Zeguang Wu^1*, Jinhong Shi^2*, Qiezhong Lamao^1*, Jinxin Yang^1*, Yuanyuan Qiu^1*, Yang Liu^2*, Feifei Liang^3*, Changya Chen⁴, Qingming Yang^2*, Chunmeng Wang^2*, Haixia Zhang^3*, Zhonghan Yang^3*, Yunyi Zhang^3*, Yuting Yi^3*, Xufen Zheng^3*, Yun Sun^3*, Kuiying Ma^5*, Lingling Yu^5*, Huihui Yang^5*, Yongjian Zhang^3*, Zhiqiang Wu^2*, Yao Wang^2*, Zhenguang Wang^3*, Catherine CL Wong^1*, Pengfei Yuan, PhD^3*, Weidong Han^2* and Wensheng Wei^1*

¹Peking University, Beijing, China
²The First Medical Center, Chinese PLA General Hospital, Beijing, China
³EdiGene Inc, Beijing, China
⁴Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
⁵Changping Laboratory, Beijing, China

Sanam Shahid, MD¹, Serena Mathew^2*, Sydney Souness^2*, Erin R. Burns^2*, Jasmine S. Um^2*, Sarah Yoo^2*, Winson Cai^2*, Mary Ann Pohl^3*, Takeshi Fujino^2*, Pu Zhang^2*, Jennifer Lewis^2*, Sean M. Devlin, PhD^4*, Ivo Lorenz^3*, Renier Brentjens, MD PhD⁵ and Anthony F. Daniyan, MD^6*

¹Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY
²Memorial Sloan Kettering Cancer Center, New York, NY
³Tri‐Institutional Therapeutics Discovery Institute, Memorial Sloan Kettering Cancer Center, New York, NY
⁴Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY
⁵Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY
⁶Department of Medicine, Cell Therapy Service, Memorial Sloan Kettering Cancer Center, New York, NY

Meijuan Huang, MD^1*, Lei Zhao, MD, PhD^2*, Yuhang Cheng^2*, Liang Huang², Jianfeng Zhou, MD, PhD^2*, Dengju Li, PhD², Jue Wang^2* and Yang Cao^3*

¹Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China, Wuhan, China
²Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
³Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, San Diego, CA

Eleni Gavriilaki, MD, PhD^1,2, Christos Demosthenous, MD^3*, Zoi Bousiou, MD^2*, Ioannis Batsis, MD^2*, Anna Vardi, MD^3*, Despina Mallouri, MD^4*, Evdoxia Koravou^5*, Nikolaos Spyridis, MD^3*, Alkistis Kyra Panteliadou, MD^3*, Georgios Karavalakis, MD^3*, Paschalis Evangelidis^6*, Marianna Masmanidou^7*, Tasoula Touloumenidou^8*, Apostolia Papalexandri, MD^3*, Christos Poziopoulos, MD^9*, Ioanna Sakellari, MD^3*, Marianna Politou^10* and Ioannis Papassotiriou, PhD¹¹

¹Aristotle University of Thessaloniki, Thessaloniki, Greece
²Hematology Department – BMT Unit, George Papanikolaou General Hospital, Thessaloniki, Greece
³Hematology Department – BMT Unit, G Papanicolaou Hospital, Thessaloniki, Greece
⁴German Oncology Center, Limassol, Cyprus, Thessaloniki, Greece
⁵Hematology Department & HCT Unit, G. Papanicolaou Hospital, Thessaloniki, GRC
⁶Second propedeutic department of internal medicine, Hippokration Hospital, Thessaloniki, Greece, Thessaloniki, Greece
⁷Hematology Dept. - BMT Unit, George Papanicolaou General Hospital, Thessaloniki, Greece
⁸Hematology Department-BMT Unit, Georgios Papanikolaou General Hospital, Thessaloniki, Greece
⁹Department of Hematology, Metropolitan Hospital, Neo Faliro, Greece
¹⁰National and Kapodistrian University of Athens, Medical School, Athens, GRC
¹¹First Department of Pediatrics, National and Kapodistrian University of Athens, School of Medicine, Athens, Attica, Greece

Devang Thakkar^1*, Brian T. Hill, MD, PhD², Rachel Kositsky^3*, Shari Tian^3*, Leonardo Biral^3*, Veronica Russell^3*, Tushar Dave^3*, Cassandra L. Love³, Caroline Roth^3*, Matthew Stuart McKinney, MD⁴, Ahmed Galal, MD⁵, Jadee Neff, MD, PhD^4*, Agrima Mian, MD, MBBS⁶, Ellen Kendall^7*, Sarah L. Ondrejka, DO⁸, Matthew Chiaramonte, BA^9*, Govind Bhagat, MD¹⁰, Kenneth N. Ofori, MHS, MD^11*, Ran Reshef, MD, MSc¹², Alexandra E. Kovach, MD^13*, Tarsheen Sethi, MD, MSc¹⁴, Emily F. Mason, MD, PhD^15*, Shakthi Bhaskar, MD¹⁶, Olalekan O. Oluwole, MD, MPH, MBBS¹⁶, Chad McCall^17*, Christopher Pallas, MD^18*, Nilanjan Ghosh, MD, PhD¹⁸, Robert Ferdman, MD^19*, George Chen, MD¹⁹, Francisco Hernandez-Ilizaliturri, MD²⁰, Joanna Zurko, MD²¹, Ashley Cunningham, MD^22*, Nirav C Shah, MD^23*, Boyu Hu, MD²⁴, Deborah M. Stephens, DO²⁴, Monalisa Ghosh, MD²⁵, Neil Bailey, MSc²⁶, Krish Patel, MD²⁷, John M. Pagel, MD, Ph.D, DSc²⁶, Kavya Kannamma Kannan, MBBS^28*, Eric D. Hsi, MD²⁹, Rakhee Vaidya, MD^30*, Andrew Ip, MD^31*, Andre Goy, MD, MS³², Swetha Kambhampati Thiruvengadam, MD³³, Robert Ohgami, MD, PhD^34*, Charalambos Andreadis, MD³⁵, Christian A Gordillo, BS^36*, Brianna Just^37*, Jonathon B Cohen, MD MS³⁸, Arielle Baim^39*, Julie Barbello^26*, Erika Cavallone^40*, Veronika Bachanova, MD, PhD⁴¹, Maureen Laschen^42*, Andinet Teferra^42*, Frederique Lorcy^43*, Sylvain Lamure, MD, PhD^44*, Guillaume Cartron, MD, PhD^45*, Valerie Dardalhon, PhD^46*, Kikkeri N Naresh⁴⁷, Magdalena Czader, MD, PhD^48*, Anupama Reddy^49*, Elizabeth Thacker^50*, Clayton Parker, MS^50*, Lanie Happ^50* and Sandeep Dave, M.D.^4*

¹Department of Medicine, Duke University, Durham, NC
²Department of Hematology and Medical Oncology, Taussig Cancer Institute, The Cleveland Clinic Foundation, Cleveland, OH
³Duke University, Durham, NC
⁴Duke University Medical Center, Durham, NC
⁵Duke University School of Medicine, Durham, NC
⁶Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
⁷National Heart, Lung, and Blood Institute, Bethesda, MD
⁸Department of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, OH
⁹Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY
¹⁰Department of Pathology & Cell Biology, Columbia University, New York, NY
¹¹Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York
¹²Division of Hematology & Oncology, Columbia University Medical Center, New York
¹³Vanderbilt University, Nashville, TN
¹⁴Hematology, Yale University School of Medicine, New Haven, CT
¹⁵Department of Pathology, Microbiology, Immunology, Vanderbilt University Medical Center, Nashville, TN
¹⁶Division of Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN
¹⁷Atrium Health Carolinas, Charlotte, NC
¹⁸Levine Cancer Institute, Charlotte, NC
¹⁹Roswell Park Comprehensive Cancer Center, Buffalo, NY
²⁰Roswell Park Comprehensive Cancer Center, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY
²¹MCW Cancer Center, Medical College of Wisconsin, Madison, WI
²²Department of Pathology, Medical College of Wisconsin, Milwaukee, WI
²³MCW Cancer Center, The Medical College of Wisconsin, Milwaukee, WI
²⁴Huntsman Cancer Institute, University of Utah, Salt Lake City, UT
²⁵University of Michigan, Ann Arbor, MI
²⁶Swedish Cancer Institute, Seattle, WA
²⁷Swedish Cancer Institute, Center for Blood Disorders and Cellular Therapy, Seattle, WA
²⁸Wake Forest University, Winston-Salem, NC
²⁹Department of Pathology, Wake Forest Baptist Medical Center, Winston Salem, NC
³⁰Wake Forest, Winston-Salem, NC
³¹Hackensack Meridian School of Medicine, John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, NJ
³²John Theurer Cancer Center, Hackensack, NJ
³³City of Hope National Medical Center, Yorba Linda, CA
³⁴ARUP Institute for Research and Innovation, Salt Lake City, UT
³⁵Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, CA
³⁶Blood and Marrow Transplantation and Cell Therapy Program, Columbia University Irving Medical Center, New York, NY
³⁷University of Wisconsin Carbone Cancer Center, Madison, WI
³⁸Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA
³⁹Medical College of Wisconsin, Milwaukee, WI
⁴⁰UCSF, San Francisco, CA
⁴¹Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN
⁴²Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN
⁴³CHU Montpellier, Montpellier, FRA
⁴⁴IGMM UMR 5535 CNRS UM, University of Montpellier, MONTPELLIER, France
⁴⁵Centre Hospitalier Universitaire de Montpellier, Montpellier, France
⁴⁶Institut de Génétique Moléculaire de Montpellier, University of Montpellier, Montpellier, France
⁴⁷Fred Hutchinson Cancer Center, Seattle, WA
⁴⁸Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN
⁴⁹Vindhya Data Science, Morrisville, NC
⁵⁰Data Driven Bioscience, Durham, NC

Dasom Lee, MD¹, Brian J. Sworder, MD, PhD², Lara Stepan, BS^3*, Abood Okal, PhD^4*, Chang-Pin Huang^3*, Xiaoman Kang, BS^5*, James Hamilton^6*, Charles Macaulay^5*, Mari Olsen, BS^7*, Chih Long Liu, PhD^7*, Maximilian Diehn, MD, PhD^8*, Leanne Peiser, DPhil^3*, David Kurtz, MD, PhD⁹ and Ash A. Alizadeh, MD, PhD⁷

¹Department of Medicine, Division of Oncology, Stanford University, Redwood City, CA
²Division of Hematology and Oncology, University of California, Irvine, Irvine, CA
³Bristol Myers Squibb, Seattle, WA
⁴Bristol Myers Squibb, Cambridge, MA
⁵Department of Medicine, Division of Oncology, Stanford University, Stanford, CA
⁶Department of Molecular Biology, UT Southwestern Medical Center, Dallas
⁷Department of Medicine, Divisions of Oncology and Hematology, Stanford University, Stanford, CA
⁸Department of Radiation Oncology, Stanford University, Stanford, CA
⁹Department of Medicine (Oncology), Stanford University, Palo Alto, CA

Zineng Huang^1*, Hao Xu^2*, Qingbai Liu^3*, Jing Li^4*, Keqing Song^5*, Yating Deng^1*, Yujia Tao^1*, Huifang Zhang^1*, Peilong Wang^1*, Heng Li, MD^1*, Yue Sheng, PhD¹, Aijun Zhou^3*, Lianbin Han^6*, Yan Fu^6*, Chenzhi Wang^6*, Saurav Kumar Choudhary^7*, Kaixiong Ye^7*, Gianluca Veggiani^8*, Avery August^9*, Zhihong Li^10*, Weishan Huang^8*, Qiang Shan^2*, Hongling Peng, MD^1* and Zheng Fu^6*

¹Department of Hematology, The Second XIANGYA Hospital, Changsha, China
²National Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China
³Lianshui People's Hospital of Kangda College Affiliated to Nanjing Medical University, Huai’an, China
⁴Key Laboratory of Cluster Science, Ministry of Education of China, School of Chemistry and Chemical Engineering, Beijing, China
⁵Tianjin Mogenetics Biotech Co., Ltd, Tianjin, China
⁶MegaRobo Technologies Co., Ltd, Suzhou, China
⁷Institute of Bioinformatics, University of Georgia, Athens
⁸Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge
⁹Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca
¹⁰Department of Orthopedics, The Second XIANGYA Hospital, Changsha, China

Cai Zihong^1*, Baiwei Luo^1*, Bailin He^1*, Li Xuan^1*, Qifa Liu, MD¹ and Hongsheng Zhou^2,3,4*

¹Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China
²Department of Hematology,Nanfang Hospital, Southern Medical University, Guangzhou, China
³Guangdong Provincial Clinical Research Center for Hematologic Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China
⁴Department of Hematology, People's Hospital of Ganzhou, Ganzhou, China

Grace Hawkins^1*, Danielle Kirkey, MD^1,2*, Nika Panahi, BS^1*, Melia Blankenfeld, BS^1*, Isabel Lira, BS^1*, Tiffany Hylkema, BS^1*, Cyd McKay^1*, Christina Root^1*, Jack H. Peplinski, MSc^1*, Logan K. Wallace, MSc^1*, Rhonda E. Ries, MA^1*, Laura Pardo, MS^3*, Michael R. Loken, PhD^3* and Soheil Meshinchi, MD, PhD¹

¹Translational Science and Therapeutics, Fred Hutchinson Cancer Center, Seattle, WA
²Division of Hematology and Oncology, Seattle Children's Hospital, Seattle
³Hematologics, Inc., Seattle, WA

Roberto Garcia-Vicente^1*, Alba Rodríguez García^2*, Raquel Ancos-Pintado^3*, Andrés Arroyo Barea^4*, Adriana Ortega-Hernandez^5*, Irene Bragado-Garcia^3*, Eva Castellano^1*, Alejandra Ortiz-Ruiz^6*, Miguel Angel Navarro-Aguadero^3*, Javier Modrego^5*, Alejandra Leivas, PhD^1*, José Sanchez-Pina^7*, Rafael Alonso Fernandez, MD^7*, Maria Hernandez-Sanchez^8*, Mariateresa Fulciniti, PhD⁹, Cecilia Carpio^10*, Pere Barba, MD¹¹, Diego Carbonell^12*, Mi Kwon, MD, PhD¹³, Mariana Bastos-Oreiro^14*, Alejandro Martín García-Sancho^15*, Ana Jiménez Ubieto^16*, Antonio Valeri, PhD^7*, Dulcenombre Gomez-Garre^17*, Joaquín Martínez-Lopez^7* and María Linares^18*

¹Department of Translational Hematology, Research Institute Hospital 12 de Octubre (i+12), Hematological Malignancies Clinical Research Unit H120-CNIO, CIBERONC, Madrid, Spain
²Department of Translational Hematology, Research Institute Hospital 12 de Octubre (i+12), Hematological Malignancies Clinical Research Unit H120-CNIO, CIBERONC, Madrid, Spain, Madrid, ESP
³Department of Translational Hematology, Research Institute Hospital 12 De Octubr, Madrid, ESP
⁴Hospital Universitario 12 De Octubre, Imas12 Madrid, Madrid, ESP
⁵Microbiota and Vascular Biology Laboratory, Hospital Clínico San Carlos-Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain
⁶Hospital 12 de Octubre, Madrid, Spain
⁷Department of Hematology, Hospital Universitario 12 de Octubre, Spanish National Cancer Research Center (CNIO), Complutense University Madrid, Madrid, Spain
⁸Department of Biochemistry and Molecular Biology, Pharmacy School, Universidad C, Madrid, ESP
⁹Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA
¹⁰Department of Hematology, Vall d'Hebron Institute of Oncology (VHIO), University Hospital Vall d'Hebron, Autonomous University of Barcelona (UAB), Barcelona, Spain
¹¹Deparment of Hematology, Vall Hebron Institute of Oncology (VHIO), Hospital Universitari Vall D'Hebron, La Garriga, Barcelona, Spain
¹²Department of Hematology, Gregorio Marañón University Hospital, Instituto de Investigación Sanitaria Gregorio Marañón,, Madrid, Madrid, ESP
¹³General University Hospital Gregorio Marañón, Madrid, Spain
¹⁴Hematology Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain
¹⁵Hematology Department, Hospital Universitario de Salamanca, IBSAL, CIBERONC, University of Salamanca, Salamanca, Spain
¹⁶Hematology Department, Hospital Universitario 12 de Octubre, Madrid, Spain
¹⁷Microbiota and Vascular Biology Laboratory, Hospital ClíNico San Carlos-I, Madrid, ESP
¹⁸Universidad Complutense de Madrid, Madrid, Spain

Niklas Deschl^1,2,3,4*, Viktoria Blumenberg, MD^5,6,7,8,9, Maria-Luisa Schubert, MD^10*, Anita Schmitt, MD^10*, Michael Schmitt, MD^10*, Marion Subklewe, MD^7,11,12,13 and Christoph Stein-Thoeringer, MD^1,2,3,4*

¹Laboratory for Translational Microbiome Sciences, University Hospital Tuebingen, Tuebingen University, Tuebingen, Germany
²M3 Institute, University Hospital Tuebingen, Tuebingen University, Tuebingen, Germany
³Department of Internal Medicine I, University Hospital Tuebingen, Tuebingen University, Tuebingen, Germany
⁴Cluster of Excellence "Controlling Microbes to Fight Infections" (CMFI), Tuebingen University, Tuebingen, Germany
⁵Department of Medicine III, University Hospital LMU Munich, Munich, Germany, Munich, Germany
⁶Department of Medicine III, University Hospital LMU Munich, Munich, Germany
⁷German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany
⁸Cellular Immunotherapy Program, Massachusetts General Hospital and Harvard Medical School, Boston, MA
⁹Laboratory for Translational Cancer Immunology, LMU Gene Center, LMU Munich, Munich, Germany
¹⁰Department of Medicine V, University Hospital Heidelberg, Heidelberg, Germany
¹¹Laboratory for Translational Cancer Immunology, LMU Gene Center, Munich, Germany
¹²Bavarian Cancer Research Center (BZKF), Munich, Germany
¹³Department of Medicine III, LMU University Hospital, Munich, Germany

Haley M. Simpson, MD, PhD¹, Amanda Novak, BS^2*, Catherine Danis, PhD³, Michael Yarnell, BSc^4*, Phoebe Duong^5*, Brett M Stevens, PhD, BS^6*, Craig T Jordan, PhD⁶ and M. Eric Kohler, MD, Ph.D⁷

¹Division of Hematology, University of Colorado, Aurora, CO
²Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO
³University of Colorado, Anschutz Medical Campus, Aurora, CO
⁴University of Colorado Anschutz Medical Campus, Aurora, CO
⁵University of Colorado, Aurora
⁶Division of Hematology, University of Colorado Anschutz Medical Campus, Aurora, CO
⁷Division of Hematology/Oncology/Bone Marrow Transplant and Center for Cancer and Blood Disorders, Ch, Aurora, CO

Melia Blankenfeld, BS^1*, Danielle C. Kirkey, MD^1,2, Guangyan Xiong^3*, Hongbing Zhang^3*, Grace Hawkins^1*, Isabel Lira, BS^1*, Cyd McKay^1*, Christina Root^1*, Concetta Quintarelli, PhD^4*, Franco Locatelli, MD⁴, Cheng Liu, PhD^3* and Soheil Meshinchi, MD, PhD¹

¹Translational Science and Therapeutics, Fred Hutchinson Cancer Center, Seattle, WA
²Pediatric Hematology/Oncology, Seattle Children's Hospital, Seattle, WA
³Eureka Therapeutics, Emeryville, CA
⁴IRCCS Bambino Gesù Children's Hospital, Rome, Italy

Emily Wolf, MD¹, Madiha Iqbal, MD¹, Zhuo Li, MS^2*, Han W. Tun, MD¹ and Ephraim E. Parent, MD, PhD^3*

¹Division of Hematology and Medical Oncology, Mayo Clinic, Jacksonville, FL
²Division of Biomedical Statistics and Informatics, Mayo Clinic, Jacksonville
³Department of Radiology, Mayo Clinic, Jacksonville, FL

Yuanyuan Zhang^1,2*, Meijuan Huang, MD^1,2*, Tianjiao Liu, MD, PhD^3*, Yuhang Cheng^1,2*, Dengju Li, PhD^1,2, Yang Cao^2,4*, Wei Mu^1,2*, Liting Chen, PhD^1,2*, Li Zhu, MD, PhD^1,2*, Tongjuan Li, MD, PhD^1,2*, Liang Huang, MD, PhD^5,6, Jia Wei^1,2, Lei Zhao, MD, PhD^1,2* and Jue Wang^1,2*

¹Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
²Immunotherapy Research Center for Hematologic Diseases of Hubei Province, Wuhan, China
³Department of Hematology and Oncology, Ningbo No.2 Hospital, Zhejiang Province, Ningbo, China
⁴Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, San Diego, CA
⁵State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, China
⁶Tianjin Institutes of Health Science, Tianjin, China

Wenjing Luo^1,2*, Jia Xu^1,2*, Chenggong Li^1,2*, Lu Tang^1*, Yingying Li^1,3*, Xindi Wang^1,2*, Wu Zhuolin^1,2*, Yinqiang Zhang^1,2*, Yu Hu^1,2* and Heng Mei, md, phd^1,2*

¹Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
²Hubei Clinical Medical Center of Cell Therapy for Neoplastic Disease, Wuhan, China
³Hubei Clinical and Research Centre of Thrombosis and Haemostasis, Wuhan, China

Viktor Lemgart^1*, Jennifer Richards^2*, Laura Strauss^2*, Jing Jiao^2*, Brandon Quido^2*, Laura Powers^2*, Allison Caron^1*, Eyoung Shin^1*, Austin Boesch^2*, Dharini Shah^2*, Tiffany Le^1*, Rasika Kunden^1*, Samantha Stewart^1*, Fazila Nasimi^1*, Sampa Maiti^1*, Mir Ali^1*, Olga Lihoradova^1*, Aaron Griset^1*, Christopher M. Borges¹, William Kuhlman^1*, Carla Lawendowski^2*, Ulrik Nielsen^2*, Valeria Fantin^2*, Daryl Drummond^1*, Donald Shaffer^2* and Andrew J Sawyer^3*

¹Genetic Medicines Unit, Sanofi, Cambridge, MA
²Oncology Research, Sanofi, Cambridge, MA
³Oncology Research, Sanofi, North Reading, MA

Erik L Kimble, MD^1,2, Salvatore Fiorenza, MBBS, PhD, BSc, FRACP, FRCPA, MPH^3,4, Alexandre V. Hirayama, MD^5,6, Austin M Gabel, BS^7*, Jordan Gauthier, MD, MSc^2,8, Aiko Torkelson, BS^8*, Abigail Chutnik, BS^8*, Henna Di, BS^8*, Jocelyn H Wright, PhD^8*, Barbara Pender, MSc^8*, Stefan Radtke, PhD⁸, Roland B. Walter, MD, PhD, MS^8,9, Hans-Peter Kiem, MD, PhD^1,2, David G. Maloney, MD, PhD⁸, Robert K. Bradley, PhD^10,11* and Cameron J. Turtle, MBBS, PhD^5,12*

¹Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA
²University of Washington, Seattle, WA
³Faculty of Medicine and Health, University of Sydney, Balwyn North, VIC, Australia
⁴Molecular Oncology and Cancer Immunology, Epworth HealthCare, Richmond, VIC, Australia
⁵Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA
⁶Division of Hematology and Oncology, University of Washington, Seattle, WA
⁷University of Washington, School of Medicine, Seattle, WA
⁸Fred Hutchinson Cancer Center, Seattle, WA
⁹Department of Medicine, Division of Hematology and Oncology, University of Washington, Seattle, WA
¹⁰Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA
¹¹Department of Genome Sciences, University of Washington, Seattle, WA
¹²University of Sydney, Sydney, NSW, Australia

Ana Belén Moreno-Castaño, MD^1*, Sara Fernández^2*, Helena Brillembourg^3*, Blanca de Moner^4,5*, Helena Ventosa-Capell^6*, Julia Martinez-Sanchez, PhD^7*, Alex Ramos^8*, Marta Palomo, PhD^9*, Patricia Molina^4*, Marc Pino^4*, Pilar Gomez-Ramirez^10*, Valentin Ortiz-Maldonado, MD, PhD, MSc^{11,12,13,14,15}, Nuria Martínez-Cibrián, MD^16*, Julio Delgado, MD, PhD^3,17*, Carlos Fernández de Larrea, MD¹⁸, Maria Queralt Salas Gay, MD^19*, Alvaro Urbano-Ispizua, MD, PhD^3,14,17, Adrián Téllez^20*, Jose Maria Nicolas^21*, Ginés Escolar^22*, Enric Carreras, MD, PhD^23*, Francesc Fernández-Avilés, MD, PhD^24,25*, Pedro Castro^20* and Maribel Diaz-Ricart, PhD^7*

¹Hemostasis and Erythropathology Laboratory. Pathology Department, Hematopathology. Centre de Diagnòstic Biomèdic. University of Barcelona. IDIBAPS, BARCELONA, Spain
²Medical Intensive Care Unit, Clínic Barcelona. University of Barcelona, IDIBAPS., Hospital Clínic, Barcelona, Barcelona, ESP
³Hematology Department, Hospital Clínic de Barcelona, Barcelona, Spain., Barcelona, Spain
⁴Hemostasis and Erythropathology, Hematopathology, Pathology Department, CDB, IDIBAPS, University of Barcelona, Hospital Clínic, Barcelona, Spain
⁵Josep Carreras Leukaemia Research Institute, Barcelona, Spain
⁶Medical Intensive Care Unit, Clínic Barcelona, Barcelona, Spain. Hospital Clinic Barcelona, Barcelona, ESP
⁷Hemostasis and Erythropathology, Hematopathology, Pathology Department, CDB, IDIBAPS, University of Barcelona, Hospital Clínic de Barcelona, Barcelona, Spain
⁸Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS. Hospital Clinic de Barcelona, Barcelona, Spain
⁹Hematology External Quality Assessment Laboratory, Centre de Diagnòstic Biomèdic, Hospital Clínic Barcelona, Spain., BARCELONA, Spain
¹⁰Laboratory of Hemostasis and Erythropathology, Hematopathology, Pathology Departm, Barcelona, ESP
¹¹Hematology Department, Hematology Department, Hospital Clínic Barcelona, Barcelona, Spain, Barcelona, ESP
¹²Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
¹³Hematology Department, Hospital Clínic Barcelona, Barcelona, Spain, Seattle, WA
¹⁴University of Barcelona, Barcelona, Spain
¹⁵Hospital Clínic de Barcelona, Barcelona, Spain
¹⁶Hematology Department, Hospital Clínic Barcelona, Barcelona, Spain, Barcelona, Spain
¹⁷Fundació de Recerca Clínic Barcelona-Institut D’Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain
¹⁸Hematology Department., Hospital Clínic de Barcelona, IDIBAPS., Barcelona, Spain
¹⁹Hematology Department, Hospital Clínic de Barcelona, IDIBAPS, University of Barcelona, Barcelona, Spain., BARCELONA, Spain
²⁰Medical Intensive Care Unit, IDIBAPS, University of Barcelona, Hospital Clínic, Barcelona, Spain
²¹Medical Intensive Care Unit, Hospital Clinic, Barcelona, ESP
²²Hemostasis and Erythropathology Laboratory, Hematopathology, Pathology Department, CDB, Hospital Clinic, IDIBAPS. University of Barcelona, Barcelona, Spain
²³Fundació Josep Carreras Contra la Leucèmia, Barcelona, Spain
²⁴Fundació de Recerca Clínic Barcelona-Institut d’Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), Barcelona, Spain
²⁵Hematopoietic Transplantation Unit, Hematology Department, Clinical Institute of Hematology and Oncology (ICMHO), Hospital Clínic de Barcelona, Barcelona, Spain

Tommaso Balestra, PhD¹, Lisa M Niswander, MD, PhD^1,2, Asen Bagashev, PhD^1*, Joseph P Loftus^1*, Savannah L Ross^3*, Robert K Chen^1*, Samantha M McClellan^1*, Jacob J Junco^4,5*, Diego Alberto Barcenas-Lopez, PhD¹, Karen R Rabin, MD, PhD^5,6, Terry J Fry, MD^3,7 and Sarah K Tasian, MD^2,8,9

¹Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA
²Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA
³Division of Hematology/Oncology/Bone Marrow Transplant and Center for Cancer and Blood Disorders, Children’s Hospital of Colorado, Aurora, CO
⁴Department of Pediatrics, Baylor College of Medicine, Houston, TX
⁵Cancer Center and Division of Pediatric Hematology/Oncology, Texas Children’s Hospital, Houston, TX
⁶Department of Pediatrics, Division of Pediatric Hematology/Oncology, Baylor College of Medicine, Houston, TX
⁷Immunology Department and HI3 Initiative, University of Colorado Anschutz Medical Campus, Aurora, CO
⁸University of Pennsylvania School of Medicine, Philadelphia, PA
⁹Division of Oncology & Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA

Viktoria Blumenberg, MD^1,2,3,4, Maryam Kazerani, PhD⁵, Tobias Straub, Ph.D.^6*, Francesco Corrado, MD^3,7*, Vadim Borisov^8*, Stephan Baumann^3*, Galina Busch^3*, Jan Wulf^3*, Agnese Petrera, PhD^9*, Kai Rejeski, MD^2,3,10,11, Christian Schmidt, MD^12*, Benjamin Tast^3*, Michael von Bergwelt-Baildon, MD, PhD^2,13*, Christoph Stein-Thöringer^8,14*, Veit L. Buecklein, MD^2,3,10* and Marion Subklewe, MD^2,3,10

¹Department of Medicine III, University Hospital LMU Munich, Munich, Germany
²German Cancer Consortium (DKTK) and Bavarian Cancer Research Center (BZKF), partner site Munich, Munich, Germany
³Laboratory for Translational Cancer Immunology, LMU Gene Center, LMU Munich, Munich, Germany
⁴Cellular Immunotherapy Program, Massachusetts General Hospital and Harvard Medical School, Boston, MA
⁵Laboratory for Translational Cancer Immunology, Cedars-Sinai Medical Center, Los Angeles, CA
⁶Core Facility Bioinformatics, LMU Biomedical Center, LMU Munich, Munich, Germany
⁷Department of Medical Oncology, Jerome Lipper Center for Multiple Myeloma Research, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA
⁸Internal Medicine I, Laboratory for Translational Microbiome Sciences, University Clinic Tübingen, Tübingen, Germany
⁹Metabolomics and Proteomics Core, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany
¹⁰Department of Medicine III, LMU University Hospital, Munich, Germany
¹¹Department of Medicine, Adult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY
¹²Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany
¹³Department of Medicine III, University Hospital, LMU Munich, Munich, Germany
¹⁴Cluster of Excellence, Controlling Microbes to Fight Infections (CMFI), University Tübingen, Tübingen, Germany

Roberto Savoldelli, PhD^1*, Alice Pievani, PhD^2*, Sarah Tettamanti^3*, Chiara Giacomini, PhD^1*, Anna Kozlowska, PhD^4*, Marta Serafini^5* and Francesco Dazzi^6,7*

¹King's College London, London, United Kingdom
²Centro Ricerca M. Tettamanti, Department of Pediatrics, University of Milan Bicocca, Monza, ITA
³"Matilde Tettamanti" Research Center, Monza, ITA
⁴Biopharma Cell Therapy R&D, AstraZeneca, Gothenburg, Sweden
⁵DIMET, University of Milano-Bicocca, Monza, ITA
⁶School of Cardiovascular and Metabolic Medicine and Sciences, King's College London, London, United Kingdom
⁷AstraZeneca Biopharma R&D, Cambridge, United Kingdom

Juliet Crabtree^1*, Akinola Emmanuel^1*, Ganapathy Subramanian Sankaran^1*, Jui Dutta-Simmons^1*, Karolina Kosakowska^1*, Tracy Dimezzo^1*, Ian Langer^1*, Prapti Vyas^1*, David Soto^1*, Akshi Thakkar^1*, Grace Chen^1*, Maja Sedic^1*, Scott Barros^1*, Allen Horhota^1*, Isin Dalkilic-Liddle^1*, LT Thiruneelakantapillai^1*, Muthusamy Jayaraman^1*, Megan Hoban^1*, Frank Neumann¹ and Robert Mabry, PhD^2*

¹Orna Therapeutics, Watertown, MA
²Orna Therapeutics, Cambridge, MA

Ajlan Al Zaki, MD, PhD¹, Margie Sutton, PhD^2*, Abdur Rehman, PhD^3*, Cao Cuong Le, PhD^4*, Seth Gammon, PhD^5*, Arianna Napoli^6*, Ping Yang^6*, Neeraj Y. Saini, MD⁷, Sairah Ahmed, MD⁸, Ghayas C. Issa, MD⁹, Partow Kebriaei, MD⁷, Michael Davies, MD, PhD^10*, Elizabeth J. Shpall, MD⁷, Jeena Varghese, MD^11*, Lesley Flynt, MD^12*, Sattva S. Neelapu, MD³ and David Piwnica-Worms, MD, PhD^5*

¹Department of Lymphoma/Myeloma and Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX
²Cancer Systems Imaging, Assistant Professor, Houston
³Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston
⁵Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX
⁶Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston
⁷Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX
⁸Department of Lymphoma/Myeloma and Stem Cell Transplantation, The University of Texas MD Anderson Cancer Center, Houston, TX
⁹Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX
¹⁰The University of Texas MD Anderson Cancer Center, Houston
¹¹Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston
¹²Department of Nuclear Medicine, The University of Texas MD Anderson Cancer Center, Houston

Zoe O'Connor, MD¹, Ashley Bui, MD^1*, Laura Coughlin, MA^1*, Shuheng Gan, MS^1*, Samuel John, MD^2*, Nicole Poulides, MS^1*, Parastoo Sabaeifard, PhD^1*, Xiaowei Zhan, PhD^1*, Stephen Lim, MD^3*, Angelica Sanjuan, MS^4*, Theodore W. Laetsch, MD^5* and Andrew Y. Koh, MD^6*

¹University of Texas Southwestern Medical Center, Dallas, TX
²Department of Pediatrics, Division of Hematology-Oncology, University of Texas Southwestern Medical Center, Dallas, TX
³Novartis Pharmaceuticals Corporation, East Hanover, NJ
⁴University of Texas at Dallas, Dallas, TX
⁵Department of Pediatrics and Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
⁶Dept. of Pediatrics; Division of Hematology-Oncology, UT Southwestern Medical Center, Dallas, TX

Ciril Abraham, BS^1,2*, Wenbin Mo, MMSc^1*, Tien Bui^3*, Mimi Chen, PhD^1*, Yuanyuan Tian, PhD^1*, Gennaro Clando^4*, Morgan Chaunzwa^4*, Ying WANG^5*, Jozef Madzo^4*, Jean-Pierre Issa^4* and Yi Zhang, MD, PhD¹

¹Center for Discovery and Innovation, Hackensack University Medical Center, Nutley, NJ
²Fels Institute and Department of Cancer Cellular Biology, Lewis Katz School of Medicine, Temple University, Nutley, NJ
³Center for Discovery and Innovation, Hackensack University Medical Center, Nutley
⁴Coriell Institute for Medical Research, Camden, NJ
⁵Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ

Joseph Durgin, MD^1*, Shadab Kazmi, PhD^2*, Andre Kelly^2*, Roddy S. O'Connor, PhD^2* and Saba Ghassemi, PhD²

¹Department of Dermatology, University of Michigan, Ann Arbor, MI
²Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA

Showkat Hamid, MD¹, Muhammad Junaid Tariq, MBBS^2*, SaeBom Lee, PhD^2*, Payal Goala, MS, BS^2*, Shannon McSain^1*, Cooper Sailer, PhD, MS^2*, Nolan Beatty^2* and Marco Davila, MD, PhD¹

¹Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY
²Roswell Park Cancer Institute, Buffalo, NY

Yue Liu, PhD^1*, Lingna An^2* and Xi Zhang, PhD³

¹Medical Center of Hematology; Xinqiao Hospital of Army Medical University, Chongqing 400037, China, Chongqing, China
²Medical Center of Hematology; Xinqiao Hospital of Army Medical University, Chongqing 400037, China., chongqing, China
³Medical Center of Hematology, Xinqiao Hospital of Army Medical University, State Key Laboratory of Trauma and Chemical Poisoning, Chongqing Key Laboratory of Hematology and Microenvironment, Chongqing, China