66th ASH Annual Meeting: 330. Vascular Biology, Thrombosis, and Thrombotic Microangiopathies: Basic and Translational: Poster III

Symposia: Vascular Biology, Thrombosis, and Thrombotic Microangiopathies: Basic and Translational Oral and Poster Abstracts
Poster

Research, Bleeding and Clotting, Bleeding disorders, Autoimmune disorders, Fundamental Science, Clinical trials, Hemophilia, Bacterial, Drug development, Translational Research, Plasma Cell Disorders, Clinical Research, Thromboembolism, Diseases, Immune Disorders, Thrombocytopenias, Treatment Considerations, Infectious Diseases, Thrombotic disorders, Adverse Events, Lymphoid Malignancies, Biological Processes, Microbiome, Technology and Procedures, Study Population, Profiling, Pathogenesis, Animal model

Halls G-H (San Diego Convention Center)

3986

Platelet Factor 4 (PF4) Binding to Neutrophil Extracellular Traps (NETs) and Von Willebrand Factor (vWF) Improves Bacterial Capture and Killing in an Electrostatic Charge-Dependent Manner

Santosh K Yadav, PhD¹^*, Abigail E Skidmore²^*, Anh T.P. Ngo, PhD³, Veronica Bochenek, BA⁴^*, Manuela Roggiani, PhD⁵^*, Mark Goulian, PhD⁵^*, Mortimer Poncz, MD⁴ and Kandace Gollomp, MD⁴

¹The Children's Hospital of Philadelphia, Philadelphia, PA
²Division of Hematology, Children's Hospital of Philadelphia, Mount Laurel, NJ
³Division of Hematology, Children's Hospital of Philadelphia, San Diego, CA
⁴Division of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA
⁵Department of Biology, University of Pennsylvania School of Arts & Sciences, Philadelphia, PA

3987

Tissue Factor Pathway Inhibitor Modulates Endothelial and Vascular Smooth Muscle Cell Functions By Drifting Cellular Phenotypes

Vanessa Bröker¹^*, Jarno JJ Koetsier¹^*, Stella Thomassen¹^*, Elisabetta Castoldi, PhD²^*, Kanin Wichapong³^*, Philip Wenzel⁴^*, Leon Schurgers, PhD⁵^* and Tilman M. Hackeng, PhD⁶

¹Maastricht University, Maastricht, Netherlands
²Department of biochemistry, Maastricht University, Maastricht, NLD
³CARIM - School for cardiovascular diseases, Maastricht, Netherlands
⁴University Medical Center Mainz, Mainz, DEU
⁵Maastricht University, Maastricht, NLD
⁶University Maastricht, Maastricht, NLD

3988

Treatment with a Novel Small Molecule Dual Factor IIa/Xa Inhibitor Protects Against Coagulopathy and Organ Dysfunction in a Baboon Model of Staphylococcus Aureus Sepsis

Robert Silasi, PhD¹^*, Ravi Shankar Keshari, PhD¹^*, Tomohiro Abe, MD, PhD¹^*, Girija Regmi, PhD¹^*, Cristina Lupu, PhD¹^*, Joe Simmons, DVM, PhD²^*, Nils Pfaff, PhD³^*, Stefan Heitmeier, PhD³^* and Florea Lupu, PhD¹

¹Oklahoma Medical Research Foundation, Oklahoma City, OK
²MD Anderson Cancer Center, Bastrop, TX
³Bayer Pharma AG, Wuppertal, Germany

3989

Role of Interferon-Gamma (IFN-γ) Signaling in Immune Checkpoint Inhibitor-Associated Thrombosis: Tissue Factor Upregulation and Proinflammatory Cytokine Signature

Young Jun Shim¹^* and Keith R. McCrae, MD^2,3

¹Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH
²Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH
³Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH

3990

Junctional Adhesion Molecule a (JAM-A) Maintains Vascular Endothelial Barrier Integrity through c-Src/Stat3-Dependent Suppression of Inhibitor of DNA-Binding 1 (Id1)

Meghna U Naik, MS and Ulhas P. Naik, PhD

Cardeza Center for Hemostasis, Thrombosis, and Vascular Biology, Cardeza Foundation for Hematology Research, Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA

3991

Role of Factor VIII in Angiogenesis, Vessel Stability and the Regulation of Extracellular Matrix Proteins

Cristina Olgasi¹^*, Alessia Cucci¹^*, Ivan Molineris²^*, Simone Assanelli¹^*, Chiara Borsotti¹^*, Chiara Sgromo¹^*, Andrea Lauria²^*, Mercello Manfredi³^*, Salvatore Oliviero²^* and Antonia Follenzi¹^*

¹Department of Health Sciences, University of Piemonte Orientale, Novara, Italy
²Università degli Studi di Torino, Torino, Italy
³Department of Translational Medicine, Università del Piemonte Orientale, Novara, Italy

3992

Very Long-Chain Saturated Fatty Acids Are Inversely Correlated with Thrombin Generation and Linked to a Reduced Risk of Coronary Artery Disease and Myocardial Infarction: Preliminary Findings from an Angiographically-Controlled Study

Marianna Spizzo¹^*, Gerardo Musuraca, M.D., Ph.D.²^*, Nicola Osti¹^*, Patrizia Pattini³^*, Martino Donini⁴^*, Annalisa Castagna, MSc, PhD⁵^*, Cathie Brocco⁶^*, Carlo Angheben²^*, Sabrina Marconcini⁷^*, Claudio Cemin²^*, Natascia Cont²^*, Marcello Baroni⁸^*, Matthieu Grusse⁹^*, Francesco Presa¹^*, Adriano Anesi⁶^*, Maurizio del Greco²^*, Patrick Van Dreden, PhD¹⁰, Francesco Bernardi⁸^*, Simonetta Friso¹¹^* and Nicola Martinelli, MD, PhD⁵^*

¹Department of Medicine, University of Verona, Italy, Verona, Italy
²Division of Cardiology, Santa Maria del Carmine Hospital, Rovereto, Italy
³University of Verona, Verona, ITA
⁴Department of Engineering for Innovation Medicine, University of Verona, Verona, Italy
⁵Department of Medicine, University of Verona, Verona, Italy
⁶Clinical Pathology Laboratory, Laboratories Department, APSS of Trento, Trento, Italy
⁷Clinical Pathology Laboratory, Laboratories Department, APSS of Trento, trento, Italy
⁸Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy
⁹Department of Clinical Research, Diagnostica Stago,, Gennevilliers, France
¹⁰Stago, Gennevilliers, France
¹¹University of Verona School of Medicine, Verona, Italy

3993

Gut Microbial Metabolite Butyrate Alleviates the Susceptibility to Septic DIC By Suppressing Caspase-11/ Gsdmd-Dependent Macrophage Pyroptosis

Yingying Li^1,2^*, Zhong Wu²^*, Huiwen Jiang, PhD²^*, Zhaozhao Chen^2,3^*, Min Xu⁴^*, Jinhui Shu, Master²^*, Jingming Wang²^*, Qinying Xie²^*, Jun Deng²^*, Yu Hu^1,2^*, Lili Luo^1,2^* and Heng Mei, md, phd^2,5^*

¹Hubei Clinical and Research Centre of Thrombosis and Haemostasis, Wuhan, China
²Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
³Hubei Clinical Medical Center of Cell Therapy for Neoplastic Disease, Wuhan, China
⁴Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of science and technology, Wuhan, China
⁵Union Hospital, Tongji Medical College, HUST, Wuhan, China

3994

Citrullination of TFPI By PAD4 Impairs Its Natural Anticoagulant Activity Towards Factors Xa, VIIa and Tissue Factor, and Reduces Binding to Its Cofactor Protein S

Bryan Bouwens, MSc¹^*, Elke Magdeleyns¹^*, Stella Thomassen¹^*, Dennis Suylen¹^*, Tilman M. Hackeng, PhD¹ and Rory R. Koenen²^*

¹Cardiovascular Research Institute Maastricht (CARIM), Dpt. of Biochemistry, Maastricht university(UM), Maastricht University Medical center (MUMC+), Maastricht, Netherlands
²CARIM - Biochemistry, Maastricht University, Maastricht, Netherlands

3995

Off-the-Shelf Cryopreserved Platelets to De-Risk Intravenous Immunoglobulin G (IVIg) Lots That Cause Platelet Activation

Curtis Jones, BS¹^* and Anand Padmanabhan, MBBS, PhD²

¹Retham Technologies, Wauwatosa, WI
²Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN

3996

Platelet-Activating Anti-PF4 Antibodies in MGUS Patients with Thrombosis

Anand Padmanabhan, MBBS, PhD¹, Noah Splinter, MS¹^*, Emily Mauch, BS¹^*, Adam Kanack, PhD¹, Rajiv K Pruthi, M.B.B.S.², Dong Chen, MD, PhD³, Angela Dispenzieri, MD⁴, Shaji Kumar, MD⁴ and Damon E. Houghton, MD, MS⁵

¹Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
²Comprehensive Hemophilia Center and Special Coagulation Laboratory, Division of Hematopathology, Mayo Clinic, Rochester, MN
³Division of Hematopathology, Mayo Clinic, Rochester, MN
⁴Division of Hematology, Mayo Clinic, Rochester, MN
⁵Department of Cardiovascular Diseases, Division of Vascular Medicine & Dept of Medicine, Division of Hematology, Mayo Clinic, Rochester, MN

3997

Variants in Complement Regulatory Genes in Patients with Thrombotic Storm

Joseph Zouein, MD, MSc¹^*, Genesis Soriano²^*, Karen Nuytemans, PhD, MSc²^*, Lisette Gomez²^*, Patrice Whitehead²^*, Margaret A. Pericak-Vance, PhD²^*, Jeffery M. Vance, MD, PhD²^* and Thomas L. Ortel, MD, PhD¹

¹Division of Hematology, Duke University School of Medicine, Durham, NC
²University of Miami, John P. Hussman Institute for Human Genomics, Miller School of Medicine, Biomedical Research Building, Miami, FL

3998

Streptococcus Gordonii Binds VWF Via Its Sialoglycan-Binding Adhesins Under Shear to Initiate Infective Endocarditis

Martha M.S. Sim, PhD¹^*, Ava Obenaus²^*, Richard Maldonado³^*, Jennie Le⁴^*, Lesley Martínez Rodríguez⁵^*, Barbara Bensing⁶^*, Paul Sullam⁶^*, Wendy Thomas²^*, Nathan Sniadecki, PhD⁷^*, Junmei Chen, PhD⁸ and Jose A. Lopez, M.D³

¹Bloodworks Northwest Research Institute, Seattle, WA
²University of Washington, Seattle, WA
³Bloodworks Research Institute, Seattle, WA
⁴Bloodworks Northwest, Seattle, WA
⁵Department of Bioengineering, University of Washington, Seattle, WA
⁶Department of Medicine, University of California, San Francisco, San Francisco, WA
⁷Mechanical Engineering, Bioengineering, University of Washington, Seattle, WA
⁸University of Washington, Bloodworks Research Institute, Seattle, WA

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^*signifies non-member of ASH