Marina E Michaud¹, Sarthak Satpathy, MSc^2*, William Pilcher^3*, Edgar Gonzalez-Kozlova, PhD^4*, Dimitra Karagkouni, PhD^5*, Lijun Yao, PhD^6*, Yered Pita-Juarez, PhD^7*, Chaitanya Acharya, PhD^8*, Mark Hamilton, MD⁸, Shivani Nanda^9*, Yizhe Song¹⁰, Julia T Wang^11*, Mojtaba Bakhtiari, MD^1*, David Avigan, MD¹², Taxiarchis Kourelis, MD¹³, Madhav V. Dhodapkar, MD PhD¹⁴, Sagar Lonial, MD^15*, Swati Bhasin, PhD¹⁶, Immune Network^17*, Li Ding, PhD^18*, Sacha Gnjatic, PhD^19*, Ioannis S Vlachos, PhD^20*, George Mulligan, PhD⁸ and Manoj Bhasin, PhD¹

¹Department of Pediatrics, Emory University, Atlanta, GA
²Department of Biomedical Informatics, Emory University, Atlanta, GA
³Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA
⁴Icahn School of Medicine At Mount Sinai, New York, NY
⁵Department of Pathology, Cancer Research Institute, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA
⁶WUSTL, Saint Louis
⁷Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA
⁸Multiple Myeloma Research Foundation, Norwalk, CT
⁹Broad Institute of Harvard and MIT, Cambridge, MA
¹⁰WUSTL, St Louis, MO
¹¹McDonnell Genome Institute, Washington University School of Medicine in St. Louis, St. Louis, MO
¹²Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA
¹³Division of Hematology, Mayo Clinic, Rochester, MN
¹⁴Winship Cancer Institute of Emory University, Atlanta, GA
¹⁵Winship Cancer Institute, Atlanta, GA
¹⁶Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA
¹⁷Immune Network, Multiple Myeloma Research Foundation, Norwalk, CT
¹⁸Washington University, St. Louis, MO
¹⁹Icahn School of Medicine at Mount Sinai, New York, NY
²⁰Beth Israel Deaconess Medical Center, Boston, MA

Adolfo Aleman, Jr.^1,2*, Leah Grossman^2,3*, Ariel Kogan Zajdman, BS^4*, Lucia Y Chen, MD^5*, Sidorela Reci, BS^1,2*, Sundar Jagannath^2,6 and Samir Parekh, MD^1,2

¹Department of Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY
²Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY
³Department of Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York City, NY
⁴UConn School of Medicine, Farmington, CT
⁵Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
⁶Icahn School of Medicine at Mount Sinai, New York, NY

Lirong Liu^1*, Le Wu^2*, Xinyu Li^3*, Xiaoyun Jin^4*, Xiaoya Chen^5*, Guangjue Tang^6*, Huixing Zhou^7*, Yuan Jian^8*, Wenming Chen^9*, Guangzhong Yang^10*, Yan Huang^6*, Fang Wang^11,12,13*, Jia Yu^1,13,14*, Wen Gao¹⁵ and Dong Wang^3,16,17*

¹State Key Laboratory of Common Mechanism Research for Major Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, CHN
²Department of Bioinformatics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China., Guangzhou, CHN
³Department of Bioinformatics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
⁴Beijing Chao-Yang Hospital Capital Medical University, Beijing, CHN
⁵Department of Bioinformatics, School of Basic Medical Sciences, Southern Medical University,Guangzhou, China., Guangzhou, China
⁶Department of Bioinformatics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, CHN
⁷Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
⁸Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
⁹Department of Hematology, Beijing Chao-Yang Hospital of Capital Medical University, Beijing, China
¹⁰Hematology, Beijing, China
¹¹Key Laboratory of RNA and Hematopoietic Regulation, Chinese Academy of Medical Sciences, Beijing, China
¹²State Key Laboratory of Common Mechanism Research for Major Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, China., Zhengzhou, CHN
¹³Institute of Blood Transfusion, Chinese Academy of Medical Sciences, Chengdu, China
¹⁴Key Laboratory of RNA and Hematopoietic Regulation, Chinese Academy of Medical Sciences, Being, China
¹⁵Department of Hematology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
¹⁶Dermatology Hospital, Southern Medical University, Guangzhou, China
¹⁷Guangdong Province Key Laboratory of Molecular Tumor Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China

Tracy T. Chow^1*, Nicholas Stong^1*, Saleh Tamim^1*, Chad C. Bjorklund^2*, Antonina Kurtova^1*, Keyur Desai^1*, Joseph T. Hadala^1*, Cynthia Donahue^1*, Phillip Koo^1*, Yue Zhu^1*, Jessica Katz¹, Anita K. Gandhi, PhD³, Suzanne Trudel, MD, MSc⁴, Nizar J. Bahlis, MD⁵, Paul G. Richardson⁶ and Michael Amatangelo, PhD^1*

¹Bristol Myers Squibb, Princeton, NJ
²Bristol Myers Squibb, Summit, NJ
³Hematology, Translational Medicine, Bristol Myers Squibb, Summit, NJ
⁴Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
⁵Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, AB, Canada
⁶Dana-Farber Cancer Institute, Boston, MA

Yijie Wang^1*, Jingyuan Ma^2*, Xiyue Sun^1*, Lixin Gong^2*, Lanting Liu^1*, Gang An^1*, Lu-Gui Qiu¹ and Mu Hao, MD^1*

¹State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology& Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
²State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China

Jeremiah C. Pfitzer¹, Razan Waliagha, M.S.^1,2*, Linda B. Baughn, PhD³, Adam B. Keeton, Ph.D.^4*, Xi Chen, Ph.D.^4*, Yulia Maxuitenko, Ph.D.^4*, Shaji Kumar, MD⁵, Brian Van Ness, PhD^6*, Gary Piazza, Ph.D.^4* and Amit K Mitra, PhD, MSc^2,7

¹Department of Drug Discovery and Development, Auburn University, Auburn, AL
²Center for Pharmacogenomics and Single-Cell Omics (AUPharmGx), Auburn University, Auburn, AL
³Department of Laboratory Medicine & Pathology, Mayo Clinic, Rochester, MN
⁴Harrison College of Pharmacy, Department of Drug Discovery and Development, Auburn, AL
⁵Division of Hematology, Mayo Clinic, Rochester, MN
⁶Department of Genetics, Cell biology & Development, University of Minnesota, Twin Cities, Minneapolis, MN
⁷Department of Drug Discovery and Development, Auburn University, AUBURN, AL

Erin M Kropp, MD, PhD¹, Sho Matono^1*, Aaron Robida^2*, Malathi Kandarpa, PhD^3*, Olivia Wang^1*, Andrew Alt^2*, Moshe Talpaz, MD⁴, Matthew Pianko⁵ and Qing Li, MD PhD^1,5,6

¹Department of Internal Medicine, Hematology Oncology Division, Michigan Medicine, University of Michigan, Ann Arbor, MI
²Center for Chemical Genomics, University of Michigan Life Sciences Institute, Ann Arbor, MI
³Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI
⁴Division of Hematology-Oncology, University of Michigan Rogel Cancer Center, Ann Arbor, MI
⁵Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI
⁶Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI

Ken Lee^1*, Yi Zhou^1*, Matthew Franklin^1*, Erica Ullman^2*, Aynur Hermann^2*, Glenn S. Kroog^1*, Anita Boyapati^3*, Karen Rodriguez Lorenc¹, Eric Smith, PhD^4*, John Lin, MD, PhD^1*, William Olson^2*, Leonardo Andres Sirulnik, MD, PhD¹ and Kara Olson, MS^5*

¹Regeneron Pharmaceuticals, Inc, Tarrytown, NY
²Therapeutic Proteins, Regeneron Pharmaceuticals, Inc, Tarrytown, NY
³Regeneron Pharmaceuticals, Inc., Tarrytown, NY
⁴Bispecifics, Regeneron Pharmaceuticals, Inc, Tarrytown, NY
⁵Regeneron Pharmaceuticals, Inc, White Plains, NY

Zainul S. Hasanali, MD, PhD¹, Alfred L. Garfall, MD², Dan T. Vogl, MD, MS², Sandra Susanibar-Adaniya, MD², Adam D. Cohen, MD³, Edward A. Stadtmauer, MD⁴, Shivani Kapur, MD³, Adam Waxman, MD^3* and David Allman, PhD^5*

¹Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
²Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA
³Division of Hematology/Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA
⁴Abramson Cancer Center, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA
⁵Department of Pathology & Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA

Umair Munawar^1*, Julia Weingart^2*, Patrick Eiring, PhD^2*, Silvia Nerreter^3*, Cornelia Vogt^3*, Shilpa Kurian^3*, Seungbin Han^3*, Max J Steinhardt^3*, Xiang Zhou, MD, BMBS⁴, Markus Sauer, PhD^2*, Hermann Einsele, MD³, Leo Rasche, MD^5*, Johannes Waldschmidt, MD³ and K. Martin Kortüm, MD^6*

¹University Hospital of Wuerzburg, Wuerzburg, Germany
²Department of Biotechnology and Biophysics, University of Würzburg, Würzburg, Germany
³Department of Internal Medicine II, University Hospital Wuerzburg, Wuerzburg, Germany
⁴University Hospital Wuerzburg, Wurzburg, Germany
⁵Department of Internal Medicine, University Hospital of Würzburg, Würzburg, Germany
⁶Department of Internal Medicine II, University Hospital of Würzburg, Wuerzburg, Germany

Domenico Maisano, PhD, MSc^1*, Tenghui Wang, BS^2,3*, Yuquan Tong, PhD^2,3*, Vanessa Favasuli, PhD^1*, Na Liu, MS^1*, Claire Gao, BS^1*, Chandraditya Chakraborty, PhD^1*, Giulia Giorgetti, MS^1,4*, Francesco Ladisa, MS^1,4*, Marcello Turi, PhD^5*, Francesca Barello, MS^5*, Michela Cumerlato, MS^1,6*, Anil Aktas-Samur, PhD^1*, Mehmet K. Samur, PhD¹, Michael Cameron, PhD^3*, Filip Garbicz, MD^7*, Ruben D. Carrasco, MD, PhD^7*, Mariateresa Fulciniti, PhD¹, Annamaria Gulla, MD⁵, Jessica Childs-Disney, PhD^3*, Matthew D. Disney, PhD^2,3,8*, Eugenio Morelli, MD^5,8,9 and Nikhil C. Munshi, MD^1,8

¹Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA
²The Scripps Research Institute, Jupiter, FL
³The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL
⁴Department of Internal Medicine and Medical Specialties (DiMI), University of Genoa, Genoa, Italy
⁵Candiolo Cancer Institute FPO-IRCCS, Candiolo, Italy
⁶Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy
⁷Department of Pathology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA
⁸Senior authors, #
⁹Department of Medical Oncology, University of Turin, Turin, Italy

J Erin Wiedmeier-Nutor, MD, MPH¹, Surendra Dasari, PhD^2*, Richard Kumaran Kandasamy, PhD³, Kiran Manalaparthi, PhD^3*, Laura Ann Bruins^4*, Gregory Ahmann⁵, Mariano Arribas^6*, P. Leif Bergsagel, MD⁷, Akhilesh Pandey, MD, PhD³, Esteban Braggio, PhD⁸ and Rafael Fonseca, MD⁹

¹Division of Hematology, Mayo Clinic, Phoenix, AZ
²Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN
³Mayo Clinic, Rochester, MN
⁴Division of Hematology/Oncology, Mayo Clinic, Scottsdale, AZ
⁵Department of Hematology/Oncology, Mayo Clinic Arizona, Scottsdale, AZ
⁶Division of Hematology/Oncology, Mayo Clinic Arizona, Phoenix, AZ
⁷Division of Hematology/Oncology, Mayo Clinic, Phoenix, AZ
⁸Division of Hematology and Oncology, Mayo Clinic, Scottsdale, AZ
⁹Division of Hematology, Mayo Clinic, Paradise Valley, AZ

Tomas Jelinek^1,2, Serafim Nenarokov^2*, Tereza Sevcikova^1,2,3*, Eva Radova^1,2*, Ondrej Venglar^1,2*, Veronika Kapustova^1,2*, Lucie Broskevicova^1,2*, Jan Vrana^1,2*, Ludmila Muronova^4,5*, Tereza Popkova, MD^4,5*, Jana Mihalyova^1,2*, Hana Plonkova, MD^4*, Michal Simicek^1,2*, Bachisio Ziccheddu^6*, Benjamin Diamond, MD⁶, Francesco Maura, MD⁷, Ola Landgren⁸, David Zihala^4,5* and Roman Hájek^1,2

¹Department of Hematooncology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic
²Department of Hematooncology, University Hospital Ostrava, Ostrava, Czech Republic
³Department of Biology and Ecology, Faculty of Science, University of Ostrava, Ostrava, Czech Republic
⁴Department of Haematooncology, University Hospital Ostrava, Ostrava, Czech Republic
⁵Department of Haematooncology, Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic
⁶Myeloma Institute, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL
⁷University of Miami, Coral Gables, FL
⁸Sylvester Comprehensive Cancer Center, Miami, FL

Ding Yan Wang, PhD^1*, Ming Liu, PhD^2*, Jamie Li, MS^3*, Raymond Qu^4*, Keva Garg^4*, Yuan Gao^4*, Xinmiao Andrew Yang^4*, Leqi Shen^4*, Jingdong Wu^4*, Xiaoyuan Liu^4*, Derek Shiqi Xu^4*, Cecilia Bonolo De Campos, PhD, MSc, DVM^5*, Jinyi Zhang, MD, PhD^2*, Anthony Gramolini, PhD^4*, Katherine Siminovitch, MD^6*, Xiao-Yan Wen, MD, PhD^7* and A. Keith Stewart, MBChB⁸

¹University of Toronto/Princess Margaret Cancer Center- University Health Network, Toronto, ON, Canada
²University of Toronto/LTRI, Toronto, Canada
³St.Cloud State University, St.Cloud, MN
⁴University of Toronto, Toronto, Canada
⁵Princess Margaret Cancer Center- University Health Network, Toronto, Canada
⁶University of Toronto/LTRI/Mount Sinai Hospital, Toronto, Canada
⁷Zebrafish Centre for Advanced Drug Discovery, Toronto, Canada
⁸Division of Medical Oncology and Hematology, University of Toronto/Princess Margaret Cancer Center- University Health Network, Toronto, ON, Canada

Minghao Dang, PhD^1*, Hans C. Lee, MD¹, Hima Bansal, PhD^2*, Maria Jose Acevedo-Calado, PhD^1*, Li Qin, PhD^1*, Wei Tan^1*, Luz Yurany Moreno Rueda, PhD, MSc^1*, David Berrios^1*, Oren Pasvolsky, MD^1*, Mahmoud R. Gaballa, MD¹, Melody R. Becnel, MD², J Christine Ye, MD, MSc¹, Krina K. Patel, MD, MSc¹, Pei Lin, MD, DM, MDPC³, Sheeba K. Thomas, MD¹, Donna M. Weber, MD¹, Linghua Wang, MD, PhD, MS^4* and Robert Z. Orlowski, MD, PhD¹

¹Department of Lymphoma & Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX
²Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX
³Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX
⁴Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Alana L. Keller¹, Zachary J. Walker, BS, MS^1*, Sarah E. Parzych, BA^1*, Tanisha N. Medha^1*, Lauren T. Reiman, BSc^1*, Peter A. Forsberg, MD¹, Jeremy Rahkola, BS^2*, Meher P. Boorgula, MS^3* and Daniel W. Sherbenou, MD, PhD¹

¹Division of Hematology, University of Colorado Anschutz Medical Campus, Aurora, CO
²Department of Medicine, Rocky Mountain Regional Veterans Affairs (VA) Medical Center, Aurora, CO
³Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO

Christophe Legendre^*, Shari Kyman^*, Felix Madrid^*, Yaden Santana^*, Bryce Turner^*, Daniel Enriquez^* and Jonathan J Keats, PhD

Translational Genomics Research Institute, Phoenix, AZ

Caleb K Stein, PhD^1*, Erin W Meermeier, PhD^2*, Yuliza Shotts, MS^1*, Yuan Xiao Zhu, PhD^1*, Chang-Xin Shi, PhD^1*, Kirsten Pfeffer, PhD^1*, Megan Du, MS^1*, Meaghen Sharik, BS^1*, Leif Bergsagel, MD³ and Marta Chesi, PhD⁴

¹Division of Hematology/Oncology, Department of Internal Medicine, Mayo Clinic, Scottsdale, AZ
²Department of Immunology, Mayo Clinic Arizona, Scottsdale, AZ
³Division of Hematology/Oncology, Mayo Clinic, Phoenix, AZ
⁴Mayo Clinic Arizona, Scottsdale, AZ

Marios Papadimitriou, MD^1*, Marilena Tauro, PhD^2*, Afsaneh Panahi, MSc^3*, Bachisio Ziccheddu^1*, Alexandra Maria Poos, PhD^4*, Abdessamad Youssfi Alaoui, PhD^1*, Dario Magaletti^2*, Mark B. Meads, PhD^2*, Kylee H Maclachlan, PhD, BSc, FRACP, FRCPA⁵, Marc S. Raab^4*, Gareth Morgan, M.D., Ph.D.^6*, Saad Z. Usmani, MD⁵, Niels Weinhold, PhD^4*, Ola Landgren¹, Kenneth H. Shain, MD, PhD², Florian Kuchenbauer, MD, PhD, FRCPC⁷ and Francesco Maura, MD⁸

¹Myeloma Institute, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL
²H. Lee Moffitt Cancer Center, Tampa, FL
³BC Cancer Research Center, Terry Fox Laboratory, Vancouver, BC, Canada
⁴Heidelberg Myeloma Center, Department of Medicine V, University Hospital Heidelberg, Heidelberg, Germany
⁵Myeloma Service, Division of Hematologic Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
⁶Perlmutter Cancer Center, Multiple Myeloma Research Program, NYU Langone Health, New York, NY
⁷Department of Medicine, Division of Hematology, University of British Columbia, Leukemia Bone Marrow Transplant Program of British Columbia and Vancouver General Hospital, Vancouver, BC, Canada, Vancouver, BC, Canada
⁸University of Miami, Coral Gables, FL

Zhenfeng Dai^1*, Yunlu Jia^2*, Jianbiao Zhou^3*, Wee-Joo Chng, FRCP, FRCPath, PhD³ and Zhen Cai^1*

¹Bone Marrow Transplantation Center, Department of Hematology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
²Department of Medical Oncology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
³National University Cancer Institute of Singapore, Singapore, Singapore

Debasmita Dutta, PhD¹, Jiye Liu, PhD^1*, Kenneth Wen, BS^2*, Annamaria Gulla, MD¹, Teru Hideshima, MD, PhD^1* and Kenneth C. Anderson, MD¹

¹Dana Farber Cancer Institute, Harvard Medical School, Boston, MA
²The Jerome Lipper Multiple Myeloma Center,Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA

Sabine Allam, MD^1,2,3*, Floris Chabrun, PhD, PharmD^1,2,3*, Jean-Baptiste Alberge, PhD^1,2,3, Grace Fleming^1*, Sungjae Kim, PhD^1,2*, Yoshinobu Konishi, MD, PhD^2,3,4, Habib El-Khoury, MD^1,5*, Luca Bertamini, MD^1,6*, Sofia Wallin^1*, Joseph Casey Flinn^1*, Dhananjay Sakrikar, PhD^7*, Derek Troske, BSc^7*, David Barnidge^7*, Mark C Perkins, PhD^7*, Stephen J. Harding, PhD⁷, Romanos Sklavenitis-Pistofidis, MD^1,2,3, Paolo Ghia^1,8, Catherine R. Marinac, PhD^1,3, Gad Getz, PhD^2,9* and Irene Ghobrial, MD^1,2,3

¹Dana-Farber Cancer Institute, Boston, MA
²Broad Institute of MIT and Harvard, Cambridge, MA
³Harvard Medical School, Boston, MA
⁴Dana-Farber Cancer Institute, Brookline, MA
⁵University of Chicago Medical Center, Chicago, IL
⁶Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, Netherlands
⁷Thermo Fisher Scientific, Waltham, MA
⁸Medical School, Università Vita-Salute San Raffaele, Milano, Italy
⁹Massachusetts General Hospital, Boston, MA

James J Ignatz-Hoover, MD, PhD¹, Pryianka Rana, PhD^2*, John D'Cruz^3*, E Ricky Chan, PhD^4*, Ehsan Malek, MD⁵ and James J. Driscoll II, MD²

¹Department of Medicine, Division of Hematology and Oncology, University Hospitals Seidman Cancer Center, Cleveland, OH
²University Hospitals Seidman Cancer Center, Cleveland, OH
³University School, Chagrin Falls, OH
⁴Case Western Reserve University, Cleveland, OH
⁵Roswell Park Comprehensive Cancer Center, Shaker Hts, OH

Ruchi Kudalkar^1*, Johnathan Altom¹, Vincent Manning^1*, Sara Taranto, PhD^2*, Joshua Galloway^1* and Francesca Cottini, MD¹

¹Division of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH
²Brescia University, Brescia, ITA

Ophélie Champion^1*, Sophie Maiga^2*, Christelle Dousset^2*, Agnès Aubry^3*, Céline Bellanger^3*, François Guillonneau^4*, Jose Antonio Moreno^5*, Ohyun Kwon^5*, Philippe Moreau, MD, PhD^6*, David Chiron, PhD^7*, Catherine Pellat-Deceunynck, PhD³, Cyrille Touzeau, MD, PhD^8* and Patricia Gomez-Bougie, PhD, PharmD^9*

¹Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes-Angers, Nantes University, Nantes, AL, France
²Nantes University and CHU Nantes, Nantes, France
³Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes-Angers, Nantes University, Nantes, France
⁴Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes-Angers, Université d'Angers, Angers, France
⁵Department of Chemistry and Biochemistry, University of California, Los Angeles, CA, USA, University of California, Los Angeles
⁶University Hospital Hôtel-Dieu, Nantes, France
⁷CRCI²NA - Nantes - Angers Cancer and Immunology Research Center, Nantes, NY, France
⁸Centre Hospitalier Universitaire de Nantes, Nantes, France
⁹Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes-Angers, Nantes University and CHU Nantes, Nantes, France

Kara Olson, MS^1*, David DiLillo^2*, Olga Sineshchekova^2*, Katja Mohrs^2*, Craig McCarthy^2*, Hassan Ahmed^2*, Sahar Rizvi^2*, Steven Quatela^2*, Elizabeth Navarro^2*, Cuiyan Lin^2*, Amanda Dorvilliers^2*, Glenn S. Kroog^2*, Karen Rodriguez Lorenc², Erica Ullman^3*, Aynur Hermann^3*, Eric Smith, PhD^4*, Jessica Kirshner^2*, William Olson^3* and John Lin, MD, PhD^2*

¹Regeneron Pharmaceuticals, Inc, White Plains, NY
²Regeneron Pharmaceuticals, Inc, Tarrytown, NY
³Therapeutic Proteins, Regeneron Pharmaceuticals, Inc, Tarrytown, NY
⁴Bispecifics, Regeneron Pharmaceuticals, Inc, Tarrytown, NY

Shannon Martin^1*, Yakinthi Chrisochoidou, PhD^1*, Andreia S. Margarido, PhD^1*, Fernando Sialana Jr., PhD^1*, Salomon Morales, MSc^1*, Marc Leiro, MSc^1*, Yigen Li, PhD^1*, Sarah Bird, BMBCh^1*, Konstantinos Mitsopoulos, PhD^1*, Esther Arwert, PhD^1* and Charlotte Pawlyn, PhD^1,2

¹The Institute of Cancer Research, London, United Kingdom
²The Royal Marsden NHS Foundation Trust, London, United Kingdom

Maria Papatsirou^1*, Christos Kontos^1*, Ioannis Ntanasis-Stathopoulos, MD, PhD, MSc^2*, Christina Sotiropoulou^1*, Christine-Ivy Liacos, MS^2*, Maria Gavriatopoulou^2*, Margaritis Avgeris^1,3*, Efstathios Kastritis, MD^2*, Meletios Dimopoulos, MD², Jerome Moreaux, PhD^4,5,6, Andreas Scorilas^1* and Evangelos Terpos, MD, PhD²

¹Department of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, Athens, Greece
²Department of Clinical Therapeutics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece
³Second Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
⁴Department of Biological Hematology, Montpellier University Hospital Center, Montpellier, France
⁵Université Montpellier, Montpellier, France
⁶Institute of Human Genetics, CNRS UM UMR 9002, University of Montpellier, MONTPELLIER, France

Torsten Steinbrunn, MD, PhD^1,2,3,4*, Ryosuke Shirasaki, MD, PhD^1,3,4,5*, Olga Dashevsky, PhD^1,3,4*, Huihui Tang, PhD^1,3,4*, Shizuka Yamano, BSc^1,4*, Phaik Ju Teoh, PhD^1,3,4,6,7*, Lisa Leypoldt, MD^1,3,4,8*, Brian Glassner, PhD^1,3,4*, Ricardo De Matos Simoes, PhD^1,3,4*, James Christensen, PhD^9* and Constantine S Mitsiades, MD^1,3,10,11

¹Department of Medicine, Harvard Medical School, Boston, MA
²Department of Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany
³Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA
⁴Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
⁵Department of Medical Oncology, Teikyo University Hospital, Tokyo, Japan
⁶Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
⁷Cancer Science Institute of Singapore, Singapore, Singapore
⁸Department of Hematology, Oncology and Bone Marrow Transplantation with Section of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
⁹Mirati Therapeutics, San Diego, CA
¹⁰Dana-Farber Cancer Institute, Boston, MA
¹¹Ludwig Center, Harvard Medical School, Boston, MA

Wen-Hui Cheng^1*, Daniela Simone Maichl^2*, Julius Arthur Kirner^1*, Stefanie Schmidt^3,4*, Carsten Patrick Ade^5*, Mengshi Yang^6*, Malik Salman Haider^6,7*, Robert Luxenhofer^6,8*, Lyudmyla Taranets^9*, Melanie Haffner-Luntzer^10*, Verena Fischer^11*, Anita Ignatius^11*, Nikita Popova^12* and Franziska Jundt, MD¹³

¹Department of Internal Medicine II, University Hospital Wuerzburg, Wuerzburg, Germany
²Department of Internal Medicine II, University Hospital Würzburg, Wuerzburg, Germany
³Department of Biochemistry and Molecular Biology, Biocenter, University of Würzburg, Wuerzburg, Germany
⁴Department of General, Visceral, Vascular and Pediatric Surgery, University Hospital Wuerzburg, Wuerzburg, Germany
⁵Department of Biochemistry and Molecular Biology, Biocenter, University of Wuerzburg, Wuerzburg, Germany
⁶Functional Polymer Materials, Chair for Advanced Materials Synthesis, Institute for Functional Materials and Biofabrication, Department of Chemistry and Pharmacy, University of Wuerzburg, Wuerzburg, Germany
⁷Department of Ophthalmology, University Hospital Wuerzburg, Wuerzburg, Germany
⁸Soft Matter Chemistry, Department of Chemistry and Helsinki Institute of Sustainability Science, Faculty of Science, University of Helsinki, Helsinki, Finland
⁹Department of Internal Medicine VIII, University Hospital Tuebingen, Tuebingen, Germany
¹⁰Institute of Orthopaedic Research and Biomechanics, University Medical Center Ulm, Ulm, Germany
¹¹Institute of Orthopedic Research and Biomechanics, University Medical Center Ulm, Ulm, Germany
¹²Department of Internal Medicine VIII, University Hospital Tuebingen, TueBingen, Germany
¹³Department of Internal Medicine II, University Hospital Wuerzburg, Estenfeld, Bayern, Germany

Tal Zvida-Bloch, MSc^1,2*, Eli Muchtar, MD³, Mali Salmon-Divon, PhD^1,4*, Angela Dispenzieri, MD³, Benjamin Bender, MD^5*, Adrian Duek, MD^6,7*, Merav Leiba, MD^6,7*, Moshe E Gatt, MD⁸, Ofer Shpilberg, MD, MPH^2,4,9* and Oshrat Hershkovitz-Rokah, PhD^1,2*

¹Department of Molecular Biology, Faculty of Natural Sciences, Ariel University, Ariel, Israel
²Translational Research Lab, Assuta Medical Center, Tel-Aviv, Israel
³Division of Hematology, Mayo Clinic, Rochester, MN
⁴Adelson School of Medicine, Ariel University, Ariel, Israel
⁵Orthopedic Department, Assuta Medical Center, Tel-Aviv, Israel
⁶Institute of Hematology, Assuta Medical Center, Ashdod, Israel
⁷Faculty of Health Science, Ben-Gurion University of the Negev, Beer Sheva, Israel
⁸Department of Hematology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
⁹Institute of Hematology, Assuta Medical Center, Tel-Aviv, Israel

Dimitra Karagkouni, PhD^1,2,3*, Giulia Cheloni, PhD^1,4*, Shivani Nanda^1,2,3*, Yuling Ma^1,2,3*, Shuoshuo Wang^1,3,5*, Leda Xanthi Katopodi, MS^3*, Isabella Saldarriaga, BS^1,4*, Yered Pita-Juarez, PhD^1,2,3*, David J. Chung, MD, PhD⁶, Nina Shah, MD^7,8, Natalie Callander, MD⁹, Binod Dhakal, MBBS¹⁰, Thinle Chodon^11*, Nikhil C. Munshi, MD^1,12, Kenneth C. Anderson, MD^1,12, Yvonne A. Efebera, MD¹³, Peiman Hematti, MD¹⁰, Hillard M. Lazarus, MD¹⁴, Ehsan Malek, MD¹⁴, Philip L. McCarthy, MD¹⁵, Ajay K. Nooka, MD, MPH¹⁶, Krina K. Patel, MD, MSc¹⁷, Aaron P. Rapoport, MD¹⁸, Robert J. Soiffer, MD^1,12, Edmund K. Waller, MD, PhD¹⁹, Marcelo C. Pasquini, MD, MS¹⁰, Jacalyn Rosenblatt, MD^1,4, David Avigan, MD^1,4 and Ioannis S Vlachos, PhD^1,2,3,5*

¹Harvard Medical School, Boston, MA
²Broad Institute of Harvard and MIT, Cambridge, MA
³Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA
⁴Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA
⁵Spatial Technologies Unit, Harvard Medical School Initiative for RNA Medicine, Beth Israel Deaconess Medical Center, Boston, MA
⁶Adult Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
⁷AstraZeneca, South San Francisco, CA
⁸Division of Hematology/Oncology, University of California San Francisco, San Francisco, CA
⁹University of Wisconsin, Carbone Cancer Center, Madison, WI
¹⁰Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI
¹¹Roswell Park Cancer Institute, Buffalo, NY
¹²Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA
¹³Blood and Marrow Transplant and Cellular Therapy Program, OhioHealth, Columbus, OH
¹⁴Case Western Reserve University, Cleveland, OH
¹⁵Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY
¹⁶Emory University, Winship Cancer Institute, Atlanta, GA
¹⁷MD Anderson Cancer Center, Houston, TX
¹⁸University of Maryland School of Medicine, Baltimore, MD
¹⁹Winship Cancer Institute, Emory University, Atlanta, GA

Ikuko Matsumura^1*, Tsukasa Oda^2*, Tetsuhiro Kasamatsu^3*, Yuki Murakami^4*, Rei Ishihara^4*, Ayane Ohmori^5*, Akira Matsumoto^6*, Nanami Gotoh^7*, Nobuhiko Kobayashi^6*, Yuri Miyazawa^6*, Yoshiyuki Ogawa^6*, Akihiko Yokohama⁸, Nobuo Sasaki^2*, Takayuki Saitoh^7* and Hiroshi Handa⁶

¹Department of Hematology, Gunma University Graduate School of Medicine, Maebashi, Japan
²Laboratory of Mucosal Ecosystem Design, Gunma University Institute for Molecular and Cellular Regulation, Maebashi, Gunma, Japan
³Medical Technology and Clinical Engineering, Gunma University of Health and Welfare, Maebashi, Japan
⁴Medical Technology and Clinical Engineering, Gunma University of Health and Welfare, Maebashi, Gunma, Japan
⁵Gunma University Graduate School of Health Science, Maebashi-Shi, GUN, Japan
⁶Department of Hematology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
⁷Gunma University Graduate School of Health Science, Maebashi, Gunma, Japan
⁸Blood Transfusion Service, Gunma University Hospital, Maebashi, Gunma, Japan

Liwen Wang^1*, Linzhi Xie^1*, Yi Zhou^1*, Yan Yu^1*, Shiming Tan^1*, Qian Cheng^2*, Rong He, MD³ and Xin Li^4*

¹Department of Hematology, The Third Xiangya Hospital of Central South University, Changsha, China
²Department of Hematology, Third Xiangya Hospital of Central South University, Changsha, China
³Division of Hematopathology, Mayo Clinic, Rochester, MN
⁴Department of Hematology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China