Katie A Matatall, PhD^1*, Trisha Wathan^2*, Minh Nguyen^3*, Josaura Fernandez-Sanchez, MD^4*, Marcus Alexander Florez, PhD⁵, Duy Le, PhD^6*, Ruoqiong Cao, MS^2*, Daniel Kennedy II, PhD^7*, Arushana Maknojia^2*, Apoorva Thatavarty^2*, Margaret Goodell, PhD⁸, Antony Rodriguez, PhD^9*, Eirini Papapetrou, MD, PhD¹⁰, Samuele Marro, PhD^11* and Katherine Y. King, MD, PhD¹²

¹Prediatrics Infectious Diseases, Baylor College of Medicine, Houston, TX
²Baylor College of Medicine, Houston, TX
³Icahn School of Medicine at Mount Sinai, New York
⁴1 Baylor plaza, Baylor College of Medicine, Houston, TX
⁵University of Texas MD Anderson Cancer Center, Houston, TX
⁶Immatics US, Houston, TX
⁷Baylor College of Medicine, Houston
⁸Department of Molecular Cell Biology, Baylor College of Medicine, Houston, TX
⁹Division of Immunology, Allergy, and Rheumatology, Baylor College of Medicine, Houston, TX
¹⁰Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY
¹¹Institute for Regenerative Medicine, Icahn School of Medicine at Mount Sinai, New York, NY
¹²Pediatric Infectious Diseases, Baylor College of Medicine, Houston, TX

Maroof Hasan^1*, Shahid Tannu^1*, Shikha Saini^2*, Manuel Ugidos, PhD^1*, Guillermo Garcia-Manero, MD³, Uwe Platzbecker, MD⁴, Ching-Pin Chang^1*, Anita K. Gandhi, PhD¹, Ricardo Garcia, PhD^5* and Rajasekhar N.V.S. Suragani, PhD¹

¹Bristol Myers Squibb, Princeton, NJ
²Hematology Translational Medicine, Bristol Myers Squibb, Summit, NJ
³MD Anderson Cancer Center, Houston, TX
⁴University Hospital Leipzig, Leipzig, Germany
⁵GeneToBe Inc.,, Ann Arbor, MI

Fanny Jiahua J. Zhou, BS, MS¹, Helen C. Wang², Michelle K. Le^3*, Wei Yang, PhD^4*, Mary Jean Sunshine^3*, Jeffrey A. Magee, MD, PhD⁵ and Robert Signer, PhD⁶

¹Division of Regenerative Medicine, Department of Medicine, Stem Cell Discovery Center, Sanford Stem Cell Institute, Moores Cancer Center, University of California San Diego, San Diego, CA
²Department of Pediatrics, Division of Hematology and Oncology, Washington University School of Medicine, St. Louis, MO
³Division of Regenerative Medicine, Department of Medicine, Stem Cell Discovery Center, Sanford Stem Cell Institute, Moores Cancer Center, University of California San Diego, La Jolla, CA
⁴Department of Genetics, Washington University School of Medicine, Saint Louis, MO
⁵Department of Pediatrics, Division of Hematology/Oncology, Washington University School of Medicine, Saint Louis, MO
⁶University of California San Diego, La Jolla, CA

William G Dunn^1*, Muxin Gu^2*, Pedro Quiros^3*, Irina Mohorianu^2*, Daniel H Wiseman, MB ChB PhD MRCP FRCPath^4* and George S Vassiliou, MD, PhD⁵

¹Wellcome-Mrc Cambridge Stem Cell Institute, Cambridge, United Kingdom
²Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, United Kingdom
³Instituto Universitario de Oncologia, Univsersidad de Oviedo, Oviedo, Spain
⁴Division of Cancer Sciences, University of Manchester, Manchester, United Kingdom
⁵Department of Haematology and Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom

Courtnee A. Clough, PhD¹, Claire Cunningham, B.S.^1*, Sophia Philbrook, B.S.^1* and Daniel Starczynowski, PhD^1,2,3,4

¹Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
²Department of Cancer Biology, University of Cincinnati, Cincinnati, OH
³University of Cincinnati College of Medicine, Cincinnati, OH
⁴University of Cincinnati Cancer Center, Cincinnati, OH

Martina Fiumara, PhD^1,2*, Raffaella Molteni, PhD^2,3,4*, Corrado Campochiaro, MD^3,5*, Roberta Alfieri, PhD^6*, Guido Pacini, PhD^1*, Alessandro Tomelleri, MD^3,5*, Elisa Diral, MD^7*, Angelica Varesi, MSc^1,8,9*, Alessandra Weber, MD^1,3*, Pamela Quaranta, PhD^1*, Luisa Albano, MSc^1*, Chiara Gaddoni, MSc^1*, Luca Basso-Ricci, MSc^1*, Davide Stefanoni, PhD^4*, Gregorio Maria Bergonzi, MD^7*, Andrea Annoni, PhD^1*, Maddalena Panigada, PhD^4*, Eleonora Cantoni, MSc^4*, Daniele Canarutto, MD, PhD^1,10*, Stephanie Z Xie, PhD⁸, Angelo D'Alessandro, PhD¹¹, Raffaella Di Micco, PhD^1,12*, Alessandro Aiuti, MD, PhD^1,3,10*, Fabio Ciceri, MD^3,13*, Giacomo De Luca, MD^3,5*, Lorenzo Dagna, MD^3,5*, Marco Matucci-Cerinic, MD^3,5*, Ivan Merelli, PhD^1,6*, Simone Cenci, MD^3,4, Serena Scala, PhD^1*, Giulio Cavalli, MD, PhD^3,4,14*, Luigi Naldini, MD, PhD^1,3,14 and Samuele Ferrari, PhD^1,3,14

¹San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy
²co-first author, Milan, Italy
³Vita-Salute San Raffaele University, Milan, Italy
⁴Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy
⁵Unit of Immunology, Rheumatology, Allergy and Rare diseases, IRCCS San Raffaele Hospital, Milan, Italy
⁶Institute for Biomedical Technologies, National Research Council, Segrate, Italy
⁷Unit of Hematology and Bone Marrow Transplantation, IRCCS San Raffaele Scientific Institute, Milan, Italy
⁸Princess Margaret Cancer Centre, Toronto, ON, Canada
⁹University of Toronto, Department of Molecular Genetics, Toronto, Canada
¹⁰Pediatric Immunohematology Unit and BMT Program, IRCCS San Raffaele Scientific Institute, Milan, Italy
¹¹Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO
¹²11 Istituto Universitario di Studi Superiori, IUSS, Pavia, Italy
¹³Hematology and Bone Marrow Transplantation Unit, I.R.C.C.S. San Raffaele Scientific Institute, Milan, Italy
¹⁴co-last author, Milan, Italy

John P Brabson, M.S.^1,2, Tiffany Leesang, BS^1,2*, Yoon Sing Yap, PhD^1,2*, Daniela A Barbieri, BS¹, Joey Pinzone^2*, Minh Quang Lam, MPH^1,2, Peter D Lyon, BS^1,3, Maria E Figueroa, MD^1,2*, Namrata S. Chandhok, MD⁴, Felipe Beckedorff, PhD^1,5*, Aristeidis Telonis, PhD^1,2* and Luisa Cimmino, PhD^1,6

¹Cancer Epigenetics Program, Sylvester Comprehensive Cancer Center, University of Miami-Miller School of Medicine, Miami, FL
²Department of Biochemistry & Molecular Biology, University of Miami-Miller School of Medicine, Miami, FL
³Medical Scientist Training Program, University of Miami-Miller School of Medicine, Miami, FL
⁴Sylvester Comprehensive Cancer Center, University of Miami-Miller School of Medicine, Miami, FL
⁵Department of Human Genetics, University of Miami-Miller School of Medicine, Miami, FL
⁶Biochemistry and Molecular Biology, University of Miami-Miller School of Medicine, Miami, FL

Alessandro Buizza, MD^1,2*, Alessia Antonella Galbussera, PhD^3*, Francesco Pesce^2*, Matteo Zampini, PhD^2*, Luca Lanino, MD^2,4, Gabriele Todisco, MD^1*, Alessia Campagna, MD^4*, Giulia Maggioni, MD^1*, Marta Ubezio, MD^4*, Saverio D'Amico, MSc^1*, Elisabetta Sauta, PhD^1*, Antonio Russo, MD^4*, Daniele Dall'Olio, PhD^5*, Francesca Ficara, PhD^1*, Stefano Polizzi, PhD^6*, Gastone Castellani, PhD^6*, Mauro Tettamanti, PhD^3*, Ugo Lucca, PhD^3* and Matteo Giovanni Della Porta, MD^1,2*

¹IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
²Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy
³Department of Health Policy, Laboratory of Geriatric Epidemiology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy
⁴IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy
⁵IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy
⁶Department of Medical and Surgical Sciences University of Bologna, Bologna, Italy

Jasmine Ryu Won Kang, BSc¹, June Kim^2*, Kimberly Skead^2*, Vanessa Bruat^2*, Michelle Harwood^2*, David Soave^2*, Quaid D. Morris, PhD^3*, Marie-Julie Fave^2* and Philip Awadalla^2*

¹Ontario Institute For Cancer Research, Toronto, ON, Canada
²Ontario Institute for Cancer Research, Toronto, ON, Canada
³Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York

Sergiu Pasca^1*, Yun Soo Hong^2*, Wen Shi^2*, Daniela Puiu^3*, Nicole J Lake^4*, Monkol Lek^4*, Eliseo Guallar^5*, Dan E Arking^2* and Lukasz P. Gondek, MD, PhD⁶

¹Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD
²McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University, Baltimore, MD
³Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD
⁴Department of Genetics, Yale School of Medicine, New Haven, CT
⁵Department of Epidemiology, School of Global Public Health, New York University, New York, NY
⁶Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD

Michihiro Kobayashi, M.D, Ph.D.¹, Haizi Cheng^2*, Aayushi Gaur^3*, Alina Syed^4*, Chika Nishida, MD^5*, Augsto Latorre^6*, Jun-Ichi Abe^7* and Momoko Yoshimoto, MD, PhD¹

¹Western Michigan University Homer Stryker MD. School of Medicine, Kalamazoo, MI
²Emory University, Atlanta, GA
³Center for Immunobiology, WMU Homer Stryker MD School of Medicine, Kalamazoo, MI
⁴Center for integrated biology and pharmacology, University of Texas Health Science Center at Houston, Houston, TX
⁵McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX
⁶Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX
⁷University of Texas MD Anderson Cancer Center, Houston, TX

Hiroki Mizumaki, MD^1*, Shouguo Gao, PhD^1*, Zhijie Wu, MD, PhD^1*, Xingmin Feng, PhD^1*, Fernanda Gutierrez-Rodrigues, PhD¹, Lemlem Alemu, BS^1*, Diego Quinones Raffo, BS^2*, Ivana Darden, RN^1*, Sachiko Kajigaya, PhD^1*, Emma M. Groarke, MD¹, Neal S. Young, MD¹ and Bhavisha A. Patel, MD¹

¹Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD
²National Heart, Lung, and Blood Institute (NHLBI)/NIH, Bethesda, MD

Bowen Yan, PhD^1*, Qingchen Yuan, MBBS¹, Prabhjot Kaur, PhD^1*, Annalisse Mckee, MS^1*, Daniil Shabashvili, PhD^2* and Olga A. Guryanova, MD, PhD¹

¹Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, FL
²University of Florida, Gainesville, FL

Kiana Kalei Guillermo, BA, MSc^1*, Xin (Helen) Huang, BS^2*, Jianhong C Heidmann, BS^2* and Angela G. Fleischman, MD, PhD³

¹Biological Chemistry, University of California, Irvine, Irvine, CA
²University of California, Irvine, Irvine, CA
³Division of Hematology/Oncology, University of California, Irvine, Irvine, CA

Casey K. Wong, BS, MSc^1*, Marco M Buttigieg, MSc^1*, Jahanara Rajwani², Caitlin Lee^1*, Caitlyn Vlasschaert, MD, PhD^3* and Michael J. Rauh, MD, PhD¹

¹Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada
²Queen's University, Kingston, ON, Canada
³Department of Medicine, Queen’s University, Kingston, ON, Canada

Geon Geon Kim, MD^1,2*, Christopher B. Hergott, MD, PhD^1,3*, Aidan P. Miller, BSc^1*, Amy Deik^4*, Meaghan Boileau, PhD^5*, Kevin Bullock^6*, Kerry Pierce^6*, Angelina Choy^6*, Wesley Shin^1*, Marie E McConkey, PhD^1*, Justin CT Loke, MD PhD¹, Birgitta Ryback, PhD^7*, Michael N Trinh, MD PhD^8*, Justine Rutter^9*, Hong Yue, PhD^7*, Paul Park^9*, Shourya SR Burman, PhD^9*, Eric Fischer, Ph.D.^7*, Scott A Armstrong, MD, PhD⁵, Clary Clish, PhD^6* and Benjamin Levine Ebert, MD, PhD⁹

¹Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
²Cancer Center, Massachusetts General Hospital, Boston, MA
³Department of Pathology, Brigham and Women’s Hospital, Boston, MA
⁴Broad Institute, Boston, MA
⁵Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA
⁶Broad Institute, Boston
⁷Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA
⁸Massachusetts General Hospital, Boston
⁹Dana Farber Cancer Institute, Boston, MA