Sasha Sharma, BSc^1*, Linnea Soon, BSc^2*, Kerstin de Wit, MBChB, MD, MSC³, Alejandro Lazo-Langner, MD, MSc, FRCPC⁴, Gregoire Le Gal, MD, PhD⁵, Shannon Bates, MD, FRCPC, MSc⁶ and Sameer Parpia, PhD^7*

¹Department of Statistics, University of British Columbia, Brampton, ON, Canada
²Department of Medicine, Queen's University, Kingston, ON, Canada
³Department of Emergency Medicine and Medicine, Queen's University, Kingston, ON, Canada
⁴Department of Medicine, Division of Hematology, Western University, London, ON, Canada
⁵Ottawa Blood Disease Centre, Ottawa Hospital Research Institute, Ottawa, ON, Canada
⁶Department of Medicine, McMaster University, Hamilton, ON, Canada
⁷Departments of Oncology and Health Research Method, Evidence & Impact, McMaster University, Hamilton, ON, Canada

Greeshma Gaddipati, MBBS¹, Boniface Mensah, MBChB, MPH^2*, Chiranjeevi Sainatham, MBBS^3*, Divya Shivakumar, MBBS^4*, Mariah Malak Bilalaga, MBBS^2*, Ramya Vasireddy, MBBS^2*, Simardeep Singh^2*, Pragnan Kancharla, MD, MBBS^2*, Mahsa Mohebtash, MD^2* and Michael Streiff, MD⁵

¹MedStar Union Memorial Hospital, Towson, MD
²MedStar Union Memorial Hospital, Baltimore, MD
³Internal Medicine, Sinai hospital of Baltimore, Baltimore, MD
⁴Kamineni academy of medical sciences and research centre, Hyderabad, India
⁵Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD

Patrick Yue, MD^1*, Emma Qu, MD^2*, Jie Pan, MSc^2*, Jeffrey Weitz, MD, FRCPC³ and Qunsheng Ji, MD, PhD^2,4*

¹Sirius Therapeutics, San Carlos, CA
²Sirius Therapeutics, Shanghai, China
³McMaster University, Hamilton, ON, Canada
⁴Sirius Therapeutics, San Diego, CA

Natasha S Bala, MD, MS¹, Zaineb Boulil, MS^2*, Emily Krava, MPH^3*, Char M Witmer, MD⁴, Sarah H. O'Brien, MD, MSc^5,6, Lingyun Ji, PhD^7* and Julie Jaffray, MD, MS⁸

¹Division of Pediatric Hematology/Oncology, Rady Children's Hospital, San Diego, CA
²Research Administration Department, Rady Children’s Hospital, San Diego, CA
³University of California, San Diego, San Diego, CA
⁴The Children's Hospital of Philadelphia, Philadelphia, PA
⁵Center for Child Health Equity and Outcomes Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH
⁶Division of Pediatric Hematology/Oncology/BMT, Nationwide Children's Hospital and The Ohio State University, College of Medicine, Columbus, OH
⁷Department of Population and Public Health Sciences, University of Southern California,, Los Angeles, CA
⁸Rady Children's Hospital San Diego, San Diego, CA

Jayalekshmi Jayakumar, MD^1*, Manasa Ginjupalli, MD^2*, Kalaivani Babu, MBBS³, Srinishant Rajarajan, MBBS³, Samridhi Sinha, MBBS, DO⁴ and Arya Mariam Roy, MD⁵

¹Internal Medicine, The Brooklyn Hospital Center, Brooklyn, NY
²The Brooklyn Hospital Centre, Brooklyn, NY
³Internal Medicine, Allegheny General Hospital, Pittsburgh, PA
⁴Hematology and Oncology, The Brooklyn Hospital Center, New York, NY
⁵Ohio State University/ The Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH

Marina Serra Carrera, MD^1*, Macarena Simón-Talero, MD, PhD^2*, Desiree Campoy, MD^3*, Gonzalo Artaza, MD^3*, Mercedes Perez Lafuente, MD, PhD^4*, Sergi Camarillas, MD^5*, Sofia Laura Muzio, MD^6*, Jonay Mendez, MD^7*, Maria Landwehr, MD^8*, Francesc Bosch, MD, PhD⁹ and Pável E Olivera, MD^10,11*

¹Department of Hematology, Vall d'Hebron Hospital, Barcelona, Spain
²Department of Hepatology, Vall d'Hebron Hospital, Barcelona, Spain
³Thrombosis and Hemostasis Unit. Department of Hematology, Vall d'Hebron University Hospital, Barcelona, Spain
⁴Vall d'Hebron Hospital, Barcelona, Spain
⁵University Hospital Vall d’Hebron, Barcelona, Spain
⁶Hematology Department, Vall d’Hebron University Hospital, Barcelona, Spain
⁷Departmentr of hematology, Vall d'Hebron Hospital, Barcelona, Spain
⁸Department of Hematology, Hospital Universitari Vall d’Hebron, Barcelona, Spain
⁹Hematology Department, Vall d’Hebron Institute of Oncology (VHIO), University Hospital Vall d’Hebron, Barcelona, Spain
¹⁰Experimental Hematology, Vall d’Hebron Institute of Oncology (VHIO), Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain
¹¹Thrombosis and Hemostasis Unit. Department of Hematology, Vall d'Hebron University Hospital, Barcelona, AL, Spain

Shengling Ma, MD, PhD¹, Jun Yang Jiang, MD^2*, Rockbum Kim, MD, PhD², Elizabeth Chiang^3*, Joyce Tiong^4*, Justine Ryu, MD⁵, Danielle Guffey, MS^6*, Raka Bandyo, MS^7*, Heidi Dowst^4*, Kaitlin N Swinnerton^8*, Nathanael R. Fillmore, PhD^9,10,11*, Jennifer La^11* and Ang Li, MD, MS⁴

¹Section of Hematology-Oncology, Baylor College of Medicine, HOUSTON, TX
²Section of Hematology-Oncology, Department of Medicine, Baylor College of Medicine, Houston, TX
³Baylor College of Medicine, houston, TX
⁴Baylor College of Medicine, Houston, TX
⁵Section of Hematology, Yale University School of Medicine, New Haven, CT
⁶Institute for Clinical & Translational Research, Baylor College of Medicine, Houston, TX
⁷Harris Health System, Houston, TX
⁸Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System, Boston, MA
⁹Harvard Medical School, Boston, MA
¹⁰Section of Hematology and Medical Oncology, Boston Medical Center, Boston, MA
¹¹VA Boston Healthcare System, Boston, MA

Tenzin Tamdin, MD^1*, Yu-Cheng Chang, MD^1*, Cho-Han Chiang, MD, MMSc^2*, Junmin Song, MD³, Kuan-Yu Chi, MD^3*, Yu Chang, MD^4*, Chun-Yu Peng^5* and Wenli Gao, MD, PhD⁶

¹Department of Medicine, Danbury Hospital, Danbury, CT
²Department of Medicine, Mount Auburn Hospital, Harvard Medical School, Cambridge, MA
³Department of Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, NY
⁴Section of Neurosurgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
⁵Department of Medicine, Danbury Hospital, Danbury
⁶Danbury hopital, Danbury, CT

Maha Al-Ghafry, MD^1,2, Sibgha Zaheer, MD, MPH³, Abraham Haimed, MD⁴, Julia Su, MD^5*, Neil Goldenberg, MD, PhD^1,2, Marisol Betensky, MD, MPH^1,2 and Suchitra Acharya, MD⁶

¹Johns Hopkins All Children's Hospital, St. Petersburg, FL
²Johns Hopkins University School of Medicine, Baltimore, MD
³University of Southern California, Keck School of Medicine/Children's Hospital Los Angeles, Los Angeles, CA
⁴Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA
⁵Children's Hospital of Los Angeles, Los Angeles, CA
⁶Cohen Children's Medical Center of New York, New Hyde Park, NY

Melissa S Stuart, BSc^1*, Rajiv K Pruthi, M.B.B.S.² and Jansen N Seheult, M.D.^3*

¹Special Coagulation Laboratory, Division of Hematopathology, Mayo Clinic, Rochester, MN
²Comprehensive Hemophilia Center and Special Coagulation Laboratory, Division of Hematopathology, Mayo Clinic, Rochester, MN
³Division of Hematopathology, Mayo Clinic, Rochester, MN

Simon Mantha, MD, MPH¹, Rohan Singh, MS^2*, Jeffrey I. Zwicker, MD² and Ang Li, MD, MS³

¹Hematology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
²Memorial Sloan Kettering Cancer Center, New York, NY
³Baylor College of Medicine, Houston, TX

Nicola Potere, MD^1*, Ranjeeta Mallick, PhD, MSc^2*, Yan Xu, MD, MSc³, Tzu-Fei Wang, MD, MPH³, Philip Stephen Wells, MD, MSc³ and Marc Carrier, MD, MSc⁴

¹Department of Medicine and Ageing Sciences, G. D'Annunzio University of Chieti-Pescara, Chieti, Italy
²Ottawa Methods Center, Ottawa Hospital Research Institute, Ottawa, ON, Canada
³Department of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada
⁴Ottawa Blood Disease Centre, Ottawa Hospital Research Institute, Ottawa, ON, Canada

Adrian Bailey, MD¹, Owen Luo, MD^2*, Shi Qi (Sarah) Zhou, BSc^3* and Phil Stephen Wells, MD, MSc, FRCP⁴

¹McGill University, ALMONTE, QC, Canada
²McGill University Health Centre, Montréal, QC, CAN
³McGill University, Montreal, QC, Canada
⁴Department of Medicine, University of Ottawa, Ottawa, ON, Canada

Junmin Song, MD¹, Yu-Cheng Chang, MD^2*, Jaeun Ahn, MD^3*, Kuan-Yu Chi, MD^1*, Yu Chang, MD^4* and Cho-Han Chiang, MD, MMSc^5*

¹Department of Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, NY
²Department of Medicine, Danbury Hospital, Danbury, CT
³Department of Internal Medicine, Eastern Virginia Medical School, Norfolk, VA
⁴Section of Neurosurgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
⁵Department of Medicine, Mount Auburn Hospital, Harvard Medical School, Cambridge, MA

Chia-Jen Liu, MD, PhD^1,2, Chun-Kuang Tsai, MD^3*, Te-Lin Hsu, MD^4* and Hao-Yuan Wang, MD³

¹Division of Transfusion Medicine, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
²Institute of Emergency and Critical Care Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
³Division of Hematology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
⁴Department of Medicine, Kinmen Hospital, Kinmen, TWN

Kevin Zablonski^1*, Mart Andrew Maravillas^2*, Elleson Harper, BS^3* and Lalitha Nayak, MD¹

¹Division of Hematology and Oncology, University Hospitals Seidman Cancer Center, Case Western Reserve University, Cleveland, OH
²Center for Clinical Research, University Hospitals, Cleveland, OH
³University Hospitals Clinical Research Center, Cleveland, OH

Cristina Verzeroli^1*, Laura Russo^1*, Sara Gamba^1*, Carmen J Tartari, PhD^1*, Silvia Bolognini^1*, Chiara Ticozzi^1*, Patricia Gomez-Rosas, MD^1,2,3*, Francesca Schieppati, MD^1,4*, Roberta Sarmiento, MD^5*, Giovanna Masci, MD^6*, Carlo Tondini, MD^7*, Fausto Petrelli, MD^8*, Francesco Giuliani, MD^9*, Andrea D'Alessio, MD^10*, Filippo De Braud, MD^11*, Armando Santoro, MD^12*, Giampietro Gasparini, MD^5*, Roberto Labianca, MD^13*, Luca Barcella, MD^1*, Marina Marchetti, PhD^1,14* and Anna Falanga, MD⁴

¹Department of Immunohematology and Transfusion Medicine, Papa Giovanni XXIII Hospital, Bergamo, Italy
²Maastricht University Medical Center (MUMC+), Cardiovascular Research Institute Maastricht (CARIM), Maastricht, Netherlands
³Hospital de Oncologia, Unidad Medica de Alta Especialidad (UMAE), Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico
⁴School of Medicine, University of Milano Bicocca, Milan, Italy
⁵Oncology Unit, San Filippo Neri Hospital, Rome, Italy
⁶Department of Oncology and Hematology, IRCCS Humanitas Research Hospital, Rozzano, Italy
⁷Oncology Unit, Papa Giovanni XXIII Hospital, Bergamo, Italy
⁸Oncology Unit, Treviglio-Caravaggio Hospital, Treviglio, Italy
⁹Oncology Unit, IRCCS Cancer Institute Giovanni Paolo II, Bari, Italy
¹⁰Medical Oncology and Internal Medicine, Policlinico San Marco, Bergamo, Italy
¹¹Oncology Unit, IRCCS National Cancer Institute, Milan, Italy
¹²IRCCS Humanitas Research Hospital, Rozzano, Italy
¹³Fondazione ARTET Onlus, Bergamo, Italy
¹⁴School of Medicine and Surgery, University, Milan, Italy

Maierdan Palihati, MD^1*, Anne K Hubben, MD^1,2, Kelsey Pandrangi, MD^2*, Paresh P Kulkarni, MD, MBBS, PhD^1* and Keith R. McCrae, MD^2,3

¹Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH
²Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
³Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH

Nicole M. Kuderer, MD, MS (Equiv.), FASCO¹ and Gary H. Lyman, MD, FRCP, MPH²

¹Advanced Cancer Research Group, Kirkland, WA
²Fred Hutchinson Cancer Center, Seattle, WA

Mariam Michel Kalds¹, Kristin Wuichet, PhD^2*, Mark Rodeghier, PhD^3* and Michael R. DeBaun, MD, MPH⁴

¹Meharry Medical College School of Medicine, Nashville, TN
²Vanderbilt University Medical Center, Nashville, TN
³Rodeghier Consultants, Chicago, IL
⁴Vanderbilt-Meharry Center of Excellence in Sickle Cell Disease, Vanderbilt University Medical Center, Nashville, TN