cheng^2*, David E. Mery, PhD², Hongwei Xu, DDS^2*, Brian Koss^3*, Behjatolah Monzavi Karbassi^4*, John D Shaughnessy, Jr, PhD^2* and Fenghuang Zhan, MD²

¹Myeloma Center, Winthrop P. Rockefeller Institute, Department of Internal Medicine, University of Arkansas for Medical, Little Rock, AR
²Myeloma Center, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR
³University of Arkansas For Medical Sciences,, Little Rock, AR
⁴Department of Pathology, University of Arkansas for Medical, Little Rock, AR

Shijun Jiang^1*, Fengjuan Fan^2*, Klaus Podar, MD, PhD^3,4, Chunyan Sun, MD^1* and Yu Hu^1*

¹Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
²Union Hospital, Tongji Medical College, Huazhong University of Science and Techn, Wuhan, China
³Division of Molecular Oncology and Hematology, Department of Basic and Translational Oncology, Karl Landsteiner University of Health Sciences, Krems an der Donau, Austria
⁴Department of Internal Medicine II, University Hospital Krems, Krems an der Donau, Austria

Shannon M Matulis, PhD^1*, Robert M Chavez^2*, Rebecca Owens, B.S.^3*, Arun P Wiita, MD, PhD⁴, Mala Shanmugam⁵, Ricardo De Matos Simoes, PhD^6*, Constantine S Mitsiades, MD^7,8, Nisha S. Joseph, MD⁹, Craig C. Hofmeister, MD¹⁰, Jonathan L. Kaufman, MD¹⁰, Madhav V. Dhodapkar, MD PhD¹⁰, Sagar Lonial, MD^11*, Ajay K. Nooka, MD, MPH¹², Vikas A. Gupta, MD PhD⁹, Jonathan D. Licht, MD¹³, Benjamin G. Barwick, PhD¹⁴ and Lawrence H. Boise, PhD¹⁵

¹Department of Hematology and Medical Oncology and the Winship Cancer Institute, Emory University, Atlanta, GA
²Emory University, Atlanta, GA
³Winship Cancer Institute, Emory Univeristy School of Medicine, Atlanta, GA
⁴Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA
⁵Department of Hematology and Medical Oncology, Winship Cancer Institute, School of Medicine, Emory University, Atlanta, GA
⁶Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
⁷Ludwig Center, Harvard Medical School, Brookline, MA
⁸Dana-Farber Cancer Institute, Boston, MA
⁹Winship Cancer Institute, Department of Hematology and Medical Oncology, Emory University, Atlanta, GA
¹⁰Winship Cancer Institute of Emory University, Atlanta, GA
¹¹Winship Cancer Institute, Atlanta, GA
¹²Winship Cancer Institute of Emory University, Atlanta
¹³University of Florida, Gainesville, FL
¹⁴Department of Hematology and Medical Oncology, Winship Cancer Institute, Atlanta, GA
¹⁵Department of Hematology and Medical Oncology, Winship Cancer Institute, Winship Cancer Institute, Atlanta, GA

Raquel Lopes^1,2*, Ana C Queirós, PhD^1*, Diana Lourenço^1*, Rita C Acúrcio^3,4*, Bjarne Bogen, MD, PhD^5*, Karine Serre, PhD^6*, Helena F Florindo, PhD^3,4* and Cristina João, MD, PhD, MSc^1,7,8*

¹Myeloma Lymphoma Research Group, Champalimaud Foundation, Lisbon, Portugal
²Faculty of Medicine, University of Lisbon, Lisbon, Portugal
³Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal
⁴Research Institute for Medicines, Lisbon, Portugal
⁵Institute of Immunology, University of Oslo, Oslo, Portugal
⁶Instituto De Medicina Molecular, Lisboa, Portugal
⁷Hemato-Oncology Unit, Champalimaud Foundation, Lisbon, Portugal
⁸NOVA Medical School, Universidade Nova de Lisboa, Lisbon, Portugal

Paula Tabares^1*, Antonio Giovanni Solimando^2*, Jayabhuvaneshwari Dhanraj^3*, Lukas Scheller, MD^4*, Matteo DA VIA, MD^5*, Alexis Gonzalez-Diaz^6*, Sanisha Sunuwar, MSc^7*, Katharina Schmiedgen^8*, Hüsniye Dagdeviren^9*, Mateo Blazevic^6*, Vanessa Desantis, PhD^10*, Francesca Lazzaroni, PhD^11*, Robin Scheler-Eckstein^6*, Martin K. Kortüm^12*, Leo Rasche, MD^13*, Johannes Waldschmidt, MD¹⁴, Max Bittrich, MD^15*, Stefan Knop^16*, Hermann Einsele, MD¹⁵ and Andreas Beilhack^15*

¹University Hospital of Würzburg, Würzburg, Germany
²Medicina interna universitaria Guido Baccelli, Ospedale Policlinico di Bari, Bari, Italy
³Interdisciplinary Center for Clinical Research Laboratory, Würzburg University Hospital, Würzburg, Germany., 97078 Würzburg, Germany
⁴Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg, Würzburg, Germany
⁵Hematology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy
⁶Department of Medicine II, Würzburg University Hospital II, Germany., Würzburg, Germany
⁷Department of Medicine II, Würzburg University Hospital II, Germany., Würzburg, DEU
⁸Interdisciplinary Center for Clinical Research Laboratory, Würzburg University Hospital, Würzburg, Germany., Würzburg, DEU
⁹Interdisciplinary Center for Clinical Research Laboratory, Würzburg University Hospital, Würzburg, Germany., Würzburg, Germany
¹⁰Department of Biomedical Sciences and Human Oncology (DIMO), Pharmacology Section, University of Bari Medical School, Bari, AL, ITA
¹¹Hematology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy, Milano, Italy
¹²Würzburg University Hospital, Wuerzburg, Germany
¹³Department of Internal Medicine, University Hospital of Würzburg, Würzburg, Germany
¹⁴Department of Internal Medicine II, University Hospital Wuerzburg, Wuerzburg, Germany
¹⁵Department of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany
¹⁶Department of Internal Medicine 5, Paracelsus Medical School, Nuremberg General Hospital, Nürnberg, DEU

Christopher Rolf Schorr^1,2, Daniela Nicoleta Petrusca, PhD², Louise Carlson^2*, Joyce Hardwick^2*, Julia Grace Reinke^2* and Kelvin P. Lee, MD³

¹Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN
²Melvin and Bren Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN
³Melvin and Bren Simon Comprehensive Cancer Center, INDIANA UNIVERSITY, INDIANAPOLIS, IN

Ceanne Elliott, BS^1*, Enze Liu, PhD^1*, Nathan Becker, MS^2*, Parvathi Sudha, MS^1*, Oumaima Jaouadi, PhD^1* and Brian A. Walker, PhD^1,3

¹Melvin and Bren Simon Comprehensive Cancer Center, Division of Hematology and Oncology, Indiana University School of Medicine, Indianapolis, IN
²Melvin and Bren Simon Comprehensive Cancer Center, Division of Hematology and Oncology, Indiana University School of Medicine, Fishers, IN
³Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN

Teng Fang, PhD^1*, Lanting Liu^2*, Hao Sun^2*, ?? ?^1*, Xiyue Sun^2*, Zhen Yu^2*, Lugui Qiu¹ and Mu Hao, MD^2*

¹State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
²State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology& Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China